• 제목/요약/키워드: Bronchitis, Chronic

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Therapeutic Potential of Medicinal Plants and Their Constituents on Lung Inflammatory Disorders

  • Kim, Hyun Pyo;Lim, Hyun;Kwon, Yong Soo
    • Biomolecules & Therapeutics
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    • 제25권2호
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    • pp.91-104
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    • 2017
  • Acute bronchitis and chronic obstructive pulmonary diseases (COPD) are essentially lung inflammatory disorders. Various plant extracts and their constituents showed therapeutic effects on several animal models of lung inflammation. These include coumarins, flavonoids, phenolics, iridoids, monoterpenes, diterpenes and triterpenoids. Some of them exerted inhibitory action mainly by inhibiting the mitogen-activated protein kinase pathway and nuclear transcription $factor-{\kappa}B$ activation. Especially, many flavonoid derivatives distinctly showed effectiveness on lung inflammation. In this review, the experimental data for plant extracts and their constituents showing therapeutic effectiveness on animal models of lung inflammation are summarized.

원발성 악성 기관 종양 3례 (Primary Malignant Tracheal Tumor : 3 Cases)

  • 고중화;전영명;신상준;주희재
    • 대한기관식도과학회지
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    • 제3권1호
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    • pp.137-147
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    • 1997
  • The rarity of primary tumor of the trachea, which was recently estimated in a circumscribed population to be 2.7 new cases per million per year, explains the relatively limited experience that has been acquired even by major institutions. Although there may already by a high degree of airway obstruction, tracheal tumors are usually misdiagnosed as bronchial asthma or chronic bronchitis because of its nonspecific symptoms. Surgery is the treatment of choice. Recently, the authors experienced three cases of primary tracheal malignant tumors ; one case of mucoepidermoid carcinoma and two cases of adenoid cystic carcinoma. The authors report on these cases with a review of the literature for give help in differential diagnosis and treatment planing of tracheal tumor.

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수도권 대기오염 개선으로 인한 건강효과의 경제적 가치평가 - 컨조인트 분석법을 이용하여 - (Valuing the Health Effects on Air Quality Improvement - Using Conjoint Analysis -)

  • 조승국;장정인;김정인
    • 자원ㆍ환경경제연구
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    • 제15권5호
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    • pp.859-884
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    • 2006
  • 대기오염물질의 직접적인 건강피해는 조기사망률과 질병률을 급속도로 증가시키는 것이고 이는 선진국과 개발도상국에서 심각한 문제로 대두되고 있다. 또한 대기오염은 사람들의 활동을 제약하거나 의료지출을 증가시키는 등 사회적으로 심각한 비용을 초래한다. 본 연구에서는 이와 같은 대기오염의 건강효과에 대한 WTP를 도출하기 위해 컨조인트 분석법을 적용하였다. 본 연구에서는 기존연구와는 달리 건강피해 속성의 편익을 측정하기 위해, 폐암사망, 유아사망, 천식, 만성 기관지염, 급성 기관지염 등 총 다섯 가지 건강 관련 속성을 식별하였다. 분석결과, 유아사망 1단위(1%) 감소를 위한 가구당 연간 MWTP는 853.85원이었으며, 폐암, 천식, 급성 기관지염, 만성 기관지염이 한 단위(1,000만 명당 1명) 감소시키기 위한 가구당 MWTP는 각각 1,672원, 34.911원, 0.018원, 2.101원인 것으로 나타났다. 이 같은 분석결과를 토대로, 개선 가능한 최고수준의 대기질에 대한 건강효과의 가구당 WTP를 계산한 결과, 연간 3만 8,856원으로 나타났으며, 수도권 전체지역의 연간 가치는 연간 약 2,528억 원에 달하는 것으로 나타났다. 본 연구에서 도출된 실증분석 결과는 소비자들의 선호가 반영된 것이므로, 대기오염 정책결정과정에 정량적인 편익을 제시해 줄 수 있으며, 다양한 정책대안들에 대해 편익을 평가할 수 있게 해 준다.

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한국인의 만성 기관지염의 급성 악화 환자를 대상으로 한 Moxifloxacin 400mg 1 일 1회 요법과 Clarithromycin 500mg 1일 2회 요법의 치료효과 및 안전성 비교 (A Multicenter, Randomized, Open, Comparative Study for the Efficacy and Safety of Oral Moxifloxacin 400 mg Once a Day and Clarithromycin 500 mg Twice Daily in Korean Patients with Acute Exacerbations of Chronic Bronchitis)

  • 김승준;김석찬;이숙영;윤형규;김태연;김영균;송정섭;박성학;김호중;정만표;서지영;권오정;이신형;강경호;이이형;황성철;한명호
    • Tuberculosis and Respiratory Diseases
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    • 제49권6호
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    • pp.740-751
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    • 2000
  • 연구배경 : Moxifloxacin은 광범위한 미생물에 대한 뛰어난 효과, 안전한profile과 유리한 약물동력을 바탕으로 기존의 fluoroquinolones보다 한단계 진보된 약물이라고 할 수 있다. 이러한 효과는 베타-락탐계 혹은 기타 항생제에 내성을 보이는 미생물들에 대해 매우 유효하다. Moxifloxacin은 특히 Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, Chlamydia pneumoniae, Legionella spp. 그리고 Mycoplasma pneumoniae에 의해 유발되는 호흡기 감염에 특히 유용하다고 알려져 있다. 방법 : 다기관, 무작위, 공개, 비교시험으로 만성기관지염의 급성악화 환자를 대상으로 moxifloxacin 400 mg 1일 1회 7일 투여와 clarithromycin 500 mg 1일 2회 7일 투여 그룹간의 안전성과 유효성을 비교하였다. 결과 : 170명의 환자 중에서 87명이 moxifloxacin 투여군 이었고 83명이 clarithromycin 투여군이었다. Moxifloxacin 투여군종에서 76명(세균학적 효과분석은 35명), clarithromycin 투여군중에서 77명(세균학적 효과분석은 31명)이 치료효과분석에 포함되었으며 모든 환자에서 안전성을 분석하였다. 임상적 성공율은 Moxifloxacin 투여군 76명중에서 70명(92.1%) 이었고 clarithromycin 투여군 77명중에서 71명(92.2%) 으로 유사하였다. 세균학적 Moxifloxacin 투여군이 73.5%, clarithromycin 투여군이 54.8% 으로 Moxifloxacin 투여군에서 높게 나타났으나 통계적으로 유의한 차이는 보이지 않았다(p=0.098). 내원시 시행한 객담의 세균 감수성 검사에서 moxifloxacin 투여군이 clarithromycin 투여군보다 Streptococcus pneumoniae, Pseudomonas aeruginosa, Klebsiella pneumoniae에서 높은 감수성을 보여주었다(p<0.001). 이상반응은 moxifloxacin 투여군 86명중에서 12.8% 에서 나타났고, clarithromycin 투여군 83명중에서 21.7%에서 발생하였다. 두통(4.7% vs 4.8%, 각각 moxifloxacin 투여군 vs clarithromycin 투여군)과 소화불량(2.3% vs 6.0%, 각각 moxifloxacin투여군 vs clarithromycin 투여군) 이 두 군에서 가장 흔한 이상 반응이었다. 결론 : 본 임상시혐의 결과, 만성기관지염의 급성악화 환자의 치료에 있어서 moxifloxacin 400 mg 1일 1회 7일간 요법은 clarithromycin 500 mg 1일 2회 요법과 비교할 때 임상적으로 동등한 결과를 나타냈으며 미생물학적으로 우월한 결과를 보여주었다.

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서울지역 미세먼지 농도가 호흡기계 및 심혈관계의 외래 방문 및 입원과 진료비에 미치는 영향 (Hospital Visits, Admissions and Hospital Costs among Patients with Respiratory and Cardiovascular Diseases according to Particulate Matter in Seoul)

  • 이형숙
    • 한국환경보건학회지
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    • 제42권5호
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    • pp.324-332
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    • 2016
  • Objectives: The annual average of PM10 in Seoul was $45{\mu}/m^3$, which surpasses the WHO annual guidelines ($20{\mu}/m^3$). Most previous analyses of the effects of PM exposure have been retrospective studies using single hospital data, and fewer studies have attempted to address the relationship of PM10 and hospital costs. This study was conducted to investigate the effects of the concentration of PM10 on hospital visits, admissions and hospital costs in patients with respiratory and cardiovascular diseases. Methods: Medical data from the National Health Insurance Service and the monthly average of PM10 from National Institute of Environmental Research were used to identify the effects of PM10 on hospital visits, admissions and hospital costs. We applied Poisson regression and linear regression to perform the analysis. Results: The relative risks for admissions per $10{\mu}/m^3$ increase in PM10 were 23.11%, 10.2% and 6.9% increases for acute bronchiolitis, asthma and bronchitis, respectively. The relative risk for hospital visits per $10{\mu}/m^3$ increase in PM10 were 10.4%, 6.7% and 5.9% for chronic obstructive pulmonary disease, asthma and chronic sinusitis, respectively. For cardiovascular disease, the relative risk for admissions per $10{\mu}/m^3$ increase in PM10 were 2.2% and 2.1% increases in angina and acute myocardial infarction, respectively. A $10{\mu}/m^3$ increase in the monthly average of PM10 corresponded to 170,723,000 won (95% CI: 125,587,000-215,860,000 won), 123,636,000 won (95% CI: 47,784,000-199,487,000 won) and 78,571,000 won (95% CI: 29,062,000-128,081,000 won) increases in hospital costs for asthma, acute tonsillitis and chronic sinusitis, respectively. Conclusion: Hospital admissions for respiratory and cardiovascular disease were associated with PM10 levels. PM10 exposure is also associated with increased costs for respiratory diseases.

Secretory Differentiation of Hamster Tracheal Epithelial Cells Increases Activation of Matrix Metalloproteinase-2

  • Shin, Chan-Young;Lee, Woo-Jong;Park, Kyu-Hwan;Ryu, Jae-Ryun;Ko, Kwang-Ho
    • Biomolecules & Therapeutics
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    • 제12권1호
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    • pp.1-8
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    • 2004
  • In chronic airway inflammatory diseases such as asthma and chronic bronchitis, it has been suggested that matrix metalloproteinases secreted from infiltrating neutrophil contribute the pathogenesis of the disease and have been a focus of intense investigation. We report here that hamster tracheal surface epithelial goblet cells (HTSE cells) produce matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of metalloproteinase-2 (TIMP-2). Matrix metalloproteinase activities were investigated using [$^3H$]collagen-digestion assay and gelatin zymography. The subtype of matrix metalloproteinases expressed from HTSE cells was MMP-2 (gelatinase A), which was determined by Western blot with various subtype selective anti-matrix metalloproteinase antibodies. The MMP-2 and TIMP-2 cDNAs from HTSE cells were partially cloned by RT-PCR and they reveal more than 90% of sequence homology with those from human, rat and mouse. The collagenolytic activity was increased with the secretory differentiation of the HTSE cell and it was found that zymogen activation was responsible for the increased MMP-2 activity in HTSE cells. The results from the present study suggest that the metaplastic secretory differentiation of airway goblet cells may affect chronic airway inflammatory process by augmenting the zymogen activation of MMP-2.

심한 호흡곤란을 보인 다발성 소결절성 폐질환 (Multiple Small Nodular Lung Lesions with Severe Dyspnea)

  • 양석철;이경상;윤호주;신동호;박성수;이정희;함시영;이철범
    • Tuberculosis and Respiratory Diseases
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    • 제43권2호
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    • pp.285-290
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    • 1996
  • 저자들은 특징적인 임상 증상과 함께 전형적인 흉부 x-선 및 고해상 흉부 전산화 단층 촬영을 보이는 미만성 법세기관지염 환자에서 흉강경을 이용한 폐생검으로 확진하여 erythromycin 소량 투여로 임상적 효과를 얻은 1예를 문헌 고찰과 함께 보고는 바이다.

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Prevalence and Impact of Comorbidities in Individuals with Chronic Obstructive Pulmonary Disease: A Systematic Review

  • dos Santos, Natasha Cordeiro;Miravitlles, Marc;Camelier, Aquiles Assuncao;de Almeida, Victor Durier Cavalcanti;Maciel, Roberto Rodrigues Bandeira Tosta;Camelier, Fernanda Warken Rosa
    • Tuberculosis and Respiratory Diseases
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    • 제85권3호
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    • pp.205-220
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    • 2022
  • This study aimed to describe the prevalence of comorbidities associated with chronic obstructive pulmonary disease (COPD) and their relation with relevant outcomes. A systematic review based on the PRISMA methodology was performed from January 2020 until July 2021. The MEDLINE, Lilacs, and Scielo databases were searched to identify studies related to COPD and its comorbidities. Observational studies on the prevalence of comorbidities in COPD patients and costs with health estimates, reduced quality of life, and mortality were included. Studies that were restricted to one or more COPD pain assessments and only specific comorbidities such as osteoporosis, bronchitis, and asthma were excluded. The initial search identified 1,409 studies and after applying the inclusion and exclusion criteria, 20 studies were finally selected for analysis (comprising data from 447,459 COPD subjects). The most frequent COPD comorbidities were: hypertension (range, 17%-64.7%), coronary artery disease (19.9%-47.8%), diabetes (10.2%-45%), osteoarthritis (18%-43.8%), psychiatric conditions (12.1%-33%), and asthma (14.7%-32.5%). Several comorbidities had an impact on the frequency and severity of COPD exacerbations, quality of life, and mortality risk, in particular malignancies, coronary artery disease, chronic heart failure, and cardiac arrhythmias. Comorbidities, especially cardiovascular diseases and diabetes, are frequent in COPD patients, and some of them are associated with higher mortality.

KAAACI Evidence-Based Clinical Practice Guidelines for Chronic Cough in Adults and Children in Korea

  • Song, Dae Jin;Song, Woo-Jung;Kwon, Jae-Woo;Kim, Gun-Woo;Kim, Mi-Ae;Kim, Mi-Yeong;Kim, Min-Hye;Kim, Sang-Ha;Kim, Sang-Heon;Kim, Sang Hyuck;Kim, Sun-Tae;Kim, Sae-Hoon;Kim, Ja Kyoung;Kim, Joo-Hee;Kim, Hyun Jung;Kim, Hyo-Bin;Park, Kyung-Hee;Yoon, Jae Kyun;Lee, Byung-Jae;Lee, Seung-Eun;Lee, Young Mok;Lee, Yong Ju;Lim, Kyung-Hwan;Jeon, You Hoon;Jo, Eun-Jung;Jee, Young-Koo;Jin, Hyun Jung;Choi, Sun Hee;Hur, Gyu Young;Cho, Sang-Heon;Kim, Sang-Hoon;Lim, Dae Hyun
    • Allergy, Asthma & Immunology Research
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    • 제10권6호
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    • pp.591-613
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    • 2018
  • Chronic cough is common in the community and causes significant morbidity. Several factors may underlie this problem, but comorbid conditions located at sensory nerve endings that regulate the cough reflex, including rhinitis, rhinosinusitis, asthma, eosinophilic bronchitis, and gastroesophageal reflux disease, are considered important. However, chronic cough is frequently non-specific and accompanied by not easily identifiable causes during the initial evaluation. Therefore, there are unmet needs for developing empirical treatment and practical diagnostic approaches that can be applied in primary clinics. Meanwhile, in referral clinics, a considerable proportion of adult patients with chronic cough are unexplained or refractory to conventional treatment. The present clinical practice guidelines aim to address major clinical questions regarding empirical treatment, practical diagnostic tools for non-specific chronic cough, and available therapeutic options for chronic wet cough in children and unexplained chronic cough in adults in Korea.

서울시(市) 대기오염(大氣汚染)이 시민보건(市民保健)에 미치는 영향(影響)에 관(關)한 조사연구(調査硏究) (Epidemiological Study of Air Pollution and Its Effects on Health of Urban Population)

  • 정규철
    • Journal of Preventive Medicine and Public Health
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    • 제2권1호
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    • pp.5-22
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    • 1969
  • The urban population of our country is rapidly increasing due to many factors of social structure, and sociologists are predicting that the increase rate of the urban population will be over 50% in 1980's. Above all, the population of the capital city of Seoul, is at present more than four millions. Such centring of people in cities, together with the improvement of the standards of living, caused rapid increase in the amount of fuel consumption, and this consumption of fuels became one of the primary sources of the air pollution in cities. Moreover, the heavy traffic, construction of many tall buildings, and the increasing number of new factories due to the industrial development-all these are contributing to make the matter of air pollution worse and worse in the Metropolitan, whose geographical location is quite unfavorable considered from the view point of air pollution. Most homes in Seoul use briquet as fuel, while oils are used in tall buildings. The CO, $SO_2$, and smoke that come from burning of these fuels are a great threat to the health of the urban population. With the purpose of examining the influence of air pollution upon the public health, written inquiries were made upon respiratory diseases, and the carboxyhemoglobin saturation in the blood was measured to determine whether the air pollution may affect the health of the urban population. Method of Health Examination (1) Investigation of Respiratory Diseases Patients' records were examined to figure out the monthly ambulance rate of respiratory patients to the total number of patients treated. On the other hand, by using the questionnaire form approved by the Medical Research Council's Committee on Research into Chronic Bronchitis, investigators interviewed the examinees and inquired into the respiratory symptoms. (2) Measuring of Carboxyhemoglobin Saturation From the ear lobe of the examinees, with the use of the melangeur for the white blood cell counting, blood was taken, and after diluting it ten times with 0.1% $Na{2}CO_{3}$, again diulting it 20 times with 0.5% $Na_{2}\;CO_{3}$, its absorbancy was measured. The following results are obtained from the investigation. (1) It was found out that 7.7% of the total patients under treatment were suffering from upper respiratory infection, acute or chronic bronchitis, bronchial asthma, pulmonary emphysema and bronchiectasis. Of them all, patients with upper respiratory infection numbered the greatest with 4.8% and patients with acute or chronic bronchitis the next with 2.1%, and their monthly ambulance rate was high from December to February during the winter, and from April to May and from September to October during the changeable seasons. (2) The daily ambulance rate of respiratory patients, it was revealed, had a close connection with the concentration of $SO_2$ and CO in the air. (3) It was found out that men were more subject to respiratory disease than women, and both men and women were more liable to the diseases with the advancing of age. (4) People living at Choong-ku with the heavy traffic and in the industrial zones of Yeungdungpo had high frequency of respiratory symptoms. (5) Considered from the view point of occupations, high frequency was found among those without job, with jobs unknown, merchants and intdustrial workers, whose social status was rather low and traffic policemen who were always exposed to the exhaust gas of cars. As for women, the frequency was detected in the order of those from high to low, housewives who were exposed to briquet gas, women with jobs unknown, women without jobs, whose social status was low. (6) Ex-smokers rather than smokers, of both sexes, had higher frequency. As for men, heavy smokers had high frequency, while in women light smokers had rather high frequency which was presumed to be due to their average old age. (7) Men's average of carboxyhemoglobin saturation was 9.48%, while women's was 11.3%, higher than men's. (p<0.05). Age meant no difference in the case of men, but as for women, the saturation was remarkably high between the ages from 20 to 60. (8) No regional difference was detected in the carboxyhemoglobin saturation. (9) The carboxyhemoglobin saturation was found, in the case of men, in the order of office workers, traffic policemen, students, the unemployed, merchants and industrial workers, drivers; and as for women, the order was housewives, office workers, merchants and industrial workers. (10) No significant correlation was found between the carboxyhemoglobin saturation and the concentration of CO detected in kitchens, or between the carhoxyhemoglobin saturation and the passing of time after exposure to briquet gas. No difference of carboxyhemoglobin saturation was detected between smokers and non-smokers, and the degrees of smoking; only, significant negative correlation was found between the passing of time after smoking and the carboxyhemoglobin saturation. It is ture that air pollution causes or aggravates the respiratory diseases, increases the carboxyhemoglobin saturation in the blood, but what seems to be more hazardous to the health is the air polluted by the briquet gas in the kitchens and on-dol rooms rather than the atmospheric air pollution.

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