• Korean Journal of Pharmacognosy
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• v.31 no.3
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• pp.264-267
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• 2000

Anti-human immunodeficiency virus (HIV) type I protease (PR) and anti-lipid peroxidation effects on Rosa davurica were investigated. Of the various parts tested from R. davurica, the water extracts of stem and leaves inhibited the HIV-1 PR activity by more than 45% at a concentration of $100\;{mu}g/mL$. Hyperoside from the percarp of title plant showed 25% inhibition on HIV-1 PR at $200\;{mu}M$. The methanol extract of the root of R. davurica reduced the level of lipid peroxides induced by bromobenzene in vivo.

• Journal of the Korean Chemical Society
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• v.10 no.1
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• pp.1-3
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• 1966

The organic yields (i.e. fraction of nuclear events resulting in organic compound formation) of the radioative neutron capture reactions of halogens in purified bromobenzene have been determined varying extraction time, at $100^{\circ}C$ for thermal effect, varying irradiation time, varying neutron flux and with additional U. V. irradiation. Among the important results are; (1) The organic yields show no remarkable fluctuations with time following neutron irradiation; (2) The organic yields show no change with thermal energy; (3) The organic yields of degassed samples are same in different length of irradiation time whereas the yields of the samples in open air appear to increase with increasing time of irradiation (4) The organic yields increase remarkably with increased neutron flux; (5) The organic yields show a sharp increase by additional U. V. irradiation after neutron irradiation.

• Proceedings of the Korean Society for Applied Microbiology Conference
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• 2004.06a
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• pp.316-320
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• 2004

• Molecular & Cellular Toxicology
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• v.1 no.4
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• pp.268-274
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• 2005

Bromobenzene (BB) is well known hepatotoxicant. Also, BB is an industrial solvent that arouses toxicity predominantly in the liver where it causes centrilobular necrosis. BB is subjected to Cytochrome P450 mediated epoxidation followed by either conjugation with glutathione, enzymatic hydrolysis or further oxidation. In this study, we focused on BB-induced gene expression at non-hepatotoxic dose. Mice were exposed to two levels of BB, sampled at 24 h, and hepatic gene expression levels were determined to evaluate dose dependent changes. When examining the toxic dose of BB treated group in other previous studies, genes related to heat shock protein, oxidative stress, and drug metabolism are expressed. Compared to these results, our study, in which non-toxic dose of BB was administrated, showed similar patterns as the toxic conditions above. The purpose of the study was to select genes that showed changes in relation to the differing dose through confirmation of the difference within transcriptomic boundaries, but those that are not detected by the existing classic toxicology tools in non-hepatotoxic dose.

• Bulletin of the Korean Chemical Society
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• v.32 no.2
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• pp.659-663
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• 2011

The photodissociation dynamics of bromobenzene near 234 nm has been investigated using a two-dimensional photofragment ion-imaging technique coupled with a state-selective [2+1] resonance-enhanced multiphoton ionization (REMPI) scheme. The nascent Br atoms are produced by the primary C-Br bond dissociation, which leads to the formation of $C_6H_5$ ($\tilde{X}$) and Br($^2P_j$, j = 1/2, 3/2). The observed translational energy distributions have been fitted by a single Boltzmann function and two Gaussian functions. Trimodal translational energy distributions of Br($^2P_j$) have been assigned to the direct/indirect dissociation mechanisms originating from the initially excited $^3({\pi},{\pi}^*)$ state. The assignments have been confirmed by the recoil anisotropy and distribution width corresponding to the individual components.

• Proceedings of the PSK Conference
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• 2000.10a
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• pp.237.3-238
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• 2000

• Bulletin of the Korean Chemical Society
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• v.15 no.9
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• pp.772-774
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• 1994

The cobalt catalyzed carbonylation of bromobenzene having protected aldehyde group gives the corresponding ester in good yields, but 2-bromobenzaldehyde gives 3-alkoxyphthalide in the noticeable yield instead of alkyl 2-formylbenzoates.

• Korean Journal of Environmental Biology
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• v.17 no.4
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• pp.513-519
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• 1999

Volatile organic compounds (VOCs) were analyzed on the seawater from 17 stations in Kwangyang Bay throughtout the year. We could not detect 10 VOCs; methylene chloride, tetrachloromethane, 1, 1, 1-trichloroethane, trichloroethane, 1, 1, 1, 2-tetrachloroethane, trichloroethylene, bromoethane, dibromoethane, bromobenzene, 1-ethyl-3-methylbenzene. The other VOCs-chloroform, 1, 2-dichloroethane, ethylbenzene, benzene, toluene, m, p-xylene, methylethylketone, styrene, hexane-were detected with a little variance according to the sampling stations and the sampling seasons. The concentrations of chloroform (0.6 ~ 49.9 $\mu$g/1) and toluene (0.42 ~ 48.3 $\mu$g/1) were high and they were detected more frequently than the other detected VOCs. We also tried to seek the correlation between the physicochemical environmental factors and VOCs. Only toluene had the high correlation coefficient with the water temperature (r = -0.524) and with the pH (r = 0.319). Correlation between VOCs themselves showed some interesting results. The benzene had high correlation coefficient (r = 0.549 ~ 0.662) with three VOCs such as toluene, m, p-xylene, ethylbenzene. From these results it is suggested that VOCs might be discharged simultaneously in Kwangyang Bay.

• Korean Journal of Pharmacognosy
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• v.29 no.3
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• pp.231-236
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• 1998

Three flavonoid glycosides have been isolated from the aerial part of Armoracia rusticana P. (Cruciferae) in Korea and identified by means of spectral analysis as $kaempferol-3-O-{\beta}-D-xylofuranoside(l)$, $kaempferol-3-O-{\beta}-D-galactopyranoside(2)$ and $kaempferol-3-O-{\beta}-D-xylofuranosyl(1\rightarrow2)-b{\beta}-D-galactopyranoside(3)$. When 1 mg/ml of the methanol extract from the aerial part of this plant was added, lipid peroxide formation in the bromobenzene-treated rat liver decreased by 64%. Among the components isolated from title plant, compounds 2 and 3 reduced the formation of lipid peroxide by 16% and 39% respectively at the concentration of ${10}^{-1}$ mg/ml.

• Natural Product Sciences
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• v.7 no.2
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• pp.49-52
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• 2001

Anti-lipid peroxidative activity and phytochemical study on the leaves of Glycine max Meer. were investigated. The methanol extract of the leaves of G. max reduced the level of lipid peroxides induced by bromobenzene in vitro. From the leaves of this plant, apigenin, genistein $7-O-{\beta}-D-glucopyranoside$, kaempferol $3-O-{\beta}-D-glucopyranoside$, and kaempferol 3-O-sophoroside were isolated and characterized by spectral data.