• Asian Pacific Journal of Cancer Prevention
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• v.16 no.17
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• pp.7935-7941
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• 2015

The aim of this study was to implement massive parallel sequencing (MPS) technology in clinical genetics testing. We developed and tested an amplicon-based method for resequencing the BRCA1 and BRCA2 genes on an Illumina MiSeq to identify disease-causing mutations in patients with hereditary breast or ovarian cancer (HBOC). The coding regions of BRCA1 and BRCA2 were resequenced in 96 HBOC patient DNA samples obtained from different sample types: peripheral blood leukocytes, whole blood drops dried on paper, and buccal wash epithelia. A total of 16 random DNA samples were characterized using standard Sanger sequencing and applied to optimize the variant calling process and evaluate the accuracy of the MPS-method. The best bioinformatics workflow included the filtration of variants using GATK with the following cut-offs: variant frequency >14%, coverage ($>25{\times}$) and presence in both the forward and reverse reads. The MPS method had 100% sensitivity and 94.4% specificity. Similar accuracy levels were achieved for DNA obtained from the different sample types. The workflow presented herein requires low amounts of DNA samples (170 ng) and is cost-effective due to the elimination of DNA and PCR product normalization steps.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.3
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• pp.1225-1233
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• 2015

This study aims to clarify the psychosocial reactions of female patients with gynecological cancer undergoing chemotherapy and in the process of suffering from alopecia and to examine their nursing support. The target group comprised female patients who had received two or more cycles of chemotherapy, were suffering from alopecia, and were aged 30-65. Data were collected from semi-structured interviews, conducted from the time the patients were informed by their doctors that they might experience alopecia due to chemotherapy to the time they actually experienced alopecia and until they were able to accept the change. Inductive qualitative analysis was employed to close in on the subjective experiences of the cancer patients. The results showed the existence of six phases in the psychosocial reactions in the process of alopecia: phase one was the reaction after the doctor's explanation; phase two was the reaction when the hair starts to fall out; phase three was the reaction when the hair starts to intensely fall out; phase four was the reaction when the hair has completely fallen out; phase five was the reaction to behavior for coping with alopecia; and phase six was the reaction to change in interpersonal human relationships. The results also made it clear that there are five types of reaction patterns as follows: 1) treatment priority interpersonal relationship maintenance type; 2) alopecia agitated interpersonal relationship maintenance type; 3) alopecia agitated interpersonal relationship reduction type; 4) alopecia denial interpersonal relationship reduction type; and 5) alopecia denial treatment interruption type. It is important to find out which of the five types the patients belong to early during treatment and provide support so that nursing intervention that suits each individual can be practiced. The purpose of this study is to make clear the process in which patients receiving chemotherapy come to accept alopecia and to examine evidence-based nursing care on patients with strong mental distress from alopecia.

• Journal of the Korean Society of Costume
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• v.67 no.1
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• pp.147-168
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• 2017

This study examines the types and characteristics of women's garments excavated in the early Joseon Dynasty before 1592. The study sorts out headgear, jacket, skirt and trousers, and coats from the historical texts in the early Joseon Dynasty and excavated women's wears in the fifteenth and sixteenth centuries, and analyzes their textiles and patterns. The Joseon women's garments convey several features. They are wide across the chest and square shaped collar with virtually straight sleeves. While their breast-ties are extremely little for the size of clothes, they do not have any inner-tie. They have broad and short dongjeongs which seem to be hard to be adjusted. There are a variety of headgear. Jang-Jeogori slit down in both sides. The Jeogori after the seventeenth century transformed a more practical form of a fitting dress to an individual body in comparison with the sixteenth jeogori. It is identified that the fabrics in the early Joseon period were woven more diversely and colorfully than the late Joseon period. Most of the excavated fabrics in the sixteenth century were in silk. Materials for adornments before 1592 were not much diverse and their designs mostly contained patterns of lotus flowers, patterns of cloud and treasures with oblique lines. The colors are mainly brown, navy and green. The Joseon women's clothes were comprised of skirts with folded hem, coat with round collars, wide leg pants, Jangot, long-sleeved coat with folding collars, and quadrangular pieces of cloth in various sizes, or mu and so forth. Joseon women's clothes, like men's wears, partake of active functions in their headgears, wide leg pants, styles in short front and long back, and coat with round collars.

• Journal of Environmental Science International
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• v.29 no.5
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• pp.519-529
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• 2020

The purpose of this study was to provide basic health care data for the climate aspects of park re-cultivation by evaluating air ions according to the type of vegetation in the valley and upper slopes of the mountain park. Simple negative or positive air ions were expected to show the same tendencies, so they were analyzed in terms of correcting the air ion index. By analyzing the air ions according to the topography, it was found that valley > slope in terms of the air ion index. When analyzing air ions according to tree species, we found that evergreen conifers in the valley > the deciduous broad-leaved trees in the valley > the evergreen conifers in the slope = the deciduous broad-leaved trees in the slope. For DBH(Diameter at breast height), the valley large pole > slope large pole > slope medium hard wood, while crown density was analyzed as valley dense > slope dense> valley proper > slope proper. Layered structure analysis showed that the multi-layer structure of the valley > multi-layer structure of the slope = the single-layer structure of the valley > the single-layer structure of the slope. The correlation coefficient was determined according to vegetation type and air ion index in the order of DBH > crown density > layer structure > geomorphic structure. In this study, limits exist except for ridge line, valley, and slopes in urban mountain parks. Therefore, analysis should be made considering both topographical structure and various vegetation types in future studies of air ions.

• Journal of Physiology & Pathology in Korean Medicine
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• v.20 no.5
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• pp.1117-1125
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• 2006

A study is made on the chest pain in the perspective of Hyungsang medicine. The following are the conclusions produced by the examination on the clinical cases of chest pain. Excessive atmospheric influences (wind, rain, cold and summer heat) are the exogenous causes of chest pain. The endogenous causes are diet, dwelling, sexual life and emotions. Persons of bird type are attacked by the chest pain because of emotional depressions. Those of running animal type get sick of chest pain when wood checks earth. Those of turtle type are a afflicted with chest pain due to depression and stagnation of Ki. Those of fish type suffer from chest pain when the ministerial fire of the liver and kidney becomes hyperactive. Chest pain is causes by leakage of Jung for the Jung kwa person, by stagnation of Ki for the Ki kwa person, by flaming fire due to deficiency of Yim for the Shin kwa person and Dy failure of water and fire in complementing each other for the Hyul kwa person. Chest pain often occurs to persons with the following characteristics upward nose, Dig eyes, chapped lips, pronounced foot of nose, red or yellow complexion, frowning face and wrinkles on the nasal radix. Among the six meridian types, chest pain is often found in the persons of Yangmyung and Taeum meridians. Women suffer from chest pain more often than men because breast is a center of life to her.

• Safety and Health at Work
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• v.10 no.3
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• pp.347-354
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• 2019

Background: The aim of this study was to describe the types of diseases that developed in semiconductor workers who have registered with the Korea Workers' Compensation and Welfare Service (KWCWS) and to identify potential common occupational characteristics by the type of claimed disease. Methods: A total of 55 semiconductor workers with cancer or rare diseases who claimed to the KWCWS were compared based on their work characteristics and types of claimed diseases. Leukemia, non-Hodgkin lymphoma, and aplastic anemia were grouped into lymphohematopoietic (LHP) disorder. Results: Leukemia (n = 14) and breast cancer (n = 10) were the most common complaints, followed by brain cancer (n = 6), aplastic anemia (n = 6), and non-Hodgkin lymphoma (n = 4). LHP disorders (n = 24) accounted for 43%. Sixty percent (n = 33) of registered workers (n = 55) were found to have been employed before 2000. Seventy-six percent (n = 42) of registered workers and 79% (n = 19) among the registered workers with LHP (n = 24) were found to be diagnosed at a relatively young age, ${\leq}40years$. A total of 18 workers among the registered semiconductor workers were finally determined to deserve compensation for occupational disease by either the KWCWS (n = 10) or the administrative court (n = 8). Eleven fabrication workers who were compensated responded as having handled wafers smaller than eight inches in size. Eight among the 18 workers compensated (44 %) were found to have ever worked at etching operations. Conclusion: The distribution of cancer and rare diseases among registered semiconductor workers was closely related to the manufacturing era before 2005, ${\leq}8$ inches of wafer size handled, exposure to clean rooms of fabrication and chip assembly operations, and etching operations.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.22 no.2
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• pp.49-57
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• 2019

The street trees increase the liveability of cities by reducing stormwater runoff, improving air quality, storing carbon, providing shade, and ameliorating the urban heat-island effect. In this study, the health status of street trees in Suwon was evaluated, and the factors affecting the growth of the trees were also derived. In order to evaluate the growth and health of street trees, field survey was carried out on a total of 125 trees in 25 sections of the Deogyeong-daero where is through the city. During the field survey, the following items were examined: Street trees health status (i.e. species, height, DBH (diameter at breast height), planting types, vigor, etc.), soil factors (i.e. soil temperature, humidity, pH, hardness, etc.), and environmental factors (i.e. landuse, road width, etc.). As the results of field survey, the main species of the street trees was Zelkova serrata, which was healthy in most of the sections. The factors such as planting types, soil temperatures, tree root cover, road extension, distance from the road were derived to affect the growth and health of street trees, and the differences were significant. The results of this study were derived the following conclusions for vigorous street trees: First, it is important to install and maintain the protection facilities like tree root cover for the growth of trees. Second, it is necessary to discuss how to plant multiple trees in narrow spaces like a street green space. Third, it is important to provide appropriate soil conditions continuously for growth of threes. Finally, it should be utilized as a mitigation measure of urban heat island effects.

• Journal of Practical Agriculture & Fisheries Research
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• v.17 no.1
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• pp.73-84
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• 2015

Comparison of the standard and instruction for grade and quality of landscape plants between Korea and foreign countries indicates that the individual country characteristically develops and uses their own standards for landscape plants. Ultimate aim of these regulations is to develop the standard of landscape plants classified by kinds, types and purposes to improve the quality of landscape plants. This study analyzed the differences of standards and instructions for landscape plants between Korea and other countries such as Germany, Switzerland, America, Canada and Japan. Our results indicated that Korea and Japan used the diameter at 1.2m above from ground surface for the diameter at breast height(DBH) whereas Germany and Switzerland at 1.0m above from ground surface. In case of America and Canada, the standard of landscape plants included crown width, height and DBH of plants. In Germany, the standard for creeping plants and herbaceous flowers was determined by the type and the root size of plants with the standard of containers(seven to eleven types). This research would be helpful for developing the practical and environmentally suitable guideline for the grade and quality of landscape plants and also for developing the standardized distribution structures and cultivation techniques for landscape plants in Korea.

• Korea Journal of Hospital Management
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• v.28 no.1
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• pp.14-23
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• 2023

Purposes: The Specialty hospital designation policy had launched in 2011 and 110 designated specialty hospitals have been operating nationwide in 2022. This study was to estimate the market share of specialty hospitals for the specific diseases compared to other types of hospitals. Methodology: Data were derived from the National Health Insurance Claim data from 2018 to 2019. Subjects were all the inpatients with MDC(Major Disease Category) that specialty hospitals specialized in. A total of 34,231,387 claims were analyzed to estimate the market share. Findings: 90 specialty hospitals were responsible for 2.4 percent of inpatient care with specific diseases for specialty hospitals. There were regional variations in the market share of the specialty hospitals as the number of specialty hospitals in regions. Specialty hospitals' market shares were relatively high in burn(31.3%), ophthalmology(16.4%), obstetrics and gynecology(7.1%), alcohol(6.0%), joint(3.7%), spine(2.7%). After adjusting the number of inpatients per hospital, hospitals specialized in burn, alcohol, ophthalmology, breast, joint, obstetrics and gynecology, and hand replantation had treated more patients than tertiary hospitals. Practical Implications: Although specialty hospitals' market share was small, some types of specialty hospitals had an impact on the regional market as well as the national level market. To improve patients' accessibility to a specialty hospital, it is necessary to government supports non-specialized hospitals to change into specialty hospitals in certain fields and regions where the number of specialty hospitals is insufficient.

• The Journal of Korean Society for Radiation Therapy
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• v.30 no.1_2
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• pp.129-138
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• 2018

Purpose : An aim of this study was to compare the effect of multi leaf collimator(MLC) types for high dimension radiotherapy in treatment sites used clinically. Material and Method : 70 patients with lung cancer, spine cancer, prostate cancer, whole pelvis, head and neck, breast cancer were included in this study. High definition(HD) MLC of TrueBeam STx (Varian Medical system, Palo Alto, CA) and millenium(M) MLC of VitalBeam (Varian Medical system, Palo Alto, CA) were used. Radiotherapy plans were performed for each patient under same treatment goals with Eclipse (Version 13.7, Varian Palo Alto USA, CA). To compare the indicators of the radiotherapy plans, planning target volume(PTV) coverage, conformity index(CI), homogeneity index(HI), and clinical indicators for each treatment sites in normal tissues were evaluated. To evaluate low dose distribution, $V_{30%}$ values were compared according to MLC types. Additionally, length and volume of targets for each treatment sites were investigated. Result : In stereotatictic body radiotherapy(SBRT) plan for lung, the average value of PTV coverage was reduced by 0.52 % with HD MLC. With SBRT plan using HD MLC for spine, the average value of PTV coverage decreased by 0.63 % and maximum dose decreased by 1.13 %. In the test of CI and HI, the values in SBRT plan with HD MLC for spine were 1.144, 1.079 and the values using M MLC were 1.160, 1.092 in SBRT plan for lung, The dose evaluation of critical organ was reduced by 1.48 % in the ipsilateral lung mean dose with HD MLC. In prostate cancer volumetric modulated arc therapy(VMAT) with HD MLC, the mean dose and the $V_{30}$ of bladder and the mean dose and the $V_{25}$ of rectum were reduced by 0.53 %, 1.42 %, 0.97 %, and 0.69 %, respectively (p<0.05). The average value of heart mean dose was reduced by 0.83 % in breast cancer VMAT with M MLC. Other assessment indices for treatment sites showed no significant difference between treatment plans with two types of MLC. Conclusion : Using HD MLC had a positive impact on the PTV coverage and normal tissue sparing in usually short or small targets such as lung and spine SBRT and prostate VMAT. But, there was no significant difference in targets with long and large such as lung, head and neck, and whole pelvis for VMAT.