• 복식문화연구
• /
• 제13권2호
• /
• pp.318-328
• /
• 2005

Our interest in human body is more and more increasing. Not only academic and art communities but also other social communities show a keen interest in the human body. Especially, the breast of women's body parts may be comparable to men's penis because it is protruded. The breast which sexually distinguishes women from men becomes an important topic in the fashion design community. Therefore, such designs which emphasize the breast are being introduced in a natural way. This paper aims at examining the reason and symbolism for the exposure of breast and analyzing the fashion design that breast is exposed. This study will help us grasp the meaning which the design has. The exposure's scope of breast in the design includes the partial exposure, total exposure and the concealment of breast. But these all have their effects in each scope. For this paper, some general things were investigated. They are as follows: the phases of breast exposure in the fashion design, the exposure of breast expressed in the works of fine art, and the alteration of breast-exposing phenomenon shown in apparels. Then, each type of breast-exposing design shown in the women's fashion was analyzed from the middle of 1980s' when the phenomenon of breast exposure occurred to the year 2004. These could be divided into 4 types. They include a suggestive type, an exaggerative type, an open type and a reproductive type. As the result of analysis of 4 types, such meanings of design as an emphasis of femininity, an expression of liberty, a symbol of maternity and a commercialization of sex could be analogized.

• Archives of Plastic Surgery
• /
• 제48권4호
• /
• pp.353-360
• /
• 2021

Background Despite evidence supporting the safety of breast implants, some women associate their implants with adverse health effects and have called this syndrome "breast implant illness." We sought to characterize breast implant illness symptoms and to report how implant removal affects their symptoms. Methods An anonymous 20 question survey was administered to the Facebook group: "UTAH Breast Implant Illness" to characterize the symptoms these women attributed to their breast implants. Several questions allowed us to evaluate how implant removal affected women's symptoms. Results Of the 182 respondents, 97% report that implants negatively affect their health and 95% identify these symptoms with breast implant illness. Ninety-six percent of respondents had implants placed for cosmetic reasons and 51% had silicone implants. The most common symptoms associated with breast implant illness are brain fog (95%), fatigue (92%), joint pain (80%), and hair loss (74%). Sixty percent of respondents learned about breast implant illness from family/friends and/or social media platforms (56%), 40% of respondents had their implants removed, and 97% report relief of their symptoms post-removal (23% complete, 74% partial). Following explantation, there was a significant improvement in all but one reported symptom. An association was found between the number of symptoms reported prior to explantation and the number of symptoms resolving following explantation. Conclusions Breast implant illness is a syndrome characterized by fatigue, decreased focus, hair loss, and joint pain after the placement of breast implants. Nearly all patients report improvement of symptoms after implant removal. Significant efforts should be made to better understand breast implant illness and its etiology.

• 대한영상의학회지
• /
• 제84권5호
• /
• pp.1176-1180
• /
• 2023

과립세포종은 신경 또는 신경 주위 세포에서 생기는 드문 연부조직 종양이다. 저자들은 유방암 과거력을 가진 69세 여자 환자에서 액와부 과립세포종 증례를 보고하고 다양한 영상 소견을 논의하고자 한다. 초음파에서 왼쪽 액와부에 경계가 분명한 타원형의 비균질한 등에코, 고에코의 종괴였으며, 흉부 전산화단층촬영에서 대흉근의 바깥쪽에 경계가 분명한 타원형의 약간 조영 증강되는 종괴로 보였다. 초음파 유도하 조직 생검을 통해 과립세포종으로 최종 진단되었다. 추적 초음파에서 변화는 없었다. 과립세포종에 대해 잘 알고 있다면 조기 진단과 후속 관리를 용이하게 할 수 있을 것이다.

• BMB Reports
• /
• 제50권5호
• /
• pp.233-234
• /
• 2017

Aberrant expression of the polypeptide N-acetyl-galactosaminyltransferase (GALNTs) has been associated with cancer, but their function(s) in metastasis remains elusive. We have recently identified GALNT14, one of the O-GalNAc glycosylation-initiating enzymes, as a prognostic marker for pulmonary relapse in breast cancer patients. Furthermore, we showed that GALNT14 promotes lung metastasis by the following novel mechanisms: 1) enhancing metastasis initiation by inhibiting the anti-metastatic effect of BMP produced from the lung stroma, 2) exploiting growth signals (e.g. FGF) supplied by macrophages, for their growth into macrometastases in the lung environment. These multi-faceted roles of GALNT14 in lung metastasis are achieved by GALNT14-mediated inhibition and activation of the BMP and FGF signaling pathways, respectively. The link among GALNT14, its downstream pathways and lung metastasis, provides us with an opportunity to develop effective therapeutic intervention for breast cancer.

• Communications for Statistical Applications and Methods
• /
• 제26권4호
• /
• pp.411-430
• /
• 2019

Tumor development is driven by complex combinations of biological elements. Recent advances suggest that molecularly distinct subtypes of breast cancers may respond differently to pathway-targeted therapies. Thus, it is important to dissect pathway disturbances by integrating multiple molecular profiles, such as genetic, genomic and epigenomic data. However, missing data are often present in the -omic profiles of interest. Motivated by genomic data integration and imputation, we present a new statistical framework for pathway significance analysis. Specifically, we develop a new strategy for imputation of missing data in large-scale genomic studies, which adapts low-rank, structured matrix completion. Our iterative strategy enables us to impute missing data in complex configurations across multiple data platforms. In turn, we perform large-scale pathway analysis integrating gene expression, copy number, and methylation data. The advantages of the proposed statistical framework are demonstrated through simulations and real applications to breast cancer subtypes. We demonstrate superior power to identify pathway disturbances, compared with other imputation strategies. We also identify differential pathway activity across different breast tumor subtypes.

• 대한영상의학회지
• /
• 제82권6호
• /
• pp.1570-1574
• /
• 2021

산후에 발생하는 젖낭종은 수유 중인 여성에게서 흔히 나타나는 양성 질환이다. 유선후층 지방층, 유방확대 보형물 주변에 생긴 젖낭종은 비교적 드문 형태이다. 34세의 출산 후 1달이 지난 여성은 2주 전부터 시작된 좌측 유방의 확대를 주소로 내원하였다. 출산 후 지속적으로 유축기를 사용해왔다. 좌측 유방은 초음파상에서 보형물 주변에서 관찰되는 고에코의 액체성분으로 관찰되었다. 초음파 유도하 세침흡인으로 모유 성상의 액체가 배액되었다. 세포검사 결과에서 젖낭종을 시사하는 결정체들이 관찰되었다. 다양한 원인, 특히 유방 보형물 관련 역형성 거대 세포 림프종으로 인해 보형물 주변에 액체가 관찰될 수 있다. 영상의학적 소견, 임상적 정보 그리고 세포학적인 분석들을 종합하여 적절한 치료에 도움을 받을 수 있을 것으로 사료된다.

• Archives of Plastic Surgery
• /
• 제35권2호
• /
• pp.193-196
• /
• 2008

Purpose: TRAM flap reconstruction has settled down as a common method for breast reconstruction after mastectomy. There are a few surgical contraindication in TRAM flap surgery. Previous abdominal liposuction has been a relative contraindication in TRAM flap surgery. The authors present 2 patients of successful breast reconstruction using pedicled TRAM flaps, who previously underwent abdominal liposuction. Methods: Case 1: A 48-year-old woman with a right breast cancer visited for mastectomy and breast reconstruction. Her past surgical history was notable for abdominal liposuction 15 years ago. Skin sparing mastectomy and breast reconstruction with a pedicled TRAM flap was performed. Case 2: A 45-year-old woman with a left breast cancer visited us for mastectomy and autologous breast reconstruction. 3 years ago, she had an abdominal liposuction and augmentation mammaplasty in other hospital. Nipple sparing mastectomy and breast reconstruction was done using pedicled TRAM flap. Results: One year after the reconstruction, partial fat necrosis was developed in one case but there was no skin necrosis or donor site complication in both patients. Conclusion: As aesthetic surgery becomes more popular, increasing numbers of patients who have a prior abdominal liposuction history want for autologous tissue breast reconstruction. In these patients, TRAM flap surgery will be also used for breast reconstruction. But, the warning of fat necrosis and the use of preoperative Doppler tracing to evaluate the abdominal perforator may be beneficial to patients who had abdominal liposuction recently.

• Korean Journal of Radiology
• /
• 제21권9호
• /
• pp.1027-1035
• /
• 2020

Objective: To assess the appropriate follow-up interval, and rate and timepoint of cancer detection in women with Breast Imaging Reporting and Data System (BI-RADS) 3 lesions on screening ultrasonography (US) according to the type of institution. Materials and Methods: A total of 1451 asymptomatic women who had negative or benign findings on screening mammogram, BI-RADS 3 assessment on screening US, and at least 6 months of follow-up were included. The median follow-up interval was 30.8 months (range, 6.8-52.9 months). The cancer detection rate, cancer detection timepoint, risk factors, and clinicopathological characteristics were compared between the screening and tertiary centers. Nominal variables were compared using the chi-square or Fisher's exact test and continuous variables were compared using the independent t test or Mann-Whitney U test. Results: In 1451 women, 19 cancers (1.3%) were detected; two (0.1%) were diagnosed at 6 months and 17 (1.2%) were diagnosed after 12.3 months. The malignancy rates were both 1.3% in the screening (9 of 699) and tertiary (10 of 752) centers. In the screening center, all nine cancers were invasive cancers and diagnosed after 12.3 months. In the tertiary center, two were ductal carcinomas in situ and eight were invasive cancers. Two of the invasive cancers were diagnosed at 6 months and the remaining eight cancers newly developed after 13.1 months. Conclusion: One-year follow-up rather than 6-month follow-up may be suitable for BI-RADS 3 lesions on screening US found in screening centers. However, more caution is needed regarding similar findings in tertiary centers where 6-month follow-up may be more appropriate.

• 대한영상의학회지
• /
• 제85권2호
• /
• pp.421-427
• /
• 2024

이소성 유방조직은 겨드랑이에서 사타구니 선까지 유방 능선을 따라 발생할 수 있으며 가장 일반적으로 발생하는 부위는 겨드랑이이다. 이소성 유방조직에서 발생하는 원발성 암종은 극히 드물다. 왼쪽 겨드랑이에 부유방조직을 절제한 병력이 있는 61세 여성이 왼쪽 겨드랑이에 만져지는 종괴로 내원하였고 종괴의 평가를 위해 액와미부 촬영을 포함한 유방촬영술, 초음파 및 유방 MRI를 시행하였으며 특히 액와미부 촬영으로 왼쪽 겨드랑이의 특징적인 악성미세석화화의 양상과 범위를 평가하였다. 초음파 유도하 생검술을 통해 이 병변은 침윤성 유방암으로 진단되었고 조영증강 복부 CT에서 다발성 간전이가 확인되어 환자는 이후 고식적 항암요법을 받았다. 저자들은 겨드랑이 부유방 조직에서 발생한 드문 원발성 유방암에 대해 액와미부 촬영을 시행한 증례를 보고하고자 한다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제17권9호
• /
• pp.4463-4467
• /
• 2016

Purpose: To review the impact of using intra-operative ultrasound guided breast conserving surgery with frozen sections on final pathological margin outcome with the current guidelines set forth by the Society of Surgical Oncology (SSO) and the American Society of Surgical Oncology (ASTRO). Materials and Methods: A retrospective review including all cases of intra-operative ultrasound guided breast conserving surgery was performed at the National Cancer Institute Thailand between 2013 and 2016. Patient demographics, tumor variables, intraoperative frozen section and final pathological margin outcomes were collected. Factors for positive or close margins were analyzed. Results: A total of 86 patients aged between 27 and 75 years with intra-operative ultrasound guided breast conserving surgery were included. Three cases (3.5%) of positive margin were detected by intra-operative frozen section and 4 cases (4.7%) by final pathology reports. There were 18 cases (20.9%) with a close margin (<1 mm). Factors affecting this result comprised multi-foci, presence of invasive ductal carcinoma (IDC) combined with ductal carcinoma in situ (DCIS) and invasive lobular carcinoma (ILC). Conclusions: With the current SSO/ASTRO for adequate margin guidelines, using intra-operative ultrasound to locate the boundary for resection with breast conserving surgery provided a high success rate in obtaining final pathology free margin outcomes and minimizing re-operation risks especially when combined with intra-operative frozen section assessment. The chance of finding positive or close margins appears higher in cases of IDC combined with DCIS, ILC and with multi-foci cancers.