• Title/Summary/Keyword: Break-out

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Analysis of a Large-scale Protein Structural Interactome: Ageing Protein structures and the most important protein domain

  • Bolser, Dan;Dafas, Panos;Harrington, Richard;Schroeder, Michael;Park, Jong
    • Proceedings of the Korean Society for Bioinformatics Conference
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    • 2003.10a
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    • pp.26-51
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    • 2003
  • Large scale protein interaction maps provide a new, global perspective with which to analyse protein function. PSIMAP, the Protein Structural Interactome Map, is a database of all the structurally observed interactions between superfamilies of protein domains with known three-dimensional structure in thePDB. PSIMAP incorporates both functional and evolutionary information into a single network. It makes it possible to age protein domains in terms of taxonomic diversity, interaction and function. One consequence of it is to predict the most important protein domain structure in evolution. We present a global analysis of PSIMAP using several distinct network measures relating to centrality, interactivity, fault-tolerance, and taxonomic diversity. We found the following results: ${\bullet}$ Centrality: we show that the center and barycenter of PSIMAP do not coincide, and that the superfamilies forming the barycenter relate to very general functions, while those constituting the center relate to enzymatic activity. ${\bullet}$ Interactivity: we identify the P-loop and immunoglobulin superfamilies as the most highly interactive. We successfully use connectivity and cluster index, which characterise the connectivity of a superfamily's neighbourhood, to discover superfamilies of complex I and II. This is particularly significant as the structure of complex I is not yet solved. ${\bullet}$ Taxonomic diversity: we found that highly interactive superfamilies are in general taxonomically very diverse and are thus amongst the oldest. This led to the prediction of the oldest and most important protein domain in evolution of lift. ${\bullet}$ Fault-tolerance: we found that the network is very robust as for the majority of superfamilies removal from the network will not break up the network. Overall, we can single out the P-loop containing nucleotide triphosphate hydrolases superfamily as it is the most highly connected and has the highest taxonomic diversity. In addition, this superfamily has the highest interaction rank, is the barycenter of the network (it has the shortest average path to every other superfamily in the network), and is an articulation vertex, whose removal will disconnect the network. More generally, we conclude that the graph-theoretic and taxonomic analysis of PSIMAP is an important step towards the understanding of protein function and could be an important tool for tracing the evolution of life at the molecular level.

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Studies on the Operation Control with Automatic Silk Reeling Process to be responded for Korean Silk Cocoon (한국원료견질에 적응하는 자동조사 공정관리의 구명에 관한 연구)

  • 송기언
    • Journal of Sericultural and Entomological Science
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    • v.17 no.1
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    • pp.1-26
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    • 1975
  • These studies were attempted to find out the optimum silk reeling system by use of automatic silk reeling machine to increase raw silk yield and reeling efficiency with various silk reelable cocoons. The obtained results are as follows; 1. The mean silk reelability ratio(X)of the Korean cocoons during the last ten years was 61 per cent, beside 64.7 per cent in autumn cocoon and 57.3 per cent in spring cocoon. However, the ratio variation of autumn cocoons was larger than that of spring cocoons. 2. A positive correlation between cocoon filament breaks during its process and silk reelability levels was shown to be significant. The cocoons of both poor and good reelability evidenced "J" shape distribution on the filament break graph by the order of reeling cocoon end. Many bave breaks were found at the inner shell of the cocoons, or in case of poor reelability cocoons. 3. The morphology of broken cocoon ends during the process was classified into A, B, C, D, E and F types, The occurrence of B type was majority, but that of F type was minority among them. 4. In case of the cocoon cooking, H-type ion-exchanged soft water was better for good reelability cocoons, Na and H-type ion exchanged neutral soft water for those of fair reelability, and alkaline (Na-type) soft water for those of poor reelability, respectively. 5. The modification of cooking water by mixing the above different types of water (50% Na-type and 50% H-type passed by standard natural water; 75% Na-type and 25% H-type passed by hard natural water; 25% Na-type and 75% H-type passed by soluble natural water) made higher yield of raw silk with tess breaks of thread. 6, In case cocoon ends groping water included sodium hexametaphosphate as much as 800 ppm. the groping efficiency and raw silk yield of cocoon was improved. The effect was pronounced in case of poor reelability cordons. 7. The most reasonable cocoon cooking and silk reeling condition for automatic silk reeling process were observed to be rather incomplete cook with good reelability cocoons and optimum cook with poor reelability cocoons succeeded by the reeling bath temperature of 45$^{\circ}C$, 8. The reasonable silk reeling velocities were observed to be about 150m per min. for good reelability cocoons, 120m per min. for fair reelability ones and 90 to 120m per min. for poor reelability ones. 9. In order to improve the raw silk yield of cocoons and reeling efficiency, the cocoon stand-by-ratio for reeling should be kept at the level of 40 per cent for good reelability cocoons or at 60 per cent for poor reelability ones beside necessary end found cocoon condition.

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Isolation and Characterization of Various Strains of Bacillus sp. having Antagonistic Effect Against Phytopathogenic Fungi (식물 병원성 곰팡이에 길항작용을 갖는 다양한 Bacillus sp.의 균주 분리와 특성에 관한 연구)

  • Kim, Hee Sook;Kim, Ji-Youn;Lee, Song Min;Park, Hye-Jung;Lee, Sang-Hyeon;Jang, Jeong Su;Lee, Mun Hyon
    • Microbiology and Biotechnology Letters
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    • v.47 no.4
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    • pp.603-613
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    • 2019
  • This study was carried out to examine the antagonistic effect against phytopathogenic fungi of isolated strains from soil samples collected from Busan, Changwon, and Jeju Island: Botrytis cinerea, Colletotrichum acutatum, Corynespora cassiicola, Fusarium sp., Rhizoctonia solani, Phytophthora capsici, and Sclerotinia sclerotiorum. According to results of our studies, isolated strains showed an antagonistic effect against phytopathogenic fungi. Such an antagonistic effect against phytopathogenic fungi is seen due to the production of siderophores, antibiotic substances, and extracellular amylase, cellulase, protease, and xylanase enzyme activities. Extracellular enzymes produced by isolated strains were significant, given that they inhibited the growth of phytopathogenic fungi by causing bacteriolysis of the cell wall of plant pathogenic fungi. This is essential to break down the cell wall of plant pathogenic fungi and thus help plant growth by converting macromolecules, which cannot be used by the plant for growth, into small molecules. In addition, they are putative candidates as biological agents to promote plant growth and inhibit growth of phytopathogenic fungi through nitrogen fixation, indole-3-acetic acid production, siderophore production, and extracellular enzyme activity. Therefore, this study suggests the possibility of using Bacillus subtilis ANGa5, Bacillus aerius ANGa25, and Bacillus methylotrophicus ANGa27 as new biological agents, and it is considered that further studies are necessary to prove their effect as novel biological agents by standardization of formulation and optimization of selected effective microorganisms, determination of their preservation period, and crop cultivation tests.

Preliminary Analysis of the Thermal-Hydraulic Performance of a Passive Containment Cooling System using the MARS-KS1.3 Code (MARS-KS1.3을 이용한 피동원자로건물냉각계통 열수력 성능 예비분석)

  • Bae, Sung Hwan;Ha, Tae Wook;Jeong, Jae Jun;Yun, Byong Jo;Jerng, Dong Wook;Kim, Han Gon
    • Journal of Energy Engineering
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    • v.24 no.3
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    • pp.96-108
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    • 2015
  • A passive containment cooling system has been designed to remove the heat inside a containment during accidents without external power supply. In this work, the PCCS was introduced in the APR1400 plant to replace the containment spray system and, then, the thermal-hydraulic performance of the PCCS was analyzed using the system thermal-hydraulic computer code, MARS. A double-ended cold-leg break accident, which is known to induce the maximum pressure in the containment, is simulated, where the thermal hydraulics of the PCCS, the reactor coolant system, and the containment are simultaneously simulated. The results of the calculations showed that the PCCS can replace the existing spray system and that the containment building and its internal structure also play a very important role for the heat removal during the accident. Some sensitivity calculations were carried out to evaluate the model uncertainty and the effects of design parameters. The limitations of the PCCS are also discussed.

The affective effect of odor products in relaxation and working contexts (휴식 및 집중 환경에서 방향 제품의 감성적 영향)

  • Suk, Hyeon-Jeong;Lee, Eun-Sol;Kim, Gok-Mi;Han, Sang-Ho
    • Science of Emotion and Sensibility
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    • v.14 no.3
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    • pp.395-402
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    • 2011
  • As the consumer market for odor products grows, companies producing healthcare products are beginning to pay more attention to the emotional aspect of an odor product in order to differentiate their products from competitors. In the following research, the affective effect of odor product was investigated while focusing on relaxation and working contexts using orange and pine scents, since these are typical odors in current domestic market. Two empirical studies were carried out. First, in experiment I, 18 subjects, all of whom were university students, spent 20 minutes sitting comfortably on a sofa while electrocardiogram assessments were made. After a five-minute break, in experiment II, the same subjects were provided with both arithmetic and geometric questions and their electroencephalogram readings was recorded from eight channels. All subjects participated in three sessions - no odor, an orange scent, and then a pine scent - with a minimum time interval of 24 hours. The results show that in the context of a pine scent, both the activation ratio of subjects' parasympathetic system and those of the Sensory Motor Rhythm waves and Mid Beta waves were at the highest peak. Therefore, the pine scent helped the subjects to feel more comfortable and more focused at the same time. In other words, it gave them a state of meditated attention. In addition, it was found that the right brain was activated twice the intensity when the subjects worked through the geometric questions, whereas both sides of the brain were activated in equal magnitude during the process of arithmetic tasks. This replicates previous studies of the functional aspect of the right brain - being responsible for spatial and creative thinking.

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Studies on the Forage Production and Utilization on Paddy Field in Korea (한국에 있어서 답리작을 이용한 양질 조사료 생산기술)

  • Seo, Sung;Yook, W.B.
    • Proceedings of the Korean Society of Grassland Science Conference
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    • 2002.09b
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    • pp.5-56
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    • 2002
  • The problems in the current domestic forage production were evaluated, and the prospective improvement was suggested in this paper. Grassland development in forest, production of high quality forages in upland and paddy land, efficient utilization of rice straw, development of new varieties of forages suitable for our environmental conditions and imported forages were described Among them, preferential production and utilization of forages using paddy field after rice harvest . should be enlarged for domestic supply of forages in Korea. Several studies were carried out to select the promising forage crops and barley cultivars for whole crop silage production, to determine productivity, nutritive value and production cost of forages produced in paddy field, and feeding effect of forages with Hanuwoo and milking cow for whole crop silage with forages produced in paddy field, 1999 to 2001, and also discussed restraint factors and activation plans for enlargement of forage production in paddy land. The promising forage crops in paddy field were rye and barley for Middle region, and rye, barley, early maturing Italian ryegrass and wheat for Southern region. The promising barley cultivars for whole crop silage in paddy field were Albori in Suwon, Keunalbori, Milyang 92, Saessalbori, and Naehanssalbori in Iksan, and Keunalbori, Albori, Naehanssalbori, and Saegangbori in Milyang, respectively. Silage production, quality and animal palatability of silage by trench and round bale were also compared. The production yields of whole crop barley silage(WBS) were 17,135kg as a fresh matter, and 6,011kg as a dry matter per ha, and the quality of WBS was 2∼3 grade, while that of rice straw silage was 4 grade as a farm basis. The production cost of WBS per kg was 83won as a fresh matter, and 238won as a dry matter. Feeding of WBS as forages on Hanwoo was very desirable for the improvement of live-weight gain, beef quality and farm income, particularly in growing stage of Hanwoo. Milk production and income were also increased, and feed cost was decreased by feeding of WBS. The daily voluntary intake of WBS in milking cow was 26.3kg as a fresh matter(DM 7.7kg) per head. Milk production when WBS was fed, was very similar to that of imported hay feeding such as Kentucky bluegrass or domestic corn silage. The issues to be solved in near future f3r stable forage production and supply in paddy land are sustainable livestock-forages policy, development & seed production of new varieties of barley, rye, Italian ryegrass and other promising forages, efficient demand & supply system of forages, solidification for mass production and utilization of forages, efficient application management of animal slurry on paddy field considering environmental agriculture/livestock industry, and break k development of bottleneck technique in production field. Domestic production & supply of high cost agricultural machine (round baler, wrapper, handler and so on), plastic wrapping film, and silage additives are also important.

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The Study of Human Rights Sensitivity and the Types of Perception in regards to Human Rights for College Students (대학생의 인권감수성 수준과 인권인식 유형에 관한 연구)

  • Shim, Tae Een;Lee, Song Yi
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.19 no.10
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    • pp.352-360
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    • 2018
  • The purpose of this study was to examine the level of human rights sensitivity and the types of perception in regards to the human rights of college students to enhance their human rights sensitivity. The study methodology included a t-test and variance analysis for the level of human rights sensitivity, and a Q-factor analysis for the perception types of human rights. As a result of examining whether there is a difference in human right sensitivity, it was found that female students were higher than male students, and juniors and seniors were higher than freshmen and sophomores. The human rights sensitivity of the students in the social and science department were the highest, and those who had volunteer experiences were more susceptible to human rights than those who did not. Students who registered for organ donation were higher than those who did not, and those who received human rights education showed higher human rights susceptibility than those who did not. Four perception types of human rights were analyzed 'universal social moralists', those who have an idealistic mindset and make decisions based on moral standards, 'practical realists', those who have no intention of breaking out of the social norm and who do not want to take any risks for human rights, 'social system advocates', those who have a clear understanding of the basic human rights concept, but don't think that they should break the rules of society for the sake of individual rights, and 'social contracts advocates', those who are willing to bend the rules of society for human rights, but not to the extent of ruining relationships. These study results are expected to contribute to the possibility of the social viewpoint that human rights sensitivity can be developed in the context of social experience as well as perception.

Simulation study of smoke spread prevention using air curtain system in rescue station platform of undersea tunnel (해저터널 구난역 플랫폼 화재연기확산 방지를 위한 에어커튼 시스템 차연성능 시뮬레이션 연구)

  • Park, Sang-Heon;An, Jung-Ju;Han, Sang-Ju;Yoo, Yong-Ho
    • Journal of Korean Tunnelling and Underground Space Association
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    • v.17 no.3
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    • pp.257-266
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    • 2015
  • This study introduce that we studied optimization and possibility of smoke spread prevention with air-curtain system in undersea tunnel named from Ho-Nam to Jeju line in domestic if a fire break out in train. To verify performance, air-curtain system is installed between rescue station platform and each door of passenger car to provide safety route to evacuator and we studied simulation model of various cases about 15 MW fire severity considering domestic specifications. As a result we verified the fact that CASE1(air jet with 15degree toward passenger car) and CASE 5 (air jet with 15degree toward passenger car and pressure air blast from cross passage) is best Smoke Spread Prevention and less inflow carbon monoxide. Through above results, we expect that air-curtain system is one of the facilities for fire safety and provide us safety platform route in undersea tunnel.

The Clinical Observations in Childhood Asthma (기관지 천식의 초기 발병시 임상적 양상에 관한 관찰)

  • Song, Kih-Yean;Park, Yong-Hyoun;Jun, Jin-Gon;Lee, Young-Hwan;Kim, Chun-Dong
    • Journal of Yeungnam Medical Science
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    • v.9 no.2
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    • pp.239-247
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    • 1992
  • A clinical analysis was done on 134 cases with bronchial asthma who were admitted to the Department of Pediatrics Yeungnam University from May 1987 to October 1991. The results were as followings; 1) The peak age of bronchial asthma was under 2 years. The sex ratio of male to female was 2.9 : 1. 2) The out-break of bronchial asthma was most common in fall, especially in September. 3) The past history of other allergic diseases were present in 22.4% of patients(30/134 cases), and the previous bronchiolitis in infancy were experienced in 12.7% of patients(17/134 cases). 4) According to the skin test for allergens done by RAST, the most common allergens were Mites and House dust. 5) Eosinophilia(T.E.C>250/min) was found in 29.1% of patients, and elevated IgE level(>200 $IU/m{\ell}$) was found in 63.2% of patients. 6) No significant differences in the serum IgE level were found between male and female patients. No significant differences in the serum IgE level were found between asthma patients with and without other allergic diseases. 7) The serum IgE level of school aged patients was significant higher than that of preschool aged(p<0.01).

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Removal of Mixed Odor(H$_2$S/CH$_3$SH) using Char Adsorbent Made from Sewage Sludge (하수슬러지 탄화물 흡착제를 이용한 혼합 악취(H$_2$S/CH$_3$SH)의 제거)

  • Han, Young-Suk;Choi, Won-Joon;Kim, Taek-Joon;Kim, Im-Gyung;Oh, Kwang-Joong
    • Journal of Korean Society of Environmental Engineers
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    • v.30 no.11
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    • pp.1132-1138
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    • 2008
  • The study was carried out to investigate adsorption characteristic on hydrogen sulfide (H$_2$S) and methylmercaptan (CH$_3$SH) odor gas using the char made by a thermal decomposition of sewage sludge. The fixed bed adsorption experiments of the optimum L/D ratio could be 1.0, and adsorption capacity and break point increased with the increase of temperature. A simultaneous adsorption characteristic of H$_2$S and CH$_3$SH increased in breakthrough time and adsorption capacity more than single adsorption experiment, and CH$_3$SH had higher effective diffusivities than H$_2$S in same condition. The adsorption capacity of CH$_3$SH increased with fast velocity. When it was compared the produced absorbent with commercial activated carbon, As to adsorbent amount, it was H$_2$S 77% and CH$_3$SH 80% of commercial activated carbon.