• 한국작물학회:학술대회논문집
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• 한국작물학회 2017년도 9th Asian Crop Science Association conference
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• pp.21-21
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• 2017

Severe lodging has recurrently occurred at strong typhoon's hitting in recent climate change. The identification of quantitative trait loci (QTLs) and their responsible genes associated with a strong culm and their pyramiding are important for developing high-yielding varieties with a superior lodging resistance. To identify QTLs for lodging resistance, the tropical japonica line, Chugoku 117 and the improved indica variety, Habataki were selected as the donor parent, as these had thick and strong culms compared with the temperate japonica varieties in Japan such as Koshihikari. By using chromosome segment substitution lines (CSSLs) in which chromosome segments from the japonica variety were replaced to them from Habataki, we identified the QTLs for strong culm on chrs. 1 and 6, which were designated as STRONG CULM1 (SCM1) and STRONG CULM2 (SCM2), respectively. By using recombinant inbred lines (BILs) derived from a cross between Chugoku 117 and Koshihikari and introgression lines, we also identified the other QTLs for strong culm on chrs. 3 and 2, which were designated as STRONG CULM3 (SCM3) and STRONG CULM4 (SCM4), respectively. Candidate region of SCM1 includes Gn1 related to grain number. SCM2 was identical to APO1, a gene related to the control of panicle branch number, and SCM3 was identical to FC1, a strigolactone signaling associated gene, by performing fine mapping and positional cloning of these genes. To evaluate the effects of SCM1~SCM4 on lodging resistance, the Koshihiakri near isogenic line (NIL) with the introgressed SCM1 or SCM2 locus of Habataki (NIL-SCM1, NIL-SCM2) and the another Koshihikari NIL with the introgeressed SCM3 or SCM4 locus of Chugoku 117 (NIL-SCM3, NIL-SCM4) were developed. Then, we developed the pyramiding lines with double or triple combinations derived from step-by-step crosses among NIL-SCM1 NIL-SCM4. Triple pyramiding lines (NIL-SCM1+2+3, ~ NIL-SCM1+3+4) showed the largest culm diameter and the highest culm strength among the combinations and increased spikelet number due to the pleiotropic effects of these genes. Pyramiding of strong culm genes resulted in much increased culm thickness, culm strength and spikelet number due to their additive effect. SCM1 mainly contributed to enhance their pyramiding effect. These results in this study suggest the importance of identifying the combinations of superior alleles of strong culm genes among natural variation and pyramiding these genes for improving high-yielding varieties with a superior lodging resistance.

• Asian Pacific Journal of Cancer Prevention
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• 제17권sup3호
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• pp.167-174
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• 2016

One of the major causes of morbidity and mortality in breast cancer patients is delay in seeking help. Leventhal's self-regulation model provides an appropriate framework to assess delay in seeking help. The aim of this study was to investigate the relationship between "illness perception" and "help seeking delay" in breast cancer patients based on Leventhal's self-regulation model. In this correlational descriptive study with convenience sampling conducted in 2013, participants were 120 women with breast cancer who were diagnosed in the last year and referred to chemotherapy and radiotherapy centers in Rasht, Iran. Data collection scales included demographic data, Revised Illness Perception Questionnaire (IPQ-R)and a researcher made questionnaire to measure the delay in seeking help. Pre-hospital delay (help seeking delay) was evaluated in 3 phases (assessment, disease, behavior). The data were analyzed using SPSS-19. The mean (SD) age calculated for the patients was $47.3{\pm}10.2$. Some 43% of the patients had a high school or higher education level and 82% were married. The "pre-hospital delay" was reported ${\geq}3months$. Logistic regression analysis showed that none of the illness perception components were correlated with appraisal and behavioral delay phases. In the illness delay phase, "time line" (p-value =0.04) and "risk factors"(p-value=0.03) had significant effects on reducing and "psychological attributions" had significant effects on increasing the delay (p-value =0.01). "Illness coherence" was correlated with decreased pre-hospital patient delay (p-value<0.01). Women's perceptions of breast cancer influences delay in seeking help. In addition to verifying the validity of Leventhal's self-regulation model in explaining delay in seeking help, the results signify the importance of the "illness delay phase" (decision to seek help) and educational interventions-counseling for women in the community.

• 한국포장학회지
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• 제21권1호
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• pp.27-34
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• 2015

전자레인지 가열용 제품에서 마이크로파에 의한 불균일한 가열이 일어남에 따라 포장재의 특정 부위에 열 변형이 발생하여 전자레인지 포장 소재에 따른 가열조리 패턴을 조사하였다. 전자레인지 가열용 포장재의 내면으로 이용되는 CPP의 grade에 따른 인장강도, 내열성 및 신장률을 비교하였다. High retortable CPP는 일반 CPP 재질과 비교하여 강한 열 접착강도 및 내열 저항성을 가지고 있었다. 국외 및 국내 CPP 제품의 인장강도 및 신장율은 차이가 있지만 대부분 $160^{\circ}C$ 정도 수준의 내열성을 가지고 있는 것으로 조사되었다. 하지만 소스의 높은 점도와 염분을 함유하는 hot spicy 제품에서는 전자파의 침투가 원활하지 못하여 전자레인지 조리 시 내용물의 균일한 가열이 어려워 국지적 또는 액위선 부위에 포장재의 열 변형이 관찰되었다. G-PET/PET/PET/CPP와 G-PET/PET/NY/CPP로 구성된 포장재를 레토르트 처리했을 때와 레토르트 후 전자레인지 가열 처리하였을 때 상태변화 및 합지강도에 대한 분석결과 합지강도의 차이는 없었으나 레토르트 처리 후 CPP 층의 변형이 관찰되었다. $TiO_2$가 포함된 유백 파우치와 투명 파우치의 열 변형 정도를 비교하였을 때는 $TiO_2$가 포함된 포장재의 열 변형이 더 심하였고, 알루미늄 호일을 부착한 후 전자레인지 가열하였을 때에는 액위선에서 열 변형이 발생되지 않았지만 바닥면에서 열 변형이 관찰되었다. 제품의 내면인 CPP 층의 개질/개선을 통한 내열안정성 확보 및 포장재의 전자파 투과-반사능을 조절하여 포장 내 전자파의 집중을 방지하는 등의 기술 도입 가능성의 검토가 필요할 것으로 판단된다.

• 한국산학기술학회논문지
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• 제10권5호
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• pp.947-954
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• 2009

본 논문에서는 하이브리드 커플러를 이용하여 구성하는 종래의 평형전력증폭기의 입력측 반사전력을 별도의 보조증폭기의 입력으로 활용하여 성능을 개선한 새로운 구조의 평형전력증폭기를 제안한다. 평형증폭기 내의 개별 단일 증폭기의 정합이 완벽하지 못하므로 여기에서 반사된 전력이 하이브리드 커플러의 격리단자에서 터미네이션 시키는 것이 종래의 구성이었다. 본 논문에서는 격리단자에 터미네이션 대신 보조증폭기를 연결하여 누설전력이 입력되고, 보조증폭기의 출력이 최종적인 평형증폭기의 출력에 더해지므로 출력전력과 효율이 개선된다. 제시한 구조를 검증하기 위하여 종래의 평형전력증폭기와 제안된 평형전력증폭기를 실제 제작하고 측정한 결과를 보인다. 제시한 평형전력증폭기는 종래의 평형전력증폭기보다 약 3dB의 출력전력특성, 5.2%의 전력부가효율, 그리고 $5{\sim}10\;dBc$의 IMB3 개선효과를 갖는다.

• 대한약침학회지
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• 제25권3호
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• pp.216-223
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• 2022

Objectives: Oxidative stress plays a key role in chronic and acute brain disorders and neuronal damage associated with Alzheimer disease (AD) and other neurodegeneration symptoms. The neuroprotective effects of berberine and Berberis vulgaris (barberry) root extract against apoptosis induced by hydrogen peroxide (H₂O₂) in the human SH-SY5Y cell line were studied. Methods: The methanolic extraction of barberry root was performed using a maceration procedure. Oxidative stress was induced in SH-SY5Y cells by H₂O₂, and an MTT assay was applied to evaluate the neuroprotective effects of berberine and barberry root extract. The cells were pretreated with the half maximal inhibitory concentration (IC₅₀) of each compound (including berberine, barberry root extract, and H₂O₂), and the anti-apoptotic effects of all components were investigated using RT-PCR. Results: The SH-SY5Y cell viability increased in both groups exposed to 75 and 150 ppm barberry extract compared with that in the H₂O₂-treated group. The data showed that exposing SH-SY5Y cells to 30 ppm berberine significantly increased the cell viability compared with the H₂O₂-treated group; treatment with 150 and 300 ppm berberine and H₂O₂ significantly decreased the SH-SY5Y cell viability and was associated with berberine cytotoxicity. The mRNA levels of Bax decreased significantly under treatment with berberine at 30 ppm compared with the control group. A significant increase in Bcl-2 expression was observed only after treatment with the IC₅₀ of berberine. The expression level of Bcl-2 in cells exposed to both berberine and barberry extracts was also significantly higher than that in cells exposed to H₂O₂. Conclusion: The outcomes of this study suggest that treatment of SH-SY5Y cells with barberry extract and berberine could suppress apoptosis by regulating the actions of Bcl-2 family members.

• 한국농공학회지
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• 제24권4호
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• pp.57-68
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• 1982

The paddy fiels slope located in Kangweon province Hwyongsung gun Gonggeun myon Shinchonri was considerably steep and so it was impossible to economically consolidate the field up to date. But for the porpose of farm mechanization, the field (32. 27ha) was consolidated by the auther under the assitance of the Ministry of Agriculture and Fishery and,;the Administration of Kangweon province. This paddy field consolidation was caused by the treatise on "Land-consolidation methods for farm mechanization in the steep-sloped paddy field", of which the auther is the same. The constrution was carried out from September, 1981 to April, 1982. During the 4esign and construction, some Peculiarities were found and discussed. That is, in design, besides the common condititions for a design, some special conditions were considered and written below; (1) The ranges of field slope in this design were 1/100-1/30. (2) Long sides of the land readjustment blocks must be arranged abreast contour line, and so they make the amount of cutting and banking decreased so as to take the maximum advantage of the configuration of the field. (3) In design, the main principles of dividing blocks were written below; i) First of all, long side of a block should be drawn straight abreast a contour line. ii) Long side of a block should arrange abreast contour line and make its length 100-150m, if not, l)reak the side in order to make a bended rectangle. iii) Length of a short side should be determinded within differences of elevation (0.6 -1. 2m) between the two adjacent blocks toward the normal to a contour line. iv) Length of a short side should be above 15m and the ratio of long and short side should be slso kept 1: (4-6). v) A new field surface leveling was determinded from the elevation which produce the least amount of cuttingand banking within the range of 0.6-1. 2m diffe rences of elevation between the two adjacent blocks. vi) In the course of dividing blocks with the same width along the line which was normal to a contour line, all blocks connot keep their shape in a retangle because of steep slope of the field and so on, and so it was also necessory to make some non-retanglar and small blocks such as a trianglar or trapezoidal shape, which was impossible to use some of farm machinery. But because this non-rectanglar and small blocks were divided, larger and many rectanglar blocks can be divided and construction cost can also be lowered. According to the conditions discussed above, the paddy field consolidation project designed and constructed. And the results of this study were obtained as below; (1) Three-forth of total cost of this paddy field consolidation was not construction cost, and these cost consist of land grading (1/4), road and canal construction cost (1/4) and the other cost (1/4) such as surveying or materials and 56 on. (2) The steeper the land slope, the greater cost was assigned for road and canal construction, and than land grading. (3) Curtailment of the road and canal construction cost depended on simplificating their strutures. (4) In the case of the land slopes were low, the land grading cost was high by 1: 1.4 in comparison with the road and canal construction cost, and conversely when the slops were steep, the road and canal construction cost was high by 1 : 5 in compa- rison with the land grading cost. (5) The densities of irrigation canal, drainage canal and trunk and branch road were 150. Sm/ha, 60. im/ha and 17. 4m/ha respectively. The density of irrigation canal of the area was high by 2 times in comparison with the average one of Kangweon Province, and the others were nearly the same. (6) Most farmers (above 85%) knew the effects of paddy field consolidation. The effects are; 1) Improvement of irrigation 2) Improvement of farm management 3) Improvement of transportarion 4) farm mechanization and 5) grouping of the scattered land. And the more farm modernization was accomplished by these projects, the more farmers wanted to live in their land. (7) In spite of the very steep sloped paddy field, the diminution rate of the net farm land caused by consolidation was 7.7% which was nearly the same as the one of Chulweon plain of Kangweon province. Land grading cost was 971, OOOwon/ha which was rather cheap by 13.2% than the one of Ghulweon plain, and unit construction cost was 5, 341, OOOwon/ha (included soil addition) which was also nearly the same as the one of Chulweon plain and FNFIA (The federation of national farmland improvement association).

• 한국전자파학회논문지
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• 제20권5호
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• pp.413-420
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• 2009

본 논문에서는 $2{\times}2$ 배열 안테나에 적용하여 분할된 원추형 빔 형성이 가능한 새로운 급전 구조를 제안한다. 제안된 급전 구조에는 네 개의 $90^{\circ}$ 하이브리드, 한 개의 크로스오버, 네 개의 $90^{\circ}$ 지연선을 사용하며, 이들은 서로 대칭적인 구조를 갖는다. 급전 구조의 성능을 검증하기 위하여 중심 주파수 2.57 GHz에서 동작하는 마이크로스트립 형태의 $2{\times}2$ 배열 안테나와 급전 구조를 제작하였고, 방사 패턴을 측정하였다. 측정된 안테나의 주 빔방향은 입력 포트의 선택에 따라 고도 방향으로는 $45^{\circ}$에서, 방위각 방향으로는 $45^{\circ}$, $135^{\circ}$, $225^{\circ}$, $315^{\circ}$에서 최대지향성을 갖는 것을 확인하였다.

• 동의생리병리학회지
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• 제18권3호
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• pp.900-907
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• 2004

The antiproliferative effect of the water extract of the branch and root bark of Ulmi Pumilae Cortex(WEUPC) was investigated on the p53-negative human leukemia cell line (HL-60). A dose- and time-dependent inhibition of cell growth was observed; this effect appears to be due to induction of apoptosis. Involvement of oxidative stress is indicated by a dose-dependent increase in intracellular reactive oxygen species levels. In addition. anti-apoptic effect was observed in the cells simultaneously treated with WEUPC and the anti-oxidant N-acetylcysteine. WEUPC did not affect the anti-apoptotic Bcl-2 and the pro-apoptotic Bax, whereas p21/sup WAF1/CIPl/ was enhanced in a dose- and time-dependent fashion; this effect was partially inhibited by N-acetylcysteine. The increase in p21/sup WAF1/CIPl/ was accompanied by a parallel accumulation of cells in the G1 phase of the cycle. These results suggest that the p53-independent induction of p21/sup WAF1/CIP/ and the induction of apoptosis may mediate the anti proliferative effect of WEUPC at least in this study; on the basis of this observation, WEUPC could be proposed as an useful adjunct to the treatment of p53-deficient tumors, which are often refractory to standard chemotherapy.

• Structural Engineering and Mechanics
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• 제66권5호
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• pp.569-582
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• 2018

Effects of crack separation, bridge area, on the tensile behaviour of concrete are studied experimentally and numerically through the Brazilian tensile test. The physical data obtained from the Brazilian tests are used to calibrate the two-dimensional particle flow code based on discrete element method (DEM). Then some specially designed Brazilian disc specimens containing two parallel cracks are used to perform the physical tests in the laboratory and numerically simulated to make the suitable numerical models to be tested. The experimental and numerical results of the Brazilian disc specimens are compared to conclude the validity and applicability of these models used in this research. Validation of the simulated models can be easily checked with the results of Brazilian tests performed on non-persistent cracked physical models. The Brazilian discs used in this work have a diameter of 54 mm and contain two parallel centred cracks ($90^{\circ}$ to the horizontal) loaded indirectly under the compressive line loading. The lengths of cracks are considered as; 10 mm, 20 mm, 30 mm and 40 mm, respectively. The visually observed failure process gained through numerical Brazilian tests are found to be very similar to those obtained through the experimental tests. The fracture patterns demonstrated by DEM simulations are mostly affected by the crack separation but the tensile strength of bridge area is related to the fracture pattern and failure mechanism of the testing samples. It has also been shown that when the crack lengths are less than 30 mm, the tensile cracks may initiate from the cracks tips and propagate parallel to loading direction till coalesce with the other cracks tips while when the cracks lengths are more than 30 mm, these tensile cracks may propagate through the intact concrete itself rather than that of the bridge area.

• 한국환경보건학회지
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• 제43권1호
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• pp.71-76
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• 2017

Objectives: This study aimed to assess the environmental factors that affect particulate matters (PM10) and to compare with outdoor PM10 concentrations in an underground subway stations. Methods: The PM10 level was determined from May 2013 to September 2013 in the Seoul subway stations in four lines. PM mini-vol portable sampler sampler was used to collect PM10 for 6 hrs. Arithmetic means of PM10 concentrations with standard deviation (SD) were calculated. Paired t-test was used to compare the differences between indoor PM10 and outdoor PM10 concentrations with correlation analysis which was used to identify the association between indoor PM10 concentrations and environmental factors. Results: There were no different PM10 concentrations significantly between line 1, 2, 3 and 4 in an underground subway stations. Passenger number was positively associated with PM10 concentration while construction year was negatively associated with PM10 concentrations. Indoor PM10 concentrations were significantly higher than those in outdoor PM10 concentrations. PM10 concentrations were higher in the stations which were constructed before 1990s rather than the stations constructed after 1990s. Conclusion: PM10 levels in the underground subway stations varied greatly depending on the construction year. Therefore, it might need to be more careful management to the stations which constructed in before 1990s.