• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 2000년도 춘계학술대회
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• pp.15-16
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• 2000

Transient forebrain ischemia results in delayed neuronal death in the CA1 region of the hippocampus after injury, which is, at least in part, a consequence of excessive generation of reactive oxygen species. Previous in vitro studies using cell cultures or brain slices have demonstrated that phospholipase D (PLD) in the nervous system is involved in the signaling mechanism in response to a variety of agonists. Several recent studies have shown that reactive oxygen species stimulate phospholipase D (PLD) activity in several kinds of cells. Therefore, this raises the possibility that PLD activity is enhanced in the ischemic brain. Meanwhile, osteopontin (OPN) was initially identified as a sialoglycoprotein in bone, but has since been found in various tissues. Although not much is known about its function, OPN seems to play an important role in inflammation and tissue repair. Recently, it was reported that OPN was upregulated in the activated microglia after focal brain ischemia, suggesting that OPN might play a role in wound healing after a focal stroke.

• Journal of Korean Neurosurgical Society
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• 제60권3호
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• pp.294-300
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• 2017

Hypothalamic hamartoma (HH) is a benign indolent lesion despite the presentation of refractory epilepsy. Behavioral disturbances and endocrine problems are additional critical symptoms that arise along with HHs. Due to its nature of generating epileptiform discharge and spreading to cortical region, various management strategies have been proposed and combined. Surgical approaches with open craniotomy or endoscopy, stereotactic approaches with radiosurgery and gamma knife surgery or radiofrequency thermos-coagulation, and laser ablation have been introduced. Topographical dimension and the surgeon's preference are key factors for treatment modalities. Endoscopic disconnection has been one of the most favorable options performed in treating HHs. Here we discuss presurgical evaluation, patient selection, surgical procedures, and complications.

• 대한의생명과학회지
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• 제17권1호
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• pp.1-5
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• 2011

Previously, we have identified 14 putative downstream target genes of Hoxc8 homeoprotein in F9 murine embryonic teratocarcinoma cells through proteomics analysis. Among those, we tested a possibility of a DNA-k type molecular chaperone, Grp78, as a direct downstream target of Hoxc8, by cloning a 2.4 kb upstream region of murine Grp78 into a reporter plasmid and by testing if Hoxc8 can regulate its expression. We observed that Hoxc8 proteins could transactivate the reporter gene, which was affected by small interference RNAs (siRNAs) against to Hoxc8, suggesting that Grp78 is a novel downstream target of Hoxc8 in vivo.

• Nuclear Medicine and Molecular Imaging
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• 제41권2호
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• pp.78-84
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• 2007

Quantitative analysis of dynamic brain PET data using a tracer kinetic modeling has played important roles in the investigation of functional and molecular basis of various brain diseases. Parametric imaging of the kinetic parameters (voxel-wise representation of the estimated parameters) has several advantages over the conventional approaches using region of interest (ROI). Therefore, several strategies have been suggested to generate the parametric images with a minimal bias and variability in the parameter estimation. In this paper, we will review the several approaches for parametric imaging with linearized methods which include graphical analysis and mulilinear regression analysis.

• 한국정보처리학회논문지
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• 제7권3호
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• pp.977-991
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• 2000

In this paper, a medical image processing system was designed and implemented for morphometric and functional analysis of a human brain. The system is composed of image registration, ROI(region of interest) analysis, functional analysis, image visualization, 3D medical image database management system(DBMS), and database. The software processes an anatomical and functional image as input data, and provides visual and quantitative results. Input data and intermediate or final output data are stored to the database as several data types by the DBMS for other further image processing. In the experiment, the ROI analysis, for a normal, a tumor, a Parkinson's decease, and a depression case, showed that the system is useful for morphometric and functional analysis of a human brain.

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.268.1-268.1
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• 2002

The G protein ${\gamma}$12 subunit (G${\gamma}$12) is widely-expressed and. given the extensive role of the ${\beta}$${\gamma}$ subunit (G${\beta}$${\gamma}$) in cell signaling. is a uniquely known substrate for protein kinase C. indicating phosphorylation as a potential regulatory mechanism. The mRNAs for numerous subtypes of putative G${\gamma}$s have been identified in mammalian tissues. but little is known about their expression in brain. so that the systemic survey of the localization of mRNAs encoding twelve of G${\gamma}$s in brain is needed to be performed. (omitted)

• 대한방사선치료학회지
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• 제17권1호
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• pp.9-17
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• 2005

목적 : 방사선치료에 있어 치료부위내의 균등한 선량분포는 환자의 치료성적 및 장해를 좌우하는 매우 중요한 인자이다. 이러한 치료부위내의 균등한 선량분포를 얻기 위해 사용하는 여러 가지 방법 중 간단한 Field-in-Field Technique의 유용성을 평가하고 다양한 크기의 전뇌(whole brain)치료 환자에게 적용가능성을 알아보고자 한다. 대상 및 방법 : 전뇌(whole brain)의 일반적인 치료기법인 대향2문조사와 Field-in-Field Technique을 적용했을 때의 선량분포도를 비교하기 위하여 phantom(acryl 16 cm spheral phantom)을 대상으로 치료계획을 수립하였으며, 선량분포평가를 위하여 저감도필름(X-Omat V-film)과 열형광선량계(TLD)를 사용하여 측정하였다. 또한 다양한 두께의 환자20명(대, 중, 소 및 소아-각각 5명)을 대상으로 Field-in-Field Technique의 적용가능성을 평가 하였다 결과 : 전뇌(whole brain)치료에 대향2문조사와 Field-in-Field Technique을 적용한 경우 각각의 치료부위내의 선량분포 및 DVH를 비교한 결과, Field-in-Field Technique을 사용한 경우 고선량(high dose)영역을 $3{\sim}4\%$이하로 줄일 수 있었고, 저감도필름(X-Omat V-film)과 열형광선량계(TLD)에 의한 측정결과 또한 유사한 수치를 얻을 수 있었다. 이러한 Field-in-Field Technique을 다양한 두께의 환자에게 동일하게 적용해도 선량분포의 변화는 $1{\sim}2\%$로 나타났다. 결론 : 전뇌(whole brain)치료에 Field-in-Field Technique를 이용하여 치료계획을 수립하여 적용하면 치료부위내의 균등한 선량분포를 얻을 수 있으므로 추가적인 치료가 필요한 경우 선량합성이 용이하여 쉽게 치료계획을 수립할 수 있었다. 그리고 균등한 선량분포를 얻기 위해 사용하는 wedge filter 및 3D compensator 의 역할을 대체 할 수 있으며, 방사선 치료 시 고선량 영역으로 인해 발생되는 장해를 최소화할 수 있을 것으로 사료된다.

• 한국동물학회지
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• 제36권2호
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• pp.285-292
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• 1993

This investigation has been carried out to clarify structural architecture of cerebral neuroendocrine systems in the fifth instar lanra of cabbage butterfly Pieris rapae. In order to examine the cerebral neurosecretorv cell systems the brain and retrocerebral neuroendocrine complex were histochemically stained with the paraldehvde fuchsin. The brain of the fifth instar laMa contains three kinds of neurosecretorv cells: medial, lateral and tritocerebral neurosecretorv cells. The axon bundles of medial and lateral neurosecretory cells form medial neurosecretory pathway(MNSP) and lateral neurosecretorv pathwav(LNSP) within the brain respectively. Especially, prior to exiting the brain, the axon bundles of medial neurosecretorH cells located in both left and right cefebral hemispheres decussate in cerebral medial region and project to contralateral retrocerebral neuroendocrine complexes. Outside the brain the axon bundles of medial and lateral neurosecretory cells form the nenri corporis cardiaca(NCC) I and II respectively. The NCC I and ll run together to the retrocerebral neuroendocrine complex, forming the large nenre bundles in both left md right sides. The anon bundles of tritocerebral neurosecretory cells which pass through the brain along the tritocerebral neurosecretory pathway (TNSP) form the Ncc III outids the train. some of the Ncc I and it terminate in the corpus cardiacum, while the others pass through the corpus cardiacum without termination. The nerve bundle which passes the corpus cardiacum forms the nenrus corforis allatum(NCA) I which runs between the corpus cardiacum and the corpus allatum. Theyt are finally innervated to the corpus allatum. The Ncc III Projects to the corpus cardiRcum. However, most of NCC III priss through the corpus cardiacum without branching and then run down for another organ.

• Journal of Acupuncture Research
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• 제20권2호
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• pp.29-41
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• 2003

Clinical observation was made on 52 cases of Stroke that were confined through brain CT, MRI scan. The Stroke cases wee classified into the following kinds cerebral infarction, cerebral hemorrhage, cerebellar or brain stem infarction, cerebellar or brain stem hemorrhage. And among the 52 cases of Stroke cerebral infarction was noticed in 75.00%, cerebral hemorrhage in 11.54%, cerebellar or brain stem infarction in 9.52%, cerebellar or brain stem hemorrhage in 3.85%. The ratio between males and females was 1.74:1 in the whole groups of Stroke and most cases were over 60 of age. As the time of hospitalization, most patients hospitalized from 1 day after stroke to 7 days after stroke. And as the course of hospitalization, most patients hospitalized first. Among the preceding disease at the onset of Stroke hypertention was noted in 32.69%, and deabetes mellitus or heart problem was noted frequently(15.39%). Electrocardiography findings were as follows: The normal was noted in 53.85%, the abnormal in 46.15%. And as the abnormal, left ventricular hypertrophy was noted in 17.54%. The predisposing factors or conditions at the onset of brain infarction were usually initiated during the time of sleeping and those of brain hemorrhage chiefly during the time of exercising like overwork or walking etc. It was noted that smoking a pack of cigarette showed highest disease rate(33.33%) among the average of smoking amount of one day in case of man. Prior to attack, the most chiefly complain was dyspnea or discomfort on chest region. And 30.70% of patients had no previous sign. There were a large number of recurrent cases. The first attack was noted in 71.15%, the 2nd attack in 23.08%, the 3rd attack in 5.77%.

• 생물정신의학
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• 제16권3호
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• pp.159-169
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• 2009

Objectives : This study aimed to investigate the difference of brain activities in viewing a common emotional situation according to perspective-taking. Methods : Using fMRI, brain activities were measured while performing the task viewing a common emotional situation on either self-perspective or third-person perspective in fourteen healthy men. The relatively activated brain areas on each perspective were investigated, then the relationship between the activated brain regions and the scores of self report about some emotion or empathic ability were explored. Results : The relatively activated brain areas on self-perspective were bilateral paracentral lobule(BA 5), right postcentral gyrus(BA 3), right precentral gyrus(BA 4), left superior temporal gyrus(BA 22), left medial frontal gyrus(BA 6), whereas on third-person perspective right inferior frontal gyrus(BA 47), left caudate body and tail, right superior temporal gyrus(BA 38), right medial frontal gyrus(BA 8) were activated. The relative activity of left superior temporal gyrus on self-perspective was positively correlated with the score of Beck Depression Inventory. Conclusion : This study demonstrated that the activated brain region according to perspective-taking were different while viewing a common emotional situation. The depressive feeling would have an influence on the brain activity related to perspective-taking.