• BMB Reports
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• v.55 no.8
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• pp.380-388
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• 2022

The B cell translocation gene 1 (BTG1) and BTG2 play a key role in a wide range of cellular activities including proliferation, apoptosis, and cell growth via modulating a variety of central biological steps such as transcription, post-transcriptional, and translation. BTG1 and BTG2 have been identified by genomic profiling of B-cell leukemia and diverse lymphoma types where both genes are commonly mutated, implying that they serve as tumor suppressors. Furthermore, a low expression level of BTG1 or BTG2 in solid tumors is frequently associated with malignant progression and poor treatment outcomes. As physiological aspects, BTG1 and BTG2 have been discovered to play a critical function in regulating quiescence in hematopoietic lineage such as Hematopoietic stem cells (HSCs) and naive and memory T cells, highlighting their novel role in maintaining the quiescent state. Taken together, emerging evidence from the recent studies suggests that BTG1 and BTG2 play a central anti-proliferative role in various tissues and cells, indicating their potential as targets for innovative therapeutics.

• Sleep Medicine and Psychophysiology
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• v.1 no.1
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• pp.76-86
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• 1994

Objectives: This research was performed in order to observe the neuropsychological implication and functional anatomical source of event related potentials(ERP) by studying of correlations between event related potentials and neuropsychological tests. Methods: The latency and voltage of P100 of visual evoked potential (VEP), and N120 and P300 of event related potentials were studied in 56 patients and their correlations with neuropsychological tests were computed. Results: The tests showing significant correlation with latency P100 were visual continous performance test(VCPT) and contingent continous performance test(CCPT) without any significant correlation with voltage of P100. In latency of N120 category test and verbal IQ of KWIS showed significant correlation, and in voltage of N120, finger tapping test, VCPT, CCPT and digit symbol test displayed significant correlations. The latency of P300 had significant correlation with trail making A test and Stroop test. In the voltage of P300 significant correlations were shown with trail making B test, digit symbol test and Wechsler memory scale, finger tapping test, stroop test, VCPT and CCPT. Conclusion : N120 may be considered to reflect the function of medial frontal lobe and P300 may be considered to be developed from the subcortical connection of medial temporal lobe, hippocampus, thalamus, basal ganglia and medial frontal lobe.

• Toxicological Research
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• v.20 no.3
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• pp.251-261
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• 2004

A large number of chemical pollutants including phthalates, alkylphenolic compounds and organochlorine pesticides have the ability to disrupt endocrine function in animals, and alter cog-nitive function. Because hormone mediated events play an important role in central nervous system development and function, the changes in cognitive function seem to be mediated by the endocrine-like action of these chemicals. The present study therefore was designed to investigate effect of bisphenol A (BPA), an endocrine disrupting chemical on neuro-behavial patterns, and expression of estrogen receptors and tyrosine hydroxylase, a limiting enzyme of dopamine synthesis pathway. BPA was treated orally for 3 weeks into 3 week old mice, and then the neuro-behavial patterns (stereo-type behaviors such as jumping rearing and forepaw tremor, climbing behavior, tail flick, rotarod and locomotor activity), and the expression of estrogen receptors and tyrosine hydroxylase were deter-mined every 3 week for 9 weeks. During the treatment of BPA, the food uptake and body weight increase were not significantly changed. BPA resulted in the increased stereotype behaviors (jump-ing, rearing and forepaw tremor) 6 or 9 weeks after treatment. The time response to tail flick and locomotor activity were decreased by the treatment of BPA, whereas the time for rotarod was increased by the treatment of BPA. The expression of estrogen receptor alpha and beta was increased in the brain and pituitary gland. Maximum expression was found in the brain after 9 week of 100 mg/kg BPA treatment and in the pituitary gland after 6 week of 100 mg/kg BPA treatment. Tyrosine hydroxylase was increased in dose and time dependent manners in the brain but no change was found in the pituitary gland. The present data show that exposure of BPA in the young mice could alter expression of estrogen receptors and dopamine synthesis pathway, thereby modulate neuro-behavial patterns (increase of stereotype behaviors but decrease locomotor activity).

• The KIPS Transactions:PartA
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• v.11A no.5
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• pp.391-400
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• 2004

Within multimodal medical image registration techniques, which correlate different images and Provide integrated information, surface registration methods generally minimize the surface distance between two modalities. However, the features of two modalities acquired from one subject are similar. So, it can improve the accuracy of registration result to match two images based on optimization of both surface distance and shape feature. This research proposes a registration method which optimizes surface distance and surface curvature of two brain modalities. The registration process has two steps. First, surface information is extracted from the reference images and the test images. Next, the optimization process is performed. In the former step, the surface boundaries of regions of interest are extracted from the two modalities. And for the boundary of reference volume image, distance map and curvature map are generated. In the optimization step, a transformation minimizing both surface distance and surface curvature difference is determined by a cost function referring to the distance map and curvature map. The applying of the result transformation makes test volume be registered to reference volume. The suggested cost function makes possible a more robust and accurate registration result than that of the cost function using the surface distance only. Also, this research provides an efficient means for image analysis through volume visualization of the registration result.

• Journal of Biomedical Engineering Research
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• v.16 no.2
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• pp.157-166
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• 1995

The Electroencephalogram (EEG) and evoked potential (EP) t;ave widely been used for study of brain functions. The EEG and EP signals acquired from multi-channel electrodes placed on the head surface are often interfered by other relatively large physiological signals such as electromyogram (EMG) or electroculogram (EOG). Since these artifact-affected EEG signals degrade EEG mapping, the removal of the artifact-affected EEGs is one of the key elements in neuro-functional mapping. Conventionally this task has been carried out by human experts spending lots of examination time. In this paper a neural-network based classification is proposed to replace or to reduce human expert's efforts and time. From experiments, the neural-network based classification performs as good as human experts : variation of decisions between the neural network and human expert appears even smaller than that between human experts.

• BMB Reports
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• v.48 no.12
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• pp.677-684
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• 2015

Cardiovascular function is regulated by the rhythmicity of circadian, infradian and ultradian clocks. Specific time scales of different cell types drive their functions: circadian gene regulation at hours scale, activation-inactivation cycles of ion channels at millisecond scales, the heart's beating rate at hundreds of millisecond scales, and low frequency autonomic signaling at cycles of tens of seconds. Heart rate and rhythm are modulated by a hierarchical clock system: autonomic signaling from the brain releases neurotransmitters from the vagus and sympathetic nerves to the heart's pacemaker cells and activate receptors on the cell. These receptors activating ultradian clock functions embedded within pacemaker cells include sarcoplasmic reticulum rhythmic spontaneous Ca²⁺ cycling, rhythmic ion channel current activation and inactivation, and rhythmic oscillatory mitochondria ATP production. Here we summarize the evidence that intrinsic pacemaker cell mechanisms are the end effector of the hierarchical brain-heart circadian clock system.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1996.04a
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• pp.45-52
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• 1996

In ancient times, respiration's perceived purpose was only to cool the blood, and nasal mucus was thought to be a discharge from the brain. Later it was demonstrated that fluids cannot travel from the brain to the nose. It appears that credit for pointing out the medical significance of bronchial secretions and the biological value of the exocrine function of the lungs belongs to Laennec. He described the “chronic idiopathic pituitous catarrh” known today as bronchorrhea, which is characterized by paroxysms of expectoration. The importance of all this is that airway secretions, and their alterations, became one of the cardinal signs of many respiratory diseases (1).

• Journal of Korean Institute of Industrial Engineers
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• v.23 no.3
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• pp.609-619
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• 1997

The concept of human emotion is recently demanded to be imbedded in industrial product and environment for enhancing quality of life. Human emotion is attempted to be qualified and quantified by physiological measurements. EEG variation, one of the physiological measurement, is observed to characterize psychological response in this study. This study is to find function and process of brain according to emotion. Twenty university students participated in this study and experienced positive and negative emotion by auditory stimulus. Delta, theta, alpha and beta waves showed characteristic variation in normalized sense according to positive and negative emotion. Local area showing significant difference between positive and negative emotion decreases with stimulus duration. Delta, theta and beta waves increase with negative emotion while alpha wave does with positive emotion.

• Biomolecules & Therapeutics
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• v.26 no.4
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• pp.350-357
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• 2018

Glial cells are receiving much attention since they have been recognized as important regulators of many aspects of brain function and disease. Recent evidence has revealed that two different glial cells, astrocytes and microglia, control synapse elimination under normal and pathological conditions via phagocytosis. Astrocytes use the MEGF10 and MERTK phagocytic pathways, and microglia use the classical complement pathway to recognize and eliminate unwanted synapses. Notably, glial phagocytosis also contributes to the clearance of disease-specific protein aggregates, such as ${\beta}$-amyloid, huntingtin, and ${\alpha}$-synuclein. Here we reivew recent findings showing that glial cells are active regulators in brain functions through phagocytosis and that changes in glial phagocytosis contribute to the pathogenesis of various neurodegenerative diseases. A better understanding of the cellular and molecular mechanisms of glial phagocytosis in healthy and diseased brains will greatly improve our current approach in treating these diseases.

• International journal of advanced smart convergence
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• v.9 no.3
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• pp.71-77
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• 2020

This study was conducted in order to determine how reductions in blood pressure during surgery affect intraoperative neuromonitoring. This retrospective study considered a total of 339 patients: 194 patients with normal neuromonitoring findings (57%), 145 (42%) with abnormal neuromonitoring findings, and 34 (10%) with postoperative neurological deficits. Comparisons between the three groups revealed that overall blood pressure during surgery, postoperative blood pressure, and the difference between the maximum and minimum blood pressure could affect the intraoperative neuromonitoring findings. While we indicate that a drop in blood pressure to below 70 mmHg could affect neuromonitoring results, differences in the dosage of anesthetic agents did not significantly affect reductions in blood pressure or neuromonitoring findings. The association of monitoring with blood pressure found in this study is expected to help future examiners. However, this study did not clarify the relationship between anesthesia and blood pressure and how it could affect intraoperative neuromonitoring. Therefore, further research on this part is thought to be necessary.