• Title/Summary/Keyword: Brain Korea 21

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Neuroprotective Effect of 8-OH-DPAT on Long-term Sequelae from Prenatal Ischemia in Rats

  • Lee, Se-Oul;Zhang, Tie-Yuan;Kim, Gun-Tae;Kim, Hee-Soo;Lee, Jong-Doo;Jahng, Jeong-Won;Kim, Dong-Goo
    • The Korean Journal of Physiology and Pharmacology
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    • v.6 no.6
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    • pp.293-297
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    • 2002
  • The role of 5-hydroxytryptamine $(5-HT)_1A$ receptor activity in prenatal ischemia was studied, by injecting 8-hydroxy-dipropylaminotetraline (8-OH-DPAT; $50{\mu}g/kg,$ s.c.), a $5-HT_1A$ agonist on gestation day 17, and 30 min later inducing transient ischemia by ligating the uterine vessels for 30 min. On postnatal day 95, rats that had experienced prenatal ischemia showed impaired motor coordination and reduced concentration of 5-HT in the cerebellum compared with Sham-operated controls. In addition, they showed increased $5-HT_1A$ receptor densities in the cerebral cortex. Pretreatment with 8-OH-DPAT ameliorated the behavioral and neurochemical sequelae measured in the present study. The results suggest that $5-HT_1A$ receptors protect the brain from ischemic insult and/or facilitate recovery after prenatally experienced ischemia.

PREVENTIVE EFFECT OF MUSHROOM PHELLINUS LINTEUS ON THE INHIBITION OF GAP JUNCTIONAL INTERCELLULAR COMMUNICATION BY $H_2O_2$ IS INVOLVED IN THE UP-REGULATION OF ERK2 AND p38

  • Kang, Kyung-Sun;Cho, Jong-Ho;Cho, Sung-Dae;Kim, Kyung-Bae;Lee, Ji-Hae;Ahn, Nam-Shik;Jung, Ji-Won;Yang, Se-Ran;Park, Joon-Suk;Yoon, Byung-Su;Kim, Sung-Hoon;Lee, Yong-Soon
    • Proceedings of the Korean Society of Toxicology Conference
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    • 2001.10a
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    • pp.159-160
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    • 2001
  • Gap junctional intercellular communication (GJIC) is a cellular event underlying the tumor promotion process and that treatment to prevent the down-regulation or to up-regulate GJIC is important in preventing tumor promotion. We evaluated the potential preventive effect of Mushroom Phellinus Linteus (PL) against the promoting action of hydrogen peroxide ($H_2O$$_2$) in WB-F344 rat liver epithelial cells.(omitted)

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