• Title/Summary/Keyword: Brachytherapy MCNPX

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Evaluation Absorbed Dose During the Breast Cancer Brachytherapy in Canine Phantom (반려견 팬텀에서 유방암 근접방사선치료 시 흡수선량 평가)

  • Kim, Jung-Hoon;Lee, Deuk-Hee
    • Journal of the Korean Society of Radiology
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    • v.14 no.5
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    • pp.523-528
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    • 2020
  • The application of breast cancer, which has the highest incidence in females among cancer that is the number one cause of death for dogs, was to be evaluated the absorbed dose during brachytherapy using simulation. MCNPX program was used for simulation, and a small size canine phantom was produced to measure absorbed dose. The results of the absorbed dose was the highest at 192Ir to 1.02E-12 Gy/# for tumors, and the same tendency was shown for internal and external absorbed dose. Therefore, the selection of appropriate sources for dog breast cancer should be considered in brachytherapy, taking into account dog breeds and exposures.

Evaluation of Absorbed Dose According to Nanoparticle Density During the Breast Cancer Brachytherapy (유방암 근접치료 시 나노입자의 밀도에 따른 흡수선량 평가)

  • Lee, Deuk-Hee;Nam, Ji-Hee;Kim, Jung-Hoon
    • Journal of radiological science and technology
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    • v.42 no.2
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    • pp.131-135
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    • 2019
  • The purpose of this study was to evaluate the efficacy of brachytherapy of breast cancer by dose assessment which a steady increased in Korea women. The dose assessment was performed using the MCNPX program, a MonteCarlo simulation technique. The sources used for brachytherapy was 192Ir. And nanoparticle which used for dose enhancement was gold. The density of nanoparticle was 7, 18 and 30 mg. Evaluation of absorbed dose according to distance is measured at a distance of 30, 50, 100 and 200 cm from the patient. As a result, The breast absorbed dose results increased in proportion to the density of nanoparticle. And the surrounding organs were not significantly different according to the density. But, in some organs, the absorbed dose decreased as the density of nanoparticles increased. Absorbed dose according to the distance was in inverse proportion to distance.

Study of Radiation dose Evaluation using Monte Carlo Simulation while Treating Extrahepatic Bile Duct Cancer with High Dose Rate Intraluminal Brachytherapy (간외 담도암 고선량률 관내근접방사선치료 시 몬테카를로 시뮬레이션을 통한 주변장기의 선량평가 연구)

  • Park, Ju-Kyeong;Lee, Seung-Hoon;Cha, Seok-Yong;Lee, Sun-Young
    • The Journal of the Korea Contents Association
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    • v.14 no.2
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    • pp.467-474
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    • 2014
  • The relative dose calculated by MCNPX and the relative dose measured by ionization chamber and solid phantoms evaluated the accuracy comparing with Monte Carlo simulation. In order to apply Monte Carlo simulation the intraluminal brachytherapy of extrahepatic bile duct cancer, 192Ir sealed radioactive source replicate, Bile duct and surrounding organs were made using KMIRD phantom based on a South Korea standard man. To check the absorbed dose of normal organs around bile duct, we set the specific effective energy and initial radioactivity to 1 Ci using MCNPX. Evaluation of the accuracy of the Monte Carlo simulation, the difference of the relative dose is the most 1.96% that satisfy the criteria that is the relative error less than 2% suggested by MCNPX code. In addition, The specific effective energy and absorbed dose of normal organs that were relatively adjacent to bile duct such as right side of kidney, liver, pancreas, transverse colon, spinal cord, stomach and small intestine were relatively high. on the contrary, the organs that were relatively distant to bile duct such as left side of kidney, spleen, ascending colon, descending colon and sigmoid colon were relatively low.

Dose Evaluation of the Man Adjacent to an Implanted Patient During the Prostate Cancer Brachytherapy (전립선암의 근접치료 시 이식환자에 근접한 사람의 선량평가)

  • Park, Euntae;Kim, Junghoon
    • Journal of the Korean Society of Radiology
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    • v.10 no.1
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    • pp.39-44
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    • 2016
  • This study is fulfilled to evaluate the exposure dose nearby a patient during the brachytherapy of the prostate cancer treatment and to minimize the radiation exposure by evaluating the exposure dose of the person near the relevant implanted patient, technicians and gardians. The experiment method is used on the study is MCNPX that is stood on the basis monte-carlo method and implant the source to MIRD-type phantom in $^{192}Ir$, $^{125}I$, and $^{103}Pd$ in virtual space. For dose evaluations according to distance, the radiation dose on the patient near the corresponding implanted patient is evaluated by each distance of 30, 50, 100, 200 cm to anterior from the implanted patient. As a result, $^{192}Ir$ showed a higher dose than $^{125}I$ and $^{103}Pd$ in every distance.

Evaluation of Absorbed Dose According to the Nanoparticle in Prostate Cancer Brachytherapy (전립선암의 근접치료 시 나노입자에 따른 흡수선량평가)

  • Park, Eun-tae;Lee, Deuk-hee;Im, In-chul
    • Journal of the Korean Society of Radiology
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    • v.12 no.2
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    • pp.167-172
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    • 2018
  • This study evaluated absorbed dose of brachytherapy according to the nanoparticle in prostate cancer which many occurred in Korean man and provided basic data. Absorbed dose evaluation was using MCNPX program which was applied Monte Carlo simulation. Source was applied $^{192}Ir$ which was many using in Korean HDR machine and gold, ferric oxide, gadolinium and iodine nanoparticle were applied. Prostate absorbed dose result was increased when using nanoparticle, in particular gold nanoparticle was the highest result as $3.13E-03J/kg{\cdot}e$. Absorbed dose of surrounding organs and distance was similar between using nanoparticle and non-using nanoparticle. Therefore, brachytherapy was used nanoparticle was increased therapeutic ratio and efficiency of radiation therapy.

Evaluation of Absorbed Dose According to the Gold Nanoparticle Density in Prostate Cancer Brachytherapy (전립선암의 근접치료 시 금 나노입자 밀도에 따른 흡수선량평가)

  • Lee, Deuk-Hee;Kim, Jung-Hoon
    • Journal of the Korean Society of Radiology
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    • v.13 no.2
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    • pp.247-252
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    • 2019
  • This study was evaluated absorbed dose according to the gold nanoparticle density in prostate brachytherapy which was constantly occurred in Korean men. Absorbed dose evaluation was using MCNPX program which was applied Monte Carlo simulation. Source were applied $^{192}Ir$ which was temporary insertion source and $^{103}Pd$ which was permanently insertion source. And gold nanoparticle density was applied 0 mg, 7 mg, 18 mg and 30 mg. The prostate absorbed dose was increased in proportion to the density 2.95E-14 Gy/e to 4.42E-14 Gy/e in $^{192}Ir$ and showed the same tendency in $^{103}Pd$. And surrounding organ absorbed dose was inversely proportional to the density. Therefore using nanoparticle in brachytherapy was increased therapeutic ratio.

Evaluation of Factors Used in AAPM TG-43 Formalism Using Segmented Sources Integration Method and Monte Carlo Simulation: Implementation of microSelectron HDR Ir-192 Source (미소선원 적분법과 몬테칼로 방법을 이용한 AAPM TG-43 선량계산 인자 평가: microSelectron HDR Ir-192 선원에 대한 적용)

  • Ahn, Woo-Sang;Jang, Won-Woo;Park, Sung-Ho;Jung, Sang-Hoon;Cho, Woon-Kap;Kim, Young-Seok;Ahn, Seung-Do
    • Progress in Medical Physics
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    • v.22 no.4
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    • pp.190-197
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    • 2011
  • Currently, the dose distribution calculation used by commercial treatment planning systems (TPSs) for high-dose rate (HDR) brachytherapy is derived from point and line source approximation method recommended by AAPM Task Group 43 (TG-43). However, the study of Monte Carlo (MC) simulation is required in order to assess the accuracy of dose calculation around three-dimensional Ir-192 source. In this study, geometry factor was calculated using segmented sources integration method by dividing microSelectron HDR Ir-192 source into smaller parts. The Monte Carlo code (MCNPX 2.5.0) was used to calculate the dose rate $\dot{D}(r,\theta)$ at a point ($r,\theta$) away from a HDR Ir-192 source in spherical water phantom with 30 cm diameter. Finally, anisotropy function and radial dose function were calculated from obtained results. The obtained geometry factor was compared with that calculated from line source approximation. Similarly, obtained anisotropy function and radial dose function were compared with those derived from MCPT results by Williamson. The geometry factor calculated from segmented sources integration method and line source approximation was within 0.2% for $r{\geq}0.5$ cm and 1.33% for r=0.1 cm, respectively. The relative-root mean square error (R-RMSE) of anisotropy function obtained by this study and Williamson was 2.33% for r=0.25 cm and within 1% for r>0.5 cm, respectively. The R-RMSE of radial dose function was 0.46% at radial distance from 0.1 to 14.0 cm. The geometry factor acquired from segmented sources integration method and line source approximation was in good agreement for $r{\geq}0.1$ cm. However, application of segmented sources integration method seems to be valid, since this method using three-dimensional Ir-192 source provides more realistic geometry factor. The anisotropy function and radial dose function estimated from MCNPX in this study and MCPT by Williamson are in good agreement within uncertainty of Monte Carlo codes except at radial distance of r=0.25 cm. It is expected that Monte Carlo code used in this study could be applied to other sources utilized for brachytherapy.