• Journal of Ocean Engineering and Technology
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• v.34 no.4
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• pp.253-262
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• 2020

This study provides a comparative analysis of experiments-based enhancements and sensitivity evaluations for the structural design of an automatic ocean salt collector under various load conditions. The sizing variables of the structural members were considered as design factors. The strength and weight performances were selected as output responses. The design of experiments used in the comparative study consisted of the orthogonal array design, Box-Behnken design, and central composite design. The response surface model, one of the metamodels, was applied to the approximate model generation. The design enhancement performance metrics, including numerical costs and weight minimization, according to the design of experiments, were compared from the best design case results. The central composite design method showed the most enhanced design results for the structural design of the automatic ocean salt collector.

• Transactions of Materials Processing
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• v.30 no.1
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• pp.27-34
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• 2021

In this study, response surface method (RSM) was used in modeling and multi-objective optimization of the parameters of AA5052-H32 in incremental sheet forming (ISF). The goals of optimization were the maximum forming angle, minimum thickness reduction, and minimum surface roughness, with varying values in response to changes in production process parameters, such as tool diameter, tool spindle speed, step depth, and tool feed rate. A Box-Behnken experimental design (BBD) was used to develop an RSM model for modeling the variations in the forming angle, thickness reduction, and surface roughness in response to variations in process parameters. Subsequently, the RSM model was used as the fitness function for multi-objective optimization of the ISF process based on experimental design. The results showed that RSM can be effectively used to control the forming angle, thickness reduction, and surface roughness.

• Microbiology and Biotechnology Letters
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• v.44 no.4
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• pp.497-503
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• 2016

This study aimed to optimize the culture conditions of recombinant Escherichia coli expressing otsBA using crude glycerol for the enhanced production of trehalose. The effects of culture temperature and isopropyl ${\beta}$-D-1-thiogalactopyranoside (IPTG)-induction were investigated. Trehalose production and cell growth were highest when cells were cultured at $37^{\circ}C$ and induced with IPTG. The concentrations of IPTG, validamycin A, and NaCl were optimized using Box-Behnken design. Statistical analyses of the experimental data revealed that the concentrations of IPTG and NaCl had significant effects on trehalose production, but that of validamycin A did not. Contour plot analysis and model calculation showed that the highest amount of trehalose could be produced at 298 mM NaCl and 0.1 mM IPTG. Under these optimal conditions, the optical density at 600 nm and trehalose production were $5.4{\pm}0.2$ and $304{\pm}15mg/l$, respectively.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.49 no.4
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• pp.375-383
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• 2023

Malic acid-catalyzed transformation has been developed to produce ginsenoside Rg3 which is increasingly in demand as a functional ingredient. The optimization of the conversion of red ginseng saponin (RGS) to ginsenoside Rg3 by acid catalyzed transformation was carried out using Box-Behnken design (BBD) based on Response Surface Analysis (RSM). The main independent variables were malic acid concentration, temperature, and reaction time. Conversion of ginsenoside Rg3 was performed according to BBD model and optimization conditions were analyzed. The concentration of the converted ginsenoside Rg3 ranged from 1.548 mg/L to 4.558 mg/L, and the highest production was obtained under the condition of reacting 1% malic acid, 50 ℃ and 9h. Consequently, The independent variables affecting the production of ginsenoside Rg3 were identified in the following order: malic acid concentration, reaction time and temperature. In addition, it was confirmed that the interaction between malic acid concentration and reaction time had a greater influence than the temperature.

• Membrane and Water Treatment
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• v.10 no.6
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• pp.431-440
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• 2019

A novel composite membrane was synthesized using crosslinked polyamide and fly ash ceramic substrate for phenol removal. Glutaraldehyde was used as crosslinker. Characterization shows that synthesized membrane possesses good permeability ($0.184l.m^{-2}.h^{-1}.kPa^{-1}$), MWCO (1.7 kDa), average pore size (1.08 nm) and good chemical stability. RSM was adopted for phenol removal studies. Box-Behnken-Design using quadratic model was chosen for three operating parameters (feed phenol concentration, pH and applied pressure) against two responses (phenol removal, flux). ANOVA shows that model is statistically valid with high coefficient of determination ($R^2$)value for flux (0.9897) and phenol removal (0.9302). The optimum conditions are obtained as pH 2, $46mg.l^{-1}$ (feed phenol concentration) and 483 kPa (applied pressure) with 92.3% phenol removal and $9.2l.m^{-2}.h^{-1}$ flux. Data validation with deviation of 4% confirms the suitability of model. Obtained results reveal that prepared composite membrane can efficiently separate phenol from aqueous solution.

• Journal of the Korean GEO-environmental Society
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• v.14 no.5
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• pp.57-63
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• 2013

In this study, the characteristics of degradation and mineralization of diazinon using a statistical approach based on Box-Behnken design (BBD, one of response surface method) was investigated in an E-beam process, and also the main factors with diazinon concentration ($X_1$), irradiatin intensity ($X_2$) and pH ($X_3$) which consisted of 3 levels in each factor was set up to determine the effects of factors and optimization. At first, effects of pH and diazinon concentration were investigated to determine the proper range of application on response surface method(RSM). In statistical approach, the regression analysis and analysis of variance (ANOVA) were applied to evaluate the quantitative comparison of each factors in order to obtain the effects were irradiation intensity>diazinon concentration>pH. The regression model predicted the optimization point using the response optimizer to consider the effects of operation conditions were $Y_1=81.73-5.58X_1+23.69X_2-14.23X{_2}^2+4.22X{_3}^2(R^2=99.7%)$, $Y_2=35.23-3.01X_1+10.79X_2-7.58X_2{^2}(R^2=97.9%)$ and 95.7% of diazinon degradation, 41.8% of TOC reduction at 12.75mg/L and 4.26kGy, respectively. The pH condition was not significantly affects on E-beam process than other advanced oxidation processes (AOPs).

• Korean Journal of Food Science and Technology
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• v.53 no.6
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• pp.739-748
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• 2021

This study focuses on the use of rice in the production of gluten-free rice udon (GFU) through an optimized mixing ratio, using the Box-Behnken response surface methodology (RSM). Different additional levels of rice flour (A, 40-60 g), acetylated distarch adipate (B, 10-20 g), and trehalose (C, 0-3 g) were used as variables, while water absorption level, volume, cooking loss, solid yield, lightness, texture properties, proximate compositions of GFU and turbidity of cooking water were set as responses in the RSM design model. The optimum mixing ratio for the preparation of gluten-free rice udon was obtained for 60.00 g of rice flour, 18.81 g of acetylated distarch adipate without the addition of trehalose. The response values of the optimized samples were water absorption (60.94%), volume (34.94%), turbidity of the cooking water (0.37), cooking loss (4.77%), solid yield (1.55 g), lightness value (70.04), hardness (2.53 N), springiness (0.18), gumminess (10.45 N), chewiness (1.83 N), and cohesiveness (2.89). This study has shown that rice flour can replace wheat flour to manufacture udon at an optimized mixing ratio successfully derived by statistical estimation method.

• 한국전산유체공학회:학술대회논문집
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• 2007.10a
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• pp.92-99
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• 2007

In this paper, optimization of the vaned centrifugal compressor was carried out at a given mass flow rate condition. Firstly, impeller optimization was conducted using response surface method (RSM) which is one of optimization methods. After the optimization of the impeller was completed, diffuser optimization was performed with the optimized impeller. In these processes, Navier-Stokes solver was used to calculate the flow inside the centrifugal compressor. And the optimization is performed with Box-Behnken design method which is efficient for fitting second-order response surfaces to reduce the number of calculations required. As a result, compared with the reference model, the efficiency and the pressure ratio of the optimized impeller and diffuser are found to be increased. The performance at off-design conditions is presented.

• Journal of the Korean Society of Tobacco Science
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• v.21 no.2
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• pp.109-118
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• 1999

A model predicted describing the effect of cigarette making materials on the level of filter ventilation was developed and evaluated. The developed model was expressed in terms of a linear and quadratic relationship which was validated with experimental measurements for different porosity of plug wrap and tipping paper, unencapsulated pressure drop of filter plug and cigarette column and vent position. Forty-six experimental frequencies were determined as a result of using three levels with five factors Box-Behnken design and analyzed by the multiple regression analysis with backward stepwise in STATISTICA/PC under restricted conditions. The four factors, except filter pressure drop variable, were statistically significant at the level of 0.05 but most of all linear by linear interactions were comparatively lower significant. By the analysis of linear and quadratic regression coefficient, filter ventilation of the cigarette was affected by porosity of plugwrap (5.87, -4.25), porosity of tip paper (5.68, -1.00), vent position (-3.87, 3.08), tobacco column pressure drop (2.56, 0.66), and filter pressure drop (1.50, 0.58) in the decreasing order. It should be emphasized that the major conclusion of this study was not that any particular parameter was linear or quadratic on any limit scale, but that there were highly significant relationships among factors involving linear, quadratic and their interaction and perhaps even linearity between and within factors. While, there is also quite strong evidence that vent position from mouth end and cigarette making materials are reverse relationship on this experimental model. On the basis of the result, it can be concluded that the porosity of the plug wrap and tipping paper has a marked effect on degree of filter ventilation rate. The F-value of plug wrap and tipping paper porosity among five factors were 39.2 and 36.8 respectively with P-value of 0.000 indicating higher significant for both factors. According to the analysis of variance, the model fitted for filter ventilation was significant at 5% confidence level and the coefficient of determination ($R^2$=0.84) was the proportion to variability in the data well fitted for by the model.

• Transactions of Materials Processing
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• v.30 no.3
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• pp.125-133
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• 2021

In this study, response surface method (RSM), back propagation neural network (BPNN), and genetic algorithm (GA) were used for modeling and multi-objective optimization of the parameters of AA5052-H32 in incremental sheet forming (ISF). The goal of optimization is to determine the maximum forming angle and minimum surface roughness, while varying the production process parameters, such as tool diameter, tool spindle speed, step depth, and tool feed rate. A Box-Behnken experimental design (BBD) was used to develop an RSM model and BPNN model to model the variations in the forming angle and surface roughness based on variations in process parameters. Subsequently, the RSM model was used as the fitness function for multi-objective optimization of the ISF process the GA. The results showed that RSM and BPNN can be effectively used to control the forming angle and surface roughness. The optimized Pareto front produced by the GA can be utilized as a rational design guide for practical applications of AA5052 in the ISF process