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Factors Affecting Breast Cancer Detectability on Digital Breast Tomosynthesis and Two-Dimensional Digital Mammography in Patients with Dense Breasts

  • Soo Hyun Lee;Mi Jung Jang;Sun Mi Kim;Bo La Yun;Jiwon Rim;Jung Min Chang;Bohyoung Kim;Hye Young Choi
    • Korean Journal of Radiology
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    • v.20 no.1
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    • pp.58-68
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    • 2019
  • Objective: To compare digital breast tomosynthesis (DBT) and conventional full-field digital mammography (FFDM) in the detectability of breast cancers in patients with dense breast tissue, and to determine the influencing factors in the detection of breast cancers using the two techniques. Materials and Methods: Three blinded radiologists independently graded cancer detectability of 300 breast cancers (288 women with dense breasts) on DBT and conventional FFDM images, retrospectively. Hormone status, histologic grade, T stage, and breast cancer subtype were recorded to identify factors affecting cancer detectability. The Wilcoxon signed-rank test was used to compare cancer detectability by DBT and conventional FFDM. Fisher's exact tests were used to determine differences in cancer characteristics between detectability groups. Kruskal-Wallis tests were used to determine whether the detectability score differed according to cancer characteristics. Results: Forty breast cancers (13.3%) were detectable only with DBT; 191 (63.7%) breast cancers were detected with both FFDM and DBT, and 69 (23%) were not detected with either. Cancer detectability scores were significantly higher for DBT than for conventional FFDM (median score, 6; range, 0-6; p < 0.001). The DBT-only cancer group had more invasive lobular-type breast cancers (22.5%) than the other two groups (i.e., cancer detected on both types of image [both-detected group], 5.2%; cancer not detected on either type of image [both-non-detected group], 7.3%), and less detectability of ductal carcinoma in situ (5% vs. 16.8% [both-detected group] vs. 27.5% [both-non-detected group]). Low-grade cancers were more often detected in the DBT-only group than in the both-detected group (22.5% vs. 10%, p = 0.026). Human epidermal growth factor receptor-2 (HER-2)-negative cancers were more often detected in the DBT-only group than in the both-detected group (92.3% vs. 70.5%, p = 0.004). Cancers surrounded by mostly glandular tissue were detected less often in the DBT only group than in the both-non-detected group (10% vs. 31.9%, p = 0.016). DBT cancer detectability scores were significantly associated with cancer type (p = 0.012), histologic grade (p = 0.013), T and N stage (p = 0.001, p = 0.024), proportion of glandular tissue surrounding lesions (p = 0.013), and lesion type (p < 0.001). Conclusion: Invasive lobular, low-grade, or HER-2-negative cancer is more detectable with DBT than with conventional FFDM in patients with dense breasts, but cancers surrounded by mostly glandular tissue might be missed with both techniques.

The Dyeability, Antibacterial Activity, and Deodorization of Chrysanthemum Boreale for Cotton and Silk Fabrics (국화지 면직물과 견직물에 대한 염색성, 항균성, 소취성에 관한 연구)

  • 오화자
    • Journal of the Korean Home Economics Association
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    • v.42 no.6
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    • pp.43-53
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    • 2004
  • The purpose of this paper is to investigate the dyeability, antibacterial activity, and deodorization of cotton and silk fabrics dyed with extracted solution from Chrysanthemum boreale. The results are as follows: 1. The optimum conditions of dyeing temperature and time for the cotton fabrics were 90$^{\circ}C$ and 60minutes, while those of the silk fabrics were 60$^{\circ}C$ and 30 minutes respectively. 2. The K/S values of cotton fabrics were slightly higher than those of silk fabrics. The K/S values of both fabrics were slightly increased by mordanting with Cr but were decreased by mordanting with Cu and Fe 3. The colors of the cotton and silk fabrics changed from GY to Y. In both cases, the values of the fabric colors were lowered, and the values of the colors continued to be lowered with Cu and Fe. The chroma and color difference of both fabrics were high and were further increased by mordanting with Cu. 4. The fastness to dry-cleaning and rubbing of the cotton and silk fabrics was very good. The fastness to washing of both fabrics was good except when mordanted with Fe. The fastness to perspiration of both fabrics was fairly good, but the fastness to acid perspiration was poorer than that to the alkaline perspiration. The fastness to light of both fabrics was very poor. 5. The cotton and silk fabrics showed excellent antibacterial activity. Both fabrics mordanted with Cu showed perfect antibacterial activity. 6. The deodorization of the silk fabrics was very good, and that of the silk fabrics mordanted with Cu and Al was excellent, while the deodorization of the cotton fabrics was fairly good.

TISSUE HEALING RESPONSE OF INCISED WOUND SUTURED BY STAPLES AND VARIOUS SUTURE MATERIALS (Staple과 수종의 봉합물의 봉합부위 창상치유 조직반응)

  • Suh, Min-Jung;Lee, Jae-Hun
    • Maxillofacial Plastic and Reconstructive Surgery
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    • v.18 no.3
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    • pp.500-514
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    • 1996
  • The purpose of this study was to observe the tissue response in applying staples and various suture materials to both scalp and buccal mucosa in rabbits. 18 rabbits were divided into 6 groups. The incised wounds of both scalp and buccal mucosa were sutured with staples, polyglactin 910, chromic catgut, mer silk and nylon. The experimental animals were sacrificed after 1, 3, 5, 7, 10, 14 days posto peratively 3 animals at one time. The tissue was stained with Hematoxylin and eosin, and Masson's Trichrom. In light microscopic examinations, the sutured sites were examined histologi cally according to 6 degrees about inflammation and collagen deposit. The results were obtained as follows, 1. The chromic catgut, an absorbable suture material, was absorbed by 7 days, whereas polyglactin 910 and mersilk began to get absorbed after 7 days. 2. Mersilk manifested a broad range of inflammation in the scalp, and both staple and nylon showed a severe inflammatory reaction in the buccal mucosa. 3. With polyglactin 910, both tissue samples showed only minor foreign body reaction, however in the scalp, the process of fibrosis took place compara tively slowly, whereas in the buccal mucosa, it occurred promptly and manifested active fibrosis by 7 days. 4. Mersilk showed widespread a matrix formation in both scalp and buccal mucosa, and showed the most severe inflammatory reaction by 3 days, which did not seem to decrease even after 7 days. 5. Both staple and nylon showed relatively a severe inflammatory reaction, however fibrosis took place rather promptly compared to the other groups. 6. Generally, in the buccal mucosa fibrosis occurred more promptly than in the scalp in both control and experimental groups. 7. Retention of the suture material and stability of the knot were the best with the staple, and better stability was manifested by the multi-stranded poly glactin 910 and mersilk than singlestranded chromic catgut and nylon. From above results, in the buccal mucosa absorbable suture materials especially polyglactin 910 showed better response in the aspect of inflammatory reaction, while in the scalp monofilament suture materials such as staple and nylon manifested a early fibrosis and collagen formation.

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The Effects of MET and ICT in Patients with Lumbago by Meridian Muscle Electrography (근에너지기법과 경근간섭파요법이 요통환자의 요방형근 경근전도에 미치는 영향)

  • Cho, Dong-In;Park, Dong-Su;Jeong, Su-Hyeon;Kim, Soon-Joong
    • Journal of Korean Medicine Rehabilitation
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    • v.24 no.3
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    • pp.121-130
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    • 2014
  • Objectives The purpose of this study is to compare the effects of MET (muscle energy technique) and ICT (interferential current therapy) on lumbago by meridian muscle electrography (MMEG). We performed MET and ICT on quadratus lumborum muscle. Methods This study was carried out on 30 lumbago patients. 30 patients were randomly divided into MET group and ICT group. MET group take treatment 10 minutes. ICT group take treatment 15 minutes. After performing MET and ICT twice, we compared both in terms of root mean square (RMS), special edge frequency (SEF), VAS and ODI. Results 1. Both MET group and ICT group showed significant improvement in VAS and ODI after treatment. 2. Both MET group and ICT group showed significant improvement in special edge frequency (SEF) of the left side after treatment. But SEF of the right side showed insignificant improvement. 3. Both MET group and ICT group showed insignificant improvement in root mean square (RMS) for both sides. 4. There are no significant differences between both groups. Conclusions According to above results, we found out that performing MET or ICT on quadratus lumborum muscle has effect in terms of VAS and ODI. But, in terms of SEF, we found out different result for both side. And we can't found out effect in terms of RMS.

A Study on the Several Important Clauses in ICC Model Distributorship Contract (국제판매점계약(國際販賣店契約)의 주요조항(主要條項) (ICC Model Distributorship Contract(Pub.518)을 중심(中心)으로))

  • Oh, Won-Suk
    • THE INTERNATIONAL COMMERCE & LAW REVIEW
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    • v.26
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    • pp.35-86
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    • 2005
  • International distributorship contract(IDC), as well as international agency contract is a type of contract which is most frequently used in international trade. But one of the main difficulties faced by parties of IDC is the lack of uniform rules for this type of contract. This means that both parties should be careful about each clause of the contract when they draw up it. The ICC prepared model form which incorporates the prevailing practice in international trade, and which aims at protecting and balancing the legitimate interests of both parties. This author examined the several important clauses in this model contract. The purpose of this examination is to help the contracting parties for better understanding and applying them in their actual contracting practice, which based on this model contract. When the supplier and the distributor execute their contract or use ICC Model Contract, they should be careful about the following points: First, some terminologies(like, "territory", "product", "competing products" and "exclusivity") should be clearly defined in their contract. Second, regarding the supplier's functions including "supplying products" and the distributor's responsibility including "undertaking not to compete", and "attaining guaranteed minimum targets", both parties should make clear about each party's right and obligation as well as one party's remedies available when other party makes breach of its obligation. Third, both parties should examine the relationship between the "exclusivity" or "sole" and competition law which is regarded as a mandatory rule in the territory. Forth, when both parties lay down "termination clause" in the contract, they should make clear about the indemnity in case of termination. Fifth, as there is not uniform law for the distributorship contract, it is inevitable to choose any local law as an applicable law in case of litigation. So both parties should keep in mind to insert arbitration clause to avoid the application of the local law. Besides, both parties should consider their individual and specific circumstances and try to reflect them in their contract by Annex I to XI attached to the end of model contract.

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Quantitative Growth Analysis of White and Reddish Sword Bean

  • Park, Sun-Young;Doo, Hong-Soo;Song, Seung-Kyoung;Ryu, Jeom-Ho
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.46 no.2
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    • pp.89-94
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    • 2001
  • Sword bean belongs to the subgenus Canavalia in the genus Canavalia. White and reddish varieties in sword bean were tested to obtain the basic information for improving the yield, quality, and cultural environments through the quantitative growth analysis. Growing plants were sampled at intervals of 10 days from 20 days after sowing. Whole plant weight increased during the period of 11-20 days after sowing in both varieties. The weight of each organ between two varieties increased similarly except leaf area. Whole plant weight changed more close to pod weight than any other characters. The leaf areas of both varieties increased from 50 days after sowing, var. white displayed S type curved line but var. reddish displayed slow S type curved line. The SGR of whole plant weight in both varieties had 3 maxima and 2 minima, 3 maxima and first minimum were shown at the same period but the second minimum was shown at different period. Both varieties showed bimodal curved line. All SGR of each organ and leaf area were shown the 2 maxima and 1 minimum in both varieties. The changes of SLA and LAR were not remarkable between two varieties but these were united together with the maximum of whole plant weight and root weight. ULWR and ULWR were shown similar in both varieties. Reddish variety was more prosperous in early growth stage than white variety because SLA, LAR and LWR were high. In surplus weight, both varieties increased rapidly during the period of 111-120 days after sowing that was applicable to the maximum SGR of pod weight. Surplus weight of var. white increased markedly during the same period comparing those of var. reddish.

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Safety Evaluation of Filamentous Fungi Isolated from Industrial Doenjang Koji

  • Lee, Jin Hee;Jo, Eun Hye;Hong, Eun Jin;Kim, Kyung Min;Lee, Inhyung
    • Journal of Microbiology and Biotechnology
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    • v.24 no.10
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    • pp.1397-1404
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    • 2014
  • A few starters have been developed and used for doenjang fermentation but often without safety evaluation. Filamentous fungi were isolated from industrial doenjang koji, and their potential for mycotoxin production was evaluated. Two fungi were isolated; one was more dominantly present (90%). Both greenish (SNU-G) and whitish (SNU-W) fungi showed 97% and 95% internal transcribed spacer sequence identities to Aspergillus oryzae/flavus, respectively. However, the SmaI digestion pattern of their genomic DNA suggested that both belong to A. oryzae. Moreover, both fungi had morphological characteristics similar to that of A. oryzae. SNU-G and SNU-W did not form sclerotia, which is a typical characteristic of A. oryzae. Therefore, both fungi were identified to be A. oryzae. In aflatoxin gene cluster analysis, both fungi had norB-cypA genes similar to that of A. oryzae. Consistent with this, aflatoxins were not detected in SNU-G and SNU-W using ammonia vapor, TLC, and HPLC analyses. Both fungi seemed to have a whole cyclopiazonic acid (CPA) gene cluster based on PCR of the maoA, dmaT, and pks-nrps genes, which are key genes for CPA biosynthesis. However, CPA was not detected in TLC and HPLC analyses. Therefore, both fungi seem to be safe to use as doenjang koji starters and may be suitable fungal candidates for further development of starters for traditional doenjang fermentation.

A RADIOGRAPHIC STUDY OF THE MANDIBULAR ASYMMETRY IN TEMPOROMANDIBULAR DISORDER PATIENTS (악관절장애 환자의 하악골 비대칭에 대한 방사선학적 연구)

  • Oh Sung Ook;You Dong Soo
    • Journal of Korean Academy of Oral and Maxillofacial Radiology
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    • v.20 no.2
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    • pp.201-210
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    • 1990
  • The purpose of this study was to observe the relationship between mandibular asymmetry and Temporomandibular Disorders by means of the cephalometry using the posteroanterior cephalogram and the submentovertex cephalogram which were taken in 35 Temporomandibular Disorder patients and 35 normal persons ranged from 20S to 30S. The results were as follows: 1. The angulation which was formed by the median line with the ANS-Menton line (MAP) was greater in patients group and there was statistically significant difference. 2. The angulation which was formed to the median line with the Menton-Odontoid process tip line (MES), the difference of the distances from the center of the posterior surface of the both condyles to the most anterior point of the chin (DD), the difference of the distances from the center of the both condyles to the horizontal reference line (DE), the difference of the angulations which were formed by the both condyles axes with the horizontal reference line (DCE), the difference of the lengths of the both condyles (CL) and the difference of the widths of the both condyles (DW) were greater in patients group and there were statistically significant differences. There was reversed correlation between MAP and the difference of the distances from the 3. bilateral points of the lateral margin of the both zygomaticofrontal sutures to the at the lateral inferior margin of the both antegonial protuberances in mandible (DH). There was reversed correlation between MES and DD, DE, DCE. 5. There was correlation between MAP and MES.

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Chinese Po corresponding to Jikryung of Chosun Era - Focusing on Yesal and Jikshin - (조선시대 直領과 관련있는 중국의 袍制 -예살과 직신을 중심으로 -)

  • 이주영;권영숙
    • Journal of the Korean Society of Costume
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    • v.50 no.6
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    • pp.127-142
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    • 2000
  • The names of Chinese Po corresponding to Korean Jikryung are Yesal and Jikshin. Thus the purpose of this paper is to review of the shapes and usage of Yesal and Jikshin and then make a comparative review between the twos and Jikryung having side Moo. Results of the study are described as follows : 1. The Chinese costume, Yesal is translated literally into Korean, Euisal or Euisal Jikryung and called Euisal Diknyung or Uisakot in Korean while Jikshin is translated into Korean, Jikryung and called Diknyung. 2. Yesal is a new type of clothing as created during the Ming period. The costume is the remnant type of Yosunoja and Byunsunoja in the periods of Sung and Yuan. Types of Yesal are classified into two, or one whose rear part's upper and lower areas are connected with each other and whose front part's upper and lower areas are net, the other in which those upper and lower areas are disconnected both in front and rear parts. 3. Types of Jikshin are classified into two, one having Pa and the other having loot. The latter is re-classified into two, one whose sleeve is large and wide, the whole length of which is long and which was usually worn by Sain, and the other whose sleeve is small and narrow, the whole length of which is short and which was by the grass root. 4. Yesal and Jikryung both having Pa have the almost same shapes except their front parts. Baerae of the former is more curved than that of the latter. Also the both were used as official uniforms worn by civil and military officials from higher to lower levels. 5. Jikshin and Jikryung both having Pa have the same shapes. Baerae of the former is more curved than that of the latter. The both were used as official uniforms worn by civil and military officials under a King and as casual costumes by Sadaeboo. In terms of color, Jikshin and Jikryung both employed red, blue and green, Especially the red color was favorably used both in China and Chosen at that time.

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The Effect of Incidence of Ankle Sprains on Both Leg Length Inequalities and Range of Motion of Ankle Joint in 20's Female University Students (20대 여대생의 양다리길이차이 및 발목관절가동범위가 발목 염좌 발생률에 미치는 영향)

  • Park, Jong-Hang;Jeong, Yeon-Woo;Kim, Tae-won
    • The Journal of Korean Academy of Orthopedic Manual Physical Therapy
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    • v.21 no.1
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    • pp.29-35
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    • 2015
  • Background: The purpose of this study was conducted to investigate the effect of incidence of ankle sprains on both leg length inequalities and range of motion of ankle joint in 20's female university students. Methods: 20's female university students were targeting 32 people attending K university in Gwangju. Both leg length inequality was measured using a tape measure, ranges of motion of ankles was measured using a goniometer. Results: The ankle sprain incidence was quite high, with 56.25% (n=18) for the right ankle, 34.38% (n=11) for the left ankle, and 9.38% (n=3) for both. As for the difference between the ankle sprain incidence and both leg length, the average value of the right leg was $83.08{\pm}3.69$, the average value of the left leg was $84.28{\pm}3.27$, making the right leg shorter than the left by 1.2cm with a higher incidence and showing a positive statistical correlation between the two (p<.05). Also showed that there was a negative statistical correlation between ankle sprain incidences and the inversion range of motion spread of the right ankle (p<.05). Conclusion: The incidence of ankle sprains was higher for the larger the difference between both leg length inequality. In addition, the smaller the inversion range of motion spread of the right ankle, the higher the incidence of ankle sprains. Therefore, The evidence suggests that the incidence of ankle sprains can be reduced by recommending stability and efficient exercises that take into consideration the both leg length as well as the ranges of motion of ankle joints.

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