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Protein Kinase C-$\beta$ Is Induced In Ionizing Irradiation Induced Pigmentation

  • Nelly Rubeiz;Park, Dee-Young;Barbara A. Gilchrest
    • Journal of Photoscience
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    • v.9 no.2
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    • pp.209-212
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    • 2002
  • Cutaneous hyperpigmentation is a well-known consequence of both acute and chronic X-irradiation, although the molecular mechanisms involved are not well understood. Recently, protein kinase C-$\beta$ (PKC-$\beta$) was shown to activate tyrosinase, a key and the rate-limiting enzyme in melanogenesis [1]. In this study, we have investigated its role in mediating ionizing radiation-induced pigmentation by exposing cultured human melanocytes to X-irradiation. Increased tyrosinase activity after the 4 Gys exposure was observed within 48 hrs and total melanin content doubled after 7 days. Interestingly, tyrosinase mRNA level was not affected by X-irradiation. However, there was a 2-3 fold increase in PKC-$\beta$ mRNA after 48 hours of irradiation, coinciding with the increase in tyrosinase activity. This induction was not due to non-specific heat generated during the irradiation because when melanocytes were incubated at 4$0^{\circ}C$, there was no induction of PKC-$\beta$ mRNA. Taken together, these data suggest that X-irradiation induces cutaneous hyperpigmentation, at least in part, by up-regulating the level of PKC-$\beta$.

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A Strategic Positioning Analysis for Container Terminals in Northern Vietnam

  • Pham, Thi Yen;Ma, Hye-Min;Yeo, Gi-Tae
    • Journal of Navigation and Port Research
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    • v.40 no.5
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    • pp.311-316
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    • 2016
  • Vietnam is one of Asia's fastest developing economies. A long coastline of nearly 3,500 km provides a comparative advantage for Vietnam in developing a seaport system. Despite accounting for only about 30% of Vietnam's traffic volume, the Northern seaports have rapidly developed over the years. However, the location of the container terminals close to the common hinterland are a cause of fierce competition among container terminals. To outperform rivals and improve competitiveness, it is essential to identify the competitive positions of container terminals. This study analyzes the competitive positioning of container terminals in the northern region of Vietnam between 2005 and 2014 by applying the Boston Consulting Group (BCG) matrix in order to assist terminal operators and policy makers to generate strategic planning as well as to improve priorities for development. Otherwise, the period from 2005-2014 aims to clarify the static and dynamic positioning of container terminals. The results demonstrate that the Hai Phong terminal dominates the market, but the Nam Hai Dinh Vu and Dinh Vu terminals are considered as "star" performers. Quang Ninh, Doan Xa, and Transvina are losing their competitive positions in Northern Vietnam.

Inspection of Ceramic Coatings Using Nanoindentation and Frequency Domain Photoacoustic Microscopy

  • Steen, T.L.;Basu, S.N.;Sarin, V.K.;Murray, T.W.
    • Journal of the Korean Society for Nondestructive Testing
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    • v.26 no.6
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    • pp.390-402
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    • 2006
  • The elastic properties and thickness of mullite environmental barrier coatings grown through chemical vapor deposition (CVD) on silicon carbide substrates were measured using frequency domain photoacoustic microscopy. In this technique, extremely narrow bandwidth surface acoustic waves are generated with an amplitude modulated laser source. A photorefractive crystal based interferometer is used to detect the resulting surface displacement. The complex displacement field is mapped as a function of source-to-receiver distance in order to extract the wavelength of the surface acoustic wave at a given excitation frequency, and the phase velocity is determined. The coatings tested exhibited spatial variations in thickness and mechanical properties. The measured surface wave dispersion curves were used to extract an effective value for the elastic modulus and the coating thickness. Nanoindentation was used to validate the measurements of the effective elastic modulus. The average elastic modulus measured through the coating thickness using nanoindentation is compared to the effective modulus found using the photoacoustic system. Optical microscopy is used to validate the thickness measurements. The results indicate that the photoacoustic microscopy technique can be used to estimate the effective elastic properties in coatings exhibiting spatial inhomogeneities, potentially providing valuable feedback for the optimization of the CVD growth process.

Intracranial anaplastic oligodendroglioma concurrent with hydrocephalus and syringomyelia in a Boston terrier dog

  • Park, Chul;Kang, Byeong-Teck;Yoo, Jong-Hyun;Kim, Ha-Jung;Jung, Dong-In;Lim, Chae-Young;Kim, Jae-Hoon;Woo, Eung-Je;Kang, Sang-Chul;Park, Hee-Myung
    • Korean Journal of Veterinary Research
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    • v.48 no.1
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    • pp.93-98
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    • 2008
  • A 6-year-old female Boston terrier dog was presented with seizure episode, forelimb paraparesis, excessive panting, and ataxia. On physical and neurological examination, episcleral vessel engorgement, delayed postural reaction, delayed pupillary light reflex (both direct and consensual), and crossed forelimb were noted. Serum biochemical profiles were not remarkable other than mildly elevated hepatic enzymes. On cerebrospinal fluid analysis, elevated protein concentration was observed. In magnetic resonance imaging scans, the left frontal brain lesion with ring enhancement strongly suggested the presence of intracranial tumor. Concurrently, secondary hydrocephalus and syringomyelia were also observed. The dog was euthanized at 4 months after initial presentation because of aggravated neurological signs. This case was definitely diagnosed as an intracranial anaplastic oligodendroglioma based on postmortem histopathologic examination.

Seasonal Changes in Sexual Allocation within Flowers of Chelidonium majus ( Papaveraceae ) (애기똥풀 ( 양귀비과 ) 꽃에서 일어나는 성적자원 분배의 계절적 변화)

  • Kang, Hye-Son;Rihard B. Primark;Nam-Kee Chang
    • The Korean Journal of Ecology
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    • v.14 no.4
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    • pp.415-433
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    • 1991
  • Seasonal variation in size and number of floral structures was examined in two massachusetts populations of chelidonium major, a self-compatible herb. All floral charcters except for anther number per flower declind significantly during a 3 week period. However, temporal patterns were not identical among characters or between popolations. The result indicate that floral characters varied in conjunction with flower diameter,but that the pattern of changes in floral characters in response to environments may not be easy to predict. Principal components analysis was conducted to environments may not be easy to predict. principal compenents analysis was conducted tl identify the functional relationship among floral male function, and female function, respectively, perhaps reflecting the functional distinction of floral characters. Based on this pattern, the relative allocation to sexual structures within flowers was examined: male allocation was relatively greater than female allocation eary or in the middle of flowering season, depending upon populations. Temporalvariation in relative allocation within flowers was not independent of seed tield components:; different combinations of the size and number of floral characters were correlated with different seed yield components, for example, either seed size or number per fruit, during a season. in particular, allocations to attractive and male structures were highly correlated with mean seed weight only earlier in the season. These result provide some evidence that flowering phenolgy is an important comportant to be considered in the study of sexual allocation.

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Pork Preference for Consumers in China, Japan and South Korea

  • Oh, S.H.;See, M.T.
    • Asian-Australasian Journal of Animal Sciences
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    • v.25 no.1
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    • pp.143-150
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    • 2012
  • Competition in global pork markets has increased as trade barriers have opened as a result of free trade agreements. Japanese prefer both loin and Boston butt, while Chinese prefer pork offal. Frozen pork has increased in terms of imports into China. Japanese consumers consider pork meat origin along with pork price when making purchase decisions. While the Chinese prefer a strong tasting pork product, South Korean consumers show very strong preferences to pork that is higher in fat. Therefore, South Korean consumers have a higher demand for pork belly and Boston butt. Consequently, the supply and demand of pork in Korea is hardly met, which means that importation of high fat parts is inevitable. In Korea there is lower preference toward low fat parts such as loin, picnic shoulder, and ham. During the economic depression in South Korea there have been observable changes in consumer preferences. There remains steep competition among the pork exporting countries in terms of gaining share in the international pork market. If specific consumer preferences would be considered carefully, there is the possibility to increase the amount of pork exported to these countries.

Roles of the Public Library for Children Education : Observation Survey on the Public Libraries in Boston and its Vicinity (아동교육을 위한 공공도서관의 역할 : 미국 보스턴주변 공공도서관 프로그램 관찰조사를 중심으로)

  • 임형연
    • Journal of Korean Library and Information Science Society
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    • v.35 no.2
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    • pp.393-414
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    • 2004
  • Traditional role of library is focused on the book collection and its reference service. However, library should be stressed the need of educational activity in the future. This study described to classify the roles of public library, which are book collecting and its reference services, educational activities, event place service for region community. Observation survey on the public libraries in Boston and its Vicinity shows that public libraries have various children's programs and they are getting more important roles. Public libraries of case study have done not only the roles for reference service space but also the informal lifelong education institute for region community. Library as the informal lifelong education institute deserve special emphasis on the development of education program.

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Economic and Environmental Impacts of Mass Tourism on Regional Tourism Destinations in Indonesia

  • Lee, Jung Wan;Syah, Ahmad Mujafar
    • The Journal of Asian Finance, Economics and Business
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    • v.5 no.3
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    • pp.31-41
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    • 2018
  • The study examines economic and environmental impacts of mass tourism on regional tourism destinations, particularly the establishment of "Ten New Bali", in Indonesia. The sample is restricted to the period of time in which annual data is available and comparable among variables from 1980 to 2015 (36 observations). All of the time series data was collected and retrieved from the World Development Indicator database published by the World Bank. This study applies cointegrating regression analysis using the fully modified OLS, canonical cointegrating regression, and dynamic OLS. The results of the study suggest that 1) there is a long-run equilibrium relationship between tourism receipts, environmental degradation and economic growth in Indonesia, 2) tourism growth and agriculture land growth are positively related to an increase of total output in the short-run in Indonesia, and 3) arable land is significant at the 0.01 level, but forest rents and CO2 from transport are not significant in the short-run in Indonesia. The results confirm that arable land is negatively related to an increase of total output in Indonesia. That is, when tourism growth in the economy is getting realized it shows that the environmental degradation increases greatly in inverse in the model, eventually negative impacts to the environment.