• Polymer Science and Technology
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• v.23 no.1
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• pp.3-12
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• 2012

• BMB Reports
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• v.43 no.10
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• pp.649-655
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• 2010

Alzheimer's disease (AD) is the most common age-dependent neurodegenerative disorder and shows progressive memory loss and cognitive decline. Intraneuronal filaments composed of aggregated hyperphosphorylated tau protein, called neurofibrillary tangles, along with extracellular accumulations of amyloid $\beta$ protein (A$\beta$), called senile plaques, are known to be the neuropathological hallmarks of AD. In light of recent studies, epigenetic modification has emerged as one of the pathogenic mechanisms of AD. Epigenetic changes encompass an array of molecular modifications to both DNA and chromatin, including transcription factors and cofactors. In this review, we summarize how DNA methylation and changes to DNA chromatin packaging by post-translational histone modification are involved in AD. In addition, we describe the role of SIRTs, histone deacetylases, and the effect of SIRT-modulating drugs on AD. Lastly, we discuss how amyloid precursor protein (APP) intracellular domain (AICD) regulates neuronal transcription. Our understanding of the epigenomes and transcriptomes of AD may warrant future identification of novel biological markers and beneficial therapeutic targets for AD.

• BMB Reports
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• v.37 no.1
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• pp.1-10
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• 2004

DNA and RNA quantifications are widely used in biological and biomedical research. In the last ten years, many technologies have been developed to enable automated and high-throughput analyses. In this review, we first give a brief overview of how DNA and RNA quantifications are carried out. Then, five technologies (microarrays, SAGE, differential display, real time PCR and real competitive PCR) are introduced, with an emphasis on how these technologies can be applied and what their limitations are. The technologies are also evaluated in terms of a few key aspects of nucleic acids quantification such as accuracy, sensitivity, specificity, cost and throughput.

• Journal of Distribution Science
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• v.9 no.2
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• pp.5-12
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• 2011

This study models the operational competence of mobile service providers as an endogenous factor that presumably impacts the mobile commerce (m-commerce) adoption of consumers and examines the relationship between the perceptions of consumers toward the operational performance of m-commerce providers and their m-commerce adoption likelihood. Quantitative research is applied with data collected from wireless Internet consumers in South Korea. The data is analyzed using factor analysis and structural equation modeling methods. The findings suggest that the operational competence of m-commerce providers is a significant antecedent to the m-commerce use and adoption of consumers in Korea. In this environment, the operational competence of mobile service providers in managing facilities, equipment, systems and technology plays a central role in enhancing m-commerce use and adoption. Based on the results, important managerial implications are discussed.

• The Journal of Asian Finance, Economics and Business
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• v.2 no.1
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• pp.29-36
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• 2015

The paper examines the antecedents of acceptance of social networking sites in retail franchise and restaurant businesses. The success of retail franchise and restaurant business operators via social networking sites depends not only on organizational benefits but also on their behavioral intentions of using it. Three hundred and twenty four samples collected from South Korean retail franchise and restaurant employees are analyzed using factor analysis, structural equation model techniques and one-way analysis of variance. The results of the study identify the three constructs of organizational benefits, perceived tangible assets and perceived intangible assets as for important antecedents to accept social networking sites for their business use. Moreover, higher position employees tend to have more favorable perception of tangible assets and acceptance of social networking sites for their business use.

• Korean Journal of Clinical Pharmacy
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• v.20 no.3
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• pp.229-234
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• 2010

섬유근통 증후군은 만성 전신 통증을 나타내며 피곤, 두통, 우울증, 수면장애 등을 동반하는 질환이다. 주로 30-50대의 여성에게서 많이 나타나며 미국에서 2-4%, 한국에서 2%의 발병률을 보이고 있다. 정확한 원인과 기전이 밝혀져 있지 않아서 진단과 치료에 많은 논란과 어려움이 있다. 현재는 증상치료에 목표를 두고 삼환계항우울약을 많이 사용하고 있으나 심각한 부작용의 문제가 있다. 이러한 문제 때문에 최근에는 selective serotonin reuptake inhibitor (SSRI) 또는 serotonin-norepinephrine reuptake inhibitor (SNRI)를 빈번히 사용하고 있다. 본 연구는 SNRI의 하나인 milnacipran의 섬유근통 증후군 치료에 대한 효능 및 안정성을 알아보기 위해, MEDLINE에 등재된 논문을 기한없이 milnacipran과 fibromyalgia로 검색하여 무작위 배정 및 이중맹검 임상연구자료들을 선별하였다. 선별된 6개의 임상연구 결과, milnacipran를 사용했을 때 일관된 효능성과 안정성이 관찰되었고 섬유근통증후군 치료와 그에 수반되는 여러증상에 효과적인 것으로 나타났다.

• The Journal of Asian Finance, Economics and Business
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• v.1 no.1
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• pp.5-14
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• 2014

This paper empirically examines the short-run and long-run causal relationship between stock market prices and exchange rates in Chinese stock markets using monthly data from January 2002 to December 2012 retrieved from the National Bureau of Statistics of the People's Republic of China. Unit root, cointegration tests, vector error correction estimates, block exogeneity Wald tests, impulse responses, variance decomposition techniques and structural break tests are employed. This study found 1) long-run causality from exchange rates to stock prices in Chinese stock markets and 2) short-run causality from Japanese yen and Korean won exchange rates to stock prices in the Shanghai Stock Exchange strongly prevails while in the Shenzhen Stock Exchange weakly prevails. The impact of the global financial crisis from 2007 to 2009 on Chinese stock markets was insignificant.

• The Journal of Asian Finance, Economics and Business
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• v.3 no.2
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• pp.41-49
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• 2016

Since World War II nations have formed alliances for reasons of security and trade. Countries have seen international integration as an appropriate approach to resolving domestic and international political issues, improving their welfare by both transforming their infrastructures and increasing their foreign trade. While the majority of these relationships are straightforward d Turkey's relationship with the European Union is more complex due to differences in religion and, at times, political ideology from other Union members. As a candidate country Turkey has made advances towards the full membership of the European Union with the customs union being the most significant. The impact of customs union membership is discussed and the effects of the customs union on Turkey's trade and economy are examined from a perspective of different economic theories.

• The Journal of Asian Finance, Economics and Business
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• v.3 no.2
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• pp.67-76
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• 2016

The paper explores determinants of corporate adoption of social media and the role of technology acceptance model in the path. This paper assimilates some components of the technology acceptance dimension and social expectation theories to determine corporate intentions to use social media. Six hundred and forty-eight samples collected from hotel staff in Korea are analyzed using factor analysis, structural equation model techniques and one-way analysis of variance. The results show that corporate needs, social expectations, ease of use and usefulness should be viewed as important antecedents explaining the firm's behavioral intention to use social media. The study also finds that the ease of use and usefulness of the technology acceptance model have positive directional mediation effects in the path diagram.

• Water Engineering Research
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• v.1 no.4
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• pp.309-320
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• 2000

In this study, laboratory study of the behavior of wastewater discharged from the Boston ocean outfall was compared with the predictions of mathematical models. The dta sets cover broad ranges of discharge conditions and oceanic conditions, and are associated with a typical type of outfall discharges with multiport diffusers. The laboratory data sets were obtained in density stratified towing tanks. These data sets were used to evaluate four commonly used models: UM, UDKHDEN, RSB and CORMI$\times$2 for minimum dilution, the height to the top of the wastefield, and wastefield thickness. For minimum diluation and height to the top of the wastefield, UM and RSB predictions agree well with laboratory data. UDKHDEN overestimated the minimum dilution and height to the top of the wastefield while CORMI$\times$2 underestimated these values. All of the model predictions for the wastefield thickness were widely scattered. about the measured values. The hydraulic model study reproduced the major features observed in the laboratory. It also afforded considerable insight into the mechanics of mixing of multiport risers which could not have been obtained either from the laboratory test or the mathematical models.