• 기본간호학회지
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• 제16권3호
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• pp.325-332
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• 2009

Purpose: This study was done to investigate the relationship among the life style, body composition, and BMD in female college students. Method: For this study, 320 female college students aged 18 through 35 were sampled. Data were collected from June to September, 2007. The BMD was measured with Dual Energy X-ray Absorptiometry, body composition with the Body Composition Analyzer, and stature was also taken. Results: Our findings indicated that the relationship among the life style, body composition and BMD significantly varied and that meal times (F=3.318, p= .038) and muscle mass (r= .240, p< .001) and fat-free mass (r= .233, p< .001) showed a significant positive relationship with BMD. Conclusions: Our findings indicated that optimal levels of the fat-free mass and muscle mass should be maintained. Since a decrease in the quantity of bones is expected to cause health issues for women after menopause, it is necessary to reduce risk factors including the unhealthy life style of college women that may lead to osteoporosis, and to introduce preventive nursing interventions against osteoporosis.

• Biomolecules & Therapeutics
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• 제29권3호
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• pp.263-267
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• 2021

Periodontal disease is primarily associated with bacterial infection such as dental plaque. Dental plaque, an oral biofilm harboring a complex microbial community, can cause various inflammatory reactions in periodontal tissue. In many cases, the local bacterial invasion and host-mediated immune responses lead to severe alveolar bone destruction. To date, plaque control, non-surgical, and surgical interventions have been the conventional periodontal treatment modalities. Although adjuvant therapies including antibiotics or supplements have accompanied these procedures, their usage has been limited by antibiotic resistance, as well as their partial effectiveness. Therefore, new strategies are needed to control local inflammation in the periodontium and host immune responses. In recent years, target molecules that modulate microbial signaling mechanisms, host inflammatory substances, and bone immune responses have received considerable attention by researchers. In this review, we introduce three approaches that suggest a way forward for the development of new treatments for periodontal disease; (1) quorum quenching using quorum sensing inhibitors, (2) inflammasome targeting, and (3) use of FDA-approved anabolic agents, including Teriparatide and sclerostin antibody.

• Journal of Korean Dental Science
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• 제17권1호
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• pp.14-35
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• 2024

The temporomandibular joint (TMJ) is one of the most unique joints in the human body that orchestrates complex movements across different orthogonal planes and multiple axes of rotation. Comprising the articular eminence of the temporal bone and the condylar process of the mandible, the TMJ integrates five major ligaments, retrodiscal tissues, nerves, and blood and lymph systems to facilitate its function. Cooperation between the contralateral TMJ and masticatory muscles is essential for coordinated serial dynamic functions. During mouth opening, the TMJ exhibits a hinge movement, followed by gliding. The health of the masticatory system, which is intricately linked to chewing, energy intake, and communication, has become increasingly crucial with advancing age, exerting an impact on oral and systemic health and overall quality of life. For individuals to lead a healthy and pain-free life, a comprehensive understanding of the basic anatomy and functional aspects of the TMJ and masticatory muscles is imperative. Temporomandibular disorders (TMDs) encompass a spectrum of diseases and disorders associated with changes in the structure, function, or physiology of the TMJ and masticatory system. Functional and pathological alterations in the TMJ and masticatory muscles can be visualized using various imaging modalities, such as cone-beam computed tomography, magnetic resonance imaging, and bone scans. An exploration of potential pathophysiological mechanisms related to the TMJ anatomy contributes to a comprehensive understanding of TMD and informs targeted treatment strategies. Hence, this narrative review presents insights into the fundamental functional anatomy of the TMJ and pathological changes that evolve with TMD progression.

• Restorative Dentistry and Endodontics
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• 제49권2호
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• pp.13.1-13.7
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• 2024

Chronic osteomyelitis with proliferative periostitis, known as Garre's osteomyelitis, is a type of osteomyelitis characterized by a distinctive gross thickening of the periosteum of bones. Peripheral reactive bone formation can be caused by mild irritation or infection. Garre's osteomyelitis is usually diagnosed in children and young adults, and the mandible is more affected than the maxilla. The following is a case report of a 12-year-old female patient with Garre's osteomyelitis of the mandible due to an infection of a root canal-treated tooth. Without surgical intervention, the patient's symptoms were relieved through nonsurgical root canal re-treatment with long-term calcium hydroxide placement. A cone-beam computed tomography image obtained 6 months after treatment completion displayed complete healing of the periapical lesion and resolution of the peripheral reactive buccal bone. Due to the clinical features of Garre's osteomyelitis, which is characterized by thickening of the periosteum, it can be mistaken for other diseases such as fibrous dysplasia. It is important to correctly diagnose Garre's osteomyelitis based on its distinctive clinical features to avoid unnecessary surgical intervention, and it can lead to minimally invasive treatment options.

• The Korean Journal of Medicine
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• 제99권1호
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• pp.11-16
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• 2024

Myelodysplastic syndrome (MDS) is a heterogeneous disorder with diverse prognoses influenced by cytopenias, genetic variants, and myeloblast proportions in the bone marrow. Accurate prognosis prediction and tailored treatment plans are essential. The International Prognostic Scoring System-Molecular (IPSS-M), which additionally reflects the impact of MDS-related genetic mutations to the clinical and laboratory information, is anticipated to offer superior prognostic accuracy compared to existing systems like the Revised International Prognostic Scoring System (IPSS-R). Despite its statistical complexity, its web-based calculation and ease of discussing results with patients using intuitive data sets provide notable advantages. Progress in MDS treatment, exemplified by effective anemia correction with an erythropoiesis-maturation agent in SF3B1-mutated cases and efforts to refine poor prognoses in TP53-mutated cases, reflects the evolving landscape of genetic-based interventions in MDS. Advancements in genetic diagnostic technology, combined with enhanced knowledge of the bone marrow niche, are anticipated to lead to significant improvement in MDS treatment outcomes in the future.

• 환경생물
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• 제26권1호
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• pp.8-14
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• 2008

본 연구는 2000$\sim$2002년 사이에 우리나라에서 사망한 야생조류의 간, 신장 그리고 뼈에서의 납과 카드뮴 농도를 분석하였다. 연구에 이용된 시료는 황새목(n=10), 기러기목 (n=3), 매목 (n=7), 도요목 (n=8), 비둘기목 (n=2) 그리고 참새목 (n=6)이었다. 간에서 납 농도는 도요목<기러기목<황새목<매목<참새목<비둘기목의 순이었다. 매목을 제외한 모든 목에서 뼈에서의 납 농도가 간에서의 납 농도보다 높았다. 본 결과는 우리나라 야생조류의 납 농도는 급성 오염이 아니라 만성적인 오염을 나타내는 것이다. 그리고 모든 조류의 간과 신장에서의 납 농도는 야생조류의 background level과 exposed level의 범위였다. 간에서의 카드뮴 농도는 도요목<황새목<기러기목<매목<참새목<비둘기목의 순이었다. 황새목, 기러기목, 매목과 참새목은 신장에서의 농도가 간에서의 농도보다 높았지만 도요목은 그렇지 않았다. 도요목을 제외한 모든 조류에서 카드뮴오염은 급성오염이 아닌 만성오염으로 생각된다. 본 연구에서 우리나라 야생조류의 카드뮴 농도는 대부분 background level이었지만 왜가리 1개체와 바다쇠오리 7개체는 toxic level이었다.

• 대한임상독성학회지
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• 제9권2호
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• pp.39-48
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• 2011

In mass casualty situation due to radiological accidents, it is important to start aggressive management with rapid triage decisions. External contamination needs immediate decontamination and internal contamination should be treated with special expertise and equipment to prevent the rapid uptake of radionuclides by target organs. Acute radiation syndrome shows a sequence of events that varies with the severity of the exposure. More severe exposures generally lead to more rapid onset of symptoms and severe clinical findings. After the massive exposure, various systems of the body reflect their severe damages that can lead to death within hours or up to several months. The disease progression has classically been divided into four stages: prodromal, latent, manifest illness, and recovery or death. Three characteristic clusters of symptoms including the hematopoietic syndrome, the gastrointestinal syndrome and the cerebrovascular syndrome are all associated with the acute radiation syndrome. The standard medical management of the patients with a potentially survivable radiation exposure includes good medical, surgical and supportive measures. Specific treatment with cytokines and bone marrow transplantation should be considered. The management of internal contamination is much the same as the treatment of poisoning. The standard decontamination should be applied to reduce uptake, and the chelating agents can be administered to enhance the clearance of radioisotopes. Radioactive iodine ($^{131}I$) as one of the nuclear fission products can increase the incidence of thyroid cancer in children. Potential benefit of potassium iodide prophylaxis is greater especially in neonates, infants and small children.

• 대한심미치과학회지
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• 제10권1호
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• pp.8-15
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• 2001

The Class III malocclusion classified in two types of Skeletal Class III and Pseudo Class III. In the case of the maxillary deficiency, the protraction H-G(facemask) with Bonded RPE can be used. For children with A-P and vertical maxillary deficiency, the preferred treatment is to move the maxilla into a more anterior and inferior position, which also increases its size as bone is added at the posterior and superior sutures. Successful forward repositioning of the maxilla can be accomplished before age 8. To resist tooth movement as much as possible, the maxillary teeth should be splinted together as a single unit. The maxillary appliance must have hooks for attachment to the facemask that are located in the canine-primary molar area above the occlusal plane. The facemask usually worn until a positive overjet of 2-5mm is achieved interincisally. Occipital chin cup is successful in those patients who can bring their incisors close to an edge-to-edge position when in centric relation. This treatment is particularly useful in patients who begin treatment with a short lower anterior facial height, as this type of treatment can lead to an increase in lower anterior facial height. If the pull of the chin cup is directed below the condyle, the force of the appliance may lead to a downward and backward rotation of the mandible.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제23권1호
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• pp.115-120
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• 2020

Klippel-Trenaunay syndrome (KTS) is a rare disorder characterized by a triad of abnormal bone and soft tissue growth, the presence of a port-wine stain, and venous malformations. Gastrointestinal (GI) manifestations of KTS are relatively common and generally do not cause significant problems. However, persistence can lead to chronic GI blood loss or even massive bleeding in rare cases. The majority of the severe GI manifestations associated with KTS present as vascular malformations around the GI tract and exposed vessels can lead to serious bleeding into the GI tract. Herein, we report a case of a 16-year-old boy with severe iron deficiency anemia who was previously misdiagnosed as hemorrhoid due to small amount of chronic bleeding. The actual cause of chronic GI bleeding was from an uncommon GI manifestation of KTS as rectal polyposis.

• 생태와환경
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• 제43권3호
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• pp.409-417
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• 2010

본 연구는 Pb의 농도와 노출 기간이 붕어(Carassius auratus) 조직의 미세구조와 생리적 변화에 미치는 영향을 조사하였다. 아가미, 뼈와 근육 조직에서 Pb의 축적 농도는 노출 40일에 증가하였다. 아가미 조직 내 Pb의 축적량은 다른 조직에 비하여 높았으며, 아가미, 뼈 및 근육 조직에서 노출기간이 길어질수록 증가하였다. Pb에 노출된 아가미, 뼈와 근육 조직의 항산화효소 활성은 아가미와 근육 조직에서 높았으며, 신장 조직에서 가장 낮은 활성을 보였다. 또한 항산화효소 중 superoxide dismutase의 활성은 대조군에 비해 2배 정도 증가하였으나, glutathion peroxidas의 활성은 매우 낮았다. Pb에 노출된 아가미 조직에서 점액세포는 수가 증가하였으며, 곤봉화와 부종이 이차새변에서 나타났다. 또한 40일간 Pb에 노출된 아가미 조직 내 미토콘드리아와 핵에서는 막의 손상이 관찰되었으며, 신장 조직 내 사구체는 수축되어 보우만 주머니의 공간이 넓게 관찰되었다. 이러한 결과로 보아 붕어 조직 이 장기간 고농도의 Pb에 노출이 되면 비정상적인 형태로 변형되며, 이에 따라 매우 유해한 영향을 받을 수 있을 것으로 생각된다.