• 대한방사선기술학회지:방사선기술과학
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• 제37권4호
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• pp.273-278
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• 2014

골밀도는 골다공증 진단에 중요하게 이용되고 있고, 치료 및 예방에 중요한 지표가 되고 있다. 그러나 골밀도는 피검자의 상태, 골밀도 측정기, 검사자 등에 의해 정밀도의 오차가 발생할 수 있다. 골밀도에 미치는 다양한 요인 중 요추 부위에 실질적인 영향을 일으킬 수 있는 장내가스, 음식, 물을 통하여 환자의 상태에 따라 어떻게 변화하는지 알아보고자 하였다. Aluminium spine phantom(ASP)을 이용하여 수조의 물 높이 변화와 가스의 유무에 따른 골밀도의 변화를 알아보았다. 또한 자원자를 대상으로 물이 증가하거나 음식물 증가에 의한 골밀도의 영향을 알아보았다. Aluminium spine phantom을 통한 골밀도 측정에서 수조의 물 높이가 증가함에 따라 골밀도가 감소하여 통계적으로 유의한 변화를 관찰하였다(p=0.026). 가스의 유무에 따른 골밀도의 유의한 차이가 없었다(p=0.587). 자원자를 대상으로 한 연구에서는 음식물의 유무에 따른 골밀도가 유의한 차이가 없었으며(p=0.812), 물의 유무에 따라서도 골밀도의 유의한 차이가 없었다(p=0.618). 따라서 요추부 골밀도 측정에서 골의 경계를 인지하는데 어려움이 없다면, 환자의 금식여부나 대장 내시경 검사 후에 시행하는 골밀도 검사는 골밀도에 큰 영향을 끼치는 인자가 아님을 알 수 있었다.

• 치과방사선
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• 제13권1호
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• pp.97-105
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• 1983

For the assessment of changes in the bone architecture of the maxilla and mandible in renal osteodystrophy, 31 chronic renal failure patients who were undergoing hemodialysis therapy were selected. They were evaluated through clinical oral examination, radiographic and biochemical examination. The results were as follows: 1. In 17 cases (54.8%), there were evidences of bony change in jawbone. 2. The most common dental radiographic finding was decreased bone density (14 cases, 45.2%). 3. The second most common dental radiographic finding was total or partial loss of lamina alveolar dura (11 cases, 35.5%). 4. The third most common dental radiographic finding was total or partial loss of inferior canal wall (8 cases, 25.8%). 5 cases showed evidences of bony change only in jawbone, and 5 cases only in hand, and 12 cases in both. 6. Serum creatinine, urea nitrogen and alkaline phosphatase values in hemodialysis group were much higher than in control group. 7. There were statistically significant correlation between bone density and lamina dura, and inferior alveolar canal wall.

• The Journal of Korean Physical Therapy
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• 제18권2호
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• pp.17-24
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• 2006

Purpose: This study was aimed for service to clinical data of physical therapy necessity of bone complication through analysis method of BMD (bone mineral density) used DEXA (dual energy X-ray absorptiometry) to their skeletal system for physical therapy assesement and intervention program in type II diabetic patients. Methods: Experimental group of 75 subjects and comparison group of 62 subjects were participated in type II diabetic patients(40-80 ages). BMD was measured by DEXA. BMD change of BMI score and BMD comparison of age and sex would be known. Results: This study was found that decreased BMD and increased osteopenea in type II diabetes. In particular, women were lower BMD and higher incidence of osteopenea than men. Men showed significant difference in normal group. Influence of type II diabetes was great on change of BMD in men. however, it showed no significant difference from normal group. Conclusion: it was found that skeletal system complication by type II diabetes had some relations. Because reduction of BMD had a great danger to induce trauma by fall or degenerative disease of system, evaluation of proper physical therapy for its prevention and improvement and intervention program are needed. In addition, it would be important to divide type II diabetic patients into osteopenea and osteoporosis changes of skeletal system at comprehensive aspect of physical therapy.

• Journal of Korean Dental Science
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• 제7권1호
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• pp.16-24
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• 2014

Purpose: This study was planned to clarify a negative view of chewing gum due to the concern that continuous gum chewing might cause a change in the gonial angle and make the lower facial appearance look square. Materials and Methods: We had 25 adults (13 males and 12 females, with an average of 27.3 years) chew 6 g of gum (spearmint) evenly with both right and left posterior teeth for one hour per day for three months. We then measured their gonial angle, the inclination of occlusal plane, facial height, bone marrow density, and masticatory force before chewing, 1, 2, and 3 month after chewing to verify its significance statistically. Result: The results showed that the gonial angle increased from $122.7^{\circ}$ to $123.3^{\circ}$ (P>0.05), and thus the jaws became slightly slimmer. There was no change in the occlusal plane inclination and facial height. Meanwhile bone marrow density in the mandibular angle and ascending ramus increased from $0.285g/cm^2$ to $0.290g/cm^2$ (P<0.05), and masticatory force also increased by 0.5 kg on the right side and 0.8 kg on the left side (P<0.05). Conclusion: Continuous chewing of gum gives an appropriate exercise effect to the stomatognathic system. As chewing gum has effect on increase bone marrow density without changing the mandibular angle and facial appearance the claim that jaw bone changes to a square jaw through chewing gum is regarded to be groundless.

• 치과방사선
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• 제25권2호
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• pp.521-533
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• 1995

This study was performed to develop and evaluate the method to detect Quantitatively the serial changes in the size of artificial lesion in the spongious bone by automatic color image analyzer. 15 intraoral radiograms taken before and after endodontic treatment of 5 cases were used for contour line analysis. 30 intraoral radiograms taken by geometrically standardized apparatus before and after serially the formation of artificial lesions of 0.80, 1.20, 1.75, 2.00mm in diameter at the periapical area and interdental area of spongious bone were used. The analysis of image according to the variance of lesion size by 0.25, 0.35, 0.55, and 0.85mm serially was performed by the histogram and the color enhancement with subtraction. The images inputted by CCDcamera were digitized and analyzed by NEXUS QUBE program with NEC PC-9801 computer. The obtained results were as follows: 1. There was no reliability in the analysis of lesions by contour line 2 .. The mean difference of the grey scale at each pixel was 1 step between reference image and the corrected images. 3. In the analysis by histogram of the artificial lesion in spongeous bone, the change over 0.55mm in the mesiodistal size was detectable by the change of the numbers of pixel showing the change in grey scale. 4. In the analysis by histogram of the artificial lesion in spongeous bone, the change over 0.25mm in the buccolingual size was detectable by the change in grey scale. 5. By color enbancement with- subtraction, each lesion was able to be isolated and the change in it's mesiodistal size was detectable visually , but not in it's buccolingual size.

• 치과방사선
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• 제27권2호
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• pp.15-25
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• 1997

This study was performed to prepare the quantitative method of judging the sensitive prognosis of chronic apical periodontitis as early as possible. The subjects were 25 cases with periapical radiolucencies of which were treated with endodontic treatment. Serial radiographs were taken by standardized method longitudinally. The density slice function of digital radiographic system were employed for quantitative and longitudinal assessment of the radiolucent area and the condensing osteitis simultaneously. Obtained results were as follows: 1. The amount of bone repair after endodontic treatment could be detected quantitatively by the density slice function of digital radiographic system. 2. Within the 6-week period after root canal filling, the prognosis could be evaluated by assessment both radiolucent area and condensing osteitis on digital radiographic system. 3. The pattern of bone repair showed peripheral type in most cases from the 6th week after root canal filling. 4. In longitudinal change, bone repair showed two patterns; the succeeding reduction of radiolucent area showing the increase of condensing osteitis in size till 6th week and following by static state or reduction tendency and the reduction following the initial increase of both areas. 5. Cases with pulpitis by trauma showed initial increase of condensing osteitis at 2nd week, marked reduction of radiolucent area and condensing osteitis at 6th week, and approximately normal bone state at 8th week after root canal filling.

• Journal of Nutrition and Health
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• 제29권7호
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• pp.778-787
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• 1996

The purpose of present study was to assess the change of bone mineral density(BMD) and the influences of anthroopometric indices and body composition on BMD in Korean women in Taegu. Subjects were 242 healthy female in the range of 7-67 years old, were divided into 4 age groups in order to assess the influence o factors on BMD according to age. Body composition and BMD measurements of lumbar spine, femur(neck, ward's triangle, trochanter) and total body were performed by dual energy X-ray absorptiometry. The analysis indicated that BMD of most region was positively related to body weight, BMI in all groups 4(50-67years), and closely related to femurs than lumbar spine. This study found correlations between BMD and both total fat body mass and total lean body mass in group 1, 2, 3, and correlations between BMD and only total fat body mass and in group 4. But on regression models the most significant prediction of BMD throughout the skeleton was total lean body mass in group 1(7-16years)and 2(17-34years, and total fat body mass in group 3 and 4. It is concluded that the our data can be used to screen early women of low bone mass. This study confirms that one of the most effective way to prevent osteoporosis and the fractures is to maximize peak bone mass in early life and to minimize bone loss through maintaining adequate weight.

• 대한의용생체공학회:의공학회지
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• 제25권6호
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• pp.525-530
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• 2004

Cage와 나사를 이용하여 유합된 추체의 3차원 유한 요소 모델을 제작하여, 골밀도의 변화에 따른 골다공증과 cage의 위치 변화에 대해, Von-Mites 최대 응력과 최대 변형량을 살펴보았다. 그 결과 해면골의 강도가 증가함에 따라서, 피질골의 응력은 감소하고, 해면골에서의 응력은 증가하였다. 또한 cage의 위치의 변화에 따라서 추체의 응력 분포의 양상이 달라짐을 알 수 있었으며, 이를 통해 수술의 성공도를 높이고자 한다.

• 한국임상약학회지
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• 제33권2호
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• pp.128-134
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• 2023

Background: This systematic review and meta-analysis aimed to evaluate the efficacy and cardiovascular safety of romosozumab compared with placebo. Methods: Randomized controlled trials (RCTs) were searched from Medline, EMBASE, Cochrane Central, and Web of Science until July 2022. Primary outcomes included the change in bone mineral density (BMD) from baseline at month 6. The secondary outcomes were the change of bone turnover markers (N-terminal propeptide of type 1 procollagen (P1NP); C-terminal telopeptide of type 1 collagen (CTX)) from baseline at month 3, and the incidence of cardiovascular adverse events for the total follow-up period. Results: A total of 7 RCTs on 8,370patients were included. Romosozumab showed better effects in improving BMD in both lumbar spine and femoral neck at month 6 (standardized mean difference, SMD 2.20 [95% CI: 1.89-2.52], SMD 0.63 [95% CI: 0.41-0.86]). In contrast to placebo, romosozumab significantly increased PINP levels and reduced CTX levels at month 3 (SMD 0.93 [95% CI: 0.65-1.22], SMD -1.03 [95% CI: -1.23~ -0.82]. However, there was no significant difference in the composite incidence of cardiovascular adverse events and major adverse cardiovascular events (OR 1.16 [95% CI: 0.82-1.65], OR 1.08 [95% CI: 0.75-1.56]). Conclusion: This analysis showed that romosozumab significantly improved BMD compared to placebo and was beneficial for change in bone turnover markers. There is no significant difference in the incidence of cardiovascular adverse events compared to placebo.

• 한국산업보건학회지
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• 제20권1호
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• pp.19-28
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• 2010

This study was designed to investigate the effect of increased blood and tibia lead on the change of bone mineral density in retired male lead workers. One hundred nine retired male lead workers who worked in 4 different lead industries and 51 nonoccupationally lead exposed male subjects were recruited from March 2004 to October 2004. Bone mineral density(BMD) was measured by broadband ultrasound attenuation(BUA) at left calcaneous bone area with broadband ultrasound attenuation method of QUS-2(Metra Biosystems Inc, USA). Tibia bone lead was measured for skeletal bone lead with K-xray fluorescence(K-XRF) and blood lead was analyzed with flameless atomic spectrophotometer. Hemoglobin, hematocrit, serum calcium and iron were also analyzed. In addition, information for smoking and drinking status and basic personal data such as age and lead exposure were also collected using questionnaire inquiry. Blood lead was correlated with tibia lead (r=0.711) and these two variables were negatively correlated with BUA in bivariate analysis. BUA and tibia lead showed significant main effects on the change of blood lead after adjusting covariates. The effect modification by the level of BMD (low: lower than the median of BUA and high: higher than the median of BUA) was observed between the association of tibia lead and blood lead after adjustment of covariates. The subjects who had higher BMD seemed to have lower blood lead by the increase of tibia lead than those of lower BMD. In the multiple regression analysis of blood lead and tibia lead on BUA after adjustment of covariates, only blood lead showed statistically significant effect on BUA. This study confirmed that BMD and blood lead were significantly associated. To verify the causal association of BMD on blood lead and vice versa, further longitudinal studies are needed.