• Korean Journal of Pharmacognosy
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• 제51권4호
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• pp.332-339
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• 2020

Lentinus edodes (LE) is the first medicinal macrofungus to enter the realm of modern biotechnology. Lentinus edodes is well-known to have anti-tumor, anti-inflammatory, and immunomodulatory effects. In this study, osteoporosis was induced by ovariectomy in female rats, and the prevention and treatment efficacy of the climacteric disease the postmenopausal type I pattern was examined using the experimental substance. Female rats were either sham-operated (sham; n = 5) or surgically ovariectomized (OVX; five animals per group) and then administered to OVX control, raloxifene hydrochloride 1 mg/kg/day, or LE (20 and 200 mg/kg/day) for 12 weeks. LE treatment suppressed the ovariectomy-induced reduction of bone mineral density in the entire tibia as well as its metaphysis with a decrease of serum osteocalcin and interleukin-6 levels. In addition, LE is suggested to elevate the serum levels of progesterone hormones and prevent bone loss in ovariectomized rats. In conclusion, LE 200 mg/kg/day may have inhibitory effects on osteoporosis in OVX rats.

• Journal of Physiology & Pathology in Korean Medicine
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• 제35권3호
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• pp.87-96
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• 2021

The purpose of this study was to investigate the effect of single herbal medicines and Korean herbal medicine complex prescriptions for osteoporosis in Korea. We targeted studies published in domestic journals from January 1, 2013 to April 1, 2021. For domestic databases, RISS, NDSL, OASIS, DBpia, KISS, KISTI, and Korean Traditional Knowledge Portal were used. Words such as "osteoporosis", "herbal medicine", "herbal combination prescription" and "herbal" were combined and searched. A total of 32 studies were selected. Among them, 8 studies were conducted exclusively for animal studies, 18 studies were conducted on cell experiments, and 6 studies were conducted on both animal and cell experiments. There were 18 studies using a single herb and 14 studies using a combination of Herbal medicine. As a result of the investigation of a single herb, it was found that 補陽藥 was most widely used, and it was found that it was mainly used in the herbal combination prescription, mainly for 補陽藥, 補氣藥, and 補陰藥. Studies in animal experiments revealed significant results mainly in bone mineral density, serological indicators, and morphological indicators of bone tissue. In the study of cell experiments, the effects were found in factors related to the differentiation of osteoclasts and inhibitors of inflammation. Through the results of this study, we are able to confirm the effective single herbal medicines and herbal medicine complex prescriptions for the treatment of osteoporosis, and it is expected that they will contribute to clinical treatment.

• Journal of Microbiology and Biotechnology
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• 제34권8호
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• pp.1580-1591
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• 2024

Menopause is induced by spontaneous ovarian failure and leads to life quality deterioration with various irritating symptoms. Hormonal treatment can alleviate these symptoms, but long-term treatment is closely associated with breast and uterine cancer, and stroke. Therefore, developing alternative therapies with novel anti-menopausal substances and improved safety is needed. In our study, heat-killed Bifidobacterium breve HDB7040 significantly promoted MCF-7 cell proliferation in a dose-dependent manner under estrogen-free conditions, similar to 17β-estradiol. This strain also triggered ESR2 expression, but not ESR1, in MCF-7 cells. Moreover, administrating HDB7040 to ovariectomized (OVX) Sprague-Dawley (SD) female rats reduced estrogen deficiency-induced weight gain, fat mass, blood triglyceride, and total cholesterol levels. It also recovered collapsed trabecular microstructure by improving trabecular morphometric parameters (bone mineral density, bone volume per tissue volume, trabecular number, and trabecular separation) and decreasing blood alkaline phosphatase levels with no significant changes in uterine size and blood estradiol. HDB7040 also significantly regulated the expression of Tff1, Pgr, and Esr2, but not Esr1 in uteri of OVX rats. Heat-killed B. breve HDB7040 exerts an anti-menopausal effect via the specific regulation of ERβ in vitro and in vivo, suggesting its potential as a novel substance for improving and treating menopausal syndrome.

• Korean Journal of Community Nutrition
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• 제6권2호
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• pp.192-204
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• 2001

Osteoporosis and other related conditions pose a growing public health problem, especially in postmenopausal women. The main purpose of the study was to investigate the correlations among BMD, maternal factors, and life styles, and intake of nutrients in postmenopausal women. One hundred participants in Kyungge-do were divided into three groups according to their BMD measurements measured by DXA. Dietary analysis, anthropometric measurements, and questionares were administered to these women. The percentage of the osteoporosis, osteopenia(Osteopinia), and normal groups were 32%, 48%, and 20% respectively. The average age was significantly the highest in the osteoporosis group. The average age at menopause was 47.2. Osteoporosis group's age at menopause was significantly the lowest. The sleeping hours of the osteoporosis and osteopenia group were significantly longer than the normal group. The intake of vitamin B$_2$was positively correlated with the BMD of femoral neck. The BMD of these two sites was positively correlated with weight, BMI, waist, and hip size and negatively correlated with the length of the menstrual cycle, duration after menopause, the age at the last delivery, and sleeping hours. Spinal BMD positively correlated with hours of outdoor activity. Therefore, maternal factors, lifestyles, and intake of nutrients contribute to BMD.

• Health Policy and Management
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• 제11권3호
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• pp.71-88
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• 2001

The purpose of this study is to analyze the cost-effectiveness of four medications for treating and preventing osteoporosis -HRT therapy(conjugated equine estrogen 0.625mg for 25 days and medroxyprogesterone acetate 5mg for 01112 days), Alendronate(10mg and 5mg), Active Vitamin D(Calcitriol), and Calcium. Total costs include the direct medical cost -examination fee, consultation fee, prescription fee, fee for preparing medications, and the price of pharmaceuticals- and the indirect cost of patients such as traffic expenses and time cost. In addition, the costs of monitoring in adverse reactions are added. The effects of four medications are expressed as BMD(Bone Mineral Density) percent change measured by DEXA(Dual Energy X-ray Absorptiometry) in lumbar spine(L2-L4) and femoral neck site. A mixed model based on meta analysis provides the estimates of effectiveness, which are then appled to the hypothetical cohort consisting of postmenopausal women at the age of 50-59. HRT therapy is the most cost-effective medication at 172,433.64 won (lumbar spine site) and 546,328.28 won (femoral neck site) per BMD percent change for osteoporosis. Alendronate 10mg is more cost-effective than Alendronate 5mg as 345,971.23 won and 378,441.63 won per lumbar BMD percent change at 0.991ｇ/$cm^2$, respectively. Alendronate 10mg is more cost-effective than Alendronate 5mg as 1,329,257.89 won and 1,467,291.23 won per femoral neck BMD percent change at 0.834ｇ/$cm^2$, respectively.

• Journal of Acupuncture Research
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• 제28권1호
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• pp.93-100
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• 2011

Objectives : The purpose of this study is to observe the general distribution that was medicated with Cheonga-won. Methods : The 278 patients who were medicated with Cheonga-won more than two weeks in Cheonan oriental hospital, Daejeon university from December 2007 to December 2010 were observed. The other general oriental therapys were also carried out according to individual condition. The 278 patients were analyzed according to the distribution of sex, age, the period of medication, symptoms, the change of VAS score and T-score, side effects and abnormal reactions. Results : 1. Cheonga-won was mostly used for Shin-huh, which induces lower back pain, knee pain, vertigo, dysuria, tinnitus. 2. More patients in their fifties, sixties and seventies were prescribed with the medication than those in their thirties and forties. 3. After medication with Cheonga-won, there are tendency in reduce chronic pain. 4. After medication with Cheonga-won, there are tendency in increase BMD(bone mineral density). 5. There are no side effects and abnormal reaction cases that related with Cheonga-won. Conclusions : Cheonga-won was used in Shin-huh symptoms, and may be effective in reduce chronic pain, improve Shin-huh symptoms and increase BMD.

• Journal of Korean Physical Therapy Science
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• 제8권1호
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• pp.851-857
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• 2001

Objectives: The objective of this study was to investigate the associated factors of low back pain in measurement of women. Methods: The data were collected from women who visited Physical Examination Center of hospital located in Daegu from July 20, 2000 to September 29, 2000. Data from 36 normal in the women. Results: The experience rate for low back pain was 58.3%. The mean age is 56 years. The the lumbar spine of healthy women in age($50\sim59$) was 73.4%, the lumbar spine of women low back pain in age($50\sim59$) was 66.7%, Variables significantly associated with low back pain were weight, education, Exercise time, menopause existence, occupation(p<0.05). The experience for LBP increased as weight increased(Odds ratio = 999.000). The experience for LBP increased as Exercise time decreased(Odds ratio = 1.090), The experience for LBP increased as menopause existence increased(Odds ratio = 0.7111), However all three variables had significant relationship. Conclusions: Results from this study indicated that a statistically significant association between LBP and weight, education. Exercise time, menopause existence, occupation, smoking in $x^2$-test. In logistic regression test. there were related variables.

• Journal of Korean Academy of Fundamentals of Nursing
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• 제15권1호
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• pp.53-59
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• 2008

Purpose: The purpose of this study was to examine the effects of treadmill walking exercise on the BMD (Bone Mineral Density) and BMI (Body Mass Index) of middle-aged women in their forties. Method: A nonequivalent control group pretest-posttest design was used for this study. The experiment was conducted for 10 weeks from May 17 to July 25, 2004 with 29 middle-aged women in their forties, who were assigned to a walking exercise group (16) or a control group (13). The experimental group had not exercised regularly before participating in this program. The control group received no exercise treatment during the research period. The BMD and BMI were measured with peripheral dual energy x-ray absorptiometry and bioelectrical impidence analysis, respectively. $X^2-test$ and Mann-Whitney U test with the SPSS version 11.0 program were used to analyze the data. Result: Treadmill walking exercise was effective for middle-aged women in increasing BMD and decreasing BMI. Conclusion: The findings of this study indicate a need to develop walking exercise protocols for middle-aged women to help them achieve a healthy life.

• Clinical and Experimental Reproductive Medicine
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• 제18권2호
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• pp.189-196
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• 1991

Long-term administration of luteinizing hormone-releasing hormone(LHRH) agonists, through a process of pituitary desensitization and down-regulation of receptors, inhibits the secretion of gonadotropin and sex-steroids and induces a reversible suppression of gonadal activity. This approach can be used as an effective endocrine therapy for some hormone-dependent tumors. We have used D-Trp6-LHRH, a long acting LHRH agonist, for the treatment of eleven patients with uterine leiomyomas, thereafter myomectomy was performed in seven cases and observed the ultrastructural changes of leiomyoma with an electron microscope. The use of LHRH agonist may be effective in reducing the size of a myoma considerably by primarily inducing medical hypophysectomy and would allow easier surgical removal. Electron microscopic findings of myoma cells after the use of LHRH agonist included the following: loss of cristae and swelling nuclear chromatin, perinuclear vacuolation in cytoplasm. Bone mineral density was slightly decreased, however, the difference was not statistically significant.

• Korean Journal of Adult Nursing
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• 제26권5호
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• pp.533-542
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• 2014

Purpose: The purpose of this study was to understand the risk of falling associated with postmenopausal women and to identify the relationships between this risk and factors such as lifestyle, metabolic syndrome, and bone mineral density. Methods: The sample was 128 postmenopausal women between 50 and 65 from one menopausal clinic in an urban city. The Risk Assessment for Falls Scale II, developed by Glydenvand and Reinboth (1982) and adapted by Park Young-Hye (2003), was modified and used for this study. Results: The average fall-risk score in postmenopausal women was 7.2 out of 33, the fall-risk score associated with lifestyle was higher in women exposed to stress frequently or who favored spicy or salty foods. The fall-risk score associated with metabolic syndrome was higher in groups with HBP or with a waist circumference of 80cm or greater. The fall-risk score in groups with three or more factors of metabolic syndrome was the highest. Conclusion: The risk of fall in post-menopausal women was higher in groups with only elementary education, unemployed, reported two or more chronic diseases or reported frequent exposure to stress and for women who preferred spicy or salty foods or exhibited three or more factors of metabolic syndrome.