• The Journal of Advanced Prosthodontics
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• v.15 no.1
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• pp.22-32
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• 2023

PURPOSE. Digital technology has enabled improvements in the fitting accuracy of denture bases via milling techniques. The aim of this study was to evaluate the trueness and precision of digital and analog techniques for manufacturing complete dentures (CDs). MATERIALS AND METHODS. Sixty identical CDs were manufactured using different production protocols. Digital and analog technologies were compared using the reference geometric approach, and the Δ-error values of eight areas of interest (AOI) were calculated. For each AOI, a precise number of measurement points was selected according to sensitivity analyses to compare the Δ-error of trueness and precision between the original model and manufactured prosthesis. Three types of statistical analysis were performed: to calculate the intergroup cumulative difference among the three protocols, the intergroup among the AOIs, and the intragroup difference among AOIs. RESULTS. There was a statistically significant difference between the dentures made using the oversize process and injection molding process (P < .001), but no significant difference between the other two manufacturing methods (P = .1227). There was also a statistically significant difference between the dentures made using the monolithic process and the other two processes for all AOIs (P = .0061), but there was no significant difference between the other two processes (P = 1). Within each group, significant differences among the AOIs were observed. CONCLUSION. The monolithic process yielded better results, in terms of accuracy (trueness and precision), than the other groups, although all three processes led to dentures with Δ-error values well within the clinical tolerance limit.

• BMB Reports
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• v.41 no.8
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• pp.568-574
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• 2008

Antisense RNA molecules are powerful tools for controlling the expression of specific genes but their use in prokaryotes has been limited by their unpredictable antisense effectiveness. Moreover, appreciation of the molecular mechanisms associated with silencing in bacteria is still restricted. Here we report our attempts to define an effective antisense strategy in E. coli, and to dissect the observed silencing process. Antisense constructs complementary to different regions of lacZ were investigated, and silencing was observed exclusively upon expression of antisense RNA hybridising the 5'UTR of lac messenger. The level of lacZ mRNA was reduced upon expression of this antisense construct, and the silencing competence was found to be closely associated with its stability. These observations may help in the design of antisense molecules directed against prokaryotic genes.

• 대학교육
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• s.160
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• pp.80-86
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• 2009

• Korean Journal of Comparative Education
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• v.27 no.1
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• pp.145-169
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• 2017

The purpose of this study is to investigate the influences of educational policy transfer on transitional countries by analyzing the impacts of the Bologna Process on the educational systems of former socialist countries in Europe including Russia, Ukraine, and Hungary. For this purpose, documents published by European Union and its associated educational institutions, as well as academic institutions and scholars were analyzed to evaluate the changes made not only in the systemic level but also institutional and personal levels. The Bologna Process, instigated by the rise of knowledge economy and globalization, is purported to be the most influential educational reform conducted by the member countries since the formation of EU. However, unlike its original intentions to promote the voluntary participation of universities and students, the Bologna Process strengthened the structure of centralized bureaucracy in the educational systems, and restricted the freedom of professors, since most of the universities in these countries relied on governments for their funding. This indicates that in analyzing the influences of educational policy transfer in transitional countries, it is important to analyze the roles and motivations of actors participating in the decision-making processes. Moreover, Bologna Process reforms, made under the direction and control of government, were often turned into cases in which administrators hurriedly implement new policies against the will of faculty members and students, thus impeding the efficient localization of the reforms. This case, thus, implies that while educational reforms driven by policy transfer can change external systems and policies of universities, the fundamental reforms in the minds of faculty and inner workings of organization can only come about after a careful consideration of the societal and cultural values embedded within society.

• KIEAE Journal
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• v.8 no.3
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• pp.51-59
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• 2008

response to the global city. It was developed to cope with the decline of the manufacturing industry, a rise in unemployment and a welfare state system in danger. In cities of the concept, there has been much change in existing urban space and accordingly wisdoms and knowledge has been accumulated. The purpose of this research is to scrutinize urban spatial modification of a regenerated model city "Bologna". The target area of analysis was a ex-factory ailing district. Field site visit, deep interview with professionals and citizens, walk through observation, and historial literature review on the site were employed. As results, its history, retrofit process and current change were systematically described. The results showed ways of thinking, attitude toward historic preservation, technology, and creativity of using existing buildings for contemporary functions. This has a significant implication on Korean urban development which mostly, has ignored the existing value of community and buildings.

• Journal of Communications and Networks
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• v.5 no.2
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• pp.104-115
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• 2003

It is well known that Multiple Input Multiple Output (MIMO) systems offer the promise of achieving very high spectrum efficiencies (many tens of bit/s/Hz) in a mobile environment. The gains in MIMO capacity are sensitive to the presence of spatial and temporal correlation introduced by the radio environment. In this paper, we examine how MIMO capacity is influenced by a number of factors e.g., a) temporal correlation b) various combinations of low/high spatial correlations at either end, c) combined spatial and temporal correlations. In all cases, we compare the channel capacity that would be achievable under independent fading. We investigate the behaviour of "capacity fades," examine how often the capacity experiences the fades, develop a method to determine level crossing rates and average fade durations and relate these to antenna numbers. We also evaluate the influence of channel correlation on the capacity autocorrelation and assess the fit of a Gaussian random process to the temporal capacity sequence. Finally we note that the particular spatial correlation structure of the MIMO channel is influenced by a large number of factors. For simplicity, it is desirable to use a single overall correlation measure which parameterizes the effect of correlation on capacity. We verify this single parameter concept by simulating a large number of different spatially correlated channels.

• BMB Reports
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• v.41 no.6
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• pp.415-434
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• 2008

Phosphoinositide-specific phospholipase C is an effector molecule in the signal transduction process. It generates two second messengers, inositol-1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. Currently, thirteen mammal PLC isozymes have been identified, and they are divided into six groups: PLC-$\beta$, -$\gamma$, -$\delta$, -$\varepsilon$, -$\zeta$ and -$\eta$. Sequence analysis studies demonstrated that each isozyme has more than one alternative splicing variant. PLC isozymes contain the X and Y domains that are responsible for catalytic activity. Several other domains including the PH domain, the C2 domain and EF hand motifs are involved in various biological functions of PLC isozymes as signaling proteins. The distribution of PLC isozymes is tissue and organ specific. Recent studies on isolated cells and knockout mice depleted of PLC isozymes have revealed their distinct phenotypes. Given the specificity in distribution and cellular localization, it is clear that each PLC isozyme bears a unique function in the modulation of physiological responses. In this review, we discuss the structural organization, enzymatic properties and molecular diversity of PLC splicing variants and study functional and physiological roles of each isozyme.

• Wind and Structures
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• v.28 no.5
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• pp.271-284
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• 2019

This paper describes the application of a novel virtual prototyping methodology to wind turbine blade design. Numeric modelling data and experimental data about turbine blade geometry and structural/dynamical behaviour are combined to obtain an affordable digital twin model useful in reducing the undesirable uncertainties during the entire turbine lifecycle. Moreover, this model can be used to track and predict blade structural changes, due for example to structural damage, and to assess its remaining life. A new interactive and recursive process is proposed. It includes CAD geometry generation and finite element analyses, combined with experimental data gathered from the structural testing of a new generation wind turbine blade. The goal of the research is to show how the unique features of a complex wind turbine blade are considered in the virtual model updating process, fully exploiting the computational capabilities available to the designer in modern engineering. A composite Sandia National Laboratories Blade System Design Study (BSDS) turbine blade is used to exemplify the proposed process. Static, modal and fatigue experimental testing are conducted at Clarkson University Blade Test Facility. A digital model was created and updated to conform to all the information available from experimental testing. When an updated virtual digital model is available the performance of the blade during operation can be assessed with higher confidence.

• Journal of Yeungnam Medical Science
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• v.41 no.4
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• pp.235-251
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• 2024

Lung transplantation is an elective treatment option for end-stage respiratory diseases in which all medical therapy options have been exhausted. The current study aimed to identify updated information on the postoperative conditions that may impair rehabilitation after lung transplantation and to provide specific considerations of their clinical relevance during the recovery process. The present study is a systematic review conducted by searching three primary databases: the United States National Library of Medicine PubMed system, Scopus, and the Cochrane Library. The databases were searched for articles published from database inception until May 2024; at the end of the selection process, 27 documents were included in the final analysis. The retrieved material identified 19 conditions of rehabilitative interest that potentially affect the postoperative course: graft dysfunction, dysphagia, postsurgical pain, cognitive impairment, chronic lung allograft dysfunction-bronchiolitis obliterans syndrome, phrenic nerve injury, delayed extracorporeal membrane oxygenation weaning, airway clearance, refractory hypoxemia, mediastinitis, reduced oxidative capacity, sternal dehiscence, coronavirus disease 2019 (COVID-19), gastroparesis, ossification of the elbow, Takotsubo cardiomyopathy, airway dehiscence, recurrent pleural effusion, and scapular prolapse. Although some patients are not amenable to rehabilitation techniques, others can significantly improve with rehabilitation.