• 천문학논총
• /
• 제14권2호
• /
• pp.79-81
• /
• 1999

We have made an extensive mapping of the $^{13}CO$ J=1-0 transition line in the dark cloud L1535. We also constructed the $100{\mu}m$ IRAS map in the region. We found a semi-detached cloud component of $^{13}CO$ in the northeast direction of the $^{13}CO$ main cloud which forms a dumbbell-like structure. This additional component with an angular size of $20'\times16'$ has not been observed before in any molecular surveys of the cloud. The IRAS map shows a similar structure with two intensity peaks whose positions coincide with those of the $^{13}CO$ clouds.

• Bulletin of the Korean Chemical Society
• /
• 제30권12호
• /
• pp.3057-3060
• /
• 2009

Ionic palladium(II) complex, [($Me_4en)Pd(L)]_2(ClO_4)_4\;(Me_4$en = N,N,N',N'-tetramethylethylenediamine; L = bis-(4-(4-pyridylcarboxyl)phenyl)methane), allows to form a monodisperse submicrosphere without any template or additive. Surface-perchlorates on the submicrosphere have been exchanged by anionic pH indicators such as thymol blue, bromothymol blue, and bromocresol green. The ionic and amphiphilic properties of the palladium(II) complex appear to be primarily associated with the formation and easy surface-anion exchange of submicrosphere. The surface-anion exchange through the electrostatic interaction is a very good tool for the surface-modification. The color of the pH indicator-exchanged submicrospheres is very sensitive to pH and Hg$^{2+}$ cation, and thus they are promising to submicrospherical indicators.

• International Journal of Industrial Entomology and Biomaterials
• /
• 제37권2호
• /
• pp.55-62
• /
• 2018

We bred a mulberry cultivar named 'Saealchan' through local adaptability test, which is under registration as a new cultivar for fruit production. Local adaptability test had been carried out at four local places (Jeonju, Gongju, Jangseong, and Sangju) for five years from 2013. This variety 'Saealchan' belongs to Morus alba L. selected from seedlings collected from mother mulberry 'Shimheung'. Saealchan was resistant to popcorn disease and high yielding variety in fruit productivity by 194% compared to control cultivar 'Shimheung (Morus alba L.)' for three years. Although fruits of 'Saealchan' was smaller in size and lower in sugar content of mulberry fruits compared to control variety 'Shimheung', it showed strong resistance to sclerotial disease compared to 'Shimheung'.

• 한국기계기술학회지
• /
• 제20권6호
• /
• pp.776-782
• /
• 2018

After CNN basic structure was introduced by LeCun in 1989, there has not been a major structure change except for more deep network until recently. The deep network enhances the expression power due to improve the abstraction ability of the network, and can learn complex problems by increasing non linearity. However, the learning of a deep network means that it has vanishing gradient or longer learning time. In this study, we proposes a CNN structure with MLP layer. The proposed CNNs are superior to the general CNN in their classification performance. It is confirmed that classification accuracy is high due to include MLP layer which improves non linearity by experiment. In order to increase the performance without making a deep network, it is confirmed that the performance is improved by increasing the non linearity of the network.

• Journal of Pharmaceutical Investigation
• /
• 제39권3호
• /
• pp.177-183
• /
• 2009

A rapid and sensitive reversed-phase high performance liquid chromatography (HPLC) method was developed for the determination of piroxicam in the rabbit plasma. After a treatment of plasma sample by liquid-liquid extraction, the drug was analyzed on an HPLC system with ultraviolet detection at 330 nm. HPLC was carried out using reversed-phase isocratic elution with a C18 column, a mobile phase of a mixture of acetonitril, doubly deionized water and acetic acid 43.74:56.00:0.26 v/v%) at a flow rate of 1.1 mL/min. The chromatograms showed good resolution and sensitivity and no interference of plasma. The calibration curve for the drug in plasma sample was linear over the concentration range of 0.01-2.0 ${\mu}$g/mL. The intra- and inter-day assay accuracies of this method ranged from 86.82% to 108.33% of normal values and the precision did not exceed 13% of relative standard deviation. The plasma concentration of piroxicam decreased to below the quantifiable limit at 12 hr after the i.v. bolus administration to rabbits following dose of 0.375 mg/kg yielding a apparen t plasma half life of 1.38 hr. The transdermal route prolongs plasma levels of piroxicam. The bioavailability, calculated from the dose-adjusted ratio of the $AUC_{transdermal}$ to the $AUC_{i.v.}$, was 7.44%. The plasma concentration of piroxicam was detected by 48 hr after the transdermal administration of patch at a dose of 32 mg/kg. This method was suitable for cutaneous absorption studies of piroxicam in the rabbit after transdermal administration of different types of dosages of the drug.

• 동의생리병리학회지
• /
• 제22권1호
• /
• pp.148-154
• /
• 2008

The butanol extract of Euonymus alatus (BEA) induced dose-dependent relaxation of phenylephrine-precontracted aorta, which was abolished by removal of functional endothelium. Pre-treatment of the endothelium-intact aortic tissues with $N^G-nitro-L-arginine methylester$ (L-NAME), and 1 H-[1,2,4]-oxadiazole- [$4,3-{\alpha}$]-quinoxalin-1-one (ODQ) inhibited the relaxation induced by BEA, respectively. BEA-induced vascular relaxation was not blocked by glibenclamide, tetraethylammonium (TEA), indomethacin, atropine, propranolol, verapamil, and diltiazem, respectively. Moreover, BEA inhibits phenylephrine-induced vascular constriction in a dose-dependent manner. These results suggest that BEA relaxes vascular smooth muscle via endothelium-dependent nitric oxide/cGMP signaling.

• 대한기계학회논문집A
• /
• 제26권3호
• /
• pp.521-527
• /
• 2002

In this paper, tensile behavior and low cycle fatigue behavior of 316L stainless steel which is currently favored structural material for several high temperature components such as the liquid metal cooled fast breeder reactor (LMFBR) were investigated. Research was performed at 55$0^{\circ}C$, $600^{\circ}C$ and $650^{\circ}C$ since working temperature of 316L stainless steel in a real field is from 40$0^{\circ}C$ to $650^{\circ}C$. From tensile tests performed by strain controls with $1{\times}10^{-3}/s,\; l{\times}10^{ -4}/s \;and\; 1{\times}10/^{ -5}/ s $ strain rates at each temperature, negative strain rate response (that is, strain hardening decreases as strain rate increases) and negative temperature response were observed. Strain rate effect was relatively small compared with temperature effect. LCF tests with a constant total strain amplitude were performed by strain control with a high temperature extensometer at R.T, 55$0^{\circ}C$, $600^{\circ}C$, $650^{\circ}C$ and total strain amplitudes of 0.3%~0.8% were used and test strain rates were $1{times}10^{-2} /s,\; 1{times}10^{-3} /s\; and\; 1{times}10^{-4} /s$. A new energy based LCF life prediction model which can explain the effects of temperature, strain amplitude and strain rate on fatigue life was proposed and its excellency was verified by comparing with currently used models.

• Journal of Pharmaceutical Investigation
• /
• 제22권4호
• /
• pp.267-279
• /
• 1992

Microencapsulations of amoxicillin and cephalexin, using Eudragit RS, RL, E, S and L were investigated. The microcapsules were prepared by the solvent evaporation process in liquid paraffin phase, which is based on dispersion of acetone/isopropanol containing the drug in liquid paraffin. Aluminium tristearate was used as an additive for the preparation of microcapsules. The size distribution, dissolution test and observation by SEM were examined. Good reproducibility in microcapsule preparation was observed. The microcapsules obtained were spherical and free-flowing particles. The dissolution rates of amoxicillin and cephalexin from the microcapsules were considerably decreased as compared with those from amoxicillin and cephalexin powder, respectively. As the dispersing agents (aluminium tristearate) increased, the particle size of microcapsules decreased and the dissolution rate increased. In order to control the release rate of drugs, microcapsules were prepared by mixing Eudragit RS/RL or Eudragit S/L. As Eudragit RL ratio in microcapsule of Eudragit RS/RL increased, the dissolution rate increased. As Eudragit L ratio in microcapsule of Eudragit S/L increased, the dissolution rate increased. Furthermore, the release rates of drugs from Eudragit RS/L or RS/polyelthylene glycol 1540 (PEG 1540) were examined. The dissolution rate of drugs increased with increasing of Eudragit L or PEG 1540 ratio. In conclusion, the release rates of drugs from Eudragit RS/RL or RS/PEG 1540 microcapsule could be controlled, and these microcapsules will be convenient for reducing frequency of administration.

• Journal of Microbiology and Biotechnology
• /
• 제14권3호
• /
• pp.532-539
• /
• 2004

For efficient lincomycin production from Streptomyces lincolnensis L1245, various vegetable oils, natural nitrogen sources, and surfactants were investigated at the pilot-scale level in the flask. Olive oil as the sole carbon source was the most suitable one for producing lincomycin. When 20 g/lof olive oil was used, the lincomycin concentration and lipase activity reached 1.01 g/land 182 U/ml, respectively, after 5 days of culture. Among the various unsaturated fatty acids, when linolenic acid was used, the cell growth and lincomycin production were markedly decreased. On the other hand, when 0.2 g/l of oleic acid was added to the culture broth, the maximum lincomycin concentration was 1.0 g/l, which was about 1.7-fold higher than that obtained without the addition of oleic acid. Among the various natural nitrogen sources, pharmamedia or soybean meal was the most suitable nitrogen source. In particular, in the case of a mixture of 10 g/l of pharmamedia and soybean meal, 1.5 g/l of lincomycin concentration and 220 U/ml of lipase activity were obtained. When Span 180 was used as the surfactant, lincomycin production, lipase activity, and oil consumption increased. The correlation between the consumption rates of oil and lincomycin production in a culture using olive oil as the sole carbon source was also investigated. The lincomycin production depended on the consumption rate of olive oil. Using these results, fed-batch cultures for comparing the use of olive oil and starch as a conventional carbon source were carried out in a 5-1 fermentor. When olive oil was used as the sole carbon source, 34 g/l of olive oil was consumed after 7 days of culture. The maximum lincomycin concentration was 3.0 g/l, which was about 2.0-fold higher than that of starch medium after 7 days of culture. The product yield was 0.09 gig of consumed carbon source, which was about 3.0-fold higher than that of starch medium after 7 days of culture.

• Journal of Microbiology and Biotechnology
• /
• 제17권7호
• /
• pp.1071-1078
• /
• 2007

Using a 50-1 airlift bioreactor, for the effective production of tylosin from Streptomyces fradiae TM-224 using raw cornmeal as the energy source, various environmental factors were studied in flask cultures. The maximum tylosin concentration was obtained at $32^{\circ}C$ and pH between 7.0 and 7.5. When seed was inoculated after 24 h of culture, the maximum tylosin concentration, 5.7 g/l, was obtained after 4 days of culture. Various concentrations of raw cornmeal were tested to investigate the optimum initial concentration for the tylosin production. An initial raw cornmeal concentration of 80 g/l gave the highest tylosin concentration, 5.8 g/l, after 5 days of culture. Of the various nitrogen sources, soybean meal and fish meal were found to be the most effective for the production of tylosin. In particular, with the optimal mixing ratio, 12 g/l of soybean meal to 14 g/l of fish meal, 7.2 g/l of tylosin was obtained after 5 days of culture. To compare raw cornmeal and glucose for the production of tylosin in the 50-1 airlift bioreactor for 10 days, fed-batch cultures were carried out under the optimum culture conditions. When raw com meal was used as the energy source, the tylosin production increased with increasing culture time. The maximum tylosin concentration after 10 days of culture was 13.5 g/l, with a product yield from raw cornmeal of 0.123 g/g of consumed carbon source, which was about 7.2 times higher than that obtained when glucose was used as the carbon source.