• 대한한의학원전학회지
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• 제21권3호
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• pp.59-68
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• 2008

The reinforcement method for reducing fever prescribe sweet and warm drugs for reinforcing the middle heater and raising Yang(陽) and sweet and cold drugs for purging the pathogenic fire. Bojung-ikgitang(補中益氣湯) is representative prescription based on the reinforcement method for reducing fever. Therefore it is ought to be regarded as prescription for syndromes to show the impairment of Gi(氣), blood, fluids, and humors for pathogenic fire.

• 대한한방소아과학회지
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• 제21권3호
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• pp.33-55
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• 2007

Objectives In the present study, the author intended to investigate whether bojung-ikgitang-gamibang(BJGB) and seonbang-paedoktang(SBPT) significantly affect in vivo and in vitro mucin secretion from airway epithelial cells. Methods In vivo experiment, mice's mucin which is on a hypersecretion of airway mucin, mice's tracheal goblet cells in hyperplasia and mice's intraepithelial mucosubstances were exposed with SO2for3weeks. Effects of orally-administered BJGB and SBPT during 1 week on vivo mucin secretion and hyperplasia of tracheal goblet cells were assessed by using both enzyme-linked immunosorbent assay(ELISA) and staining goblet cells with alcian blue. In vitro experiment, confluent hamster tracheal surface epithelial(HTSE) cells were metabolically radiolabeled with 3H-glucosamine for 24hrs and chased for 30 min in the presence of each agent to figure out the effectiveness of 3H-mucin secretion. Total elution profiles of control spent media and treatment sample through Sepharose CL-4B column were analyzed. The effects of each agent on contractility of isolated tracheal smooth muscle and effects of each agent on MUC5AC gene expression in cultured HTSE cells were investigated. Also, possible cytotoxicities of each agent were assessed by measuring lactate dehydrogenase(LDH) release. Additionally, effects of BJGB and SBPT on both MUC5AC gene expression in cultured HTSE cells and TNF- or EGF-induced MUC5AC gene expression in human airway epithelial cells (NCI-H292) were investigated. Results (1) BJGB and SBPT inhibited hypersecretion of in vivo mucin. SBPT also inhibited the increase the number of goblet cells. However, BJGB did not affect the increase of number of goblet cells; (2) BJGB significantly increased mucin secretion from cultured HTSE cells, without significant cytotoxicity, and chiefly affected the 'mucin' secretion; (3) SBPT did not affect mucin secretion from cultured HTSE cells without significant cytotoxicity, and also did not affect the secretion of the other releseable glycoproteins; (4) BJGB and SBPT did not affect Ach-induced contraction of isolated tracheal smooth muscle; (5) SBPT significantly inhibit the expression levels of MUC5AC gene and BJGB significantly increased the expression levels of MUC5AC gene in both HTSE cells and NCI-H292 cells. Conclusions BJGB and SBPT can not only affect the secretion of mucin but also affect the expression of mucin gene. The author suggests that the effects BJGB and SBPT with their components should be further investigated and it is highly desirable to find from oriental medical prescriptions, novel agents which might regulate hypersecretion of mucin from airway epithelial cells.

• 대한한의학원전학회지
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• 제22권3호
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• pp.1-6
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• 2009

"Byeonjeungbang-yakjeongjeon(辨證方藥正傳)" was written in the year of 1946 by Lee Sanghwa(李常和) by adding on the original "Bang-yakhappyeon(方藥合編)". 850 formulas based on experience from the times of old and present were added to the original 588 of "Bang-yakhappyeon" and Kimsamul(金四物)'s Samultang(四物湯) modification[加減], Yun Chochang(尹草窓)'s Ijintang(二陳湯) and Pyeong-wisan(平胃散) modification, Idongwon(李東垣)'s Bojung-ikgitang(補中益氣湯) modification, and Pung(馮)'s Yukmijihwangtang(六味地黃湯) modification were added. The 60 medical texts that he consulted greatly influenced the formulas that were added, and of those books the ones of interest include "Seoksilbirok(石室秘錄)", "Byeonjeungrok(辨證錄)", "Byeonjeunggimun(辨證奇聞)" and "Bucheongjunamnyeogwa(傅靑主男女科)". If we analyze the 850 formulas of "Byeonjeungbang-yakjeongjeon", 290 of them, 34%, are related to Jinsatak(陣士鐸)'s medical texts, and of those 290, 15 are from "Seoksilbirok"(5%), 49 are from "Bucheongjunyeogwa"(17%), and 226 are from "Byeonjeungrok"(78%). So, the added formulas of Leesanghwa's "Byeonjeungbang-yakjeongjeon" have been greatly influenced by Jinsatak(陳士鐸), and by looking through Jin(陳)'s medical ideas one can find the origin of prescriptions and become more flexible.

• 대한한의학원전학회지
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• 제22권2호
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• pp.337-347
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• 2009

"Dong-uisusebowon("東醫壽世保元")", written by Ijema(李濟馬), is about the treatment and prevention of diseases according to the four constitutions, Soeum, Soyang, Taeeum and Taeyang. He presents a precise pathogenic mechanism along with specific treatment methods of the Ulgwang(鬱狂) Syndrome which are Seungbo(升補) and Ikgiseung-yang[益氣而升陽] in comparing Mang-yang(亡陽) and Ulgwang Syndromes. However, in the case of the Mang-yang Syndrome, he merely presents formulas without mentioning details of the treatment methods. In this study, the formulas of the Mang-yang Syndrome and Ulgwang Syndrome were thoroughly compared and analyzed, leading to the conclusion that the concept of the Ikgi(益氣) method matches that of the Bojung-ikgitang(補中益氣湯) of Idongwon(李東垣), consisted of ingredients such as Ginseng, Radix Astragali, Radix Angelicae Gigantis, Rhizoma Atractylodis Macrocephalae etc,, and the concept of Seung-yang matches that of Gyejitang(桂枝湯). Furthermore, we have examined the addition of Radix Aconti Lateralis Preparata[附子] to the Ikgiseung-yang[益氣而升陽] method to be aimed at restoring the Yanggi(陽氣). Lastly, through comparison of formulas according to the progress of the Mang-yang Syndrome and Ulgwang Syndrome, we have presented a more detailed explanation of the concept of each treatment methods: the Mang-yang Syndrome focuses more on Seung-yang(升陽), Ulgwang leans more towards Ikgi(益氣).

• 대한한의학원전학회지
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• 제21권3호
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• pp.1-25
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• 2008

Myeong(明) Dynasty Period put together clinically various medical theory in Song(宋) Dynasty and Geum-Won(金元) age, organized medical system. They have been developed in theory, which thought of Byeonjeungronchi(辨證論治) more important, and clinical part which included diagnosis, therapy, prevention. In that age reactional medical thought was in fashion because of affect of Ihak(理學), therefore pediatrics have been affected from them. Especially, looking at the symptom of Byeonjeungronchi doctors, Manjeon(萬全), Nobaeksa(魯伯嗣), Wangdaeryun(王大綸), Wanggeungdang(王肯堂), Nuyeong(樓英) had succeed to Jeoneul(錢乙)' the five viscera Byeonjeung(辨證) system. Manjeon advocated Samyuyeosabujokron(三有餘四不足論) about Jangbu(臟腑) and organized the curative principle about Ojangheosil(五臟虛實). Gupyeong(寇平), commented on diagnosis of five viscera and classification of disease of five viscera. Wangdaeryun in the close of Myeong Dynasty Age explained main pulse, pulse of illness in detail according to weakness or strength of five viscera, pathological or physiological features of five viscera and Saenggeuk(生克) relation of Ohaeng(五行) in the book of "Yeongdongryuchwe(嬰童類萃)". Wanggeungdang and Nuyeong had organized system of argument which classified disease as a result of symptom of five viscera. "Yugwajeungchijunseung(幼科證治準繩)" and "Uihakgangmok(醫學綱目) Soabu(小兒部)" had been written by this principle. Nobaeksa had arranged the principle of cure about five viscera and explained method of common use about each organ's disease. Besides, Seolgi(薛己), Janggyeong-ak(張景岳), insisted about Myeongmun(命門) because he thought of Bisin(脾腎) of children and vigor by nature importance. Seolgi had applied and used very well Bojung-ikgitang(補中益氣湯) based on Idongwon(李東垣)'s Biwiseol(脾胃說) and controled and helped spleen and stomach. At the same time, he took a serious view about supplementing children's Sin-gi(腎氣) according to so many spleen and stomach disease was fallen because they couldn't make warm the spirit of Jungju(中州), result of weakening Hwa(火) of Myeongmun. Also Janggyeong-ak took a serious view strengthen of Bisin, so he assorted and used Insam(人蔘) and Buja(附子) to supplement children's weaken energy in kidney Jeonggi(精氣).