• The Journal of Korean Medicine
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• v.34 no.3
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• pp.126-142
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• 2013

Objectives: Previous reports have shown that Bogijetong-Tang (BJT) is effective in peripheral neuropathy induced by taxol and crush injury. In this study, we researched the effects of BJT on diabetic neuropathy induced by STZ in the mouse. Methods: We performed both in vitro and in vivo experiments to verify the effects of BJT on diabetic neuropathy induced by STZ in mice. Changes in axonal recovery were observed with immunofluorescence staining using NF-200, Hoechst33258, $S100{\beta}$, caspase 3 and anti-cdc2. Proliferation and degeneration of Schwann cells were investigated by immunofluorescence staining and western blot analyses. Results: BJT showed considerable effects on neurite outgrowth and axonal regeneration in diabetic neuropathy. BJT contributed to the creation of NF-200, GAP-43, Cdc2, phospho-vimentin, ${\beta}1$, active ${\beta}1$, ${\beta}3$ integrin, phospho-Erk1/2 protein. Conclusions: Through this study, we found that BJT is effective for enhanced axonal regeneration via dynamic regulation of regeneration-associated proteins. Therefore, BJT had a pharmaceutical property enhancing recovery of peripheral nerves induced by diabetic neuropathy and could be a candidate for drug development after more research.

• The Journal of Internal Korean Medicine
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• v.34 no.4
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• pp.384-404
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• 2013

Objectives : Effects of Bogijetong-tang (BJT) on peripheral nerve regeneration have been reported in a previous study on BJT but additional study on a damaged peripheral neuropathy where its damage level is physically and chemically more severe was needed. Plus, this study was conducted because there haven't been any studies for BJT on central nerve regeneration. Methods : In order to check the effect on central nerve regeneration, the study on cerebellum cells was started and the sciatic nerve was used to observe the effects on a peripheral nerve which was severely damaged both physically and chemically. Nerve recovery effects were observed by analyzing target proteins such as phospho-extracellular signal-regulated kinase, ${\beta}1$ integrin, neurofilament 200, growth-associated protein-43, cyclin-dependent kinase 1, phospho-vimentin, phospho-Smad, and caspase 3. Results : The significant changes of target protein in cerebellum neurons have been observed. The changes of index protein on the axon regeneration and the nerve recovery in the sciatic nerve have been observed and the effects on cell protection were observed, as well. Conclusions : This study confirmed that BJT made a significant influence on nerve protection and recovery of a damaged peripheral neuropathy and it also made a possibility of its regeneration in a damaged central nerve injury.

• Journal of Haehwa Medicine
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• v.23 no.2
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• pp.33-38
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• 2015

The purpose of this study was to report the effect of Bogijetong-tang on post-herpetic neuralgia(PHN). The main symptoms were numbness, pain, burning, paresthesia on left dorsum pedis and insomina. We prescribed Bogijetong-tang (BJT) three times a day and performed acupuncture and moxibustion twice a day. We observed the change of symptoms to evaluate the therapeutic effect. The symptoms were evaluated with numerical rating scale(NRS). After the treatment, pain decreased from 8 to 3, burning from 5 to 1, paresthesia from 7 to 5, numbness from 5 to 3 and insomina improved. Above the results, Bogijetongtang is effective in treating post-herpetic neuralgia.

• The Journal of Korean Medicine
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• v.31 no.6
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• pp.58-63
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• 2010

Objective: We present a case of chemotherapy-induced neuropathic pain with the aim of driving further study evaluating the effectiveness of Oriental medical treatment on patients with neuropathic pain. Method: We prescribed Bogijetong-tang (BJT) two times a day and performed acupuncture and moxibustion once a day over one month of hospitalization. Laboratory tests were performed twice a month during this period. To evaluate the therapeutic effect, Total Symptom Score (TSS) or Visual Analog Score (VAS) was examined at intervals of 7 days. Result: Laboratory data showed no abnormal signs compared with those of initial examination. The patient's subjective symptoms were rapidly relieved within one month. Also, the sums of TSS scores (upper limbs/lower limbs) decreased from 13.64/7.32 to 3.32/3.32 points, and VAS scores (upper limbs/lower limbs) improved from 19/10 to 6/8 points. Conclusion: This case presents a possibility that Oriental medical treatment may offer potential benefits (from an approach aimed at relieving of pain) for patients with chemotherapy-induced neuropathic pain.