• BMB Reports
• /
• 제48권5호
• /
• pp.239-240
• /
• 2015

Dysregulation of cytokine expression causes inflammatory diseases or chronic infection conditions. We have identified that Tat-activating regulatory DNA-binding protein-43 (TDP-43) is involved in cytokine RNA processing in order to promote an optimal immune response. The interaction of TDP-43 with spliceosomal components from the Cajal body leads to the formation of a novel sub-nuclear body called the Interleukin (IL)-6 and IL-10 Splicing Activating Compartment (InSAC). TDP-43 binds to the IL-6 and IL-10 RNAs in a sequence-dependent manner. In cell-based studies, we observed that lipopoly-saccharide (LPS) stimulation induces the formation of the InSAC through TDP-43 ubiquitination, thereby influencing the processing and expression levels of IL-6 RNA. Moreover, TDP-43 knockdown in vivo results in a decrease in IL-6 production and its RNA splicing and stability. Thus, these findings demonstrate that the InSAC is linked to the activation and modulation of the immune response. [BMB Reports 2015; 48(5): 239-240]

• The Journal of Korean Physical Therapy
• /
• 제25권5호
• /
• pp.316-321
• /
• 2013

Purpose: The aimed of this study was to investigate muscle activation related to postural stability according to different frequency of whole body vibration during quiet standing, to identify the most effective training conditions that cause the highest neuromuscular responses, and to evaluate the difference of EMG activation according to the anatomical position of the muscle - proximal or distal from the vibration platform. Methods: Eighteen healthy subjects voluntarily participated in this single-group, repeated-measures study in which EMG data from upper trapezius, rectus abdominalis, external oblique abdominalis, elector spinae, gluteus maximus, rectus femoris, semitendinosus, and gastrocnemius were collected over different frequencies (0-5-10-15-20-25Hz) for each subject during quiet standing. Results: We observed a statistically significant difference in the mean values of %RVC of muscular activation according to different frequencies of whole body vibration during quiet standing in all muscles (p<0.05). Conclusion: Our results indicate that lower frequencies of vibration result in low muscular activation, and higher frequencies elicit high muscular activation. However, the most effective training condition that caused the highest activation was 20 Hz. In addition, the proximally located lower extremity muscles (GCM, RF, ST, GM) showed higher activation than the distally located trunk and neck muscles (ES, EO, RA, UT) together with increasing frequency.

• International Journal of Aeronautical and Space Sciences
• /
• 제17권2호
• /
• pp.139-148
• /
• 2016

The passive control methods such as horizontal and vertical fences on the lower surface of the bluff body were applied to suppress the vortex shedding and enhance the aerodynamic stability of flow. For investigating the effects of the passive control methods, wind tunnel experiments on the unsteady flow field around a bluff body near a moving ground were performed. The boundary layer and velocity profiles were measured by the Hot Wire Anemometer (HWA) system and the vortex shedding patterns and flow structures in a wake region were visualized via the Particle Image Velocimetry (PIV) system. Also, it is a measuring on moving ground condition that the experimental values of the critical gap distances, Strouhal numbers and aerodynamic force FFT analyses. Through the experiments, we found that the momentum supply due to moving ground caused the vortex shedding at the lower critical gap distance rather than that of fixed ground. The horizontal and vertical fences increase the critical gap distance and it can suppress the vortex shedding. Consequently, the stability characteristics of the bluff body near a moving ground could be effectively enhanced by the simple passive control such as the vertical fences.

• Journal of Korean Academy of Nursing
• /
• 제30권5호
• /
• pp.1318-1332
• /
• 2000

The purpose of this study was to determine the effect of walk training on leg strength, flexibility, postural stability, balance and gait in home bound elderly women. Eighteen elderly women of the experimental group aged between 70 and 90 years image who have normal vision, hearing and Romberg test. They participated in the 12 week walk training. The subjects of the experimental group practiced walk training 3 times a week for during 12 weeks. During the 40 minute workout, the subjects practiced 5 minutes of warming-up exercises, 30 minutes of conditioning exercises and 10 minutes of a cool-down exercise. The intensity for the conditioning phase was determined by subject' heart rates, which ranged from 60% to 70% of age-adjusted maximum heart rates. The body composition, leg strength, flexibility, postural stability, balance and gait were measured prior to and after the experimental treatment. The body fat, lean body mass, leg strength (ankle dorsiflexor, plantarflexor, inversor and eversir, knee flexor, extensior), flexibility (range of motion of ankle dorsiflexion, plantarflexion, inversion and eversion), and postural stability of the experimental group were significantly greater than those of the control group. Duration of standing on the right foot and that of standing on the left foot of the experimental group was greater than that of the control group. Total balance scores of the experimental group were significantly higher than those of the control group. Among 13 items for balance, the scores of experimental group in balance with eyes closes, turning balance, sternal nudge, neck turning, one leg standing balance and back extension were higher than those of the control group. Total scores of gait of the experimental group were significantly higher than those of the control group following the walking training. Scores of experimental group in step height, step length and walk stance while walking among 9 items for gait were significantly higher than those of the control group. The results suggest that walk training can improve physical fitness for prevention in home bound elderly women.

• Journal of the Korea Convergence Society
• /
• 제11권4호
• /
• pp.87-93
• /
• 2020

The purpose of this study was to examine the convergence correlation between physical characteristics and functional movement screen(FMS). Overall, 193 adults with normal single measurement values participated in the study. For data analysis, we used the SPSS Ver. 26.0 statistical program to perform t-tests and to determine Pearson's correlation coefficients for variables. Data analysis revealed significant sex differences in the active straight-leg raise and trunk stability push up tests (P<.05). In addition, our data analysis also revealed a negatively correlation between body fat percentage and FMS tests, except in the shoulder mobility and active straight leg raise test. In the active straight leg raise, the quality of functional movement was higher in women than in men; while in the trunk stability push ups, the quality of functional movement was higher in men than in women. Therefore, we conclude that men should reinforce the flexibility of the lower extremities, and females should apply upper body muscular strength for better trunk stability movement.

• Physical Therapy Korea
• /
• 제6권3호
• /
• pp.11-21
• /
• 1999

Human balance is maintained through a complex process involving sensory detection of body motions, integration of sensorimotor information within the central nervous system, and execution of appropriate musculoskeletal responses. The basic task of balance is to position the body center of gravity (COG) over some portion of the support base. When the COG extends beyond the base of support, the person has exceeded the limits of stability (LOS). At this point, a step or stumble is required to prevent a fall. Automatic postural responses operate to keep the COG over the base of support. They are a set of functionally organized, long-loop responses that act to keep the body in a state of equilibrium. There are four commonly identified automatic postural responses, or strategies. These are ankle strategy, hip strategy, suspensory (knee) strategy, and stepping strategy. Thus, the purpose of this study was to evaluate the LOS using various knee strategies. Forty subjects participated in this study. The subjects were comprised of 20 males and 20 females who were without neurologic, orthopaedic or balance performance impairments. The LOS was measured with a Balance Performance Monitor (BPM) Dataprint Software Version 5.3. The results of this study were as follows: 1) Knee joint angle which is to increase stability of standing balance with using knee strategy was at mid-range. 2) There were statistically significant differences in anteroposterior LOSs according to the knee strategy. 3) There were no statistically significant differences in mediolateral LOSs according to the knee strategy. 4) There were statistically significant differences of anteroposterior LOSs with using knee strategy according to gender. 5) There were no statistically significant differences in mediolateral LOSs with using knee strategy according to gender.

• The Journal of Korean Physical Therapy
• /
• 제32권4호
• /
• pp.203-209
• /
• 2020

Purpose: This study examined the effects of a physical stability exercise program on the functional movement and balance of middle school volleyball players to provide future management and training data to improve the performance of volleyball players. Methods: The subjects were 20 volleyball players from Y Middle School in Mokpo. The results of comparing and analyzing the effects of the physical stability exercise program on the functional movement and balance of middle school volleyball players for 10 weeks are as follows. Results: The number of participants who showed power and agility (p<0.01) was increased significantly, and the response time was shortened significantly (p<0.01). On the evaluation of functional movement, the total score showed a significant difference between the pre-test at 10.90±1.30 points and the post-test at 13.81±.60 (p<0.001). The subjects' balance showed a significant difference from 84.11±7.53 to 97.65±8.47 (p<0.001), and the Right Composite Score showed a significant difference from 83.74±6.64 to 97.27±8.48 (p<0.001). Conclusion: The application of a physical stability exercise program for 10 weeks is effective in improving the speed, agility, functional movement, and balance to volleyball players who are weakened and at risk of injury. This is believed to prevent or reduce injury.

• Transactions of the Korean Society of Automotive Engineers
• /
• 제16권3호
• /
• pp.127-136
• /
• 2008

Vehicle stability is a very important subject in vehicle design and control, because vehicle safety is closely dependent upon its dynamic stability. The control logic for four-wheel steering(4WS) systems, in which maintaining at least the specified stability region is the control objective, was constructed using the simplified vehicle model of 3 degree-of-freedoms. The improvement of vehicle stability was verified through computer simulations for the slalom and the double lane change maneuver using the multi-body dynamic model in MSC.ADAMS.

• Journal of the Korean Society of Safety
• /
• 제12권2호
• /
• pp.146-152
• /
• 1997

The number of accidents due to slipping, falling and awkward postures are estimated to account for over forty percent of annual industrial accidents in Korea. To prevent such accidents, stability-maintaining capabilities of workers should be understood before any other approach. This research was aimed to analyze capabilities of the workers with the help of yours male students maintaining standing postures on a tiltable stability platform. The experimental result showed that tilting direction, height of pivoting point, and permissible degree of swaying made significant effects on stability-maintaining duration. Besides, humans are more capable of maintaining their standing body postures on a platform tiltable fore and aft rather than or one tiltable sideways. The number of falling or tripping supported this phenomenon. A mechanical and physical discussion on the stability was added.

• Journal of the Korean Society for Precision Engineering
• /
• 제22권6호
• /
• pp.118-126
• /
• 2005

There are many types of walking robots in the world. For dynamic walking of the robots it is necessary to keep its dynamic stability. The dynamic stability is influenced by the position of ZMP (zero moment point). In this paper we study the control of the ZMP position of walking robot. For experiment we developed a quadruped robot and analyzed the dynamic stability of the robot. Developed robot has 2 joints at each leg and WBO (weight balancing oscillator) on the body of the robot. The WBO is designed to move linearly from side to side when the robot walks dynamically. Walking test was performed to verify the validity of the proposed methods. Especially we showed that the dynamic stability of the robot can be improved without sacrifice of the walking speed by control the WBO.