• Food Science of Animal Resources
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• v.44 no.3
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• pp.533-550
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• 2024

Peptides with bioactive effects are being researched for various purposes. However, there is a lack of overall research on pork-derived peptides. In this study, we reviewed the process of obtaining bioactive peptides, available analytical methods, and the study of bioactive peptides derived from pork. Pepsin and trypsin, two representative protein digestive enzymes in the body, are hydrolyzed by other cofactors to produce peptides. Bicinchoninic acid assay, sodium dodecyl sulfate-polyacrylamide gel electrophoresis, chromatography, and in vitro digestion simulation systems are utilized to analyze bioactive peptides for protein digestibility and molecular weight distribution. Pork-derived peptides mainly exhibit antioxidant and antihypertensive activities. The antioxidant activity of bioactive peptides increases the accessibility of amino acid residues by disrupting the three-dimensional structure of proteins, affecting free radical scavenging, reactive oxygen species inactivation, and metal ion chelating. In addition, the antihypertensive activity decreases angiotensin II production by inhibiting angiotensin converting enzyme and suppresses blood pressure by blocking the AT1 receptor. Pork-derived bioactive peptides, primarily obtained using papain and pepsin, exhibit significant antioxidant and antihypertensive activities, with most having low molecular weights below 1 kDa. This study may aid in the future development of bioactive peptides and serve as a valuable reference for pork-derived peptides.

• Journal of the Korean Dietetic Association
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• v.5 no.1
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• pp.10-20
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• 1999

This study aimed at investigating correlation of nutrients intake and serum lipids of industrial workers. 226 for adult aged 20yr~59yr (average age 35.9yr) were selected as subjects during 6 months, from June to December, 1997. Nutrients intake was investigated by questionnaire, 24-hour recall method. Antropometric assessments, serum lipids and blood pressure of the subjects were investigated. The results as follows ; In total subjects, calories, calcium, vitamin A, vitamin $B_1$, and vitamin $B_2$ were below Korean RDA(recommended dietary allowances) and protein, iron, vitamin C, niacin and phosphorus were above Korean RDA. Distribution of BMI groups were underweight groups(7.9%), normalweight groups(63.3%) and overweight groups(28.8%). In BMI groups, intakes of calories, carbohydrates, protein, fats, iron, niacin and potassium of overweight groups were higher than those of other groups, significantly(P<0.001). Intakes of calcium of underweight groups were lower than those of other groups, significantly(P<0.05). BMI increased with age. Total cholesterol, triglyceride, apo(b) and atherogenic index of overweight groups were higher than those of other groups, significantly(P<0.001). Calories, carbohydrates, protein, fats, iron, vitamin $B_1$, vitamin $B_2$, niacin, natrium and potassium were positively correlated with BMI, significantly(P<0.001). Calcium and vitamin C were positively correlated with BMI, significantly(P<0.01). vitamin A and phosphorus were positively correlated with BMI, significantly(P<0.05). Total lipid, total-chol., triglyceride, apo(b) and atherogenic index were positively correlated with BMI, significantly(P<0.001). HDL-chol. were negatively correlated with BMI, significantly(P<0.001). Above results, the more BMI and age increased, the worse patterns of serum lipid, so that increased atherogenic index that increased risk of atherosclerosis and degenerative chronic disease connected with serum lipid. After classified by BMI, age and lipid pattern, it will be managed individually for health management of industrial workers. Development and application of efficient program will be urgent for harmonious nutrition counseling and guidance.

• Journal of Preventive Medicine and Public Health
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• v.39 no.3
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• pp.235-242
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• 2006

Objectives: We wanted to determine the distribution of the clustering of the metabolic risk factors and we wanted to evaluate the related factors in young schoolchildren. Methods: A cross-sectional study of metabolic syndrome was conducted in an elementary school in Seoul, Korea. We evaluated fasting glucose, triglyceride, HDL cholesterol, blood pressures and the body mass index, and we used parent-reported questionnaires to assess the potential risk factors in 261 children (136 boys, 125 girls). We defined the metabolic risk factors as obesity or at risk for obesity ($\geqq$ 85th percentile for age and gender), a systolic or diastolic blood pressure at $\geqq90th$ percentile for age and gender, fasting glucose at $\geqq110mg/dl$, triglyceride at $\geqq110mg/dl$ and HDL cholesterol at $\leqq40mg/dl$. Results: There were 15.7% of the subjects who showed clustering of two or more metabolic risk factors, 2.3% of the subjects who showed clustering for three or more risk factors, and 0.8% of the subjects who showed clustering for four or more risk factors. A multivariate analysis revealed that a father smoking more than 20 cigarettes per day, a mother with a body mass index of = $25kg/m^2$, and the child eating precooked or frozen food more than once per day were associated with clustering of two or more components, with the odds ratios of 3.61 (95% CI=1.24-10.48), 5.50 (95% CI=1.39-21.73) and 8.04 (95% CI=1.67-38.81), respectively. Conclusions: This study shows that clustering of the metabolic risk factors is present in young schoolchildren in Korea, with the clustering being associated with parental smoking and obesity as well as the child's eating behavior. These results suggest that evaluation of metabolic risk factors and intervention for lifestyle factors may be needed in both young Korean children and their parents.

• Journal of the Korea Society of Computer and Information
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• v.26 no.4
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• pp.119-131
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• 2021

In this study, I compared the pattern design method of classic shirts focused on the men's clothing consturction textbook. It was intended to select a shirt pattern drawing method suitable for men in their 20s by conducing a appearance evaluation with a 3D simulation program. Pattern drawing method, sizes, appearance evaluation, garment pressure. were evaluated, and SPSS 26.0 program was used for analysis. According to the Pattern drawing method, there were differences in application sizes, and there were many parts where designated sizes were applied. The shirt pattern is mostly the same for the front chest and back chest, front waist and back waist. However, if there is a front and back difference of the chest and the waist circumference, the fit was considered better. B pattern was evaluated as the best in appearance evaluation, color distribution, and mesh condition through 3D simulation, and B pattern was analyzed as the most suitable method for men in their 20s. Since this study applied the average sizes of the 7th Korean Human Body Dimension Survey report in 20s, it is thought that caution should be paid to apply them to all 20s. In the future, it is also thought that research on the actual fit and patterns of various body types and materials in their 20s should be carried out.

• Journal of Life Science
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• v.19 no.10
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• pp.1374-1381
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• 2009

This study was designed to investigate the differences of physiological variables by age group in alcohol-consuming men. The thirty year old-age group had the lowest waist-hip ratio (WHR), right and left cardio-ankle vascular index (R-CAVI and L-CAVI), right and left ankle-brachial index (R-ABI and L-ABI), amylase, high sensitivity C-reactive protein (hs-CRP), and creatine phosphokinase (CPK) levels, and the highest body weight (BW), interleukin-6 (IL-6), right and left intraocular pressure (R-IP and L-IP), hematocrit (Hct), hemoglobin (Hb), erythrocyte, red blood cells distribution width (RDW), alanine aminotransferase (ALT), total cholesterol (TCH), triglyceride (TG), and ferritin levels. The forty year old-age group was the highest in hs CRp and CPK levels, but the lowest in ferritin level. The fifty year old-age group possessed the highest WHR, diastolic blood pressure (DBP), R- and L-ABI, eosinophil, and amylase levels. The sixty year old-age group had the highest R- and L-CAVI, mean corpuscular volume (MCV), ALP, $\gamma$-glutamyltranspeptidase ($\gamma$-GTP), rheumatoid factor (RF), $\alpha$-fetoprotein (AFP) and prostate specific antigen (PSA) levels and the lowest BW, DBP, R-IP, L-IP, Hct, Hb, leukocyte, platelet, RDW, eosinophil, monocyte, ALT, amylase, TG, and CPK levels. These findings indicate that there may be differences of physiological variables depending on age group in alcohol-consuming men. Further studies should be focused on the physiological differences between alcohol-consuming men and women.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.44 no.7
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• pp.585-592
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• 2016

Visualization was done by using $CH^*$ chemiluminescence images and PMT measurements in order to understand the origin of fluctuating pressure and chemical luminosity at about 500 Hz frequency even in stable combustion, which was observed in recent experimental tests, and to find the physical correlation leading to Low Frequency Instability(LFI) in terms of phase angle. In stable combustion, chemical reactions are distributed along the shear layer flow showing a negative coupling(about 180 degree in phase angle) with combustion pressure. However, phase difference is shifted to a positive coupling showing less than 90 degree in unstable case. Also a periodic change in the distribution of chemical reactions is observed along with local flame extinction and the appearance of big scale vortex flow. In the transition to LFI, local flame extinction and small vortex flow start to appear in a row. As seen in the bluff body wake in reactive flow, the periodic appearance of vortex flow seems to share the same physical process of BVK(Bernard Von Karman) instability generation. Thus, the appearance of local extinction in 500 Hz fluctuations is gradually amplified to complete extinctions of about 20 Hz, and it leads into LFI.

• Journal of Sasang Constitutional Medicine
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• v.8 no.1
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• pp.349-376
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• 1996

In orther to find the characteristics of each constitution, the examinee of Kyung Hee medical center was diagnosed constitution, and resulted body measures and diagnosis. That was considered and the results are as follows 1. The Diagnosis result of Sa-sang Constitutional Medicine is that there are 110 persons of Taeum-In(56. 1%), 58 persons of Soum-In(29.6%), 28 persons of Soyang-In(14. 3%). 2. The distribution of occupation, there are many of Taeum-In who are engaged in business, administeration, and management and many of Soeum-In who are engaged in reserch. 3. QSCC(I) has a tendency that other constitutions diagnose to Taeyang-In, the quastionare 1 has the accuracy of 76. 4% to diagnose Soeum-In. 4. Taeum-In sweats easily but Soeum-In doesn't sweat easily, Taeum-In has a good appetite and likes cold food and digests well, but Soeum-In has a poor appetite and like hot food and digest poorly. 5. The degree of obesity is the highest in Taeum-In. 6. The systoric blood pressure and diastolic blood pressure is high in Taeum-In and the high blood pressure are frequent in Taeum-In. 7. Triglyceride is the highest in Taeum-In and the Hyperlipidemia is the most frequent in Taeum-In, but Total cholesterol has no difference among constitutions. 8. GPT GGT is higher in Taeum-In than Soyang-In, but GOT has no difference among constitutions. 9. The frequency of fatty liver is the highest in Taeum-In.

• Preventive Nutrition and Food Science
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• v.2 no.4
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• pp.338-347
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• 1997

Apo E polymorphism(e2, e3, e4) was among the first reported genetic polymorphism that explained part of the normal vairation in plasma cholesterol concentrations. Both alleles E2 and E4 are significantly more frequent in patients with mixed forms of hyperlipidemia and contribute on the observed differences in CHD risk among different populations. Effects of apo E polymorphism on the distribution of plasma lipid profiles were studied in 89 normolipidemic healthy females, aged 19 up to 22 years. The relative frequencies of E3/3 was 0.787, E3/2 was 0.101, E3/4 allele was 0.112 and no E2/2, E2/4 and E4/4 were found. Weight, height and %LBM were elevated in E2 than those in E3&E4. No differences in the blood pressure among apo E isomers were found, otherwise the pulsation was higher in E4 than that in the others. There were no differences in plasma total-, total DL-, HDL$_3$-, HDL$_2$ cholesterol, apo B-100 and apo A-I, However, phenotype means rank E3/2>E3/3>E3/4 in average TG levels(p<0.0001) significantly, and rank E3/4>E3/3>E3/2 in LDL cholesterol levels. These results were related to the correlation between atherogenic indiced (AI) such as LDL/HDL, (TC-HDL)/HDL, HDL$_3$/HDL$_2$. The ratio of HDL$_3$& HDL$_2$was significantly increased in E2 & E4 than that in E3(P=0.043). LCAT activity was not different between E2 and E3 but was highly increased in E4 (p<0.0001 among apo E isomers), but CETP was not different. Since the negative correlation between LCAT and CETP in apo E2(r=-0.491) was stronger than that in apo E3, E2 allele impacts the clearance of plasma apo E mediated lipoproteins. In conclusion firstly, E4 mediated alteration through LDL or E receptors results in lower TG or higher $\beta$-lipoprotein levels and E2 shows reciprocal effects of E4, respectively. Second, E4 allele was more atherogenic than E2 allele because the higher levels of AI such as HDL$_3$/HDL$_2$ were criticized.

• Transactions of the Korean Society of Mechanical Engineers
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• v.16 no.4
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• pp.723-736
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• 1992

Most degeneating diseases and back pains in the orthopaedic disease are originated from the unbalance of stress distribution in the low-lumbar spine. Therefore the stress analysis of lowerback is indispensible to the clinical diagnosis for the developing reason and the developing process of diseases. Therefore the same model materials as following are eveloped to analyze the stress distributions of lower-back by photoelastic experiment. The verterbral body and the process are molded from epoxy resin(the weight ratio of Araldite and hardner is 10 to 3), models are geometrically identical to them in vivo respectively and the ratio of their elastic modulus to that of model material is 1 to 10. It is assured that KE-1300 Silicon(E=0.8MPa), TSE-3562 Silicon(0.5MPa) and the composite silicon(3MPa) (the weight ratio of KE-1300 silicon and Jioreal : 10 to 4) are respectively effective as the model materials of ligament, musles and intervertevral disc which is essential to the movement of low-lumbar spine. All the elements associated with the movement of the low-lumbar spine are molded through the molding method developed in this research and assembled with the angles between the verterbra and the disc in the normal human lumbosacral spine. The stress distributions of the assembled model are analyzed by photoelastic experiment. It is certified by comparing the results of photoelastic experimebt with the clinical situations that the loading dveice and the loading conceptions used in this paper are effective.

• The Korean Journal of Physiology
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• v.2 no.2
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• pp.33-43
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• 1968

Histamine, 0.5 mg as histamine base in 4 ml of normal saline solution, was injected into rabbits anesthetized with nembutal and the mean blood pressure was kept in the range of $52{\sim}80\;mmHg$ for over one hour by supplemental additions. Following the injection of the test substances, 300 mg of urea and 200 mg of antipyrine intravenously, serial blood samples were obtained from the femoral artery and the internal jugular vein at $0.5{\sim}3$ minutes interval. The decreasing patterns in the concentrations of arterial and venous blood plasma samples were compared with each other. The ratio of the concentration of brain tissue to that of the final arterial plasma was also studied. By these measures the degrees of penetration of the test substances in the brain in the control and in the histamine treated rabbits were observed. The concentrations of antipyrine and urea in the arterial blood plasma were decreasing exponentially with respect to the time elapsed. The venous concentrations were anticipated to increase initially and to cross the arterial concentration curve in the point of equlibrium between the plasma and the tissue. On the contrary to the expectation venous concentration also revealed the decreasing tendency similar to that of arterial plasma. The similarity between these two curves, arterial and venous, would be atributable to the fact that the cerebral blood flow rate was large enough and the rising phase in the venous concentration curve was instantly over before serial blood samples were taken. Inspite of some similarity in the decreasing tedency in both concentration curves there were appreciable discrepancies between the arterial and venous plasma which would reflect the situation far from the equlibria among several compartments in the brain. Changes in plasma potassium levels caused by the injection of histamine or bleeding were observed, too. Using 8 rabbits as the control and 12 rabbits for the histamine treated group following results were obtained: 1. Both of the concentration curves, arterial and venous, declined rapidly at_first and slowly later on and approached same equilibrium concentration with the passage of time after a single injection. The time at which attained the same concentration was $2.0{\pm}0.54\;min.$ in the control and $4.3{\pm}1.92\;min.$ in the histamine treated group with respect to antipyrine. On the other hand in the case of urea they were $2.4{\pm}0.59\;min.$ in the control and $4.4{\pm}1.31\;min.$ in the histamine group, respectively. In the histamine treated group enlarged spaces for distribution of test substances were postulated. 2. The concentration of antipyrine in the brain tissue water revealed no significant differences between the control and experimental groups, showing $212{\pm}40.2\;mg/l$ in the control and $206{\pm}64.1\;mg/l$ in the histamine treated group. On the other hand urea revealed higher value in the histamine treated group than in the control, showing an enhanced penetration of urea into the tissue after injection of histamine. Urea concentration in the brain water was $32.3{\pm}3.36\;mg%$ in the control and $39.2{\pm}4.25\;mg%$ in the histamine treated group. 3. The distribution ratio of antipyrine in the brain tissue was very close to unity in the histamine treated animals as well as in the control. 4. The average of the distribution ratio of urea in the control animals was 0.77 and it showed the presence of blood-brain barrier with regard to urea. However in the histamine treated animals the distribution ratios climbed up to 0.86 and they were closer to unity than in the control animals. Out of 12 cases 5 were greater than 0.9 and 8 exceeded 0.85. It appeared that histamine enhanced the penetration of urea through the barrier. 5. Histamine injection and or hemorrhage caused an elevation of the concentration of potassium in plasma. In the event that histamine and hemorrhage were applied together the elevation of potassium exceed the elevation seen at the histamine alone. There was no evidence that the leakage of potassium from the brain tissue was dominant in comparison with the general leakage from the whole body.