• 한국자기공명학회논문지
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• 제9권1호
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• pp.61-66
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• 2005

$^{11}B MAS NMR$ spectra of binary glass system $xV_2O5-B_2O_3$ and ternary glass system $xV_2O5-B_2O_3-yNa_2O$ (x = $V_2O_5 mol%/$B_2O_3$ mol%, y = $Na_2O$ mol$/$B_2O_3$ mol%) were acquired. $BO_3$ units are dominant components in the spectra of $xV_2O_5-B_2O_3$glass systems while both $BO_3$ and $BO_4$ unit appear in comparable amounts in the spectra of $xV_2O_5-B_2O_3-yNa_2O$ glass systems. More $BO_3$ units were monitored for higher $V_2O_5$ contents while more $BO_4$ unit for higher $Na_2O$ contents. Quadrupole parameters such as $e^2qQ$ and $\eta$ obtained form spectral simulation indicate that $e^2qQ$ has a maximum value at x = y 1 and $\eta$ decreases and increases as x or y grows, respectively. Our results suggest that $V_2O_5$ and $Na_2O$ play opposite roles in the ternary glasses.

• 융합보안논문지
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• 제12권6호
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• pp.51-59
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• 2012

본 논문에서 제안하는 학습몰입모형 "BoX" 는 B-Boy들이 대회에서 우승하기 위해 분산인지(distributed cognition) 경쟁을 능동적으로 즐기는 문화에서 그 발상의 기초를 두고 있다. "Battle"은 경쟁을 의미하며 X는 본 연구에서 제안하려는 교수법 적용과목이다. 본 논문의 목적은 학습자가 높은 수준의 학습몰입 상태에서 창조적 문제해결능력을 배양하는 학습모형을 제시하는 것이다. "BoX" 구현의 핵심은 개인인지부하를 줄이는 분산인지 활동을 극대화하도록 학습자간의 경쟁질서와 통제원리를 설계하는 것이다. 두 학기의 IT교육과정에서 비교학생군의 학습 성취도를 분석한 결과, "BoX" 학습모형이 기존의 수업방식에 비해서 학습몰입도와 학습 성취도를 크게 높이는 것을 확인하였다.

• Korean Journal of Acupuncture
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• 제30권4호
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• pp.230-242
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• 2013

Objectives : DongUiBoGam is a representative medical literature in Korea. This research intends to structurally grasp how DongUiBoGam understands the human body and review the methods of acupuncture and moxibustion in the NaeGyeong chapter of it using text mining. Methods : The structure of DongUiBoGam was analyzed with specific parts of the book that described contents, major premises of understanding the human body, and processes of treatment. We analyzed characteristics of each acupoints in a relationship with causes of diseases & symptoms in the NaeGyeong chapter using a Term Frequency - Inverse Document Frequency(TFIDF). Results : Three different categories of pattern identification(PI) were formed after structural analysis of DongUiBoGam. Every causes of diseases & symptoms were transformed according to the three categories of PI. After analyzing the relationship between acupoints and causes of diseases & symptoms, 114 acupoints were visualized with TFIDF values of three PI categories. Conclusions : The selection of acupoints in NaeGyeong chapter of DongUiBoGam were linked to causes of diseases & symptoms based on the three PI categories. Through visualization of bipartite relationships between acupoints and causes of diseases & symptoms, we could easily understand characteristics of each acupoint.

• 한국전기전자재료학회논문지
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• 제18권1호
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• pp.57-61
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• 2005

The microwave dielectric properties of 0.6TiTe$_3$O$_{8}$-0.4MgTiO$_3$ ceramics with H$_3$BO$_3$-SnO were investigated to improve the sintering condition for the LTCC. According to the X-ray diffraction patterns, 0.6TiTe$_3$O$_{8}$-0.4MgTiO$_3$ ceramics with H$_3$BO$_3$-SnO had the columbite structure of TiTe$_3$O$_{8}$ phase and the ilmenite structure of MgTiO$_3$ phase and there were no second phase. Increasing the addition of H$_3$BO$_3$-SnO, the density and dielectric constant of the 0.6TiTe$_3$O$_{8}$-0.4MgTiO$_3$ ceramics were increased but the quality factor was decreased. The temperature coefficient of resonant frequency was shifted to the negative(-) direction with addition of H$_3$BO$_3$-SnO.EX>-SnO.

• 생명과학회지
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• 제14권4호
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• pp.567-572
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• 2004

노화억제, 항균, cholesterol 저하작용 등 다양한 생리활성을 가지고, 기관지염, 천식 등 호흡기 질환에도 옛부터 효과가 있는 것으로 알려져 있으며 식품으로 애용되고 있는 적채를 metanol (BOM)로 먼저 추출하고 이를 hexane 분획물(BOMH), ethyl ether 분획물(BOMEE), ethyl acetate 분획물(BOMEA), butanol 분획물(BOMB) 및 물 분획물(BOMA) 등 다섯가지의 각 용매별로 분획하여 적채의 항균, 암세포 증식 억제 및 QR유도 효과를 연구하였다. 먼저 적채의 각 분획물을 Streptococcus mutans, Bacillus subtilis, Escherichia coli. Pseudomonas aeruginosa 및 Aspergil-lus oryzae의 5가지 균주에 첨가시료농도를 증가시키면서 첨가하였다. 즉, 각 분획 별 시료를 500, 1000, 1500 및 2000 $\mu{g}$/ml의 농도로 사용균주에 각각 처리하였을때 BOMEA에서 비교적 높은 항균 활성 효과를 나타내었고, 그 다음으로는 BOMEE이었다. 적채의 암세포 증식억제 효과(cytotoxicity)를 MTT assay 로 실험한 결과, 3종의 암세포주 HepG2, HeLa 및 MCF-7은 모두 BOMEE에서 높은 암세포 증식억제 효과를 보였으며, HepG2 세포주를 이용한 암예방 QR 유도 활성은 다른 분획층에 비해 비극성 용매층인 BOMH과 BOMEE에서 유의적으로 QR유도 활성을 증가시키는 것으로 나타났다. 이 결과를 기초로 독특한 보라색을 띄며 식탁에서 널리 애용되고 있는 자주색 대표식품인 적채의 항균 및 암세포 성장저지 및 QR 유도 효과를 일으키는 생리활성 물질의 존재와 기전 규명에 유익한 자료가 될 것으로 사료된다.

• 한국세라믹학회지
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• 제53권6호
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• pp.712-718
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• 2016

In this study, we investigate the effect of the$Li_3BO_3$ additive on the densification and ionic conductivity of garnet-type $Li_7La_3Zr_2O_{12}$ solid electrolytes for all-solid-state lithium batteries. We analyze their densification behavior with the addition of $Li_3BO_3$ in the range of 2-10 wt.% by dilatometer measurements and isothermal sintering. Dilatometry analysis reveals that the sintering of $Li_7La_3Zr_2O_{12}-Li_3BO_3$ composites is characterized by two stages, resulting in two peaks, which show a significant dependence on the $Li_3BO_3$ additive content, in the shrinkage rate curves. Sintered density and total ion conductivity of the system increases with increasing $Li_3BO_3$ content. After sintering at $1100^{\circ}C$ for 8 h, the $Li_7La_3Zr_2O_{12}-8$ wt.% $Li_3BO_3$ composite shows a total ionic conductivity of $1.61{\times}10^{-5}Scm^{-1}$, while that of the pure $Li_7La_3Zr_2O_{12}$ is only $5.98{\times}10^{-6}Scm^{-1}$.

• 한국의사학회지
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• 제18권1호
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• pp.23-47
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• 2005

The study is written for the purpose of examining Na Cheon Ik(羅天益)'s medical ideology mentioned in Euian(醫案) of "Wi-saeng-bo-gam 衛生寶鑑". The publication of this book is reflected in the 13th century perplexed conditions. In this thesis, after the writer analyzed Na Cheon Ik(羅天益)'s medical theory in "Wi-saeng-bo-gam 衛生寶鑑", knew that he emphasized practical use on all occasions. So far, Na Cheon Ik(羅天益)'s medical ideology in "Wi-saeng-bo-gam 衛生 寶鑑" is hardly studied. "Wi-saeng-bo-gam 衛生寶鑑" is a medical book which was written in the process of systemic recognized of medical theories of various and special academic parties in the period J inYuan(金元). The medical theory that appears in "Wi-saeng-bo-gam 衛生寶鑑" is rooted in Li Dong Yuan(李東垣)'s theory, but also Na Cheon Ik(羅天益)'s medical ideology is distinguished from Li Dong Won(李東垣)'s ideology. First of all, Na Cheon Ik(羅天 益) recognized the importance of discerning not only On-Bo(溫補) but also Han-Ha-To(汗下吐) and various ways in medical treatment. Secondly, the fact that Na Cheon Ik(羅天益) made good use of moxibustion tells the difference between the two. In conclusion, "Wi-saeng-bo-gam 衛生寶鑑" holds systemic medical information which was originated with Na Cheon Ik(羅天益)'s various and special experience. He had contributed in the clinical experience and medical information by having an effect on the ages to come.

• Journal of Animal Science and Technology
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• 제63권2호
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• pp.248-261
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• 2021

Attributable to their major function in pathogen recognition, the use of bovine leukocyte antigens (BoLA) as disease markers in immunological traits in cattle is well established. However, limited report exists on polymorphism of the BoLA gene in zebu cattle breeds by high resolution typing methods. Thus, we used a polymerase chain reaction sequence-based typing (PCR-SBT) method to sequence exon 2 of the BoLA class II DRB3 gene from 100 animals (Boran, n = 13; Sheko, n = 20; Fogera, n = 16; Horro, n = 19), Hanwoo cattle (n = 18) and Bangladesh Red Chittagong zebu (n = 14). Out of the 59 detected alleles, 43 were already deposited under the Immuno Polymorphism Database for major histocompatibility complex (IPD-MHC) while 16 were unique to this study. Assessment of the level of genetic variability at the population and sequence levels with genetic distance in the breeds considered in this study showed that Zebu breeds had a gene diversity score greater than 0.752, nucleotide diversity score greater than 0.152, and mean number of pairwise differences higher than 14, being very comparable to those investigated for other cattle breeds. Regarding neutrality tests analyzed, we investigated that all the breeds except Hanwoo had an excess number of alleles and could be expected from a recent population expansion or genetic hitchhiking. Howbeit, the observed heterozygosity was not significantly (p < 0.05) higher than the expected heterozygosity. The Hardy Weinberg equilibrium (HWE) analysis revealed non-significant excess of heterozygote animals, indicative of plausible over-dominant selection. The pairwise FST values suggested a low genetic variation among all the breeds (FST = 0.056; p < 0.05), besides the rooting from the evolutionary or domestication history of the cattle. No detached clade was observed in the evolutionary divergence study of the BoLA-DRB3 gene, inferred from the phylogenetic tree based on the maximum likelihood model. The investigation herein indicated the clear differences in BoLA-DRB3 gene variability between African and Asian cattle breeds.

• 대한생식의학회:학술대회논문집
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• 대한불임학회 1999년도 제38차 추계 학술대회
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• pp.76.1-76.1
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• 1999

• BMB Reports
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• 제39권5호
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• pp.642-647
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• 2006

Botulinum neurotoxin A (BoNT/A) has been used therapeutically to treat muscular hypercontractions and sudomotor hyperactivity and it has been reported that BoNT/A might have analgesic properties in headache. PEP-1 peptide is a known carrier peptide that delivers fulll-ength native proteins in vitro and in vivo. In this study, a BoNT/A gene were fused with PEP-1 peptide in a bacterial expression vector to produce a genetic in-frame PEP-1-BoNT/A fusion protein. The expressed and purified PEP-1-BoNT/A fusion proteins were efficiently transduced into cells in a time- and dose-dependent manner when added exogenously in a culture medium. In addition, immuno-histochemical analysis revealed that PEP-1-BoNT/A fusion protein efficiently penetrated into the epidermis as well as the dermis of the subcutaneous layer, when sprayed on mice skin. These results suggest that PEP-1-BoNT/A fusion protein provide an efficient strategy for therapeutic delivery in various human diseases related to this protein.