• 한국위성정보통신학회논문지
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• 제12권4호
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• pp.110-114
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• 2017

재난안전망에 소형의 이동무선통신망을 보조적으로 사용하면 소규모의 전파 음영지역 해소, 재난지역의 트래픽 과부하 해소 그리고 접근이 어려운 지역에서 신속하게 재난통신망을 구축하는데 유용하게 활용할 수 있다. 휴대형 이동기지국은 소형의 이동무선망을 구축하는데 필요하며, TVWS(TV White Space)를 활용하는 이동형 기지국은 전파의 활용과 무선망의 구축비용 측면에서 효과적이다. 논문에서는 TVWS에서 동작하는 이동기지국용 전력증폭기를 설계 및 구현하였다. 구현한 전력증폭기는 TV대역인 470 ~ 698MHz에서 동작하며, 이득은 20.1dB 이상, 입출력 반사손실은 11.4dB 이상, 출력을 off 하였을 때 격리도는 39.9dB 이상이었다. 전력증폭기의 IMD(Intermodulation Distortion) 특성은 470MHz에서 18.8dBm을 출력할 때 61.0dBc, 550MHz에서 18.6dBm 출력시 59.3dBc 그리고 690MHz에서 19.0dBm 출력시 56.5dBc의 특성을 갖는다. 본 논문에서 구현한 전력증폭기는 국내 전파법 규정을 만족하므로 이동 기지국용 전력증폭기로 사용할 수 있다.

• 한국전자통신학회논문지
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• 제9권12호
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• pp.1331-1336
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• 2014

본 논문은 X대역 고출력증폭기의 전력 결합 손실을 최소화 하기위하여 Al2O3 박막 기판으로 제작한 divider/Combiner 회로를 X-대역의 PAM(Power Amplifier Module)에 적용하여 25W 급 전력증폭기 모듈을 구현하였다. 제작은 MMIC 칩과 수정된 형태의 10way traveling wave divider/Combiner회로를 사용하였으며 제작된 Traveling wave구조의 전력증폭기는 출력전력 45.2dBm, 16dB 이득, PAE 26 % 특성을 얻었으며 IMD3 는 17dBc@44dBm의 특성을 보였다. 본 연구의 divider/Combiner 회로는 다단계 구조의수동 결합기 및 분배기에 사용될 수있으며 협소한 크기의 전력증폭기에 사용될 수 있다.

• 대한전자공학회논문지TC
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• 제40권5호
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• pp.197-203
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• 2003

본 논문에서는 cascode 하모닉 발생기를 이용하여 고변환이득 특성의 밀리미터파 subharmonic 믹서를 설계 및 제작하였다. 밀리미터파 subharmonic 믹서는 0.1 ㎛ GaAs PHEMT와 CPW 라이브러리를 이용하여 설계되었다. 설계된 cascode 하모닉 발생기의 출력 특성 측정결과, 14.5 GHz의 신호를 10 dBm 전력으로 인가하였을때, 1차, 2차 및 4차 하모닉 성분은 각각 -21.62 dBm, -32.65 dBm 및 -13.45 dBm의 결과를 얻어 가장 큰 4차 하모닉 성분을 얻었으며, 제작된 밀리미터파 subharmonic 믹서의 측정결과 14.5 GHz LO 신호를 13 dBm의 크기로 입력하였을 때 3.4 dB의 높은 변환이득 특성을 얻었다. 또한 -53.6 dB의 LO-to-IF, -46.2 dB의 우수한 LO-to-RF 격리 특성을 나타내었다. 제작된 밀리미터파 subharmonic 믹서는 기존에 발표된 밀리미터파 대역의 subharmonic 믹서에 비해 가장 높은 변환이득 특성을 나타내었다.

• Journal of Microbiology and Biotechnology
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• 제6권5호
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• pp.321-325
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• 1996

Mutants having altered levels and/or types of EPS in exopolysaccharide biosynthesis were isolated after NTG mutagenesis of Zoogloea ramigera 115SLR. Mutant candidates were classfied with five groups based on the observed characteristics for EPS biosynthesis pattern. The recombinant plasmids pLEX3BS and pLEX3BM were constructed from pEX3B which was previously isolated from genomic DNA of Z. ramigera 115SLR. Plasmid pLEX3BM with a 7.8 kb insert DNA contains an additional 1.8kb DNA fragment which is not present in pLEX3BS containing 13 kb insert DNA. Plasmid pLEX3BM was able to complement the mutation responsible for the changes in morphology of Z. ramigera 115SLR. However, the complementation of EPS negative mutant strains was not successful with pLEX3BM. Plasmid pLEX3BS on the other hand complemented the mutation responsible for the loss of EPS biosynthesis, resulting in the restoration of Z. ramigera 115SLR phenotype. But this plasmid was not able to complement the morphological mutant strain, Z. ramigera 115SLR.

• Asian Pacific Journal of Cancer Prevention
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• 제15권3호
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• pp.1233-1239
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• 2014

Background: The incidence of brain metastases (BM) varies in patients with non-small cell lung cancer (NSCLC), calls into question the value of prophylactic cranial irradiation (PCI). It is possible that clinicopathologic characteristics are associated with the development of BM, but these have yet to be identified in detail. Thus, we conducted the present meta-analysis on risk factors for BM and the value of PCI in patients with NSCLC. Methods: Eligible data were extracted and the risk factors for BM and the value of PCI in patients with NSCLC were analyzed by calculating the pooled odds ratio (OR). Heterogeneity was detected using Q and I-squared statistics, and publication bias was tested by funnel plots and Egger's test. Results: Six randomized controlled trials with a focus on the value of PCI and 13 eligible studies with a focus on risk factors for BM were included. PCI significantly reduced the incidence of BM in patients with NSCLC (p=0.000, pooled OR=0.34, 95% confidence interval = 0.37-0.59). Compared with non-squamous cell carcinoma, squamous cell carcinoma was associated with a low incidence of BM in patients with NSCLC (p=0.000, pooled OR=0.47, 95% confidence interval =0.34-0.65). The funnel plot and Egger's test suggested that there was no publication bias in the current meta-analysis. Conclusions: This meta-analysis provides statistical evidence that compared with non-squamous cell carcinoma, squamous cell carcinoma can be used as a predictor for BM in patients with NSCLC, and PCI might reduce the incidence of BM in patients with NSCLC, but does not provide a survival benefit.

• Asian-Australasian Journal of Animal Sciences
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• 제33권11호
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• pp.1837-1847
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• 2020

Objective: To evaluate the pancreatic differentiation potential of α-1,3-galactosyltransferase knockout (GalTKO) pig-derived bone marrow-derived mesenchymal stem cells (BM-MSCs) using epigenetic modifiers with different pancreatic induction media. Methods: The BM-MSCs have been differentiated into pancreatic β-like cells by inducing the overexpression of key transcription regulatory factors or by exposure to specific soluble inducers/small molecules. In this study, we evaluated the pancreatic differentiation of GalTKO pig-derived BM-MSCs using epigenetic modifiers, 5-azacytidine (5-Aza) and valproic acid (VPA), and two types of pancreatic induction media - advanced Dulbecco's modified Eagle's medium (ADMEM)-based and N2B27-based media. GalTKO BM-MSCs were treated with pancreatic induction media and the expression of pancreas-islets-specific markers was evaluated by real-time quantitative polymerase chain reaction, Western blotting, and immunofluorescence. Morphological changes and changes in the 5'-C-phosphate-G-3' (CpG) island methylation patterns were also evaluated. Results: The expression of the pluripotent marker (POU class 5 homeobox 1 [OCT4]) was upregulated upon exposure to 5-Aza and/or VPA. GalTKO BM-MSCs showed increased expression of neurogenic differentiation 1 in the ADMEM-based (5-Aza) media, while the expression of NK6 homeobox 1 was elevated in cells induced with the N2B27-based (5-Aza) media. Moreover, the morphological transition and formation of islets-like cellular clusters were also prominent in the cells induced with the N2B27-based media with 5-Aza. The higher insulin expression revealed the augmented trans-differentiation ability of GalTKO BM-MSCs into pancreatic β-like cells in the N2B27-based media than in the ADMEM-based media. Conclusion: 5-Aza treated GalTKO BM-MSCs showed an enhanced demethylation pattern in the second CpG island of the OCT4 promoter region compared to that in the GalTKO BM-MSCs. The exposure of GalTKO pig-derived BM-MSCs to the N2B27-based microenvironment can significantly enhance their trans-differentiation ability into pancreatic β-like cells.

• Asian-Australasian Journal of Animal Sciences
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• 제25권6호
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• pp.800-805
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• 2012

Rice straw is an important roughage resource for ruminants in many rice-producing countries. In this study, a rice brittle mutant (BM, mutation in OsCesA4, encoding cellulose synthase) and its wild type (WT) were employed to investigate the effects of a cellulose synthase gene mutation on rice straw morphological fractions, chemical composition, stem histological structure and in situ digestibility. The morphological fractions investigation showed that BM had a higher leaf sheath proportion (43.70% vs 38.21%, p<0.01) and a lower leaf blade proportion (25.21% vs 32.14%, p<0.01) than WT. Chemical composition analysis showed that BM rice straw was significantly (p<0.01) higher in CP (crude protein), hemicellulose and acid insoluble ash (AIA) contents, but lower in dry matter (DM), acid detergent fiber (ADFom) and cellulose contents when compared to WT. No significant difference (p>0.05) was detected in neutral detergent fiber (NDFom) and ADL contents for both strains. Histological structure observation indicated that BM stems had fewer sclerenchyma cells and a thinner sclerenchyma cell wall than WT. The results of in situ digestion showed that BM had higher DM, NDFom, cellulose and hemicellulose disappearance at 24 or 48 h of incubation (p<0.05). The effective digestibility of BM rice straw DM and NDFom was greater than that of WT (31.4% vs 26.7% for DM, 29.1% vs 24.3% for NDFom, p<0.05), but the rate of digestion of the slowly digested fraction of BM rice straw DM and NDF was decreased. These results indicated that the mutation in the cellulose synthase gene could improve the nutritive value of rice straw for ruminants.

• 치위생과학회지
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• 제18권1호
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• pp.42-49
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• 2018

The computer-aided design/computer-aided manufacturing (CAD/CAM) system was introduced to shorten the production time of all-ceramic restorations and the number of patient visits. Among these types of ceramic for dental CAD/CAM, they have been processed into inlay, onlay, and crown shapes using leucite-reinforced glass-ceramics to improve strength. The purpose of this study was to observe the mechanical properties and microstructure of leucite-reinforced glass-ceramics for dental CAD/CAM. Two types of leucite-reinforced glass-ceramic blocks (IPS Empress CAD, Rosetta BM) were prepared with diameter of 13 mm and thickness of 1 mm. Biaxial flexural testing was conducted using a piston-on-three-ball method at a crosshead speed of 0.5 mm/min. Weibull statistics were used for the analysis of biaxial flexural strength. Fracture toughness was obtained using an indentation fracture method. Specimens were observed by field emission scanning electron microscopy to examine the microstructure of the leucite crystalline phase after acid etching with 0.5% hydrofluoric acid aqueous solution for 1 minute. The results of strength testing showed that IPS Empress CAD had a mean value of $158.1{\pm}8.6MPa$ and Rosetta BM of $172.3{\pm}8.3MPa$. The fracture toughness results showed that IPS Empress CAD had a mean value of $1.28{\pm}0.19MPa{\cdot}m^{1/2}$ and Rosetta BM of $1.38{\pm}0.12MPa{\cdot}m^{1/2}$. The Rosetta BM sample exhibited higher strength and fracture toughness. Moreover, the crystalline phase size and ratio were increased in the Rosetta BM sample. The above results are expected to elucidate the basic mechanical properties and crystal structure characteristics of IPS Empress CAD and Rosetta BM. Additionally, they will help develop leucite-reinforced glass-ceramic materials for CAD/CAM.

• International Journal of Industrial Entomology and Biomaterials
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• 제18권1호
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• pp.8-12
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• 2009

A study has been made to know the effect of a phytoecdysteroid 'Sampoorna' on uniform maturation of silkworms during spinning and its effect on diseased silkworms infected by major silkworm disease viruses, Bombyx mori nuclear polyhedrosis virus (BmNPV) and Bombyx mori infectious flacherie virus (BmIFV). In the present investigation, the effect of the phytoecdysteroid "Sampoorna" on Grasserie disease caused by BmNPV have shown an average cocoon melting of 11.91% with a disease incidence of 5.83%. The values of 't' test for different treatments of BmNPV indicated low survival rate and cocoon traits were drastically reduced. Another major disease Flacherie caused by BmIFV has shown considerable levels of larval disease incidence (22-32%) and cocoon melting (3-7.67%) with an average melting of 12.95% and 20.24% disease incidence. There is a drastic reduction in survival rate, cocoon yield and other economic traits. The control batches were indicated negligible values for disease incidence and cocoon melting with Sapoorna application and without the inoculation of the two disease-causing viruses. The application of Sampoorna on already infected batches with major pathogens triggered high mortality and disease incidence and melting percentage was also significantly increased with reduced economic traits. Hence, it is suggested that application of Sampoorna in infected batches should be done only in the extreme conditions of rearing. Application of Sampoorna on healthy batches led to uniform maturation and improvement in productivity with the added advantage of better quality cocoons and labour saving.

• 한국정보통신학회:학술대회논문집
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• 한국해양정보통신학회 2003년도 추계종합학술대회
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• pp.411-415
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• 2003

본 논문에서는 고주파 특성이 우수한 NEC사의 ne71300-N MESFET를 이용하여 24GHz 대역 국부 발진기용 주파수 체배기를 설계 및 제작하였다. 멀티하모닉 로드 풀 시뮬레이션을 통하여 최적의 고조파 소스ㆍ부하 임피던스를 선택하였다. 리플렉터를 이용하여 변환 이득을 개선할 수 있었고, 대역 저지필터를 이용하여 기본파와 3차 고조파 성분을 억제하였다. 측정한 결과 0dBm의 입력신호에ㆍ대해 출력주파수인 24GHz에서의 출력 전력은 -3.776dBm이고, 변환 이득은 0.736dB, 41.064dBc의 고조파 억압 특성을 얻었다.