• 전기전자학회논문지
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• 제11권3호
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• pp.108-116
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• 2007

This paper proposed an analyzable parameter and its analytic method to provide more accurate information than currently employed 4 channels system which uses pulse wave velocity (PWV) information of the volume pulse wave measured from 4 arterial channels for the characterization of arterial vessel. In order to verify the volume pulse waves on 4 sites were simultaneously acquired subjects aged from 12 to 81 years old. and the proposed parameters were extracted from time (UT) was then compared with blood pressure. Then, the regression analyses were done relationships among the proposed parameter and others, such as aging, pulse transit time pressure (BP). The followings are the results of linear regression analysis of the proposed parameter for total 50 normal subjects. We selected any two subjects (58 years and 27 years) and measured PPG (photoplethysmogram) and BP of before and after exercise. The coefficient of correlations between BP and UT observed was -0.928 for 50 years subject, and -0.922 for 20 years subject. For total 50 normal subjects, in case of correlation between the pulse transit time and BP, the result showed -0.170 on left side and -0.233 on right side, and the coefficient value of correlation between the pulse transit time and UT was -0.607 on left side and -0.510 on right side. UI is strongly correlated with the pulse transit time than BP. Hence, we believe that the proposed parameter is related with the index of arterial stiffness.

• 대한융합한의학회지
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• 제6권1호
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• pp.5-20
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• 2024

Objectives: This study was aimed to evaluate the hemodynamic feasibility using pulse parameters as a way to establish safe dose guidelines for Chunwangbosim-dan, and to provide a foundation for developing evidence-based guidelines for clinical use. Methods: Forty-one volunteers were recruited to participate in a study examining the changes in pulse wave characteristics following the ingestion of Chunwangbosim-dan, over a period of 2 weeks, and pulse wave measurements were taken before and after the administration. Pulse wave parameters were measured in this study using a 3-dimensional radial pulse tonometry device(DMP-Lifeplus). In addition, questionnaire, blood pressure, temperature, and body composition were also measured as secondary measures. Results: Fifteen minutes after administration of Chunwangbosim-dan, the non-adverse event group(non-AE) exhibited a statistically significant increase in several power and pressure-related parameters, including h1, h3, h4, h5, SA, PA and PW, while the adverse event group(AE) showed a trend of decreasing stroke volume and increasing Systemic Vascular Resistance Index(SVRI) and applied pressure. After 2 weeks of administration, non-adverse event group(non-AE) exhibited significant changes in standard deviation of pulse rate and HRV_LH ratio. Notably, there are significant differences between AE group and non-AE group in h4/h1, w/t, applied pressure, SV and pulse rate. Conclusion: These findings suggest that pulse parameters may be a useful way to establish safe dosing guidelines for Chunwangbosim-dan. Further research is needed to confirm these results and to develop evidence-based guidelines for clinical use.

• The Korean Journal of Physiology
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• 제9권1호
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• pp.45-56
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• 1975

Various factors influencing the lymph flow from thoracic duct were investigated in an attempt to evaluate their contributing degree and the mechanisms. Sixteen mongrel dogs weighing between 10 and 16 kg were anesthetized and polyethylene catheters were inserted into the thoracic duct and femoral veins. Arterial blood pressure, heart rate, central venous pressure, lymph pressure and lymph flow were measured under various conditions. Electrical stimulation of left sciatic nerve, stepwise increase of central venous pressure, manual application of rhythmical depressions onto abdomen, injection of hypertonic saline solution and histamine infusion were employed. Measurement of cental venous pressure was performed through the recording catheter inserted into abdominal inferior vena cava. Changes in central venous pressure were made by an air-ballooning catheter located higher than the tip of the recording catheter in the inferior vena cava. Lymph flow from thoracic duct was measured directly with a graduated centrifuge tube allowing the lymph to flow freely outward through the inserted cannula. The average side pressure of thoracic lymph was $1.1\;cmH_2O$ and lymph flow was 0.40 ml/min or 1.9 ml/kg-hr. Hemodynamic parameters including lymph flow were measure immediately before and after (or during) applying a condition. Stimulation of left sciatic nerve with a square wave (5/sec, 2 msec, 10V) caused the lymph flow to increase 1.4 times. The pattern of lymph flow from thoracic duct was not continuous throughout the respiratory cycle, but was continuous only during Inspiration. Slow and deep respiration appeared to increase the lymph flow than a rapid and shallow respiration. Relationship between central venous pressure and the lymph flow revealed a relatively direct proportionality; Regression equation was Lymph Flow (ml/kg-hr)=0.09 CVP$(cmH_2O)$+0.55, r=0.67. Manual depressions onto the abdomen in accordance with the respiratory cycle caused the lymph flow to increase most remarkably, e.g,. 5.5 times. The application of manual depressions showed a fluctuation of central venous pressure superimposed on the respiratory fluctuation. Hypertonic saline solution (2% NaCl) administered Intravenously by the amount of 10 m1/kg increased the lymph flow 4.6 times. The injection also increased arterial blood pressure, especially systolic Pressure, and the central venous pressure. Slow intravenous infusion of histamine with a rate of 14-32 ${\mu}g/min$ resulted in a remarkable increase in the lymph flow (4.7 times), in spite of much decrease in the blood pressure and a slight decrease in the central venous pressure.

• 대한의용생체공학회:의공학회지
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• 제41권1호
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• pp.8-13
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• 2020

To develop cardiovascular simulator capable of implementing pulse waves similar to the human body, accurate information about reflection wave is required. However, the conclusion is still not clear and various discussions are underway. In this study, the pulse wave velocity of the tube used in the experiment was first determined by measuring the pressure waves at two points in a single tube system with the experimental device to implement the pulse wave transmission of blood vessels, and the superposition time and characteristics of the reflection wave were confirmed. After that, an air chamber was set at the reflection site, and the effect of the change of air volume on the reflection wave was investigated. Finally, the effect of the number of branches connected to a single tube on the reflection wave was investigated. The superposition time of the reflection wave can be controlled by the air volume of the air chamber, and the magnitude of the reflection wave is influenced by the number of reflection sites that generate the reflection wave. The results of this study may be of practical assistance to simulator researchers who want to implement pulse wave similar to clinical data. It is expected that the more results similar to clinical are provided, the greater the scope of the simulator's contribution to clinical cardiovascular research.

• 한국감성과학회:학술대회논문집
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• 한국감성과학회 1997년도 한국감성과학회 연차학술대회논문집
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• pp.85-89
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• 1997

We present several biosignal measurement results and analysis algorithms for the visual stimulus from International Affective Picture Sytem. Sine human body is nonlinear dynamic system, we investigated both linear and nonlinear methods. We found that the alpha wave of EEG, the chaos of peripheral blood pressure, the LF/HF of HRV and thd retutn map of RR interval were good parameters for the measuremet of human sensibility. These can be used as the parameters for the measurement of human sensibility.

• 대한의용생체공학회:의공학회지
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• 제43권3호
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• pp.136-146
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• 2022

In this study, it is intended to provide basic data that can help develop a cardiovascular simulator for performance evaluation of pulse wave detectors by identifying the development status of domestic and overseas cardiovascular simulators. A total of 119 papers were selected by excluding duplicate literature, gray literature, and literature not related to a cardiovascular simulator. Based on the selected literature, the research trend of cardiovascular simulators was analyzed. As a result of analyzing the purpose of the study, most of the simulators were developed to evaluate the hemodynamic properties of artificial hearts and valves. In addition, it was used for simulation evaluation or hemodynamic studies such as pulse wave studies. As a result of analyzing configurations of the simulators, a heart most often consisted of only one left ventricle. For blood vessels, the Windkessel model was most often constructed using chambers and valves. In most studies, blood was reproduced by mixing glycerin and water to reproduce both density and viscosity. In addition, as a result of analysis from the perspective of medical device performance evaluation, simulators for evaluating artificial heart and artificial valves have been studied a lot, whereas simulators for blood pressure, pulse wave, and blood flow devices have been relatively insignificant. Based on the review results, we suggested considerations when developing a simulator for performance evaluations of a pulse wave detector.

• 한국정보전자통신기술학회논문지
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• 제4권3호
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• pp.167-173
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• 2011

맥파를 정량적으로 측정하기 위해 다양한 맥진기가 개발되어 왔으며, 맥진기는 비침습적으로 맥파를 측정하기 위해 압력센서를 이용한다. 이러한 맥진기에 사용되는 맥진 센서 모듈은 압력센서와 압력센서의 와이어링을 보호하기 위한 코팅이 사용되는데, 코팅의 재질 또는 모양에 따라 측정 겨로가에 영향을 미칠 수 있다. 본 논문에서는 맥진센서에 압력을 가하였을 때 PDMS 코팅 형태에 따라 압력센서에 전달되는 응력분포를 비교하기 위해 6종류의 코팅모델에 두 가지 방법의 압력을 가하여 유한요소해석을 실시하였다. 결과적으로 맥진센서 중앙에 압력을 가하여 해석을 수행 하였을 때 맥진센서 모듈의 PDMS 코팅두께를 0.3mm씩 줄일수록 중앙의 압력센서에 전달되는 응력은 24%씩 증가하였고 주변의 압력센서로 전달되는 응력은 4.9%씩 감소하였다. 그리고 코팅에 가이드가 있는 경우 주변 압력센서로 전달되는 응력의 비율이 2.7% 더 적게 나타났다.

• 한국전자파학회논문지
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• 제16권5호
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• pp.511-517
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• 2005

최근 성장기에 있는 청소년들의 장시간 휴대폰 사용이 건강에 유해한 영향을 미칠 수 있다는 사회적인 문제가 제기되면서 휴대폰 사용이 인체에 미치는 영향에 관한 연구가 활발하게 이루어지고 있다. 국외에서는 주로 GSM방식의 휴대폰 사용에 의한 성인의 혈압과 맥박수 변화에 대한 자원자 연구는 수행되었으나, CDMA 방식의 휴대폰 사용에 의한 청소년의 인체 영향에 관련한 연구는 거의 이루어지지 않았다. 국내의 경우에도 자원자를 대상으로 한 CDMA 방식의 휴대폰 사용이 인체에 미치는 영향에 관한 연구는 거의 없어 국내 실정에 맞는 연구가 필요하다. 파라서 본 연구에서는 청소년 21명, 성인 21명의 자원자를 대상으로 30분간 300 mW의 CDMA 휴대폰 전자파에 노출 시 맥박, 혈압 및 교감신경의 흥분을 나타내는 호흡수, 피부 저항의 변화를 정량적으로 측정하였다. 그 결과, 청소년 집단의 피부 저항에서만 변화가 있었고 그 외 모든 측정치에서는 변화가 없었다. 청소년 집단에서의 피부 저항은 휴대폰의 실제 노출 하에서 통계적으로 유의하게 감소하였고, 노출 중지 후에는 가역적 반응을 보였다.

• 센서학회지
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• 제25권2호
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• pp.138-142
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• 2016

A pulse measurement by tonometry provides useful information for diagnosis, including not only blood pressure and heart rate but also parameters for estimating a condition of the cardiovascular system. Currently, various pulse measurement devices based on the tonometry have been developed. A reliability of these devices is determined by a positioning technic between the sensor and the blood vessel and a controlling technique of the pressurization level. An angle of the sensor for the pulse measurement seems to be highly related with a measured signal, however, the objective studies for this issue have been not published. In this paper, the variation of the pulse signals by tonometry direction was experimentally assessed according to the angle of the sensor. In order for guaranteeing the repeatability of the experiment, we used a pulse generator device, which can generate human pulse signal by using silicon tube and fluid pump, and developed a structure for precise adjustment of the angle and the pressurization level of the sensor. The angle of the sensor was acquired by an inclinometer, which was attached at the opposite side of the sensor. As results, a coefficient of variation (CV) of a maximum amplitude (MA) of the pulse wave was largely increased over the angle range of $-9{\sim}9^{\circ}$. Furthermore, the changes of the pulse shape showed different aspects according to the sign of the angle tilted along the blood vessel. It is expected that the results of this study can be helpful for developing more precise pulse measurement devices based on the tonometry and applying in clinic.

• The Korean Journal of Physiology
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• 제24권2호
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• pp.403-411
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• 1990

The present investigation was performed to see a possible influence of the dorsal raphe nucleus (DRN) on pancreatic exocrine secretion in anesthetized rats since the DRN had been known to exert a regulatory mechanism on sympathetic activity which was known to be very important for pancreatic exocrine secretion, particularly in rats. Twenty-nine Sprague-Dawley rats fasted for 24 hours were anesthetized by i.p. injection of 1 g/kg of urethane. The pancreatic duct was cannulated to collect pancreatic juice while bile juice was diverted into the jejunum. The duodenopyloric junction was tightly ligated. After surgery for collection of pancreatic exocrine secretion and recording of carotid blood pressure, a coaxial electrode was stereotaxically inserted in the DRN with a guide of a brain atlas. And then, electrical stimulus of biphasic square wave with 2 v, 2 msec, 40 Hz was applied on the electrode for 10 minutes. Pancreatic volume flow and protein output secreted in 10 min were measured. Either bilateral cervical vagotomy or spinal cord transection at the level of $C4{\sim}C5$ was performed 20 min prior to stimulation of the DRN. 1) Electrical stimulation of the DRN resulted in significant (p<0.05) increase in pancreatic volume flow and protein output. These stimulatory effects were not affected by cervical vagotomy but completely abolished by cervical cord transection. 2) Electrical stimulation of the DRN also resulted in significant (p<0.05) rise of blood pressure of the carotid artery. The hypertensive effect was not affected by cervical vagotomy but completely abolished by cervical cord transection. The results strongly suggest that the DRN, a part of the central serotonergic system, could exert a stimulatory influence on pancreatic exocrine secretion by increasing the sympathetic activity in anesthetized rats.