• 한국정밀공학회지
• /
• 제31권5호
• /
• pp.459-466
• /
• 2014

An index was developed that estimates cardiovascular health degree with easily available physiological information such as survey and noninvasive measurement. The survey score was calculated by utilizing questions related to personal disease history, self-feeling, and management state. The measurement score was calculated using physiological parameters such as blood pressure, accelerated plethysmograph(APG), and heart rate variability(HRV), and augmentation index(AI). In order to evaluate effectiveness of the cardiovascular index and modify weighting factors used in each item, a clinical trial was done in a general hospital. The cardiovascular index showed a clear correlation of 0.685 with the doctor's score on the cardiovascular health degree. The correlation between the self-estimated score and doctor's score was as low as 0.217. The large gap between these two scores demonstrated necessity of more objective tools like the cardiovascular index. The cardiovascular score showed a significant difference between normal persons and patients suffering hypertension or diabetes. (p=0.000).

• Journal of Korean Biological Nursing Science
• /
• 제22권3호
• /
• pp.157-171
• /
• 2020

Purpose: The purpose of this study was to analyze the characteristics and effects of the forest therapy programs for adult patients. Methods: Six databases (PubMed, Cochrane library, CiNii, PsychoInFO, AGRICOL, EMBASE) and six domestic databases were systematically searched with language restrictions of Korean, English, and Japanese. The systematic review was based on the Preferred Reporting Items Systematic Reviews and Meta-Analysis (PRISMA) flow diagram. Results: Twenty five studies met the inclusion criteria. A systematic review identified adult patients classified as 1) disease of the circulatory system, 2) mental and behavioral disorders, 3) malignant neoplasms, 4) etc. (diabetes mellitus, chronic pain). This integrative review showed a positive effect of the forest therapy program for adult patients on physiological indices such as blood pressure, heart rate, heart rate variability, level of stress hormone, and natural killer cells as well as social·psychological indices such as the Profile of Mood States (POMS), anxiety, depression, and quality of life. Conclusion: The results of this study could be useful key principles in developing and applying the forest therapy programs in nursing intervention. Further research should be conducted to develop the forest therapy programs suitable for each patient group and measure its effectiveness.

• BMB Reports
• /
• 제40권1호
• /
• pp.29-35
• /
• 2007

During the past decade, many salivary parameters have been used to characterize disease states. Ghrelin (GAH) is recently-discovered peptide hormone secreted mainly from the stomach but also produced in a number of other tissues including salivary glands. The aim of this work was to examine the relationship between active (aGAH) and inactive (dGAH) ghrelin in the saliva and other salivary parameters in type II diabetic patients and healthy controls. Salivary parameters were assessed in a single measurement of unstimulated whole saliva from 20 obese and 20 non-obese type II diabetes patients, and in 22 healthy controls. Total protein and alpha-amylase were determined by colorimetric methods, and glucose by the glucose-oxidase method. Saliva aGAH and dGAH levels were measured using a commercial radioimmunoassay (RIA) kit. Salivary concentrations of aGAH and dGAH ghrelin were more markedly decreased in obese diabetic subjects than in the two other groups. Glucose and alpha-amylase levels were higher in diabetic subjects than in controls. Furthermore, there were correlations between GAH levels and BMI, and between GAH and blood pressure. However, there was no marked variability in saliva flow rates among the groups. These results indicate that measurement of salivary GAH and its relationship to other salivary parameters might help to provide insight into the role of ghrelin in diabetes.

• 한방안이비인후피부과학회지
• /
• 제36권3호
• /
• pp.12-26
• /
• 2023

Objectives : The purpose of this study is to analyze the acupuncture and transcutaneous electrical nerve stimulation(TENS) for tinnitus to identify the trend, effectiveness and mechanism. Methods : Research studies related to objectives were gathered through Pubmed, RISS, KISS, KCI, OASIS with keywords such as 'Tinnitus', 'Autonomic', 'ANS', 'HRV', 'acupuncture', 'transcutaneous' and analyzed. Results : 4 studies were included. Acupuncture was used in 1 study and TENS was used in 3 studies. Tinnitus handicap inventory(THI), fMRI and 'heart rate and blood pressure' were used in 1 study each and heart rate variability(HRV) was used in 3 studies as evaluation tools. Each treatment showed a significant effect. Conclusions : Our findings indicate that acupuncture and TENS could be a potential therapy for tinnitus, however additional well designed RCT are required to establish high level of evidence.

• Journal of Korean Neurosurgical Society
• /
• 제61권1호
• /
• pp.35-41
• /
• 2018

Objective : Rehemorrhage is the most severe complication of postoperative patients with spontaneous intracerebral hemorrhage. The aim of the present study was to assess independent predictors of rehemorrhage and find the possibility of preventing rehemorrhage in postoperative patients with spontaneous intracerebral hemorrhage (sICH). Methods : Medical records of 263 postoperative patients with sICH from our Hospital were reviewed. The relationships between rehemorrhage and parameters were examined by univariate and multivariate analyses. The parameters include time from onset to surgery, hematologic paremeters, neuroimaging characteristics, level and variability of systolic blood pressure, medical histories, operation duration, and blood loss. In addition, relationship between rehemorrhage and clinical outcome were analyzed by using multivariate analyses. Results : Thirty-five (13.31%) patients experienced rehemorrhage after operation. Multivariate analyses indicated that the following factors were independently associated with rehemorrhage : history of diabetes mellitus (odds ratio [OR], 2.717; 95% confidence interval [CI], 1.005-7.346; p=0.049), and midline shift (for every 1 mm increase, OR, 1.117; 95% CI, 1.029-1.214; p=0.009). Rehemorrhage was an independent risk factor of poor functional outcome (OR, 3.334; 95% CI, 1.094-10.155; p=0.034). Conclusion : Our finding revealed that history of diabetes mellitus and admission midline shift were possibly associated with rehemorrhage in postoperative patients with sICH.

• 근관절건강학회지
• /
• 제23권1호
• /
• pp.1-8
• /
• 2016

Purpose: This study was to examine the effects of 12-week Tai Chi exercise on the autonomic nervous system activity and risk factors of metabolic syndrome in patients with metabolic syndrome. Methods: A single group pre-posttest was used. Subjects were 16 participants aged 51~71 years with metabolic syndrome. All of the subjects were met the criteria of the National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATP III). The Tai Chi exercise consisted of 19 movements from Yang and Sun styles provided twice a week for 3 months. Metabolic syndrome risk factors including waist circumference, blood pressure, glucose, triglyceride, high density lipoprotein cholesterol (HDL-cholesterol) were measured. A heart rate variability device was used to measure the activity of autonomic nervous system. Results: After 12-week Tai Chi exercise, systolic pressure, waist circumference, and HDL-cholesterol improved significantly. Tai Chi exercise had no effect on the autonomic nervous system activity. Conclusion: The 12-week Tai Chi exercise was partially effective in managing risk factors of metabolic syndrome. A larger study with longer period to improve the autonomic nervous system activity in patients with metabolic syndrome is needed.

• 전자공학회논문지SC
• /
• 제45권3호
• /
• pp.59-67
• /
• 2008

최근 휴대폰 보급률이 증가하면서 휴대폰 전자파로 인해 두통, 불면증, 단기간의 기억력 소실 등의 정신 신경 생리학적 증상을 호소하는 휴대폰 전자파 과민증(EHS, Electromagnetic Hypersensitivity) 환자들이 나타나고 있다. 그러나 휴대폰 전자파 과민반응의 원인이 막연한 불안감 때문인지 혹은 전자파 노출로 인한 증상 인지에 대하여 확실한 원인규명이 되지 않고 있다. GSM 방식의 휴대폰의 경우 전자파 노출 시 EHS 군을 대상으로 혈압, 맥박수 변화 및 자각 증상 등의 과민 반응에 대한 연구들이 수행되었으나 일반인과 EHS 군의 실험-대조군 연구로 생체신호, 자각증상 및 전자파 인지 여부에 대한 복합적인 연구와 CDMA 휴대폰 EHS 연구는 거의 없는 실정이다. 본 연구에서는 일반인 19명과 EHS 17명을 대상으로 30분간 300 mW의 CDMA 휴대폰 전자파에 노출 시 교감신경의 흥분을 나타내는 맥박, 호흡수, HRV(heart rate variability)의 변화를 측정하고, 전자파 노출 시 전자파 인지여부와 두통, 피로 등의 자각증상을 조사하였다. 그 결과, 일반인과 EHS 군 모두 전자파 노출여부에 따라 맥박, 호흡수, HRV의 변화가 없었고, 자각증상의 차이도 없었다. 전자파 인지 조사 결과 EHS 군이 일반인 군에 비하여 전자파를 더 잘 인지한다고 볼 수 없었다.

• 동의생리병리학회지
• /
• 제35권2호
• /
• pp.71-80
• /
• 2021

Parkinson's disease is one of the typical neurodegenerative disease and it is caused by the destruction of substantia nigra in brain leading to lack of dopamine secretion, and it presents 4 major motor symptoms such as tremor, bradykinesia, stiffness, postural instability. Furthermore, it causes many non-motor symptoms such as anosmia, REM sleep conduct disorder, orthostatic hypotension, dementia and autonomic ataxia such as lack of adjusting blood pressure, hyperhydrosis, constipation. Dopaminergic therapy is the most commonly used strategy, but long term treatment of levodopa induce various adverse effects. Thus, many people are focusing on new therapies other than established therapies, and there are many tries and approaches with paradigm shift. Our medical team was able to get 4 cases of PD patients who are hospitalized in our hospital, treated by Whole Body Gi-Hyeol Therapy consisting of acupuncture therapy, herbal therapy, and mental therapy, and their conditions improved in perspective of Unified Parkinson's Disease Rating Scale(UPDRS), Heart Rate Variability(HRV), and Quality of life. Among all 4 cases, UPDRS score and quality of life score is gotton better, and among 2 cases SDNN, RMS-SD, TP, LF, HF scores are finely increased. And PDQ-39 score which shows quality of life is also improved. However, in spite of these improvements and positive results, there were no meaningful improvement in a hurt from a fall which is important to the aged, muscular atrophy which causes bone fracture and SMI(Skeletal Muscle Mass Index) which is indicator of osteoporosis. Thus, supplementary treatment about Whole Body Gi-Hyeol Therapy such as more active nutrition intervention, safe and effective kinesitherapy is needed, and from now on continuous case reports and systematic clinical research which has control group must be carried out.

• 한국임상약학회지
• /
• 제21권2호
• /
• pp.170-181
• /
• 2011

Purpose: There is considerable variability in rates of hospitalization for patients with community-acquired pneumonia (CAP) in part because of physicians' uncertainty in assessing the severity of illness at presentation. The purpose of the study was to examine the current treatment patterns and factors influencing the Pneumonia Severity Index (PSI) and clinical outcomes in the patient with CAP. Method: The retrospective data collection of the patients with CAP was conducted and the data were reviewed. The collected data included demographic, clinical, laboratory and microbiological medical information. All patients were stratified into three risk groups according to PSI: low risk (PSI score I-II), moderate risk (III) and high risk (IV-V) groups. The examined treatment patterns were the appropriateness of admissions, category of antibiotics used. The prognostic factors associated with PSI and clinical outcomes were examined. Results: One hundred and six patients' medical data were reviewed. The overall appropriateness of admissions was low presenting many of patients were admitted or intensely treated in the hospital despite of lower risk of prognosis and treated with intravenous antibiotics instead of oral fluoroquinolones. Primary pneumonia pathogens were Klebsiella pneumoniae (27%) and Streptococcus pneumoniae (21.6%). Mean LOS was 8.5 days and was significantly longer (10.0days) (p<0.001) in high risk group. The patients with age >65 (p<0.001), diabetes mellitus (p<0.001), mental alteration (p<0.001), and/or $PaO_2$ <60 mmHg (p<0.001) had a tendency to have higher PSI. The prognostic factors associated with longer LOS were age >65 years (p=0.008), mental status alteration (p<0.001), dyspnea (p=0.002) and PSI score (p=0.001). The prognostic factors associated with mortality were congestive heart failure (p=0.038), systolic blood pressure <90 mmHg (p=0.002) and arterial pH <7.35 (p=0.013). Conclusion: Most of patients were found to over-utilize medical service according to appropriateness of admissions. The elderly, mentally altered patients with low $PaO_2$ had higher PSI score with increased risk of LOS. The mortality could be increased in the patient with disease state of congestive heart failure, high blood pressure, and/or acidosis.

• Journal of Biosystems Engineering
• /
• 제35권5호
• /
• pp.357-365
• /
• 2010

Workers in the agricultural industry have been exposed to many work-related musculoskeletal disorders. So, our objectives in this study were to measure and analyze worker's physiological bio-information to reduce musculoskeletal disorders in relation to agricultural works. We investigated worker's bio-information of physiological signals during the repeated lifting work such as body temperature, heart rate, blood pressure, physical activity, and heart rate variability. Moreover, we analyzed the workloads of lumbar spine during the repeated lifting work using the 3-axis acceleration and angular velocity sensors. The changes of body temperature was not significant, but the mean heart rate increased from 90/min to 116/min significantly during 30 min of repeated lifting work (p<0.05). The average worker's physical activity(energy consumption rate) was 206 kcal/70kg/h during the repeated lifting work. The workers' acute stress index was more than 80, which indicated a stressful work. Also, the maximum shear force on the disk (L5/S1) of a worker's lumbar spine in static state was 500N, and the maximum inertia moment was 139 $N{\cdot}m$ in dynamic state.