• Journal of the East Asian Society of Dietary Life
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• v.20 no.3
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• pp.372-381
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• 2010

This study was designed to examine the effects of sea buckthorn (SBT) on the plasma blood glucose and cholesterol level in diabetic rats. Diabetes mellitus was induced in male Sprague-Dawley rats weighing 200~220 g by an injection of streptozotocin (STZ) dissolved in a citrate buffer into the tail vein at a dose of 45 mg/kg of body weight. Sprague-Dawley rats were fed an AIN-93 recommended diet and the experimental groups were fed a modified diet containing 10% and 20% of SBT powder for 4 weeks. The experimental groups were divided into 6 groups which consisted of normal (N)-control group, N-SBT 10% and N-SBT 20% treated groups, STZ-control, STZ-SBT 10% and STZ-SBT 20% treated groups. The rats' body weight, aminotransferase activities and hematocrit (Hct) values were measured along with plasma levels of blood glucose and cholesterol. Body weight losses were observed by diabetic groups While the nondiabetic rats gained weight. There were significant differences between the control group and the diabetic groups in the weight of kidney. Aspartate aminotransferase activity was lower in the non-diabetic group compared to diabetic experimental groups. The blood glucose were significantly decreased in the 10% SBT of diabetic group. The cholesterol level of STZ-SBT 10% and STZ- SBT 20% were significantly lower than for the STZ-control group. These results show that the supplementation of sea buckthorn leave powder may have favorable influence on reducing blood glucose and cholesterol level in STZ-induced diabetic rats.

• Health Policy and Management
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• v.31 no.3
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• pp.292-300
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• 2021

Background: Medication adherence in hypertension is the most important to control blood pressure and prevent major complications. The purpose of this study was to identify factors affecting medication adherence and to examine the relationship between medication adherence and blood pressure control in Korea. Methods: This study used data from the 7th Korea national health and nutrition examination survey (2016-2018) of the Korea Disease Control and Prevention Agency. We selected 4,063 hypertensive patients from the data. And we choose socio-demographic, health behavior, healthcare utilization, and severity characteristics as hypertensive patient characteristics. Results: Of the patients with hypertension, 92.3% had shown adherence to medication as of 2016-2018 and shows variation according to the characteristic of patients. The cases with male, under 50 years old, urban area, single household, unmet medical services, less than 5 years of hypertension duration, no comorbidities (diabetes mellitus, myocardial infarction) showed significantly low medication adherence. After adjusting for confounders, adherent patients tended to have lower current systolic blood pressure (β=-10.846, p<0.001) and diastolic blood pressure (β=-5.018, p<0.001) than nonadherent patients. And, adherent patients increased the control odds of blood pressure compared with nonadherent patients (odds ratio, 3.02; 95% confidence interval, 2.21-4.12). Conclusion: This study confirmed that adherence to antihypertensive drugs was effective in controlling blood pressure. In order to more actively manage hypertensive patients at the national level, it is necessary to make an effort to improve the medication compliance of nonadherent groups, such as early-diagnosis patients, young patients under 50 years of age, and patients living alone.

• Journal of Oriental Neuropsychiatry
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• v.10 no.1
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• pp.79-93
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• 1999

This experiment was done to investigate the effects of Ojajiwhangeumja(OJWEJ) to the symptoms of senility. To prove the effects of OJWEJ we injected scopolamine(1mg/kg) to the vein of rats. And we measured the blood cells(WBC, RBC, Platelet), constituents of serum(BUN, creatinin, glucose, uric acid), endurance of films of the red blood cell to erythrocyte hemolises, the activity of cholinesterase in serum, TBA and the activity of catalase, SOD in the purified microsome of brain tissue of rats. The results were as follows; 1. The number of white blood cells, platelet was increased significantly in the group treated by OJWEJ in comparison with control group. 2. The number of BUN, creatinin, glucose of serum decreased significantly in the OJWEJ treated group compared with control group. 3. The erythrocyte hemolises in red blood cells restrained significantly in the group treated by OJWEJ in comparison with control group. 4. The activity of cholinesterase in OJWEJ treated group increased significantly compared with control group. 5. The amounts of malondialdehyde of serum decreased significantly in the OJWEJ treated group in comparison with control group. 6. The catalase in the microsome of rat brain was activated significantly in the group treated by OJWEJ compared with control group. 7. The superoxide dismutase in the group treated by OJWEJ activated significantly in comparison with control group. According to this experiment it is suggested that OJWEJ accelerates the activity of colinesterase and restrains the creation of erythrocyte hemolises and accumulation of senile substance. But I look forward to see the further research to be made.

• Korean Journal of Pharmacognosy
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• v.37 no.3
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• pp.169-176
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• 2006

This study was designed to observe the effects of Korean mistletoe(Viscum album L. var. coloratum Ohwi) hot-water extract administration on the improvement on the lipid components, apolipoprotein and blood pressure level in spontaneously hypertensive rats (SHR, Wistar strain, male) fed the experimental diets for 33 days. Concentrations of total cholesterol, triglyceride (TG), LDL-cholesterol, free cholesterol and atheroscieotic index in serum were significantly lower in the Korean mistletoe extract administration group [group KM(Korean mistletoe 10.0 g% hot-water extract)] than those in the control group. In the ratio of HDL-cholesterol concentration Korean mistletoe 10.0% hot-water extract administration group were higher percentage than in the control group. However, concentrations of total cholesterol and TG in liver and brain were significantly lower in the group KM than those in the control group. But the components of apolipoprotein (Apo) A-I and Apo A-II in serum were significantly higher in the KM group than in the control group. However, components of Apo C-II, Apo C-III, Apo E and ratio of Apo B to Apo A-I in serum were fairly reduced in the group KM than in the control group. The levels of systolic and diastolic blood pressure were significantly lower in KM cup than control group. From these results, Korean mistletoe hot-water extract administration were effective on the improvement of the lipid components, coronary heart disease and hypertension in spontaneously hypertensive rats. And particularly, Korean mistletoe extract administration were more effective as a therapeutic regimen for the control of blood pressure in hypertension.

• The Korea Journal of Herbology
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• v.31 no.2
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• pp.39-45
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• 2016

Objectives : Abnormal regulation of glucose and impaired lipid metabolism that result from a defective or deficient insulin are the key etiological factor in type 2 diabetes mellitus. The our study investigated the effects of Gamioknyeo-jeon (GO) on blood glucose and lipid metabolism improved by it in db/db mice (a murine model of type 2 diabetes mellitus).Methods : The animals were divided into 3 groups: Normal groups were not-treated C57BL/6 mice; Control groups were treated orally with DW in db/db mice; GO groups were treated orally with GO (200 ㎎/㎏/day) in db/db mice. After mice were treated with GO for 5 weeks, we measured AST, ALT, creatinine, BUN, body weight, food intake, blood glucose, insulin and lipid levels (total cholesterol, HDL cholesterol, and LDL cholesterol and atherogenic index(AI) and cardiac risk factor(CRF).Results : Serum AST, ALT, creatinine, BUN levels were not changed by GO do not show any toxic effects. GO groups were decreased in body weight, food intake and blood glucose level among compared to Control groups. Also, GO groups were found to have atherogenic Index and cardiac risk factor as well as lipid metabolism improvement (total cholesterol and LDL cholesterol decrease). Finally, GO groups were increased the insulin compared to Normal and control groups.Conclusions : We suggest that GO may have the control effects of diabetes mellitus by improving blood glucose control and lipid metabolism.

• Journal of Nutrition and Health
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• v.34 no.1
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• pp.3-13
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• 2001

This study was conducted to investigate the effect of soyligosaccharides on improvement of diabetes mellitus. Sprague Dawley rats were divided into three groups. Control and one experimental group were fel AIN-93G diet(mixed diet) and the other experimental group was fed a similar diet containing 5% soyligosaccharides(oligosaccharide diet) for 6 weeks. Experimental groups were divided into two sub-groups after streptozotocin(STZ) injection and fed th mixed diet or the oligosaccharide diet for the next 2 weeks. Followings are final experimental and control groups: MM (mixed dietlongrightarrowSTZ injectionlongrightarrowmixed diet). MO(mixed dietlongrightarrowSTZ injectionlongrightarrowoligosaccharide diet), OM( oligosaccharide dietlongrightarrowSTZ injectionlongrightarrowmixed diet), OO(oligosaccharide dietlongrightarrowSTZ injectionlongrightarrowoligosaccharide diet), C(mixed dietlongrightarrowplacebo injectionlongrightarrowmixed diet). Blood glucose was analyzed at d1, d8 and d12 after streptozotocin injection. At the end of the experimental period, fecal bifidobacteria, plasma insulin, total lipid, triglyceride, cholesterol, and leptin concentrations was analyzed, After STZ injection, blood glucose level was significantly elevated in experimental group compared to a control group. Elevated blood glucose level declined faster in OO group compared to the other experimental groups. Meanwhile, insulin concentration decreased in all experimental groups compared to a control group. The number of bifidobacteria was significantly increased in oligosaccharide diet groups after STZ injection (MO and OO) than a mixed diet group(MM). Plasma cholesterol concentration significantly decreased in oligosaccharide diet groups(MO and OO) compared to mixed diet groups (MM and OM) after SZ injection. Plasma triglyceride and liver cholesterol concentrations significantly decreased in MO group compared to other experimental groups. Meanwhile, plasma leptin concentration was significantly lower in oligosaccharide diet groups after STZ injection(MO and OO) compared to a control group. The results in this study suggest that the dietary soyoligosaccharides has strong on reduction of reduction of blood glucose and lipid concentrations in streptozotoicin-induced diabetic rats. Thus, the use of soyoligosaccharides at a diet for IDDM patients may help to improve diabetes mellitus symptoms.(Korean J Nutrition 34(1) : 3-13, 2001)

• Journal of the Korean Applied Science and Technology
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• v.32 no.3
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• pp.394-404
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• 2015

This study investigated the pharmacodynamics of betaine on the blood profile and short chain fatty acid levels in meat ducks exposed to heat wave. 400 heads of Cherry valley (Anasplatyrhynchos) meat ducks were completely randomized to 5 treatments (4 repetitions each), and were raised for 42 days. They were grouped into T1 (heat wave control group without betaine), T2 (betaine 400 ppm), T3 (betaine 800 ppm), T4 (betaine 1200 ppm), and T5 (normal control group without betaine). Compared to T1, the betaine addition groups showed higher body weight gain at shipment, with T3 showing the highest significant difference. For hematological indictors measured (red blood cells and platelets), the betaine addition groups showed significantly higher values than the heat wave control group. The pH of the former was lower but their electrolytes ($K^+$, $P^+$, and $Cl^-$) were significantly higher compared to the latter. For blood gas concentration, the former showed a significantly higher value than the latter. For the total short chain fatty acids, acetic acid, and propionic acid, the betaine addition groups and group fed broiler-high temperature diet showed higher values than the heat wave control group. On the other hand, the former showed significantly lower values in butyric acid, isobutyric acid, valeric acid, and isovaleric acid than the latter group. These results suggest that betaine has the pharmacodynamics that mediate heat stress, via the maintenance and control of the blood profile, osmotic pressure, gas concentration, and short chain fatty acid, of meat ducks under heat wave.

• Imaging Science in Dentistry
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• v.44 no.2
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• pp.149-154
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• 2014

Purpose: This study assessed the effectiveness of three antimicrobial mouthrinses in reducing microbial growth on photostimulable phosphor (PSP) plates. Materials and Methods: Prior to performing a full-mouth radiographic survey (FMX), subjects were asked to rinse with one of the three test rinses ($Listerine^{(R)}$, $Decapinol^{(R)}$, or chlorhexidine oral rinse 0.12%) or to refrain from rinsing. Four PSP plates were sampled from each FMX through collection into sterile containers upon exiting the scanner. Flame-sterilized forceps were used to transfer the PSP plates onto blood agar plates (5% sheep blood agar). The blood agar plates were incubated at $37^{\circ}C$ for up to 72 h. An environmental control blood agar plate was incubated with each batch. Additionally, for control, 25 gas-sterilized PSP plates were plated onto blood agar and analyzed. Results: The mean number of bacterial colonies per plate was the lowest in the chlorhexidine group, followed by the Decapinol, Listerine, and the no rinse negative control groups. Only the chlorhexidine and Listerine groups were significantly different (p=0.005). No growth was observed for the 25 gas-sterilized control plates or the environmental control blood agar plates. Conclusion: The mean number of bacterial colonies was the lowest in the chlorhexidine group, followed by the Decapinol, Listerine, and the no rinse groups. Nonetheless, a statistically significant difference was found only in the case of Listerine. Additional research is needed to test whether a higher concentration (0.2%) or longer exposure period (two consecutive 30 s rinse periods) would be helpful in reducing PSP plate contamination further with chlorhexidine.

• Journal of Chest Surgery
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• v.23 no.2
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• pp.268-274
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• 1990

Bleeding after cardiopulmonary bypass remains a cause for concern, requiring reexploration of the chest in approximately 3 percent of patients who have had operations on the heart. We examined the possibility that this problem might be alleviated by desmopressin acetate [DDAVP], synthetic vasopressin analogue that lacks vasoconstrictor activity. In a prospective, randomized trial, we studied the effect of intraoperative desmopressin acetate in 20 patients [the treated group 10 patients and the control group 10 patients] undergoing various cardiac operations requiring cardiopulmonary bypass. The result showed that the early postoperative [during first 24hrs] and mean postoperative blood loss [first 3 days] of the treated group were significantly reduced than the control group[447\ulcorner199ml in the treated group versus 746\ulcorner199ml in the treated group versus 746\ulcorner295 ml in the control group, p=0.014; mean\ulcornerstandard deviation and 675\ulcorner276 ml in the treated group versus 1006\ulcorner303 ml in control group, p=0.019]. The mean red-cell transfusion in first 3days were reduced in the treated group than the control group [3.3\ulcorner1.7 units vs 4.9\ulcorner1.7units, P=0.051]. There were no untoward side effects of desmopressin acetate. We conclude that the administration of desmopressin acetate can be recommended to reduce blood loss and blood conservation in patients undergoing cardiac operations.

• Journal of Aquaculture
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• v.12 no.3
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• pp.205-212
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• 1999

A feeding trial was conducted to evaluate dietary protein sources replacing fish meal for parrot fish, Oplegnathus fasciatus. A control diet with white fish meal as a protein source was included. White fish meal in the isonitrogenous diet was replaced with each of 22% meat meal, 17% blood meal, or 31% soybean meal. Triplicate groups of 25 fish initially averaging 26 g were fed four experimental diets for 7 weeks in a flow-through tank system. Weight agin and feed efficiency in fish fed diet containing 17% blood meal (this diet also contained 45% white fish meal) were not significantly different from those in fish fed the control diet (P>0.05). Fish fed diet containing 22% meat meal had lower weight gain and feel efficiency than those of fish fed the control diet (P<0.05). weight gain of fish fed diet containing 31% soybean meal was not different from that of fish fed the control diet, but feed efficiency of fish fed the diet was lower than that of fish fed the control diet.