• 동의생리병리학회지
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• 제22권5호
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• pp.1250-1255
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• 2008

Onchungeum(OCE), a herbal formula, has been used for treatment of anemia, discharging blood and skin diseases. In the previous study, we investigated the anti-cancer effect of OCE by G1 arrest of the cell cycle in human hepatocarcinoma cells, Hep3B cells. In this study, it was examined that the difference of anti-proliferative mechanisms by change in the ratio of OCE composition (OCE I) in Hep3B cells. Treatment of OCE I exhibited a relatively strong anti-proliferative activity and caused various morphological changes such as membrane shrinkage and cell floating. In addition, OCE-I arrests the cell cycle at G1 phase, which was associated with the down-regulation of cyclin D1 and Cdk6 expressions. The G1 arrest was also associated with the induction of Cdk inhibitors p27 and p21. Moreover, both p21 and p27 were detected by immunoprecipitation with anti-Cdk4 and anti-Cdk2 antibodies in OCE I-treated cells but in case of OCE, p21 did not make any complexes with Cdk4 and Cdk2. These results suggest that the change in the ratio of OCE composition might induce different mechanisms in anti-cancer efficacy of OCE, which may confer characteristic principles in oriental medical formula.

• Journal of Acupuncture Research
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• 제18권6호
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• pp.151-160
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• 2001

Objective : Assuming that the characteristic of meridian system has been similar to this of electric potentials in human body and that measurements of electric potential at well(井穴) and sea(合穴) points in branches of the twelve meridians will be representative of measurements of the twelve meridians, to measure the electric potentials in twenty aged and fifty aged healthy volunteers groups at sleeping(SG) and awakening(AG), and then to find out the characteristic of meridian system among 2 groups. Methods : We selected who thirty healthy volunteers were diagnosed by a blood test, urine examination and differentiation of syndromes by five viscera(五臟辨證) among volunteers. Their electric potential of well and sea points in the meridians were simultaneously measured by physiograph. Results : Measurements were analyzed by statistical factor analysis, we obtained that the both left and right side electric potential of well and sea points in branches of the twelves meridians were unclearly divided into four factors according to age and whether sleeping or not, which were the three Yin meridians of the hand, the three Yang channels of the hand, the three Yin meridians of the foot, and the three Yin meridians of the foot. Conclusion : In conclusion, using the sequently measuring method, we obtained that electrical potentials of well and sea points in branches of the twelves meridians were divided into two factors, but the simultaneously measuring method, those were divided into four factors. The latter result means that the electrical potentials of twelve meridians were reflected by the function of the viscera and bowels.

• Journal of Electrical Engineering and Technology
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• 제2권1호
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• pp.136-141
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• 2007

The Purpose Of This Paper Is To Use A Tactile Sensor To Compensate The Error Rate. Most Automated Sphygmomanometers Use The Oscillometric Method And Characteristic Ratio To Estimate Systolic And Diastolic Blood Pressure. However, Based On The Fact That Maximum Amplitude Of The Oscillometric Waveform And Characteristic Ratio Are Affected By Compliance Of The Aorta And Large Arteries, A Method To Measure The Artery Stiffness By Using A Tactile Sensor Was Chosen In Order To Integrate It With The Sphygmomanometer In The Future Instead Of Using Photoplethysmography. Since Tactile Sensors Have Very Weak Movements, Efforts Were Made To Maintain The Subject's Arm In A Fixed Position, And A 40hz Low Pass Filter Was Used To Eliminate Noise From The Power Source As Well As High Frequency Noise. An Analyzing Program Was Made To Get Time Delay Between The First And Second Peak Of The Averaged Digital Volume Pulse(${\Delta}t_{dvp}$), And The Subject's Height Was Divided By ${\Delta}t_{dvp}$ To Calculate The Stiffness Index Of The Arteries($Si_{dvp}$). Regression Equations Of Systolic And Diastolic Pressure Using $Si_{dvp}$ And Mean Arterial Pressure(Map) Were Computed From The Test Group (60 Subjects) Among A Total Of 121 Subjects(Age: $44.9{\pm}16.5$, Male: Female=40:81) And Were Tested In 61 Subjects To Compensate The Error Rate. Error Rates Considering All Subjects Were Systolic $4.62{\pm}9.39mmhg$, And Diastolic $14.40{\pm}9.62mmhg$, And Those In The Test Set Were $3.48{\pm}9.32mmhg,\;And\;14.34{\pm}9.67mmhg$ Each. Consequently, Error Rates Were Compensated Especially In Diastolic Pressure Using $Si_{dvp}$, Various Slopes From Digital Volume Pulse And Map To Systolic-$1.91{\pm}7.57mmhg$ And Diastolic $0.05{\pm}7.49mmhg$.

• Journal of Acupuncture Research
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• 제29권1호
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• pp.139-150
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• 2012

1. 형상의학(形象醫學)에서는 사람을 얼굴형태에 따라 정(精) 기(氣) 신(神) 혈(血)과로 이목구비(耳目口鼻)의 기능에 따라 어(魚) 조(鳥) 주(走) 갑류(甲類)로 분류하며, 이러한 분류에 따른 장부(臟腑)의 특성을 사암침(舍巖鍼) 운용에 활용하면 임상에서 활용도가 높다. 2. 어류(魚類)는 수(水)의 기운(氣運)이 많아 수체(水體)라고도 하며 신장(腎臟)이 발달하여 신장(腎臟)과 관련된 병이 오기 쉽다. 그 본치(本治)가 보정보기(補精補氣)이며 주로 신정격(腎正格)을 운용하고 신양허쇠(腎陽虛衰)인 경우 신열격(腎熱格), 신음허(腎陰虛)인 경우 신한격(腎寒格)을 쓰며 정혈(精血)의 휴손(虧損)이 심한 경우 간정격(肝正格)도 운용할 수 있다. 3. 조류(鳥類)는 화(火)의 기운(氣運)을 많이 받아 화체(火體)라고도 하며 심장(心臟)이 발달하여 심장병(心臟病) 신경성 질환이 잘 온다. 그 본치(本治)가 자음강화(滋陰降火)며 심장(心臟)의 음혈(陰血)을 보(補)하고 화(火)를 내리는 심한격(心寒格)을 위주로 하여, 심화(心火)를 사(瀉)하면서 음혈(陰血)을 보해주고 신지(神志)를 안정시키는 심승격(心勝格), 심기(心氣)가 부족한 경우 심정학(心正格), 심담(心膽)이 모두 허(虛)한 경우 담정격(膽正格)을 운용할 수 있다. 4. 주류(走類)의 목(木)의 기운(氣運)이 많아 목체(木體)라고도 하며 간(肝)이 발달(發達)하여 간(肝)과 관련된 병(病)이 잘 온다. 그 본치(本治)가 청열사습(靑熱瀉濕), 자혈양근(滋血養筋)이므로 간정격(肝正格)을 주로 운용하고, 간화(肝火)가 동(動)하거나 간실증(肝實證)이 나타난 경우 간한격(肝寒格)이나 간승격(肝勝格)을, 간기(肝氣)가 항진(亢進)으로 인해 비기(脾氣)가 허(虛)해져 있는 경우 비정격(脾正格)을, 습열이 너무 성(盛)한 경우 대장정격(大場正格)을 운용할 수 있다. 5. 갑류(甲類)는 금(金)의 기운(氣運)이 많아 금체(金體)라고도 하며 폐(肺)가 발달하여 폐(肺)와 관련된 병이 잘 온다. 그 본치(本治)가 해울소담(解鬱消痰)이므로 폐정격(肺正格)을 통해 보폐순기(補肺順氣)하며 울증(鬱症)이 심한 경우 폐승격(肺勝格)으로 통해 소담(消痰)시켜주고 기울방(氣鬱方)으로 해울(解鬱)하기도 한다. 6. 정과(精科)는 그 특성상 정(精)의 누설(漏泄)에 의한 증상 및 정부족(精不足), 양허증상(陽虛證狀)과 정(精)의 과도한 응집(凝集)에 의한 습열(濕熱)이 기본 병리이며 기본처방은 신기(腎氣)를 강화하는 신정격(腎正格)을 중심으로 하여, 신열격(腎熱格) 신한격(腎寒格) 등을 변증에 따라 운용하며 습열(濕熱)이 성한 경우 대장정격(大腸正格) 비승격(脾勝格) 등 습열(濕熱)을 다스리는 처방과 비정격(脾正格), 습담방(濕痰方) 등 습담(濕痰)을 다스리는 처방이 운용될 수 있다. 7. 기과(氣科)의 기본 병리(病理)는 기울(氣鬱), 기체(氣滯)에 의한 구기(九氣), 칠기(七氣), 중기(中氣), 매핵기(梅核氣), 불면증(不眠症) 등 신경성 질환이 많고 특히 여자의 경우 손발과 하복부가 차고 대소변이 안좋으며 징가(癥痂), 현벽(痃癖) 등의 질환이 많다. 또한 지나친 발산(發散)으로 인하여 기허증(氣虛證)이 나타나기도 한다. 따라서 기본처방은 기울방(氣鬱方), 담음방(痰飮方), 담현방(痰眩方), 기수방(氣嗽方), 폐승격(肺勝格), 삼초정격(三焦正格) 등이며, 기허증(氣虛證)이 나타나는 경우 폐정격(肺正格)을 사용할 수 있다. 8. 신과(神科)의 기본병리는 칠정울결(七情鬱結)이나 담화(痰火), 화성음허(火盛陰虛)이며 대표적인 증상은 경계(驚悸), 정충(怔忡), 건망(健忘), 불면(不眠), 전간(癲癎), 전광(癲狂) 등이다. 따라서 기본처방은 심한격(心寒格), 심승격(心勝格), 심정격(心正格), 담정격(膽正格), 비한격(脾寒格)을 중심으로 열담방(熱痰方), 군화방(君火方), 상화방(相火方), 화울방(火鬱方) 등을 사용할 수 있다. 9. 혈과(血科)의 기본병리는 어혈(瘀血) 및 출혈이며 대표적인 증상은 구규출혈(九竅出血)과 어혈(瘀血), 혈허증(血虛證)이다. 따라서 기본처방은 간정격(肝正格), 손혈방(損血方), 심한격(心寒格) 비한격(脾寒格) 심비한격(心脾寒格), 소장정격(小腸正格), 소장한격(小腸寒格), 어혈방(瘀血方), 뉵혈방(衄血方) 등을 사용할 수 있다.

• 농업과학연구
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• 제43권5호
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• pp.810-817
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• 2016

The aim of this experiment was to determine the effect of a high-energy diet on the level of serum metabolites and on carcass characteristics of Hanwoo steers. High energy diets have been used for enhancing intramuscular adipose tissue in high quality beef cattle. However, there is not much information about the physiological reactions to this diet. We hypothesized that a high energy diet would increase blood metabolites and the meat quality of Hanwoo steers during the early and final fattening periods. A $2{\times}2$ factorial arrangement (High, Control, and Early, Final) in a completely randomized design was used to feed 24 Hanwoo steers. Two steers were kept in the same pen and 12 pens were used for the experiment. Blood was drawn from each steer on the first week of every other month from 11 to 28 months. Overall Average Daily Gain (ADG) and feed efficiency were not different between high energy and control diets (p > 0.05). However, Dry Matter Intake (DMI greater with the control diet than DMI with the high energy diet during the final fattening period (p < 0.05). Serum non-esterified fatty acid (NEFA) concentrations were greater in the control diet group than in the high energy diet group during the final fattening period (p < 0.05). However, serum albumin, glucose, total protein, triglyceride, and phosphorus were greater in the high energy group than those of the control group (p < 0.05). Carcass traits or physico-chemical characteristics were not different between high energy diet treatment and the control. These data indicated that a high energy diet (+ 3% TDN) increased serum triglyceride during early fattening periods and decreased non-esterified fatty acids during final fattening periods in Hanwoo steers.

• Clinical and Experimental Emergency Medicine
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• 제5권4호
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• pp.219-229
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• 2018

Objective We compared the predictive value of the National Early Warning Score+Lactate (NEWS+L) score with those of other parameters such as the pre-endoscopic Rockall score (PERS), Glasgow-Blatchford score (GBS), and albumin, international normalized ratio, altered mental status, systolic blood pressure, age older than 65 years score (AIMS65) among patients with upper gastrointestinal bleeding (UGIB). Methods We conducted a retrospective study of patients with UGIB during 2 consecutive years. The primary outcome was the composite of in-hospital death, intensive care unit admission, and the need for ${\geq}5$ packs of red blood cell transfusion within 24 hours. Results Among 530 included patients, the composite outcome occurred in 59 patients (19 inhospital deaths, 13 intensive care unit admissions, and 40 transfusions of ${\geq}5$ packs of red blood cells within 24 hours). The area under the receiver operating characteristic curve of the NEWS+L score for the composite outcome was 0.76 (95% confidence interval, 0.70 to 0.82), which demonstrated a significant difference compared to PERS (0.66, 0.59-0.73, P=0.004), but not to GBS (0.70, 0.64-0.77, P=0.141) and AIMS65 (0.76, 0.70-0.83, P=0.999). The sensitivities of NEWS+L scores of 3 (n=34, 6.4%), 4 (n=92, 17.4%), and 5 (n=171, 32.3%) were 100%, 98.3%, and 96.6%, respectively, while the sensitivity of an AIMS65 score of 0 (n=159, 30.0%) was 91.5%. Conclusion The NEWS+L score showed better discriminative performance than the PERS and comparable discriminative performance to the GBS and AIMS65. The NEWS+L score may be used to identify low-risk patients among patients with UGIB.

• 농업과학연구
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• 제45권4호
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• pp.665-675
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• 2018

A total of 80 pigs [(Landrace ${\times}$ Yorkshire) ${\times}$ Duroc] with an average body weight of $72.9{\pm}2.6kg$ were used in the present study to investigate the effects of fermented whole crop wheat and barley with or without supplementing inoculums throughout the restricted feeding in finishing pigs. There were 4 replicate pens per treatment. Pigs were fed ad libitum throughout the experiment as the control (CON), and the other four groups were restricted to 10% in the CON diet and fed ad libitum fermented whole crop cereals: fermented whole crop barley with inoculums; fermented whole crop barley without inoculums; fermented whole crop wheat with inoculums; and fermented whole crop wheat without inoculums. During the entire experiment, the average daily feed intake (ADFI) decreased in the fermented barley and fermented wheat groups compared to the CON, while no difference was observed in the average daily gain (ADG), feed efficiency (gain : feed ratio, G : F) between the control and fermented whole crop barley, wheat diet group. Dry matter and nitrogen digestibility did not show a significant difference among the treatments. In the blood constituents, concentrations of blood urea nitrogen were significantly lower in pigs fed fermented whole crop barley without inoculum diets compared with the other treatments. In conclusion, restricted feeding with fermented whole crop barley and wheat regardless of the supplementing inoculums showed no significant difference in growth performance compared to the CON. This suggests that there is a possibility that fermented whole crop barley and wheat could replace part of the conventional diets.

• Korean Journal of Radiology
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• 제22권12호
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• pp.1964-1973
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• 2021

Objective: To investigate the diagnostic performance of CT fractional flow reserve (CT-FFR) for myocardial bridging-related ischemia using dynamic CT myocardial perfusion imaging (CT-MPI) as a reference standard. Materials and Methods: Dynamic CT-MPI and coronary CT angiography (CCTA) data obtained from 498 symptomatic patients were retrospectively reviewed. Seventy-five patients (mean age ± standard deviation, 62.7 ± 13.2 years; 48 males) who showed myocardial bridging in the left anterior descending artery without concomitant obstructive stenosis on the imaging were included. The change in CT-FFR across myocardial bridging (ΔCT-FFR, defined as the difference in CT-FFR values between the proximal and distal ends of the myocardial bridging) in different cardiac phases, as well as other anatomical parameters, were measured to evaluate their performance for diagnosing myocardial bridging-related myocardial ischemia using dynamic CT-MPI as the reference standard (myocardial blood flow < 100 mL/100 mL/min or myocardial blood flow ratio ≤ 0.8). Results: ΔCT-FFR_systolic (ΔCT-FFR calculated in the best systolic phase) was higher in patients with vs. without myocardial bridging-related myocardial ischemia (median [interquartile range], 0.12 [0.08-0.17] vs. 0.04 [0.01-0.07], p < 0.001), while CT-FFR_systolic (CT-FFR distal to the myocardial bridging calculated in the best systolic phase) was lower (0.85 [0.81-0.89] vs. 0.91 [0.88-0.96], p = 0.043). In contrast, ΔCT-FFR_diastolic (ΔCT-FFR calculated in the best diastolic phase) and CT-FFR_diastolic (CT-FFR distal to the myocardial bridging calculated in the best diastolic phase) did not differ significantly. Receiver operating characteristic curve analysis showed that ΔCT-FFR_systolic had largest area under the curve (0.822; 95% confidence interval, 0.717-0.901) for identifying myocardial bridging-related ischemia. ΔCT-FFR_systolic had the highest sensitivity (91.7%) and negative predictive value (NPV) (97.8%). ΔCT-FFR_diastolic had the highest specificity (85.7%) for diagnosing myocardial bridging-related ischemia. The positive predictive values of all CT-related parameters were low. Conclusion: ΔCT-FFR_systolic reliably excluded myocardial bridging-related ischemia with high sensitivity and NPV. Myocardial bridging showing positive CT-FFR results requires further evaluation.

• Tuberculosis and Respiratory Diseases
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• 제39권1호
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• pp.7-14
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• 1992

연구배경 : 동맥혈가스 변화에 따른 호흡곤란 및 의식장애는 만성 폐쇄성 폐질환 환자들을 포함한 여러 호흡기 질환 환자들에게서 비교적 흔히 관찰할 수 있다. 그러나 실제로는 같은 질환이라 할지라도 동맥혈가스 변화에 따른 호흡곤란 및 의식장애의 정도는 환자에 따라 매우 다양하다. 한편 만성 폐쇄성 폐질환은 폐기종 우세형과 기관지염 우세형의 두가지 임상군으로 구분할 수 있는데, 이에 저자들은 만성 폐쇄성 폐질환에서 호흡곤란을 느낄 당시의 중추신경계의 반응과 의식장애에 많은영향을 미치는 동액혈가스 소견이 임상군에 따라 차이가 있는지를 규명하고자 본 연구를 시행하였다. 방법 : 16명의 만성 폐쇄성 폐질환 환자들을 대상으로 동맥혈가스 및 인지기능의 척도로 이용되고 있는 trail-making B test를 실시한 후, 다시 이들을 폐기종 우세형군과 기관지염 우세형군으로 분류하고, 각 환자군에서의 인지기능 및 인지기능과 동맥혈가스와의 상관관계를 서로 비교하였다. 결과 : 1) 평균 TMB score는 폐기종 우세형군이 $266.33{\pm}171.62$초, 기관지염 우세형군이 $200.29{\pm}123.13$초로서, 폐기종 우세행군이 기관지염 우세형군에 비해 호흡 곤란을 느낄 당시의 인지기능장애가 다소 심한 경향이 있었다. 2) 두 환자군 모두 저산소혈증, 과탄산혈중 및 산혈증이 심할수록 인지기능장애가 심해지는 경향을 보였다. 3) 폐기종 우세형군에서 TMB score와 동맥혈가스와의 상관계수(r)는 각각 TMB $PaO_2$: -0.477, TMB $-PaCO_2$ : 0.693, TMB-pH : -0.375, TMB-$HCO_3$ : 0.665로서, 폐기종 우세형군에서는 $PaCO_2$가 인지기능의 변화에 가장 많은 영향을 미치는 것으로 나타났다. 4) 기관지염 우세형군에서의 TMB score와 동맥혈 가스와의 상관계수(r)는 각각 TMB-$PaO_2$ : -0.306, TMB-$PaCO_2$ : 0.347, TMB-pH: -0.526, TMB-$HCO_3$ : 0.366으로서, 기관지염 우세형 환자군에서는 pH가 인지가능 변화에 가장 많은 영향을 주는 것으로 나타났다. 5) 저산소혈증, 과탄산혈증시의 인지기능장애는 폐기종 우세형군이 기관지염 우세형군에 비해 다소 심한 경향을 보였으며, 산혈증시의 인지기능장애는 오히려 기관지염 우세형군이 폐기종 우세형군에 비해 다소 심한 경향을 보였다. 결론 : 이상의 연구 결과 만성 폐쇄성 폐질환 환자들에서 호흡곤란을 느낄 당시의 중추신경계의 반응은 페기종 우세형군이나 기관지염 우세형군간에 근본적인 차이는 없지만, 인지기능에 많은 영향을 미치는 동맥혈가스 소견은 서로 다르다는 것을 알았다.

• 한국가금학회지
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• 제35권2호
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• pp.123-129
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• 2008

본 연구의 목적은 고에너지 사료 내 항생제와 효모제의 첨가가 육계의 생산성, 혈액 성상 및 도체 특성에 미치는 영향을 알아보기 위하여 실시하였다. 2일령 Arbor Acre broiler (male, female) 480수를 공시하였고, 사양 시험은 5주간 실시하였다. 시험사료는 옥수수-대두박 위주의 사료인 대조구(CON; basal diet), 고에너지 사료 처리구(HED; high energy diet), 효모제 사료 처리구(YD; HED without virginiamycin + 0.2% Saccharomyces cerevisiae, $15{\times}10^{10}$)로 3개 처리를 하여 처리당 8반복, 반복당 20수씩 완전 임의 배치하였다. 전체 사양 시험 기간동안 증체량은 고에너지 사료를 급여한 HED 처리구가 다른 처리구들에 비해 높은 경향을 보였으나, 처리구간에 유의적인 차이는 없었다. 사료 섭취량은 효모제 사료를 급여한 YD 처리구가 다른 처리구들에 비해 높은 경향을 보였으나, 처리구간에 유의적인 차이는 없었다. 사료 요구율에서는 고 에너지 사료를 급여한 HED 처리구가 다른 처리구들에 비해 유의적으로 낮게 나타났다(P<0.05). RBC(red blood cell), WBC (white blood cell), lymphocyte 모두 처리구간에 유의적인 차이는 없었으며, 간 무게 및 생체중에 대한 간 무게 비율, 허벅지육 무게 및 생체중에 대한 허벅지육 비율, 가슴육 무게 및 생체중에 대한 가슴육 무게 비율, 복강 지방 무게 및 생체중에 대한 복강 지방 무게 비율 모두에서 유의적인 차이가 없었으나, 종료시 체중에서는 HED 처리구가 유의적으로 가장 높았으며, 다음으로 YD, CON 순이었다(P<0.05). 결론적으로, 고에너지 사료 처리구가 사료 요구율에서 유의적으로 가장 영향을 미쳤으며, 효모제 처리구는 CON 처리구와 많은 차이를 보이지 않았다.