• Journal of Preventive Medicine and Public Health
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• v.32 no.3
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• pp.415-420
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• 1999

Objectives: We investigated the effects of changes in obesity and life style factors, such as cigarette smoking, alcohol drinking, and exercise, on the changes in blood pressure and serum cholesterol among Korean men. Methods: This study included 7,205 healthy male employees in the steel manufacturing industry. Each subject underwent health examination in 1994 and was re-examined in 1997. The study subjects were classified into four categories, according to changes in body mass index (BMI) (loss; stable; mild gain: severe gain), cigarette smoking (quitter; nor-smoker; smoker continued; smoker started), alcohol drinking (quitter; non-drinker; drinker continued; drinker started) and exercise (more exercise; continuous regular exercise; continuous irregular or no exercise; less exercise), respectively. We evaluated the relationship between the categories of change in those independent variables and the changes in blood pressure and serum cholesterol, adjusted for BMI in 1994 and age by analysis of variance. Results: The change in systolic blood pressure was positively associated with the changes in BMI (p<0.001) and drinking (p=0,001), but negatively with smoking (p=0,004), compared to the first category of each independent variables. The systolic blood pressure was significantly less increased in the continuous smoking group than quitter or hon-smoker. The changes in diastolic blood pressure and serum cholesterol appeared to have statistically significant linear relationships only with the change in BMI. The change in exercise showed a marginal significance with diastolic blood pressure (p=0.088). Conclusions: These prospective data emphasize the importance of obesity as a determinant of the changes in blood pressure and serum cholesterol. In addition, the changes in smoking and drinking habits can affect systolic blood pressure.

• Journal of agricultural medicine and community health
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• v.28 no.2
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• pp.123-133
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• 2003

Objectives: To examine the association between serum gamma-glutamyltransferase(GGT) activity level and blood pressure, serum lipids in the male residents of rural area, we analyzed cross-sectionally the data of 379 male health examinees aged 40 years and older from rural areas in Gyeongsangnam-do prefecture in Korea. Methods: Blood pressure and concentration of serum lipids were compared between high and low level of serum GGT activity by t-test or Wilcoxon rank sum test. Possible confounding effects of age, body mass index and coffee drinking were adjusted by analysis of covariance. Results: Adjusted values of systolic and diastolic blood pressure were higher in the group of high level of serum GGT activity in non-drinkers(P=0.055 and P=0.074 respectively) and drinkers(P=0.284 and P=0.398) of alcohol. Adjusted serum total cholesterol level was also higher in the group of high level of serum GGT activity in non-drinkers(P=0.052) but not in drinkers(P=0.981) of alcohol. In serum triglyceride, adjusted level was significantly higher in the group of high level of serum GGT activity in both non-drinkers(P=0.035) and drinkers(P=0.002) of alcohol. Conclusions: These results suggest the association of serum GGT activity and serum triglyceride, total cholesterol, or blood pressure in non-drinkres of alcohol.

• Journal of Nutrition and Health
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• v.32 no.7
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• pp.793-801
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• 1999

The purposes of this study are to assess iron status in mothers and their newborn infants at birth and to analyze the influence of maternal iron status on their newborn babies. Venous bloods samples were drawn from 144 pregnant women just before delivery and cord bloods of their newborn babies were collected immediately after birth for measurement of hemoglobin, hematocrit, serum iron, ferritin, total binding capacity and transferrin saturation. The values of hemoglobin and hematocrit were significantly lower in the mothers(10.9$\pm$1.43g/dl and 33.7$\pm$3.67%) than in their newborn infants(14.7$\pm$1.43g/dl and 45.3$\pm$4.76%)(p<0.0001). At delivery, serum iron levels in cord blood were about twice as high as those in the maternal blood, and serum ferritin levels in the cord blood were about four times higher than those in the maternal blood. The serum ferritin levels of multigravidas were higher than those of primigravidas,. but there was no difference between the serum ferritin levels of their infants. The serum ferritin levels of the mothers and their infants were higher in maternal group with iron supplement regularly than in other maternal group without iron supplement during pregnancy. Among the mothers, 26.4% had a serum ferritin levels below 12ng/ml(i.e. depleted iron stores)and 78.9% had a hemoglobin below 12g/dl(i.e.iron deficient anemia). When the maternal group was classified according to their serum ferritin levels by 9ng/ml, 12ng/dl or 20ng/ml, there was no significant difference in the iron status of their newborn infants among the three groups. The hemoglobin and serum ferritin levels of the mothers were well correlated with those of their babies. The maternal hemoglobin values negatively correlated with infant birth weight. It is possible that the demands of iron of the mother might be increased in the case of a newborn infant of greater size. The results of this study provide useful information regarding establishment of RDA for iron in pregnant women and guidance about the need for iron supplement during pregnancy.

• Journal of the East Asian Society of Dietary Life
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• v.7 no.4
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• pp.429-444
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• 1997

This study aimed at investigating correlation of nutrients intake and serum lipids in middle-aged korean male and female workers. One hundred sixty eight(male ;105, female ;63) for adult aged 30-59yr(average age male ;36.5yr, female ;44.5yr) were selected as subjects during 2 months, from April to May, 1996. Nutrients intake status was investigated by questionnaire, 24-hour recall method. Antropometric assessments, serum lipids and blood pressure of the subjects were investigated. The results as follows: 1. Nutrients intake status ; male was superior to female. Vitamin A intakes of 40-49yr group were inferior to other group but amounts of intake were above Korean RDA(recommended dietary allowances), Intakes of calcium and vitamin C of 30-39yr and over 50yr group in female were below Korean RDA. In overweights group of male and underweight group of female, most nutrients intake were increased than other groups. 2. Antropometric assessments ; female was higher than male in BMI (body mass index). All subjects increasingly with age were increased in BMI. 3. Blood components were above normal range in triglyceride in both sexes and all subjects increasingly with age were increased In level of serum lipids and blood pressure, especially in male's forty and in female's fifty were higher than other groups In serum lipids and blood pressure. In overweights group, serum lipids and blood pressure had a significantly($\alpha$=0.05) increasing tendency in both sexes. 4. Serum lipids and connected factors; atherogenic index correlated positively with triglyceride, total-chol(total cholesterol), LDL-chol(low density-lipoprotein cholesterol) and negatively with HDL-chol(high-density-lipoprotein cholesterol) significantly(P＜0.001). Systolic blood pressure correlated positively with total-chol and diastolic blood pressure correlated positively with total-chol, LDL-chol significantly(P＜0.05). 5. Serum lipids and nutrients intake status: energy correlated positively(P＜0.05) with BMI, dietary fiber correlated positively with LDL-chol(P＜0.05), calcium correlated positively with triglyceride, atherogenic index and dietary fiber correlated negatively with BMI in male significantly(P＜0.05). Triglyceride correlated positively with vitamin C and phosphorus correlated negatively with BMI in female significantly(P＜0.05). Above results, in male's forty and in female's fifty were liable to variation in terms of serum lipids and blood pressure. As increasing triglyceride, total-chol, LDL-chol and decreasing HDL-chol Increased atherogenic index that suggest increasing risk of atherosclerosis. But, this point will be considered more subdivided study.

• Journal of Nutrition and Health
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• v.15 no.3
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• pp.171-180
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• 1982

The nutritional survey and blood sampling was conducted from May 23 to 27, 1971, in order to investigate the state of the nutritional intake in relation to blood contents of rural women. This survey covered a total of 47 women residing in Youngam-gun, Cholla-namdo, Korea. The daily diet of these subjects was observed by 24-hour recall method and weighing method for 3 days and hemoglobin (Hb), hematocrit(Hct), mean corpuscular hemoglobin concentration (MCHC), serum protein, serum albumin, A/G ratio, serum iron, total iron binding capacity (TIBC), transferrin saturation (TS), serum cholesterol and blood specific gravity (SG) were measured. The results were summarized as follows ; The rate of intake of vegetable foods was high, especially cereals, and that of animal foods was low, especially eggs and milk and milk products. The daily intake of niacin was sufficient, and the intakes of energy and iron were also tend to be adequate. On the contrary, the intakes of vitamin A, $B_2$ and C, calcium and protein were insufficient. The mean red blood cell number was $410.8{\pm}26.4{\times}10^{4}/mm^{3},$ the mean values of Hb, Hct and MCHC were $12.5{\pm}0.9gm%$, $37.5{\pm}2.4%$ and $33.2{\pm}0.5%$ thus the anemic prevalences were 21.3%, 12.8% and 93.6% comparing with the anemic criteria of WHO. The levels of serum protein and serum albumin were $7.1{\pm}0.4gm\;%$ and $4.3{\pm}0.3gm\;%$so the A/G ratio was indicated $1.6{\pm}0.2.$. The levels of serum iron and TIBC were $91.9{\pm}27.5{\mu}g/100ml and $297.5{\pm}31.4{\mu}g/100ml,$ so TS was calculated $31.2{\pm}9.7\;%$. The mean value of SG was $1.044{\pm}0.002,$ and the level of serum cholesterol was $164.3{\pm}25.4mg/dl$. In the relation between each of bloood content, Hb showed positive correlation not only with Hct but also protein at the level of significance of 1 per cent and 5 per cent, and protein also showed a positive correlation with serum cholesterol at the 1 per cent level of significance. In the relation between the nutrient intake and blood contents, vitamin C intake showed a positive correlation with Hb, serum protein and serum iron at the level of significance of 1 per cent, iron intake also showed a positive correlation with serum iron and serum cholesterol at the same significant level, and protein intake showed a positive correlation with serum iron at the at the level of significance of 5 per cent.

• Nutrition Research and Practice
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• v.1 no.1
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• pp.65-69
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• 2007

We examined the associations between adiponectin or leptin and serum ICAM-1 levels in seventy-six hypercholesterolemic patients (mean age 59 yrs, 25 males and 51 females, LDL-cholesterol>=130mg/dL at screening). Blood lipid profiles and HOMA-IR derived from fasting glucose and insulin concentrations were determined. Serum levels of adiponectin, leptin and ICAM-1 were analyzed using ELISA The results showed that serum levels of leptin were positively associated with serum levels of ICAM-1 independent of age, sex and BMI (r=0.392, p<0.001). Serum levels of adiponectin were negatively associated with serum levels of ICAM-1 independent of age, sex and BMI (r=-0.343, p<0.005). Stepwise multiple linear regression analysis showed that serum leptin was an independent factor to be associated with serum ICAM-1 levels after adjusting for age, sex, BMI, alcohol intake, smoking status, blood lipids such as total cholesterol, triglyceride, HDL cholesterol and LDL cholesterol and HOMA-IR (p<0.001). With respect to adiponectin, its association with serum ICAM-1 was attenuated but still significant when further adjustments were made for age, sex, BMI, alcohol intake, smoking status, blood lipids such as total cholesterol, triglyceride, HDL cholesterol and LDL cholesterol and HOMA-IR (p<0.005). In conclusion, this study suggests that adiponectin and leptin are associated with endothelial derived inflammation.

• Journal of Veterinary Clinics
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• v.18 no.1
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• pp.74-77
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• 2001

A ten-year-old, male cat presented with recent loss of body weight, depression, vomiting, anorexia, polydipsia, and polyuria. General physical findings included depression, weakness, severe dehydration and a strong acetone odor on the breath. A complete blood count and serum biochemical profiles were leukocytosis, hyperglycemia (286 mg/dl), hypokalemia (2.6 mEq/L), hyponatremia, and high serum fructosamine (600 $\mu$mol/L). In blood gas analysis the cat had acidosis (pH 7.127, p$CO_2$26.7 mmHg). In urinalysis glycosuria and ketouria were appeared. On the basis of clinical signs, serum chemistry, blood gas analysis and urinalysis, diabetic ketoacidosis was diagnosed. Treatment included subcutaneous administration of protamine zinc insulin (0.75 U/head) and intravenous administration of 0.9% saline. Potassium phosphate and sodium bicarbonate was added to the fluids. Serum fructosamine for assessment of glycemic control was measured on occasion calls. On day 296, the patient improved clinically and did not experience any problems resulting from diabetic ketoacidosis.

• Korean Journal of Human Ecology
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• v.7 no.2
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• pp.1-11
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• 2004

The purpose of this study was designed to observe the effects of the feeding Cynanchum wilfordii extract on the improvement of the blood glucose, lipid components in the serum of dietary hyperlipidemic and streptozotocin(STZ) -induced diabetic rats(S.D. strain, ♂) fed the experimental diets for 5 weeks. Concentrations of total cholesterol, atherosclerotic index, LDL, LDL-Cholesterol, free-cholesterol. cholesteryl ester, TG, PL and blood glucose in serum were significantly higher in the cholesterol administration groups((group 2(cholesterol+water), 4(cholesterol+Cynanchum WIlfordii 3.5g% extract)) than those in the control group (group1 , basal diet+water). But the concentrations of total cholesterol. atherosclerotic index, LDL, LDL- cholesterol. free-cholesterol, cholesteryl ester, TG, PL and blood glucose in serum were remakably lower in the group 4 than those in the group 2. In the STZ(55mg/kg B.W.)-induced diabetic groups((group 3(STZ, IP.)+water), 5(STZ(IP.)+Cynanchum WIlfordii 3.5g% extract? the serum total cholesterol, atherosclerotic index, LDL, LDL-cholesterol, free-cholesterol. cholesteryl ester, TG, PL and blood glucose concentrations actions were rather lower in the group 5 than those in the group 3. In the ratio of HDL -cholesterol concentration to total cholesterol and HDL-cholesterol concentration, Cynanchum wilfordii extract administration groups were higher percentage than III the groups 2 and 3. The activities of aspartate aminotransferase(AST), alanine aminotransferase(ALT), alkaline phosphatase (ALP) and lactate dehydrogenase(LDH) in serum were rather lower in the Cynanchum wllfordii extract administration groups (group 4,5) than in the cholesterol diet group(group 2) and STZ-induced diabetic group (group 3). From the above research, the physiological activity substances in Cynanchum wllfordii were effective on the improvement of the blood glucose, lipid compositions in serum of dietary hyperlipidemic and STZ-induced diabetic rats. And particularly, physiological activity substance in Cynanchum wilfordii was more effective therapeutic regimen for the control of metabolic derangements in adult disease.

• Journal of Korean Biological Nursing Science
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• v.10 no.1
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• pp.62-68
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• 2008

Purpose: This study was conducted to test the effect of the 12 weeks brisk walking exercise program on body composition, blood pressure, blood glucose and blood lipid for middle-aged woman with obesity. Method: The subject were 25 obese women in 40-64 yr old who were composed of over 30% body fat. For the analysis, descriptive statistics, paired t-test were used for statical analysis with SPSS 15.0. Result: The results were summarized as follows: first, the body weight, body mass index (BMI), % body fat of the obese woman were significantly decreased after implementing the 12 weeks brisk walking exercise program (p<.5). Second, the systolic blood pressure, diastolic blood pressure and blood glucose were significantly decreased after the 12 weeks brisk walking exercise program (p<.5). Third, the serum cholesterol was significantly decreased (p<.05) but serum triglyceride was not significantly decreased the after 12 weeks brisk walking exercise program. Conclusion: These results suggest that the brisk walking exercise program has an effect on decreasing body weight, BMI, percent body fat, blood pressure and serum cholesterol in middle-aged woman with obesity to reduce obesity and prevent chronic disease.

• Asian-Australasian Journal of Animal Sciences
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• v.12 no.5
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• pp.682-688
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• 1999

Thirty nine pregnant Javanese thin-tail ewes (20 and 19 carried a single and multiple [2 to 3] fetuses, respectively), and six nonpregnant ewes as controls were used to measure maternal serum hormone and blood metabolite concentrations as predictors of number of fetuses carried during pregnancy. Serum hormones (progesterone, estradiol, triiodothyronine, and cortisol) and blood metabolites (b-hydroxy butyric acid [BHBA], and blood urea nitrogen [BUN]) were determined every four weeks during pregnancy and were used to predict litter size by discriminant analysis. The results of data analysis indicated that serum progesterone and estradiol concentrations at weeks 8, 12, 16 of pregnancy could be used to predict the number of fetuses carried with precision of 86.7 to 95.6%. Serum triiodothyronine, cortisol, BHBA, and BUN concentrations during pregnancy, however, were not good predictors of the number of fetuses carried. Serum progesterone and estradiol concentrations as early as 8 weeks of pregnancy in sheep could predict the number of fetuses carried with 86.7% precision.