• The Journal of Internal Korean Medicine
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• v.44 no.4
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• pp.661-674
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• 2023

Abstract: This retrospective study delved into the effects and safety considerations associated with the concomitant usage of hypoglycemic agents and herbal extracts, specifically Pyeongwi-san (PWS) or HyangsaPyongwi-san (HSPWS) in the context of type 2 diabetes mellitus management. Methods: The investigation involved 38 inpatients with type 2 diabetes mellitus who received PWS or HSPWS treatment at Kyung Hee University Korean Medical Hospital from January 2012 to December 2022. By investigating clinical attributes and conducting laboratory assessments, this study aimed to discern the impact of these herbal extracts on blood glucose levels, encompassing fasting blood sugar (FBS) and mean 2-hour postprandial glucose (PP2) levels. Furthermore, the safety profile of the herbal extracts was assessed by comparing liver function indicators, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), and γ-glutamyl transferase (GGT), alongside kidney function markers, such as blood urea nitrogen (BUN) and creatinine (Cr). Results: Following the administration of the herbal extracts, no statistically significant alterations in FBS and mean PP2 levels emerged compared to the baseline levels. Notably, the safety evaluation revealed no significant differences in liver and kidney function parameters following herbal extract administration. Conclusion: The results of this research indicate that using PWS or HSPWS alongside hypoglycemic medications could be a beneficial additional method for addressing digestive symptoms in individuals with type 2 diabetes mellitus. Notably, this combination seems to have no negative interactions with other drugs.

• Food Science and Preservation
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• v.24 no.5
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• pp.658-665
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• 2017

The current study was performed to investigate the changes of bio-activities of Salicornia europaea (SE) depending on the different dry methods. The ethanol extracts were prepared from the freeze-drying SE (FD), hot-air drying SE (HD), and shade drying SE (SD). Their anti-oxidant and anti-thrombosis activities were compared. The yields of ethanol extraction in FD, HD, and SD were 14.4, 13.2 and 11.9%, respectively. The highest contents of total polyphenol (4.6 mg/g) and total sugar (23.4 mg/g) were shown in FD, whereas, the highest content of reducing sugar (14.6 mg/g) was observed in HD. In anti-oxidation activity assay, the FD and HD showed similar radical scavenging activities and reducing power. However, in SD, nitrite scavenging activity and reducing power were severely decreased. In anti-coagulation activity assay, the thrombin time (TT), prothrombin time (PT) and activated partial thromboplastin time (aPTT) of FD, HD and SD did not show significant changes at 5 mg/mL concentration. But the HD at 7 mg/mL had strong inhibitions against thrombin and blood coagulation factors. The platelet aggregation and hemolysis activities were not affected by dry methods. Our results suggest that both FD and HD are effective to maintain the functional ingredient of SE, and HD is economic and efficient dry process for production of functional food.

• Clinical and Experimental Pediatrics
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• v.50 no.11
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• pp.1041-1048
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• 2007

Not a few patients in children and adolescents are suffering from right ventricular (RV) dysfunction resulting from various conditions such as chronic lung disease, left ventricular dysfunction, pulmonary hypertension, or congenital heart defect. The RV is different from the left ventricle in terms of ventricular morphology, myocardial contractile pattern and special vulnerability to the pressure overload. Right ventricular failure (RVF) can be evaluated in terms of decreased RV contractility, RV volume overload, and/or RV pressure overload. The management for RVF starts from clear understanding of the pathophysiology of RVF. In addition to correction of the underlying disease, management of RVF per se is very important. Meticulous control of volume status, inotropic agents, vasopressors, and pulmonary selective vasodilators are the main tools in the management of RVF. The relative importance of each tool depends on the individual clinical status. Medical assist device and surgery can be considered selectively in case of refractory RVF to optimal medical treatment.

• Journal of Ginseng Research
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• v.21 no.3
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• pp.153-159
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• 1997

Living organisms have antioxidant enzymes, such as superoxide dismutase, catalase SE glutathione peroxidase, that protect themselves from the toxic effect of superoxide free radicals. Some report says that intracellular oxidation stress is involved in pathogenesis of chronic complications of diabetes mellitus. This study was performed to evaluate the effect of red ginseng on lipid peroxidation of red blood cell and antioxidant SOD activity of serum in NIDDM patients. As a result, there were trends for decrease of lipid peroxidases of RBC and Increase of SOD activity of serum in ginseng group but that were not statistically significant. Therefore, we suggest long term and large sized control study is necessary to confirm the protective effects of red ginseng on oxidative damage in NIDDM patients.

• Proceedings of the Korean Society of Toxicology Conference
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• 1997.05a
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• pp.20-27
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• 1997

Chinin is the second most plentiful natural polymer. Currently, chitin and chitosan are manufactured commercially in large scale from crab and shrimp shell as fish processing waste. They is being used in many commercial application because of their various functional properties. Chitosan, in particular, is being evaluated as biomedical materials in a number of food and pharmaceutical industries. Despite their potential abilities, the perfect safety had been demonstrated until now. However, the long-term feeding with chitin was not any negative effect the body weights and serum enzymatic activities in mice. And, in rats supplied with $5\%$ of chitosan diet for 450 days, there was no changes of Ca concentration in blood, bone and other organs except for in muscle. Consequently, there was no direct toxicity of chitin and chitosan against some animals such as rat and mouse by recently reports.

• Korean Journal of Veterinary Research
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• v.48 no.4
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• pp.501-503
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• 2008

An adult one-year-old male Eurasian beaver (Castor fiber) died of a traumatic injury to its right leg from a fall. At necropsy, fibrinopurulent exudates were observed in the thoracic cavity. Histopathologic examination showed that the pericardium, thoracic wall, pulmonary pleura and the lungs were markedly thickened due to mixtures of necrotic cellular debris, neutrophils, fibrin, red blood cells, and bacterial aggregates. Pure culture of Klebsiella (K.) pneumoniae was isolated from the thoracic exudates, pleura and heart tissues. Based on these findings, this is the first report describing pleuritis and pericarditis associated to K. pneumoniae in a beaver.

• Natural Product Sciences
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• v.6 no.1
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• pp.31-35
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• 2000

Effects of red ginseng acidic polysaccharides (RGAP) on immune system were studied. The proliferation of spleen cells was induced by RGAP treatment per se. Cotreatment of lipopolysaccharide $(100\;{\mu}g/ml)$ or concanavalin A $(1\;{\mu}g/ml)$ with RGAP further stimulated the spleen cell proliferation. BALB/c mice treated with RGAP showed a slight splenic hyperplasia and increased antibody forming cell response to sheep red blood cells. Flow cytometry analysis revealed an influx of macrophages in the mice treated with RGAP.

• International Journal of Vascular Biomedical Engineering
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• v.2 no.1
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• pp.1-10
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• 2004

Circulatory disease is the number two cause of death next to cancer in Korea, while the cardiovascular disease alone is the number one cause of death in the US. In the present article, some background, current status and future prospects of biomedical engineering esearch on circulatory disorders are discussed in terms of the origin of atherosclerosis, computational fluid dynamics and medical imaging techniques, clinical treatments and fluid dynamics, advances in stents, hemodynamic analysis of artificial heart, and artificial blood. In particular, the importance of close collaboration of medicine and fluids engineering is emphasized.

• Journal of Dairy Science and Biotechnology
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• v.24 no.1
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• pp.29-42
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• 2006

Recent trend of consumers' for health give rise to the interest in health and functional foods. Functional yogurt is a primary item in USA, EU, and Japan that are leaders in health and functional food industry and its market is going to be enlarged. Also in Korea, functional yogurt has been recognized as health food by consumers. Concept of functional yogurt is various by health of intestine, stomach, and liver, and lowering blood pressure in Korean market. However, functional yogurt is not registered as health and functional foods in Health/Functional Food Act of Korea. Under these circumstances, the results of trustable and scientific research on the efficacy of functional yogurt should be accumulated to obtain the consumers' solid recognition of functional yogurt as health and functional food.

• Proceedings of the KOSOMBE Conference
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• v.1990 no.11
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• pp.86-91
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• 1990

혈중 산소농도는 의료 분야에 기초적인 간으로 쓰이고, 이의 측정법은 오랜 역사를 가지고 있다. 현재까지 인체의 혈액 중 산소 포화도는 혈액을 직접 추출하여 조사할 수 있었으나, 이러한 직접추출 방법은 생리학적인 제조건의 변화에 따라 변할 수 있어서, 인공심장 등의 응용으로 사용될 때에는 신속한 정보를 알아야 하므로 부적합하다. 본 연구에서는 비추출식 산소 포화도를 광학적인 방법으로 연구하는데 필요한 자료 조사 및 기본 이론 분석에 있다.