• 제목/요약/키워드: Blood Pressure, Normal

검색결과 787건 처리시간 0.029초

Antihypertensive Effect of Milk Fermented by Lactiplantibacillus plantarum K79 on Spontaneously Hypertensive Rats

  • Sang-Dong Lim;Kyungwon Lee;Taewon Han;Hyunjhung Jhun;Ah-Ram Han;Yongjin Hwang;Sangpil Hong
    • 한국축산식품학회지
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    • 제44권1호
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    • pp.178-188
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    • 2024
  • The aim of this study is to investigate whether milk fermented by Lactiplantibacillus plantarum K79, which exhibits angiotensin-converting enzyme inhibitory activity, has an effect on lowering the blood pressure of hypertensive rats and to investigate biomarker changes in their blood. Experimental group: normal group (NG, Wistar-Kyoto rats): distilled water, control group [NCG, spontaneously hypertensive rats (SHR)]: distilled water, high treatment group (HTG, SHR): 500 mg/kg/day, medium treatment group (SHR): 335 mg/kg/day, low treatment group (SHR): 170 mg/kg/day, positive control group (PCG, SHR): Enalapril, 10 mg/kg/day. The experimental animals used in this study were divided into groups composed of 8 animals. In terms of weight change, a significant difference was observed between the NG and the SHR group, but there was no significant difference between the SHR group. After 8 wk of feeding, blood pressure was lowered more significantly in the HTG (209.9±13.3 mmHg) than in the NCG (230.8±7.3 mmHg). The treatment group has an effect of lowering blood pressure by significantly suppressing blood pressure-related biomarker protein expression than NG. The results obtained can be used as an antihypertensive material in a variety of food raw materials.

Calculus Bovis-Fel Uris-Moschus Pharmacopuncture's Effect on Regional Cerebral Blood Flow and Mean Arterial Blood Pressure in Rats

  • Park, Soo-Jung;Lee, Ho-Young;Choi, Na-Rae;Kwon, Young-Mi;Joo, Jong-Cheon
    • 대한약침학회지
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    • 제16권4호
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    • pp.30-35
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    • 2013
  • Objectives: This study was designed to investigate the effects of Calculus Bovis-Fel Uris-Moschus pharmacopuncture (BUM) on the regional cerebral blood flow (rCBF) and the mean arterial blood pressure (MABP) in normal and cerebral ischemic rats and to investigate a possible pathway involved in the effects of BUM. Methods: The changes in the rCBF and the MABP following BUM into Fengfu (GV16) were determined by using a laser-Doppler flow meter and a pressure transducer, respectively. Results: BUM significantly increased the rCBF and decreased the MABP in normal rats in a dose-dependent manner. The effect on the rCBF was significantly inhibited by pretreatment with methylene blue (0.01 mg/kg, intraperitoneal), an inhibitor of guanylate cyclase, but was not affected by pretreatment with indomethacin (1 mg/kg, intraperitoneal), an inhibitor of cyclooxygenase. The BUM-induced decrease of the MABP was changed neither by methylene blue nor by indomethacin pretreatment. In the cerebral ischemic rats, the rCBF was stably increased upon cerebral reperfusion in the BUM group in contrast to the rapid and marked increase in the control group. Conclusion: This study demonstrated that BUM into Fengbu (GV16) increased the rCBF in a dose-dependent manner in the normal state; furthermore, it improved the stability of the rCBF in the ischemic state upon reperfusion. Also, the effects of BUM on the rCBF were attenuated by inhibition of guanylate cyclase, suggesting that the effects involved the guanylate cyclase pathway.

본태성 고혈압 환자의 자기실현 및 욕구구조에 관한 연구 (Manifest Weeds and Self-Actualization of Patients with Essential Hypertension)

  • 강익화
    • 대한간호학회지
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    • 제8권1호
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    • pp.163-180
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    • 1978
  • Much of a person's energy is spent in the effort of becoming a productive member of to-day's complex society. This activity may cause tension, and chronic unrelieved tension is an influential factor in blood pressure elevation. The problem of this study was to identify manifest needs and self-actualization of patients with essential hypertension, and to analyse and compare their manifest needs and selt-actualization with the selected general characteristics of We, sex, religion, occupation and level of education with a control group of patients with normal blood pressure readings. The purpose was to contribute to the planning of nursing interventions toward reducing the impact of complex psycho-somatic factors on the anxiety of patients with essential hypertension. The instruments used included selected items from the Edwards (1959) Personal Preference Schedule (EPPS) as adapted by Hwang (1965) and from the Personal Orientation Inventory (POI) (Shostrom 1964, 1974) adapted by Kim and Lee (1977) to measure manifest needs and self-actualization. The convenience sample was chosen from 149 persons who presented themselves for general physical examinations at Ewha University Medical Centre and 41 patients diagnosed with essential hypertension at three general hospitals in Seoul during June 1 and August 31, 1977. Forty-nine persons from the Ewha group with blood-pressure readings exceeding 150/90 were added to the experimental group. Data were analysed by the S.P.S.S. computer programme using t-test and tests for statistical significance. Statistically significant findings were as follows: A. Blood Pressure and Manifest Needs. 1. with the exception of Autonomy, patients with hypertension had significantly high scores on all variables Abasement, Achievement, Affiliation, Aggression, Dominance, Emotionality, Exhibitionism and Sex. 2. When mean scores of normal persons were compared by age groups, normal persons had higher scores in the following order on Abasement (50's, 40's, 20's, 30's), Achievement (50's, 30's, 40's, 20's), Affiliation (50's, 40's, 30's, 20's), Dominance (50's, 40's, 40's, 20's) and Exhibitionism (30's, 50's, 40's, 20's). In each case, there was a significant difference between the first and last age group scores. 3. When the mean scores of normal persons were compared by sex, normal men had higher scores than women on Achievement, Affiliation, Aggression, Dominance, Exhibitionism and Sex. Male patients had higher scores than female patients on Achievement, Dominance, Exhibitionism and Sex, but female patients scored higher in Emotionality. 4. Normal persons had higher scores related to religion in the following order on Achievement (Buddhism, no religion, Christianity). Hyper tensive patients had higher scores on. Exhibitionism (no religion, Christianity, Buddhism). 5. Normal persons had higher scores related to occupation in the following order on Achievement and Exhibitionism (unemployed, office workers, teachless, businessmen), Emotionality (office workers, unemployed, businessmen, teacher) and Sex (office workers, unemployed, teachers, businessmen). Hypertensive patients had higher scores on Achievement and Aggression (teachers, businessmen, office worker, unemployed), Dominance and Exhibitionism (businessmen, teacher, of ace workers, unemployed) and Sex (teachers, office worker, businessmen, unemployed). 6. Normal persons had higher scores related to level of edification in the following order on Abasement, Emotionality and Autonomy (secondary school graduation, university). Hypertensive patients had higher scores on Abasement (no education, primary, university, secondary), Achievement (no education, secondary, university, primary) , Dominance (university, no education, secondary, primary), Exhibitionism (university, secondary, no education, primary), and Sex (university, secondary, primary, no education). B. Blood Pressure and Self_Actualization 1, Patients with hypertension had significantly lower scores on all variables. 2. Normal persons had higher scores related to age groups in the following order on Existentiality (20's, 30's, 40's, 50's). Hypertensive patients showed no significantly different scores. 3. Normal women had higher scores than men on Time Competence. Normal men had higher scores on Feeling Reactivity. Male patients had higher scores than women on Self-Actualizing Value and Self-Regard. 4. Normal persons ha 1 higher scores related to religion on spontaneity (Buddhism, no religion, Christianity). Hypertensive patients had higher scores on Time Competence and Nature of Man (Buddhism, Christianity, no religion). 5. Normal persons had higher scores related to occupation in the following order on Existentiality (teachers, office workers, businessmen, unemployed) and Self-Regard (unemployed, office workers, teachers, businessmen). Hypertensive patients showed no significantly different scores. 6. Normal persons had higher scores related to level of education in the following order on Existentiality and Self-Acceptance (university, secondary). Hypertensive patients had higher scores on inner-Director (university, secondary, no education, primary) and Existentiality (university, secondary, primary, no education). Recommendations for nursing interventions with hypertensive patients with emotional problems or low self-actualization were made. 1. The nurse should encourage the patient through her interactions with other members of the medical team to accept counselling and health education. 2. Through her therapeutic interpersonal relationships with the patient, the nurse should help him discover the causes of his emotional tension. 3. Through her health teaching with the family, the nurse should encourage them to participate with the medical team in the patient's therapeutic plan and in providing him with the minimum possible emotional support. 4. Through frequent counselling with the obsessive-thinking and inflexible patient, the nurse should reevaluate the patient's behaviour and her interventions. 5. Seriously ill patients should be given needed reeducation by members of the professional medical team.

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경구기관삽관법과 경비기관삽관법의 심혈관계 영향에 대한 비교 (A Comparison of Cardiovascular Effects between Orotracheal Intubation and Nasotracheal Intubation)

  • 김동옥;최영규
    • 대한치과마취과학회지
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    • 제1권1호
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    • pp.10-15
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    • 2001
  • Background: This prospective study was designed to compare the cardiovascular response to endotracheal insertion of either an orotracheal tube or a nasotracheal tube Methods: 120 ASA physical status I and II surgical patients requiring general anesthesia and tracheal intubation were studied and assigned to two groups: orotracheal intubation group (n = 60) and nasotracheal intubation group (n = 60). Patients were premedicated with midazolam 0.05 mg/kg and glycopyrrolate 0.005 mg/kg intramuscularly and anesthesia was induced with thiopental sodium 5 mg/kg and succinylcholine 0.1 mg/kg intravenously. Systolic blood pressure (SBP), diastolic blood pressure (DBP). mean arterial pressure (MAP) and heart rate (HR) were assessed noninvasively before induction of anesthesia and immediately after intubation, 1 min, 2 min, 3 min, and 5 min after intubation. Results: Cardiovascular responses such as SBP, DBP, MAP and HR were similar for both techniques and no significant differences between two groups were observed until 5 min after intubation. Conclusions: In healthy ASA I and II patients with normal blood pressure, induction doses of thiopental sodium 5 mg/kg and succinylcholine 0.1 mg/kg didn't attenuated the cardiovascular response to laryngoscopy and tracheal intubation. Insertion of an endotracheal tube may be the most invasive stimulus during intubation procedures. (JKDSA 2001; 1: 10-15)

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일부지역 노인의 영양 및 건강상태에 관한 연구 II. 체위, 혈압, 혈액성상, 질병보유상태 및 비만도 (The Nutrition and Health Survey of Aged People in a Rural Area II. Anthropometry, Blood Pressure, Blood Constituents, Diseases and Obesity Rate)

  • 조영숙
    • Journal of Nutrition and Health
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    • 제19권6호
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    • pp.382-391
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    • 1986
  • This survey was carried out to study the relationship between observable factor such as anthropometry, blood pressure, food habit, the score of THI and diseases of 459 persons (male: 188, female: 271) aged 60 and over in the rural area of Kurye - Gun Chonnam from April 28 to May 1, 1986. The results obtained were as follo\ulcornerws 1) Body weight and height was below Korean average. The mean obesity rate in male and female showed -2.3% and 3.4%, respectively, and BMI showed 25.8 and 26.0 respectively. 2) The systolic and diastolic blood pressure was normal in both sexes. The pro opotion of hypertension by WHO level showed 19.6% and 20.3% in male and fem\ulcornerale, respectively_ The proportion of anemia showed 57.9% and 41.7% in male and female, respectively. The concentration of total protein, albumin, cholesterol and gl\ulcornerucose and white blood cell number showed normal range in both sexes. 3) The proportion of the disease showed 68% of male and 83% of female and among them 50% of male and 43% of female suffered from one kind of disease and there are more female who suffered from many kinds of diseases than male. The most common disease is neuralgia and nexts are digestive diseases, diabetes melli\ulcornertus, urinary disturbance, motion disturbance, arthritis, respiratory diseases, tubecu\ulcornerlosis and hepatitis. 4) There was a significant correlation between body height and weight and the score of food habit. 5) There was a considerable relation between the score of each item of TIll and the status of diseases. 6) There appeared profound relation between obesity rate and the data of anth\ulcornerropometry, but weak relation between that and blood constituents, and no relation between that and the score of food habit.

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대나무 추출액과 죽력의 혼합물이 국소 뇌혈류량 및 평균 혈압에 미치는 영향 (Effects of Mixture of Bambusae Caulis in Liquamen and Bamboo Extract on the Regional Cerebral Blood Flow and Mean Blood Pressure in Rats)

  • 김천중;장경선;조수인;김계엽;정현우
    • 동의생리병리학회지
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    • 제20권3호
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    • pp.575-580
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    • 2006
  • This Study was designed to investigate the effects of Mixture of Bambusae Caulis in Liquamen and Bamboo Extract on the change of regional cerebral blood flow (rCBF) and mean arterial blood pressure (MABP) in normal and cerebral ischemic rats. Experimental materials were as follows ; BE- 1 was Bamboo Extract (BE) extracted with 70% ethyl alcohol, BE-11 was BE extracted with distilled water at $121^{\circ}C$ for 30 min, BE-111 was BE extracted with distilled water at $121^{\circ}C$ for 3 hrs, MLC was mixture of Bambusae Caulis in Liquamen (BCL) and BE-111 mixed at the ratio of 1 to 100 (MLC100), 1 to 50 (MLC50), 1 to 20 (MLC20), 1 to 10 (MLC10), 1 to 5 (MLC5). The results were as follows , The Changes of BE- 1 on the rCBF and MABP in normal rats were not showed, BE- 11 significantly decreased rCBF in a dose-dependent manner Dut increased MABP in a dose-dependent manner. BE-111 increased rCBF in a dose-dependent manner, MLC significantly increased rCBF in a dose-dependent manner and increased MABP in a dose-dependent manner. rCBF was significantly and stably increased by MLC5 (1 mg/kg, i.p.) during the period of cerebral reperfusion, which contrasted with the findings of rapid and marked increase in control group. As results above ; The present author thought that BE- 111 and MLC increased rCBF by dilating pial arterial diameter.

소회향이 흰쥐의 국소뇌혈류량 및 평균혈압에 미치는 영향 (Effects of FOENICULI FRUCTUS on the Regional Cerebral Blood Flow and Mean Arterial Blood Pressure in Rats)

  • 김남순;정현우;강성용
    • 동의생리병리학회지
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    • 제21권3호
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    • pp.652-657
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    • 2007
  • This experimental study was designed to investigate the effects of FOENICULI FRUCTUS freeze dry powder (FF) on the change of cerebral hemodynamics [regional cerebral blood flow (rCBF) and mean arterial blood pressure (MABP)] in normal and further to determine the mechanism of action of FF. The results in normal rats were as follows ; FF significantly increased rCBF in a dose-dependent, but decreased MABP, This results were suggested that FF significantly increased rCBF by dilating PAD. The FF-induced increase in rCBF was significantly inhibited by pretreatment with 1H[1,2,4]oxadizolo[4,3-a]quinoxalin-1-one (ODQ, 10 ${\mu}$g/kg, i.p.), an inhibitor of guanylate cyclase and indomethacin (IDN, 1 mg/kg, i.p.), an inhibitor of cyclooxygenase and propranolol (PPN, 3 mg/kg, i.p.), a blocker of adrenalic f receptor and Lu-Nitro-L-Arginine (L-NNA, 1 m9/kB, i.p.), an inhibitor of nitric oxide synthase. The FFE-induced decrease in MABP was significantly increased by pretreatment with L-NNA and was increased by pretreatment with PPN, Dut was inhibited by pretreatment with ODQ and IDN, This results were suggested that the mechanism of FF was mediated by nitric oxide synthase and adrenalic ${\beta}$ receptor.

전북지역 일부 남녀 고등학생을 대상으로 한 청소년의 혈압 및 혈중 콜레스테롤에 대한 연구 (Report on Blood Pressure and s-Cholesterol of Highschool Students in Jeonbuk, Korea)

  • 김락형;강신화;강현철;장인수
    • 대한한방소아과학회지
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    • 제15권1호
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    • pp.117-129
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    • 2001
  • Objective : Hyperlipidemia and hypertension are well recognized risk factors of cerebrovascular disease. So it's very important to evaluate blood pressure and s-cholesterol in adolescence. Material and Methods : April 1999, we were requested health examinaion for high school students of a boys high school and a girls high school in Jeonbuk, Korea. The subjects were 360 students, boys were 317 and girls were 343. They were checked their height, body weight, blood pressure, and s-cholesterol. Results and Conclusion : The mean of systolic blood pressure of study subjects was $111.89{\pm}12.43mmHg$. In boys, it was $116.25{\pm}11.78mmHg$, and in girls, it was $107.87{\pm}11.64mmHg$. The mean of diastolic blood pressure of study subjects was $68.45{\pm}9.40mmHg$. In boys, it was $66.92{\pm}10.00mmHg$, and in girls it was $69.85{\pm}9.40mmHg$. Hypertensives were 18(5.68%) in boys, 10(2.92%) in girls. The mean of s-cholesterol of study subjects was $174.95{\pm}32.28mg/dL$. In boys, it was $178.91{\pm}34.51mg/dL$, and in girls, it was $171.29{\pm}29.66mg/dL$. Hypercholesterolemias were 91(28.71%) in boys, 39(11.37%) in girls. The mean of BMI of study subjects was $21.12{\pm}3.27kg/m2$. In boys, it was $21.05{\pm}3.26kg/m2$, and in girls, it was $21.18{\pm}3.29kg/m2$. Obese boys were 18(5.68%), obese girls were 13(3.79%). The mean of diastolic blood pressure in obese boys was significantly higher than that of normal boys(p=0.001, Mann-Whitney test). The mean of s-cholesterol in obese boys($BMI{\ge}274$) was significantly higher than that of normal boys.(P=0.26, Mann-Whitney test).

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청심강화환(淸心降火丸)이 고혈압(高血壓) 및 고지혈증(高脂血症)에 미치는 영향(影響) ('The effects of Chungsimgangwhawhan (淸心降火丸) on blood pressure and hyperlipidemia')

  • 송미덕;고창남;조기호;김영석;배형섭;이경섭
    • 대한한의학회지
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    • 제16권1호통권29호
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    • pp.403-418
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    • 1995
  • In order to study the effects of Chungsimgangwhawhan on blood pressure in normal rats and rabbits, and hyperlipidemia induced by 1% cholesterol diet, triton WR-1339, and 75% fructose in mice and rats, the amount of total cholesterol, triglyceride, phospholipid and blood pressure were measured. The results were as follows : 1. After per os medication of Chungsimgangwhawhan, blood pressure in rats were increased but were not significant. 2. Chungsimgangwha-Whan showed strong effects on decreasing blood pressure, depending on the concentration in blood vessels of rabbits. 3. In the model of hyperlipidemia induced by 1% cholesterol diet in mice, Chungsimgangwhawhan showed decreasing effects on total cholesterol level in serum significantly (p<0.05) depending on the concentration, and on triglyceride (p<0.01) and phospholipid level (p<0.001) in serum. 4. In the model of hyperlipidemia induced by triton WR-1339 in rats, Chungsimgangwhawhan showed mild decreasing effects on total cholesterol level in serum, but was not significant. 5. In the model of hyperlipidemia induced by 75% fructose in rats, Chungsimgangwhawhan showed decreasing effects on total cholesterol and triglyceride level in serum significantly(p<0.01) depending on the concentration. According to the above results, Chungsimgangwhawhan showed significant decreasing effects on blood pressure and hyperlipidemia, and it is considered that it is appropriate to apply for hypertension and hyperlipidemia.

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고혈압관리에서의 스마트케어 서비스의 효과 (The effect of Smart Care ubiquitous health service on hypertension management)

  • 정영순;문미경;이창희
    • 한국산학기술학회논문지
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    • 제14권3호
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    • pp.1213-1220
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    • 2013
  • 본 연구는 지식경제부가 주도한 u-Health 공공시범 사업의 하나인 스마트케어서비스의 효과를 분석하고자 시도되었다. 2011년 12월 1일부터 2012년 8월 30일 까지 연구에 동의한 51명의 고혈압 대상자(수축기압 140mmHg이상)들은 기존의 1차 의료기관의 내원진료와 투약을 유지하면서 원격모니터링을 포함한 24주간의 원격건강관리서비스를 받았다. 24 주 동안의 평균 자가 측정 혈압 모니터링 횟수와 원격 상담횟수는 121회와 14.8회였다. 24주 스마트케어 서비스 후 수축기와 이완기혈압은 유의하게 감소하였으며, 서비스 초기 수축기압이 140mmHg 이상이던 전체 대상자의 86.3%가 24주후 정상 수축기혈압을 유지하였다. 스마트케어서비스는 고혈압대상자의 혈압변화에 있어 긍정적인 영향을 미치는 것으로 나타났다.