• Journal of Nutrition and Health
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• 제32권6호
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• pp.671-680
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• 1999

In order to investigate the relationship between plasma renin activity and metabolism of Ca and Na in blood pressure, the habitual dietary intakes of Na and Ca urinary excretion of Ca, Na and K, and plasma level of renin activity, aldosterone, and indices of Ca metabolism were measured in 27 untreated hypertensive women and 30 age-matched normal women on a free diet. Hypertensive subjects were classified into high renin hypertensive (HH), medium renin hypertensive(HM) and low renin showed no significant difference among normotensive, LH, MH and HM groups. It appeared that 25-(OH) Vit D3 level of HH group was significantly higher than LH group(p<0.05). There was significant difference in habitual intake of Ca between normotensive and LH groups. However, habitual intake of Na showed no significant difference among normotensive, LH, MH and HH group. Positive correlation of systolic and diastolic blood pressure with PTH(r=0.324, r=0.375) and urinary Ca(r=0.496, r=0.278) and a negative correlation of systolic blood pressure with habitual Ca intake(r=-0.371) existed(p<0.05). A relative magnitude of factors affecting hypertension was analyzed by multiple regression analysis. Overall results about relative influence of independent variables to dependent variable (systolic blood pressure) indicated that urinary Ca was the higher correlation in all subjects(p<0.0001), followed by age and aldosterone. PTH showed a significant correlation for relative influence on diastolic blood pressure in all subjects. The above results indicated that renin-aldosterone system and Ca regulating hormone had a mutual relationship in hypertension.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1995년도 제3회 추계심포지움
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• pp.115-124
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• 1995

The purpose of the present study was to address whether the in vivo noradrenergic neural activities in the locus coeruleus are involved in the regulation of blood pressure. Two groups of the animals were prepared, 1) SHR and 2) age-matched normotensive control, WKY. At the age of 6 and 16 weeks, blood pressure and the releases of NE from the locus coeruleus in SHR and KWY were measured by in vivo microdialysis at three different conditions: 1) normal, 2) elevated state of blood pressure by systemic injected phenylephrine and 3) increased state of neural activity by perfused phenylephrine into the locus coeruleus. The basal release of NE of SHR were significantly higher than that of WKY, Phenylephrine treatment caused elevation of blood pressure in both SHR and WKY in dose-dependent manner. Following phenylephrine injection, the releases of NE from the locus coeruleus of SHR were significantly decreased, whereas the significant change of NE in WKY was observed in the highest dose of phenylephrine. Phenylephrine perfusion into the locus coeruleus through microdialysis probe caused pressor responses and the pressor response in SHR was greater compared with that in WKY. The results from the present study suggests that the noradrenergic nervous system in the locus coeruleus may contribute as one of the development and maintenance factors for hypertension in SHR.

• 기본간호학회지
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• 제23권3호
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• pp.275-282
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• 2016

Purpose: This study was done to examine the relationship between nursing students' hearing levels and accuracy of blood pressure (BP) measurements. Methods: Participants were 107 students who had finished their fundamental nursing practice and clinical practicum and who used earphones. Data were collected from October 13 to November 30, 2014 and from April 30 to May 19, 2015. Students' hearing thresholds were examined using an audiometer. Students were assigned to take two BP measurements on BP measurement training simulators, but only the second measurement was used for analysis. Results: All nursing students' hearing levels were within normal range, and there was no significant difference found among the settings for diastolic blood pressure. However, there were significant differences between low systolic blood pressure (SBP) (below 120mmHg) and high SBP (over 140mmHg) (z=9.02, p=.011). Measurement error in SBP showed a positive correlation with hearing threshold in the right ear at frequencies of 1000Hz and 500Hz. Conclusion: Findings indicate that BP measurement error is correlated with hearing threshold at some frequencies. To reduce measurement error, nursing students should be provided with health education about hearing and to improve training for students, further studies need to examine other factors influencing BP measurement error.

• 대한의용생체공학회:의공학회지
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• 제13권3호
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• pp.189-194
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• 1992

As people's income and intake of animal fat rapidly increase, so does choresterol concentration in blood. Thus diseases such as non-insulin-dependent diabetes mellitus(NIDDM)myocardial infraction, high blood pressure, cerebral stroke resulting from atherosclerosis rapidly increase recently. It is very difficult to diagnose atherosclerosis early since its progress is so slow and there is no sypmtoms in the beginning of the disease. In this study a mechanical characteristic, compliance, of the lower leg arteries was measured noninvasively. Changes of blood volume and pressure were measured using impedance plethysmgraphy and mercury sphygmomanometer, respectively. The compliance was calculated by dividing the change of blood volume by the change of pulse pressure ( systolic-diastolic pressure ) . Subjects were 24 asymptomatic persons ranging (rom 30 Ic 58yeras and 14 diabetics from 41 to 59years. The compliances, mean, and systolic pressures were statistically analyzed using a t-test be- tween the healthy and diabetic groups. The average compliance of the healthy and diabetic group was measured 2.79 and 1.82U1/mmHg/cm, respectively and these were significantly different(p<0.01). It was also found that the compliance is a better parameter in differentiating the vascular disease than mean or systolic blood pressure.

• 생약학회지
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• 제9권1호
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• pp.41-47
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• 1978

Total saponins and ether extracts of red and white ginseng were obtained and their effects on blood pressure in cat and their histamine liberating activities in rabbits were measured. 1) Ether extract of red ginseng showed a transient hypotensive effect and subsequently showed a remarkable and persistent hypotensive effect, whereas other three fractions, such as saponin fractions of red and white ginseng and ether extract of white ginseng showed only a initial transient hypotensive effects. 2) Histamine levels liberated into blood after administration of each fractions measured by the bioassay with guinea pig ileum. Ether extract of red ginseng immediately increased histamine contents in plasma but the histamine levels decreased to normal level within 10min in spite of decreased blood pressure was sustained. Although white ginseng saponin lowered blood pressure immediately when it is administered, histamine release was observed after 10min. The results suggest that hypotensive effects of ginseng seems to have no correlation with the histamine liberating activity. Ginseng appears to show hypotensive effect via some other mechanisms.

• 한국산학기술학회논문지
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• 제14권9호
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• pp.4342-4348
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• 2013

본 연구는 혈청지질과 비만 및 혈압과의 관련성을 검토하기 위하여 2011년 1월부터 12월까지 1년 동안에 대전광역시의 한 대학병원에서 종합건강검진을 받았던 30세에서 69세의 여성 1,381명을 대상으로 TC, TG, HDL-C, LDL-C, SBP, DBP, 비만도, 체지방률을 측정하여 혈청지질과 비만 및 혈압과의 관련성을 분석하였다. 연구결과, TC, TG, LDL-C, 비만도, 체지방률은 30대에서부터 60대에 걸쳐 단계적으로 상승하는 경향을 보였다. TC, TG 및 LDL-C는 혈압이 높아짐에 따라 상승하였으며, 정상혈압군에 비해 고혈압군에서 유의하게 높은 값을 보였다. TC, TG, SBP 는 비만도가 높아짐에 따라 단계적으로 상승하였고, 정상군에 비해 비만군에서 유의하게 높았으며, HDL-C는 비만도가 높아짐에 따라 감소하는 경향을 보였고, 정상군에 비해 비만군에서 유의하게 낮았다. TC, TG, LDL-C, 체지방률 및 비만도는 상호간에 유의한 정상관을 보인 반면, HDL-C와는 음의 상관을 보였다. 주성분분석 결과 제1주성분은 고혈압 인자, 제2주성분은 비만관련 인자, 제3주성분은 연령과 고지혈증 인자, 제4주성분은 고단백지콜레스테롤 인자가 선정되었다. HDL-C와 관련된 요인을 다중회귀분석을 사용하여 검토한 결과 HDL-C에 영향을 미치는 변수로는 연령, TC, TG 및 체지방률이 선정되었다. 위와 같은 결과는 비만도가 높고 혈압이 높은 군일수록 혈청지질치가 높아짐을 시사하고 있다.

• 동의생리병리학회지
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• 제17권4호
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• pp.1013-1018
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• 2003

Cheonghunhwadam-tang(CHT) have been used in oriental medicine for many centuries as a therapeutic agent of vertigo by wind, fire and phlegm. CTG was CHT adding Aurantii FructusㆍGastrodae Rhizoma. CTG was significantly increased regional cerebral blood f1ow(rCBF) in a dose-dependent, and CTG was decreased mean arterial blood pressure(MABP) compared with normal MABP(100%) in a low dosage, but was increased MABP in a dose-dependent, was aliked with normal MABP in a high-dosage. Therefore, purpose of this Study was to investigate experimental mechanism of CHTAG on the cerebral hemodynamics(rCBF, MABP) in rats. The changes of rCBF and MABP were determinated by Laser-Doppler Flowmetry(LDF). The results were as follows ; Pretreatment with indomethacin(3㎎/㎏, i.v.) was significantly inhibited CTG induced increase of rCBF and pretreated with propranolol(3㎎/㎏, i.v.) was inhibited CTG induced increase of rCBF, but pretreatment with methylene blue(10㎍/㎏, i.v) was increased CTG induced increase of rCBF. Pretreatment with indomethacin was decreased CTG induced increase of MABP, but pretreatment with propranolol and methylene blue were increased CTG induced increase of MABP. This results suggest that the mechanism of CTG is mediated by cyclooxygenase.

• 동의생리병리학회지
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• 제20권1호
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• pp.25-30
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• 2006

This Study was designed to investigate the effects of Patholobi Caulis on the change of regional cerebral blood flow (rCBF) and blood Pressure (MABP) in normal and Cerebral ischemic rats. And, this Study was designed to investigate the inhibition of lactate dehydrogenase (LDH) activity in neuronal cells. The results were as follows : In normal rats, Patholobi Caulis significantly increased rCBF in a dose-dependent manner, and MABP was somewhat increased. In ischemia rats, rCBF was significantly and stably increased by Patholobi Caulis (10 mg/kg, i.p.) during the period of cerebral reperfusion, which contrasted with the findings of rapid and marked increase in control group. Patholobi Caulis significantly inhibited LDH activity in neuronal cells. It was suggested that Patholobi Caulis had an anti-ischemic effect through the improvement of cerebral hemodynamics and inhibitive effect on the brain damage.

• Journal of Nutrition and Health
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• 제46권4호
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• pp.324-331
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• 2013

We investigated dietary effects of green tea powder (GTP) on plasma lipids, platelet aggregation, hemolysis, plasma TBARS, and liver enzymes. Thirty one volunteer diving women living on Jeju island consumed 4 g green tea powder daily for a period of four weeks and data for the study subjects were analyzed on the basis of diagnostic criteria for blood pressure (BP)(${\geq}$ 140/90 mmHg), plasma total cholesterol (TC)(${\geq}$ 200 mg/dL), and triglyceride (TG)(${\geq}$ 150mg/dL). Subjects with high BP had significantly higher TC and TG than those with normal BP. Subjects with higher TC had higher TG, and those with higher TG had lower HDL cholesterol. Platelet aggregation in the initial slope was significantly higher in subjects with normal BP, normal TC, or normal TG than their counterparts in high BP, TC, and TG. HDL cholesterol after GTP intake increased only in subject groups with normal BP, normal TC, or normal TG, and plasma TG after GTP intake decreased only in groups with higher BP, higher TG, or higher TC. Plasma TC and TG in subjects with normal BP increased after GTP intake. GTP intake caused a decrease in the initial slope of platelet aggregation in all subject groups with little effect on maximum aggregation. Total bilirubin showed a significant increase and GOT increased in all subject groups after GTP intake. Beneficial effects of short term intake of green tea powder might differ depending on the subject conditions in terms of blood pressure, plasma lipids, and other cardiovascular conditions. However, with the hypolipidemic, antithrombotic, and antioxidant actions of its bioactive flavonoids, long term usage of GTP or brewed green tea may provide preventive effects against cardiovascular disease.

• Clinical and Experimental Pediatrics
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• 제51권6호
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• pp.604-609
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• 2008

목 적 : 비만은 고혈압의 위험 인자로서 소아 청소년기의 비만이 성인기의 비만으로 발전하기 때문에 결국 소아 청소년기의 비만으로 심혈관계 등 여러 문제가 유발된다고 볼 수 있다. 따라서 소아 청소년기 비만증에서 정확한 혈압의 측정은 매우 중요하겠다. 본 연구에서는 소아 청소년 비만 환자들을 대상으로 수시 혈압 측정으로 선별 검사한 후 이들의 24시간 혈압을 측정함으로 ABPM의 유용성과 의미에 대해 고찰해보고자 하였다. 방 법 : 2006년 2월 1일부터 2007년 12월 1일까지 한동대학교 선린병원의 소아 청소년과를 방문하여 ABPM을 시행한 모든 환자들을 대상으로 하였다. 자료의 분석은 수축기, 이완기 혈압측정을 수면 혈압과 이를 제외한 각성 혈압으로 나누어 분석하였고 야간 혈압 강하(night dip)를 평가하였다. 환자는 정상군(1군)과 체질량계수만 95 백분위수가 넘는 비만군(2군) 그리고 비만이면서 외래혈압이 120/80 mmHg이상인 비만 위험혈압군(3군)으로 구분하였다. 결 과 : ABPM을 시행한 환자는 모두 49명이었고 비만군이 18명이었고 비만 위험혈압군이 12명이었다. 정상군은 19명이었다. 각 군의 수축기 평균혈압을 비교하였을 때 모든 군에서 통계학적으로 의미 있는 차이를 나타내었고(1군, $105.1{\pm}4.7$; 2군, $111.0{\pm}7.1$; 3군, $117.8{\pm}6.6mmHg$), 이완기 평균 혈압의 경우 1군과 3군에서만 통계학적으로 의미 있는 차이를 나타내었다($69.1{\pm}5.3$, $77.9{\pm}6.3mmHg$). 각성 혈압을 비교한 결과도 1군과 3군간에만 통계적으로 유의한 차이가 있었다. 수면혈압인 경우 수축기 혈압은 3군이 1, 2군에 비해 통계적으로 유의하게 높았으나, 이완기 혈압은 다른 경우와 마찬가지로 1군과 3군간에만 유의한 차이가 있었다. 본 연구에서 각 군간에 야간 혈압 강하를 조사해보니 통계적으로 의미 있는 차이를 보이지 않았다. 결 론 : 본 연구에서 ABPM을 시행한 결과 비만 위험혈압군에서 통계적으로 유의하게 혈압이 높았다. 소아 청소년에서, 특히 향후 심혈관 질환 및 여러 질환의 위험인자로 알려진 비만아에서 ABPM의 적극적인 활용이 필요로 하겠다.