• 제목/요약/키워드: Blood Biochemical

검색결과 1,117건 처리시간 0.027초

일 대학교 교직원의 생활습관과 체질량지수 및 생화학적 지수에 관한 연구 (One University Staff Members' Life Styles, Body Mass Indices, Lipid Profiles and Plasma Glucose Levels)

  • 이혜경;박연숙;김현숙;백승순;지현순
    • Journal of Korean Biological Nursing Science
    • /
    • 제13권3호
    • /
    • pp.298-306
    • /
    • 2011
  • Purpose: To analyze the differences of the Body Mass Index (BMI), blood biochemical indices (TC, TG, HDL, PP2) among college faculty members depending on their life styles and thereupon, provide for some basic data useful for healthcare education. Methods: 163 faculty members were sampled for a questionnaire survey and a medical checkup, both conducted from Jan. 20 to Jan. 26, 2010. Results: First, such blood biochemical indicesas BMI, TG, HDL and PP2 differed significantly depending on gender, while TC, TG and HDL differed significantly depending on age. Second, BMI differed significantly depending on drinking. Third, smokers showed significantly lower BMI and PP2 than non-smokers. Among the smokers, those smoking for 1-10 years showed a significantly lower level of TG. Fourth, those exercising as hard as sweating 3 times a week showed significantly lower BMI, TC and TG. Fifth, BMI was correlated positively with TC and TG, while being correlated negatively with HDL. On the other hand, TC was correlated positively with the TG which was correlated negatively with the HDL which was correlated positively with PP2. Conclusion: In order to prevent chronic diseases and live a healthy life, it must be necessary to control drinking, stop smoking and exercise regularly.

Dietary Protein Restriction on Growth and Immuno-biochemical Response of Crossbred Calves during Post-ruminant Phase of Life

  • Sahoo, A.;Mishra, S.C.;Pathak, N.N.
    • Asian-Australasian Journal of Animal Sciences
    • /
    • 제15권8호
    • /
    • pp.1121-1127
    • /
    • 2002
  • Sixteen crossbred (Bos indicus${\times}$Bos taurus) calves were randomly distributed in two groups (NP and LP) of eight calves each to study the effect of restricted (75%) protein supply on growth and immuno-biochemical response as an indicator of production and health of under-nourished animals during 3 to 9 months of age. The normal requirement of protein was provided to group NP and a less of 25% to group LP through calculated amount of concentrate and roughage in their daily ration. Assessment was made for weekly change in live weight, periodic alteration in blood metabolites and immunological status at six months of age in calves. An initial (during 3 to 6 months of age) depression (p<0.05) in growth was seen in low protein fed group (LP) compared to NP, which became non-significant in the later period of life (6 to 9 months of age). There was no significant effect on haemoglobin, total protein, albumin and globulin concentration except that of urea, which was decreased significantly (p<0.05) in animals fed on low protein diet ($19.83{\pm}1.25$ vs $25.93{\pm}1.29mg/dl$). The treatment effect that was seen in different periods of life was not uniform for other parameters except for urea, which showed a regular depression in LP compared to NP. The assessment of immunological status by indirect haemagglutination (IHA) test against Pasteurella multocida (P52 strain) was considerably (p<0.05) reduced in animals on LP ration compared to those on NP. It is thus argued that with poor nutrition (low protein) and state of compromised immunological response the production and health of the animals will be adversely affected.

Marginal Zinc Deficiency Affects Biochemical and Physiological Parameters in Beef Heifer Calves

  • Engle, T.E.;Nockels, C.F.;Hossner, K.L.;Kimberling, C.V.;Toombs, R.E.;Yemm, R.S.;Weaber, D.L.;Johnson, A.B.
    • Asian-Australasian Journal of Animal Sciences
    • /
    • 제10권5호
    • /
    • pp.471-477
    • /
    • 1997
  • A study detennined whether certain biochemical and physiological variables were altered during marginal Zn deficiency. Ten weaned crossbred Hereford Angus heifer calves, weighing $163{\pm}2kg$, were utilized. Five calves were fed a Zn - deficient (- Zn) brome-alfalfa hay diet containing 17 mg Zn/kg diet DM, and five calves were fed a Zn-adequate (+Zn) diet with 23 mg Zn/kg diet DM from $ZnSO_4$ added to the - Zn diet (total diet, 40 mg Zn/kg diet DM), for 32 d. At 21 d the - Zn calves had a reduction (p < .05) in feed efficiency. By 25 d, plasma Zn and alkaline phosphatase concentrations were reduced (p < .05) in the - Zn calves. Blood urea nitrogen, glucose, insulin, IGF-I, Cu plasma concentration and Zn and Cu concentrations of red blood cell (RBC) and liver were not altered (p > .05) by the - Zn diet through 25 d. In response to a single i. m. injection of dexamethasone (20 mg) on d 25, calves fed the two dietary Zn amounts showed no changes (p > .05) in plasma or RBC Zn and Cu concentrations, serum IGF-I, insulin, and glucose when measured at 6, 12, 24, 48, 72, and 96 h after injection. In response to an intradermal injection of phytohemagglutinin on d 30, cell mediated immune (CMI) response was reduced (p < .05) in the - Zn calves. These observations indicate that during a marginal Zn deficiency in calves, there was a decrease in feed efficiency, plasma Zn, serum alkaline phosphatase, and CMI response.

Comparison of Stress and Physiological Variables between Diabetic and Nondiabetic Adults

  • Han, Byung-Jo;Choi, Seok-Cheol;Moon, Seong-Min;Kim, Dae-Sik;Hyun, Kyung-Yae
    • 대한의생명과학회지
    • /
    • 제18권4호
    • /
    • pp.384-390
    • /
    • 2012
  • Diabetes mellitus (DM) is considered to be a serious metabolic disease which may cause systemic complications. The present study was designed to clarify a difference on stress, physiological variables and their correlation between diabetic (DM group) and nondiabetic adults (control group). The levels of body weight, waist circumference, blood pressure, body mass index, body fat mass, total cholesterol (TcH), triglyceride (TG), aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyltransferase (GGT), total bilirubin (TB), autonomic balance (AB), stress index (SI), fatigue index (FI), and heart rate (HR) were all significantly higher in the DM group than in the control group. However, the levels of autonomic activity (AA), stress resistance (SR), and electrocardiac stability (ES) were significantly lower in the DM group than in the control group. The percentages of persons with abnormal levels in the Tch, high density lipoprotein, low density lipoprotein, TG, AST, ALT and GGT were significantly greater in the DM group than in the control group. In the correlation of glucose and hemoglobin A1c (HBA1c) to stress indices, the DM group had a significant relationship with AB, SR, SI, FI, ES, and HR, whereas the control group had no significant relationship with these, excepting AB. These results suggest that DM was harmfully associated with body, biochemical and stress indices and that blood glucose and HBA1c levels must be exhaustively regulated.

고지방식이 병행섭취 시 연잎, 연 줄기, 연자방 분말가루가 흰쥐의 혈중 생화학적 인자에 미치는 영향 (The Effect of Lotus (Nelumbo nucifera) Leaf, Stem, and Yeonjabang Powder Extract on the Biochemical Factors in Serum in Mice Fed a High-Fat Diet)

  • 김용환;최경순;신경옥
    • 한국식품영양학회지
    • /
    • 제29권5호
    • /
    • pp.684-691
    • /
    • 2016
  • In this study, we analyzed the biochemical factors in lotus (Nelumbo nucifera) leaf, stem, and yeonjabang and their effects on serum factor levels in mice fed a high-fat (HF) diet. The loutus leaf showed $9.47{\pm}0.30%$ moisture content, $8.25{\pm}0.39%$ ash, $21.45{\pm}1.25%$ crude protein, and $2.21{\pm}0.13%$ crude fat content; the lotus stem showed $11.84{\pm}0.43%$ moisture, $10.21{\pm}0.64%$ ash, $17.55{\pm}0.92%$ crude protein, and $4.16{\pm}0.23%$ crude fat content; and the lotus yeonjabang showed $11.86{\pm}0.50%$ moisture, $6.81{\pm}0.51%$ ash, $18.71{\pm}1.02%$ crude protein, and $3.95{\pm}0.15%$ crude fat. Blood triglyceride levels were higher in the HF group ($146.43{\pm}38.81mg/dL$), and lower in the HF+yeonjabang groups ($98.00{\pm}17.18mg/dL$). In particular, blood triglyceride levels were significantly lower in the groups that had 10% dry yeonjabang powder added to the high-fat diet. The inclusion of excessive high-fat diet increased concentrations of serum insulin and leptin. Serum leptin concentrations were highest in the HF group mice ($3.00{\pm}1.35ng/dL$), whereas they were significantly lower in the HF+yeonjabang groups by $1.34{\pm}0.52ng/dL$ (p<0.05). Thus, addition of dry yeonjabang powder to the high-fat diet was more effective in regulating the levels of serum triglycerides and leptin in mice. Additional studies would help in the development of yeonjabang as a functional food.

산양의 anaplasmosis에 대한 역학적 조사 III. 혈액치의 계절적 변화 (A study on the epidemiology of caprine anaplasmosis in Korea III. Seasonal variation in hematologic profiles)

  • 백병걸;손구례
    • 대한수의학회지
    • /
    • 제35권1호
    • /
    • pp.137-142
    • /
    • 1995
  • Anaplasmosis is a tick-borne disease of large and small ruminants, causing losses through mortality, abortion, weight loss and reduced milk production. In one dairy farm, for example, 250 of a total of 800 imported goats were diagnosed with a mysterious type of anemia during the summer and autumn of 1992. The etiologic agent was identified as Anaplasma spp by acridine orange and ultrastructure by electron microscopy. In order to monitor variations in blood biochemical and hematological parameters associated with the disease, blood samples were collected by jugular venipuncture from 50 goats at 3 month intervals between the period of February and October, 1993. The levels of RBCs, HB and HCT decreased from $18.48{\pm}1.96$ to $13.47{\pm}2.48X10^6/mm^3$, $12.25{\pm}1.41$ to $9.54{\pm}1.77g/dl$, and $43.09{\pm}4.75$ to $30.93{\pm}5.78%$, respectively. The values of MCH(Mean corpuscular hemoglobin), MCHC(Mean corpuscular hemoglobin concentration) and PLT(Platelet) were elevated from $6.58{\pm}0.30$ to $7.05{\pm}0.47pg$, $28.40{\pm}1.20$ to $30.82{\pm}1.85g/dl$ and $1688.34{\pm}750$ to $2046.82{\pm}783X10^3/mm^3$, respectively. Percent parasitized erythrocytes(PPE) increased from $0.61{\pm}0.5$ to $2.22{\pm}1.9%$, clinical biochemical parameters aspartate aminotransferase and alanine aminotransferase were $66.64{\pm}23.1K.U$ and $14.90{\pm}6.59K.U$, respectively and persisted at high levels throughout the observation period. The level of albumin(2.46)0.52 g/dl) was decreased corresponding to an elevated globulin and a reduced albumin/globulin ratio in October as compared with the values in February. It is concluded that caprine anaplasmosis may be an important cause of anemia and hepatic malfunction in goats.

  • PDF

Single-dose Intravenous Injection Toxicity of Water-soluble Danggui Pharmacopuncture (WDP) in Sprague-Dawley Rats

  • Park, Sunju;Park, Hae-Mo;Sun, Seung-Ho
    • 대한약침학회지
    • /
    • 제21권2호
    • /
    • pp.104-111
    • /
    • 2018
  • Objective:This study is to evaluate both the single-dose intravenous injection toxicity and the approximate lethal dose of Water-soluble Danggui Pharmacopuncture (WDP) in Sprague-Dawley (SD) rats. Methods: Toxicity experiments were conducted at Good Laboratory Practice (GLP) laboratory in Biotoxtech Co., according to the regulations of GLP. WDP injection of dose 0.125, 0.25, and 0.5 mL/animal were experimental groups and normal saline injection group was control group. WDP and normal saline were injected once to 6- week old 5 male and 5 female SD rats at the tail veins at approximately 2 mL/min. During 14 days after the injection, general symptoms were observed and weight were measured. After the observation period, hematological and blood biochemical examination, macroscopic autopsy, topical resistance test at the injection area were performed. Results: RThe WDP 0.5 mL/animal injection group in 4 cases of male rats and all cases of female rats showed hematuria 30 minutes after the administration. However, after 1 hour, no more abnormal general symptoms were observed. The WDP did not affect weight, hematological and blood biochemical examination, macroscopic autopsy, and topical resistance test at the injection area. Conclusion: WDP single dose intravenous injection results showed that WDP have no toxic effects and a lethal dose of WDP should be over 0.5 mL/animal in male and female rats under the study condition. So WDP may be safe.

병원자료에 근거한 혈액 및 혈액화학 검사항목의 참고구간 설정 (Reference Intervals from Hospital-Based Data for Hematologic and Serum Chemistry Values in Dogs)

  • 권영욱;박선일
    • 한국임상수의학회지
    • /
    • 제27권1호
    • /
    • pp.66-70
    • /
    • 2010
  • Reference interval is critical for interpreting laboratory results, monitoring response to therapy and predicting the prognosis of the patients in clinical settings. The aim of the present study was to update established reference intervals for routine hematologic and serum chemistry values for a population of clinically healthy dogs (range, 1-8 years) seen in an animal hospital. Blood was obtained by venipuncture while animals were physically restrained, and samples were analyzed for 9 chemistries on MS9-5H (Melot Schloesing Lab, France) and 6 hematology on Vet Test 8008 (IDEXX, USA). Data from 105 dogs (52 males and 53 females) for hematology and 113 dogs (37 males and 76 females) for chemistry were used to determine reference intervals using the parametric, nonparametric and bootstrap methods. Prior to analysis, all parameters were tested for normal distribution using Anderson-Darling criterion. Of the 9 biochemical analytes, alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, creatinine, total protein, and glucose concentrations did not fit normal distribution for both original and transformed data. All but eosinophil count satisfied normal distribution for either original or transformed data. Parametric method can be used for original cholesterol concentrations, RBC, WBC, and neutrophil counts. This technique can also be used for power-transformed values of blood urea nitrogen concentrations and for logarithm of lymphocyte and monocyte counts. Non-parametric or bootstrap method was the preferred choice for the remaining 7 biochemical parameters and eosinophil count as they did not follow normal distributions. All three statistical techniques performed in similar reference intervals. When establishing reference intervals for clinical laboratory data, it is essential to assess the distribution of the original data to increase the accuracy of the interval, and non-parametric or bootstrap methods are of alternative for the data that do not fit normal distribution.

초오 약침액의 13주 반복 시술 독성에 관한 연구 (Thirteen Weeks Repeated-dose Toxicity Study on Aconitum ciliare Decaisne Pharmacopuncture Solution in Mice)

  • 임성철;김재수;이봉효;이현종;이현;이윤규
    • Korean Journal of Acupuncture
    • /
    • 제35권3호
    • /
    • pp.139-148
    • /
    • 2018
  • Objectives : This study was performed to examine the toxicity on the long term procedure of Aconitum ciliare Decaisne pharmacopuncture(ADP) solution. Methods : To evaluate the long term toxicity of 3 different repeated doses, 60, 150, and 300 mg/kg/day for 13 weeks were injected into BALB/c mice, respectively. The ADP solution was injected into near ST36 of the right leg and normal saline of the same volume was used for the vehicle control group. To evaluate the toxicity of 60, 150, and 300 mg/kg of repeated doses for 13 weeks, toxic symptoms, weight measurement, hematological test, blood biochemical test, visual examination and weight measurement of major organs, and histopathological test were conducted. Results : No significant changes in toxic symptoms, weight measurement, hematological test, blood biochemical test, visual examination and weight measurement of major organs, and histopathological test were observed in different doses of ADP solution treated groups compared to vehicle control group. Conclusions : As a result, repeated dose at a concentration of 300 mg/kg or less is considered to be not harmful for clinical treatment.

Evaluation of the Oral Acute Toxicity of Black Ginseng in Rats

  • Lee, Mi-Ra;Oh, Chang-Jin;Li, Zheng;Li, Jing-Jie;Wang, Chun-Yan;Wang, Zhen;Gu, Li-Juan;Lee, Sang-Hwa;Lee, Jae-Il;Lim, Beong-Ou;Sung, Chang-Keun
    • Journal of Ginseng Research
    • /
    • 제35권1호
    • /
    • pp.39-44
    • /
    • 2011
  • We studied the acute oral toxicity of black ginseng (BG) produced by heat process in rats. Single acute BG extract doses of 0, 5, 10, and 15 g/kg dissolved in saline were administered by oral gavage and the animals were kept under observation for 14 days. The single administration of BG extract up to 15 g/kg did not produce mortality, behavioral change or abnormal clinical signs in the rats. These results indicated that the oral $LD_{50}$ of the BG extract in the rats is higher than 15 g/kg. Compared to the control group, no treatment-related biologically significant effects of BG extract were noted in the measurements of the body weight or food intake. At the end of the period, the biochemical parameters and hematological parameters were analyzed in the plasma and blood. A histopathological examination of the liver and kidney was also conducted. Only the blood nitrogen urea and potassium levels in the biochemical indices showed significant differences at 10 and 15 g/kg doses of BG extract compared to the control group. These changes were not considered to be due to the toxicity. None of the other clinical chemistry parameters were affected. Therefore, these results indicate that the BG by heat processing is virtually nontoxic.