• Journal of radiological science and technology
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• v.32 no.3
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• pp.325-334
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• 2009

Purpose : This study was conducted to assess how effective the permeability ratio and relative cerebral blood volume ratio are to tumor through perfusion MRI by measuring and reflecting the grade assessment and differential diagnosis and the permeability and relative cerebral blood volume of contrast media plunged from blood vessel into organ due to breakdown of blood-brain barrier in cerebral. Subject and Method : Subject of study was 29 patients whose diagnosis were confirmed by biopsy after surgery and 550 (11 slice$\times$50 image) perfusion MRI were used to make image of relative cerebral blood volume with the program furnished on instrument. The other method was to transmit to private computer and the image analysis was made additionally by making image of relative cerebral blood volume-reformulated singular value decomposition, rCBV-rSVD and permeability using IDL.6.2. In addition, Kruskal-wallis test tonggyein non numerical average by a comparative analysis of brain tumors Results : The rCBV ratio (Functool PF; GE Medical Systems and IDL 6.2 program by analysis) and permeability ratio of tumors were as follows; high grade glioma(n=4), (14.75, 19.25) 13.13. low grade astrocytoma(n=5) (14.80, 15.90) 11.60, glioblastoma(n=5) (10.90, 18.60), 22.00, metastasis(n=6) (11.00, 15.08). 22.33. meningioma(n=6) (18.58, 7.67), 5.58. oliogodendroglioma(n=3) (23.33, 16.33, 15.67. Conclusion : It was not easy to classify the grade with the relative cerebral blood volume ratio measured by using the relative cerebral blood image by type of tumors, however, permeability ratio measured by permeability image revealed that the higher the grade of tumor, the higher the measured permeability ratio, showing the assessment of tumor grade is more effective to differential diagnosis.

• Journal of Acupuncture Research
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• v.31 no.2
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• pp.65-74
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• 2014

Objectives : The purpose of this study is evaluating the effect of Hoelen Herbal-acupuncture (HO-HA) at $KI_{10}$(Umgok) on Lipopolysaccharide(LPS) induced nephritis in rats. Methods : The experimental rats were assigned to four groups; normal, LPS, saline, HO-HA groups. LPS(2 mg/kg) was administered to the rats in LPS, saline and HO-HA groups to induce acute inflammatory kidney damage. Saline injection and HO-HA were administered at $KI_{10}$ three times a week. Blood samples were taken from the rats for analysis of white blood cell(WBC), neutrophil, blood urea nitrogen(BUN), creatinine TNF-${\alpha}$, CINC-1. Urine samples were taken from the rats for analysis of urinal volume, creatinine and total protein. The kidney samples were taken from the rats for analysis of renal myeloperoxIdase(MPO). Results : HO-HA suppressed the increases of WBC and neutrophils in blood, BUN, creatinine, TNF-${\alpha}$ and CINC-1 in serum, and MPO in kidney of LPS-stimulated rats. In addition, HO-HA inhibited the decrease of urinary volume in LPS-stimulated rats. Conclusions : HO-HA has therapeutic effects on LPS-induced inflammatory kidney damage in rats. Further studies may be needed for clinical use of HO-HA.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.61 no.2
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• pp.270-275
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• 2012

This paper presents a portable and compact optical device which can conveniently be used to perform a functional analysis of human liver function. The proposed system employed red/green LEDs, as a light source, and CMOS image sensor, which is commonly used in cellular phones. With this system, several blood serum samples have been evaluated for liver functional analysis by measuring light absorption level through the blood serum samples depending on aspartate aminotransferase (AST), alanine aminotransferase (ALT), and total bilirubin concentration. The light absorption through the blood serum samples containing AST, ALT, or total bilirubin can provide their concentrations. The green light absorption is more sensitive to the concentration of AST or ALT, and the red light absorption is more sensitive to the total bilirubuin concentration. Additional calibration steps were performed by using a MATLAB program in order to eliminate the light scattering effects from the extraneous particles existing in each blood serum sample. From the blind test, three standard light intensity curves through each enzyme have been obtained and the enzyme concentration values have been compared to those obtained from a commercially available biochemistry analyzer (Toshiba 200 FR). The average percent difference in the obtained concentrations from two systems for AST, ALT, and total bilirubin concentration came out to be 7.79%, 7.98%. and 7.56%, respectively, with the adjusted coefficient of determination (R2) higher than 0.98. This system can possibly lead to a low-cost and simple system that can be used as a point-of-care (POC) system in a condition without advanced equipments.

• The Journal of Internal Korean Medicine
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• v.38 no.6
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• pp.902-916
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• 2017

Objectives: The aim of this study was to review the clinical research on antihypertensive effects of Korean herbal medicines that function by inducing diuresis. Methods: Literature searches were performed using PubMed, Cochrane, CNKI, Wanfang, Cinii, Oasis, KISS, NDSL, RISS, DBPia, with the keywords "利水", "利尿", "高血壓", "hypertension", and "lishui." The search range included only randomized controlled trials that verified the effects of Korean herbal medicine interventions on hypertension. The selected studies were assessed by risk of bias (RoB). Results: 26 reports were selected from a total of 532 identified. For these reports, meta-analysis was performed using Revman 5.3. From this analysis, it was observed that the combined treatment of Korean medicine and antihypertensive drugs had a significantly higher total effective rate (TER) and improvement in systolic blood pressure (SBP) and diastolic blood pressure (DBP) than did the use of a single antihypertensive drug. The risk ratio of TER for lowering blood pressure was 1.25. The mean differences of SBP, DBP were -19.63 mm Hg (95% confidential interval (CI), -22.45 mm Hg, -16.80 mm Hg, p<0.00001), and -5.39 mm Hg (95% CI, -7.36 mm Hg, -3.42 mm Hg, p<0.00001) respectively. The use of Korean medicine only did not improve blood pressure, as compared to the use of an antihypertensive drug. Most of items of RoB were unclear, and the methodological quality was low. Conclusions: The combination of antihypertensive drugs and Korean medical treatment can effectively improve SBP, DBP, and TER. This finding could be widely utilized in clinical practice in Korean medicine.

• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.2
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• pp.401-407
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• 2004

Purpose : This study investigated reliability of Oriental DB & GY(obstetrics & gynecology) Questionnaires's items which was used by Dong-Eui OB & GY through analysis of oriental OB & GY books. Method : This study investigated differentiation of syndrome through analysis of oriental OB & GY book's. Result: This study investigated differentiation of syndrome through analysis of oriental OB & GY disease and pathogenesis. This study's pathogenesis was such that deficiency of Ki, deficiency of blood, stagnation of Ki, stagnated blood, deficiency of Yang, deficiency of Um, cold syndrome, heat syndrome, dampness, dryness, phlegm, kidney, liver, heart, spleen, wind, lung. We except lung from Questionnaires's pathogenesis because it is stuck for importance. We except wind from Questionnaires's pathogenesis because it is stuck for preguence. Oriental OB & GY Questionnaires's pathogenesis consist of 15 items such that deficiency of Ki, deficiency of blood, stagnation of Ki, stagnated blood, deficiency of Yang, deficiency of Um, cold syndrome, heat syndrome, dampness, dryness, phlegm, kidney, liver, heart, spleen. Oriental OB & GY Questionnaires construct pathogenesis's question and guide post through we examined it's reasonableness.

• Herbal Formula Science
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• v.25 no.2
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• pp.303-324
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• 2017

Objectives : Consumptive is an unhealthy condition that are caused by lack of blood and essence, and that means also some stages of chronic diseases. The purpose of this study is to analysis 108 Prescriptions of Consumptive part in Dongui Bogam. Methods : The 108 Prescriptions of Consumptive part in Dongui Bogam analysed frequency of basic prescriptions, symptoms of prescriptions and the pathology. Results : Ssangbohwan, Yiuihwan, Gamrihwan were used for tonifying were mostly used as basic prescriptions in whole Consumptive part respectively. There are common symptoms in consumptive part in Dongui Bogam. That symptoms are "tidal fever, night sweating, nocturnal emission, cough, sputum, skinny body, weak pulse, spontaneous sweating, deafness, dim vision and tuberculosis". Qi blood(yin yang) pathologies in prescriptions on consumptive part are "yin deficiency, yin deficiency with effulgent fire, yang qi deficiency, dual damage of qi and blood, non-interaction between fire and water, collapse of yang and exhaustion of yin, less blood". viscera and bowels pathologies in prescriptions on consumptive part are "heart and kidney deficiency, spleen-stomach weakness, spleen and kidney great deficiency, weakness of kidney qi, meridian waste in heart, spleen and kidney, damage in heart and lung". Conclusions : As a result of Study on Analysis all Prescriptions of Consumptive part in Dongui Bogam, We can understand more about basic prescriptions, symptoms of prescriptions and the pathology that are using for curing consumptive. We expected that this study will can help to give rationale for future study of consumptive caring.

• Journal of Physiology & Pathology in Korean Medicine
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• v.22 no.5
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• pp.1057-1061
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• 2008

For the purpose of investigating the reasonable logics contained in physiognomy of east and old western medicine. hypothetical researches based on hydromechanics theory were performed concerning facial types of form and pathologic features, especially 4 types of Dr. Jisan-Essence, Qi energy. Emotional Activity and Blood(EQAB). In order to infer the functional relation between facial type forming and EQAB factors, EQAB were supposed as fluid grounded on their continual flowing or periodical change and pressure effect from its congestion. and a premise that there's a linear corresponding relationship between the appearance of organ and its physical conditions of its inner vessels is formed too. Through this work, the unit fluid model(UFM) of Essence can be assumed as circle shape formed by the high viscosity and surface tension, the UFM model of Qi energy as quadrangular shape by the scattering features to outer four directions, and the UFM of emotional activity as inverted triangular shape by the flippant and uprising features, and the UFM of blood as ellipsoid triangle by the heavy and descending features in spite of circulation. The shapes made from each UFM are reproduced in the process of human development and manifest respective facial shape through the self-reproduction method like fractal theory in the last. Conclusively. it is said that the facial form analysis method like EQAB type theory can be the useful methodology to understand the human pathological and physiological features in view of hydromechanics.

• Journal of Biomedical Engineering Research
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• v.16 no.4
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• pp.525-532
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• 1995

In this paper, a new try to measure nonlinear propagation characteristics of the pulse along blood vessel by using bispectral analysis is introduced, and the possibility of its application to the medical diagnosis is shown. In this method, the waveforms of pulse motion of blood vessel at two separated measuring points on the wall were detected from Doppler frequency modulation of transmitted probing ultrasonic waves. Then the auto- and crossbispectrum of detected waveforms are calculated to estimate the quadratic NTF (nonlinear transfer function) between the two measuring positions. In order to show relationships between the NTF and the nonlinear propagation characteristics, computer simulations have been performed. As the propagation distance increases, harmonic frequency components in NTF increases broadly due to the nonlinear effect in the propagation of blood pulse. In order to represent this phenomena quantitatively, we propose a new parameter, dispersion ratio of WTF. Basic experimental system was constructed by using 3.5MHz probing ultrasonic waves and the preliminary experiments were carried out on ague phantom and human body. Experimental results showed the validity of the measurement system enoughly.

• Journal of Preventive Medicine and Public Health
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• v.34 no.4
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• pp.437-443
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• 2001

Objectives : This study was peformed to assess the association between the social support and blood pressure(BP) in a rural community. Methods : A cross-sectional survey, comprising a health examination including BP, height and weight and a questionnaire-based interview which investigated social support, demographic factors, smoking, drinking, and etc. was peformed between February 10th and March 5th, 1998. The survey included 318 persons who were over than 30-year-old in the rural community of Kwangju, Republic of Korea. We excluded persons who taking antihypertensive medications or who provided incomplete information; we subsequently analyzed the data from 284 persons. In order to test the hypothesis of an association between BP and social support controlling confounders such as age, educational level, working time, body mass index, smoking and drinking, the data was analyzed using multiple linear regression analysis. Results : The subjects were composed of 109(38.4%) males and 175(61.6%) females with mean ages of 62.0 years and 61.1 years, respectively. The hypertension prevalence was 41.3% among males and 45.1% among females. In the correlation analysis, higher total social support scores correlated significantly with lower systolic BP in both males and females. The hypertension prevalence increased significantly with the decreasing of the social support in males. In multiple regression analysis, systolic and diastolic blood pressure showed a negative association with social support in both males and females, although this was not statistically significant. Conclusions : Larger and broader studies are required in the future in order to identify the association between the social support and BP.

• The Journal of Korean Obstetrics and Gynecology
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• v.28 no.1
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• pp.102-112
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• 2015

Objectives: This study was performed to obtain reference data of traditional Korean medicine diagnostic methods for the practical usage in women infertility. Methods: The study involved 38 female patients of age 20-38 years that had diagnosed of infertility. All the subjects answered to pattern identification questionnaire and Questionnaire for the Sasang Constitution Classification (QSCC II). Pattern identification scores and constitution types have been analyzed with variables of infertility factors and age. Statistical analysis was performed by adopting descriptive and inferential tests. Results: In pattern identification questionnaire analysis, the patterns were observed in order of frequency: liver stasis; blood deficiency; kidney-yang deficiency; kidney-yin deficiency; damp-heat; blood stasis; and phlegm. The group, less than 35 years old, had the higher average score of liver stasis (p<0.05). Also, the group with tubal and peritoneal factors, had the higher average score of blood deficiency (p<0.05). In QSCC II analysis, So-yang type had the higher average score of liver stasis, kidney-yang deficiency, and kidney-yin deficiency. So-eum type had the higher average score of liver stasis, kidney-yang deficiency, kidney-yin deficiency, and blood deficiency. While, Tae-um type had the higher average score of liver stasis and phlegm. Conclusions: We would accumulate the clinical data for the practical usage of traditional Korean medicine diagnostic methods in women infertility.