• Proceedings of the KSME Conference
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• 2007.05b
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• pp.2947-2950
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• 2007

A 3D human ventricular model is proposed to simulate an integrative analysis of heart physiology and blood hemodynamics. This consists of the models of electrophysiology of human cells, electric wave propagation of tissue, heart solid mechanics, and 3D blood hemodynamics. The 3D geometry of human heart is discretized to a finite element mesh for the simulation of electric wave propagation and mechanics of heart. In cellular level, excitations by action potential are simulated using the existing human model. Then the contraction mechanics of a whole cell is incorporated to the excitation model. The excitation propagation to ventricular cells are transiently computed in the 3D cardiac tissue using a mono-domain method of electric wave propagation in cardiac tissue. Blood hemodynamics in heart is also considered and incorporated with muscle contraction. We use a PISO type finite element method to simulate the blood hemodynmaics in the human ventricular model.

• Proceedings of the KOSOMBE Conference
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• v.1994 no.05
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• pp.72-74
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• 1994

This paper describes the effect of autonomic nervous activity on Heart rate variability and peripheral blood pressure with power spectral analysis and its characteristics of chaotic attractors. The aim of this paper is to access the applicability of spectral and dimension analysis of heart rate variability and peripheral blood pressure, attributed to changes in autonomic nervous system activity. About 60 mininutes of Heart rates and synchronized peripheral blood pressure were recorded on 10 healthy man while various mental and physical conditions. The results shows the availability to evaluate the autonomic nervous activities.

• Journal of Environmental Health Sciences
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• v.16 no.2
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• pp.113-119
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• 1990

Many studies on the analysis of cations in blood have been reported. However, no suitable method for the pretreatment of blood for the determination of cations by Ion Chromotography. As a result, pretreatment method that the membrane filtration of plasma a diluted 1 to 100 fold acidified pH 3.5 was found to be the most suitable. The recoveris of monovalent cations in blood were yield 101%(Na$^{+}$). 102%(NH$^{+}_{4}$) and 101%(K$^{+}$) Determinations of divalent cations(Mg and Ca ions) in blood by Ion chromatography were summarized as followed conditions Separator Column : CS$_{3}$. Suppressor Column : CMMS. Eluent conen : 25m M-HCl/2mM-Histidine. Regenerant conen: 40mM-Ba(OH)$_{2}$.

• Journal of Sensor Science and Technology
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• v.15 no.1
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• pp.28-33
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• 2006

Optical-fiber sensors have been developed to determine the concentrations of glucose and lactic acid in blood samples. Fluorescence dye [tris(2,2'-biphenyridine)-ruthenium(II)-chloride (RuBPY)] was entrapped by using a silicon to the unclad tip of a glass optic fiber. Enzymes like glucose oxidase (GOD) and lactate oxidase (LOD) have been immobilized by acrylamide resin adhesive, adsorption with zeolite or covalent bonding with aminopropyl-triethoxysilan. The fiber-optic glucose/lactate sensor was then used to analyze the concentrations of glucose and lactate in blood samples. The results were compared with the results of HPLC analysis and their difference was in error by less then 5 %.

• Proceedings of the IEEK Conference
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• 2001.06e
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• pp.195-198
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• 2001

We developed the portable blood analysis system, which can be measured pH of the blood. This system is composed to electronic circuit, mechanism, and system software. Electronic circuit is composed to the sensor, pre-amp part, temperature regulation part, fluid sensing part, A/D(analog to digital) conversion part, main and peripheral device processing part. And the mechanism is composed to the flow cell and the liquid flow part. The liquid flow part is consisted of blood and washing control system under the control of the 6-channel solenoid valve and syringe rump. The system software is composed to measurement program, calibration program, washing and diagnostic program. The program of each routine is designed as sequential process for an efficiency. And the portable pH analysis system used two-point calibration method using the two types of corrective liquid. As a result, we obtained the calibration curve and calculated the value of pH. For verifying the system, we confirmed the output voltage of the sensor, and estimated reappearance of system using the standard liquid.

• Journal of Korea Multimedia Society
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• v.25 no.10
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• pp.1512-1523
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• 2022

Artificial intelligence application in digital health care has been increasing with its development of artificial intelligence. The convergence of the healthcare industry and information and communication technology makes the diagnosis of diseases more simple and comprehensible. From the perspective of medical services, its practice as an initial test and a reference indicator may become widely applicable. Therefore, analyzing the factors that are the basis for existing diagnosis protocols also helps suggest directions using artificial intelligence beyond previous regression and statistical analyses. This paper conducts essential diagnostic prediction learning based on the analysis of blood cancer factors reported previously. Blood cancer diagnosis predictions based on artificial intelligence contribute to successfully achieve more than 90% accuracy and validation of blood cancer factors as an alternative auxiliary approach.

• The Journal of Korean Obstetrics and Gynecology
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• v.24 no.1
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• pp.74-86
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• 2011

Objectives: The purpose of this study was to examine correlation between Heart Rate Variability and urine analysis of women with urinary disturbance. Methods: We studied 34 patients visiting ${\bigcirc}{\bigcirc}$hospital from January 2010 to September 2010. The subjects were categorized in two groups, symptom group (n=11) and no symptom group(n=23). We studied the difference of Heart Rate Variability and urine analysis between two groups by Student T-test and correlation between Heart Rate Variability and urine analysis by Pearson's correlation coefficient test using SPSS for windows (version 17.0). Results: Occult blood of symptom group was significantly higher than no symptom group. SDNN, TP and HF of symptom group was significantly lower than no symptom group. Occult blood and SDNN, occult blood and RMS-SD, occult blood and HF significantly showed negative correlation coefficient. pH and TP, pH and LF significantly showed positive correlation coefficient. Conclusion: The results suggest that urinary disturbance can be related to decreased activity of autonomic nervous system. Also urine from women with urinary disturbance tend to show higher occult blood.

• The Journal of Korean Medicine
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• v.44 no.2
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• pp.1-9
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• 2023

Objectives: To study symptom differentiation for yang deficiency and blood heat based on 117 psoriasis patients. Methods: Obtained frequency analysis (%), mean (%), and OR, CL(P-value) with prospective pre-post intervention design and multiple regression analysis. Results: There were no statistically significant differences as to sex, BMI, smoking and marital status, but there were statistically significant differences in variables of average age, family history, and alcohol consumption (P<0.05). There were no statistically significant differences in psoriasis symptoms as to initial age of onset, morbidity span, area of the initial onset, and the progression of psoriasis during the last three months of each patient. However, the type of psoriasis showed a statistically significant difference (p=0.011). While there were no statistically significant differences as to common cold, condition of psoriasis after recovering from the cold, skin condition, exercise, and seasonality, irregular perspiration showed significant difference (p<0.00). When confounding factors have been controlled the blood heat patient group as the comparison group, multiple regression analysis showed OR, CI(95%) of 1.06(0.31-3.63) for men, 0.28(0.08-1.06) for aged 30 to 49,0 and 0.18(0.04-0.80) for aged 50 and older. it was 0.06(0.01-0.7) for family history, 1.06(0.29-3.88) for drink alcohol, 19.90(2.53-156.7) for seasonality, and 10.28 (3.19-33.11) for perspiration problems. In these variables, Sex, age, smoking, and alcohol consumption showed no statistically significant results, but family history(p=0.049), seasonality(p=0.005), and irregular perspiration (p=0.017) were statistically significant. Conclusion: Family history, seasonality and irregular perspiration are the determining factors for yang deficiency and blood heat in psoriasis.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.5 no.1
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• pp.59-67
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• 1995

Blood lead assay by $D_2$ lamp background correction method of atomic absorption spectrophotometer(AAS) with wavelength of 283.3 nm is most popular in occupational health practice in Korea. On the other hand, $D_2$ lamp background correction method with wavelength of 217.0 nm is also often used in general chemical analysis for lead assay in general purpose. But both methods have some weakness of background correction which brought direct effect on the results of analysis. Recently blood lead assay with polarized Zeeman effect of AAS was introduced and is now preferred in many laboratory than $D_2$ correction method in blood lead analysis. But still AAS with $D_2$ lamp are widely used in the field of occupational health in Korea. This study compared blood lead assay data with $D_2$ correction methods(283.3 and 217.0 nm) and with that of polarized Zeeman effect correction method to evaluate the validity of 02 correction methods. The results obtained were as follows; 1. Taking the value of polarized Zeeman effect method as reference value of 1.00, the mean relative value of $D_2$ correction method with wavelength of 217.0 nm was 0.92 and that with wavelength of 283.3 nm was 0.90 respectively in the analysis of blood lead whose value were below $20.0{\mu}g/dl$(p<0.001). Both mean values were statistically smaller than polarized Zeeman effect correction method. But in the analysis of blood whose value were between 20.0 to $20.0{\mu}g/dl$, the mean relative value of $D_2$ correction method was 0.96 in both wavelength and did not differ from polarized Zeeman effect method(p<0.001). There was no difference of blood lead between $D_2$ correction method and polarized Zeeman effect method in the analysis of blood lead whose value were over $40.0{\mu}g/dl$. 2. The variations of background correction value in polarized Zeeman effect method were not changed by increase of blood lead, but those in $D_2$ correction methods were increased by the increase of blood lead. While then relative standard deviation(RSD) of data measured by Zeeman effect method were decreased by the increase of blood lead, those by $D_2$ methods were nol differed by the increase of blood lead.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.57 no.6
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• pp.1095-1101
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• 2008

The desirable method to diagnose abnormal blood pressure is to measure and manage blood pressure continuously and regularly. However, the sphygmomanometers that are based on a cuff have faults in that they can not measure the blood pressure continuously and they cause an unpleasant feeling. Therefore, it is essential to develop a new measuring method that causes no pain and that can obtain blood pressure continuously without any unpleasant feeling. Thus, we propose here a regression method to estimate the systolic blood pressure by using the PTTL(pulse transit time on leg) with some body parameters which are chosen from the relational analysis with systolic blood pressure. The data we use to make the regression model were obtained in triplicate from each of 50 males who were from 18 to 35 years. And we made estimation experiments of blood pressure on 10 males who did not take part in the making the regression model. According to the results, the proposed method showed a mean error of 4.00 mmHg and the standard variance was 2.45 mmHg. When we comparing the results of the proposed method with the rule of American National Standards Institute of the Association of the Advancement of Medical Instruments(ANSI/AAMI), the results satisfied the rule of a mean error less than 5 mmHg and a standard variance less than 8 mmHg. Therefore we were able to validate the usefulness of the proposed method.