• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.41 no.5
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• pp.335-341
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• 2013

The variation of systematic bias errors in the wind tunnel testing has been studied. A Design of Experiments(DOE) approach to an experimental study of fuselage drag and stability characteristics of a helicopter configuration was applied. When forces and moments measured in one time block differ significantly from measurements made in another time block under assumption that sample observations can be expected to yield same results within permissible measuring errors. The practical implication of this paper is that the systematic error can not be assumed not to exist. The those error reduction could be achieved through the process of randomization, blocking, and replication of the data points.

• BMB Reports
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• v.37 no.3
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• pp.383-385
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• 2004

RNA interference (RNAi) is a process of sequence-specific gene silencing, which is initiated by double-stranded RNA (dsRNA). RNAi may also serve as an antiviral system in vertebrates. This study describes the inhibition of herpesvirus-6B (HHV-6B) replication by short interference RNAs (siRNAs) that are targeted to the U38 sequence that encodes DNA polymerase. When virus-infected SupT1 cells were treated by siRNA, these cells blocked the cytopathic effect (CPE) and detected the HHV-6B antibody-negative in indirect immunofluorescence assays (IFA). Our result suggests that RNAi can efficiently block Herpesvirus-6B replication.

• Proceedings of the Korean Information Science Society Conference
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• 2011.06b
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• pp.338-341
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• 2011

프로그램 코드 사이즈는 내장형시스템 구성에 있어서 고려해야 할 핵심 요소중의 하나이다. 프로그램 사이즈는 해당 시스템의 메모리 크기, 전력소모, 성능, 가격 등에 영향을 미치기 때문이다. 프로그램 코드 사이즈를 최적화하기 위하여 활용할 수 있는 시스템 자원 중에서 효과적인 것 중 하나가 복수 로드/스토어 명령어(Multiple Load/Store Instruction, MLS)이다. MLS 명령어는 하나의 명령어로 하나이상의 메모리 값을 레지스터로 블록 전송 (block transfer)하는 것이 가능하기 때문이다. 본 연구에서는 MLS명령어를 기존보다 효과적으로 생성함으로써 코드 크기를 감소시키는 최적화 기법에 대해 논의한다. 실험을 통하여 Mediabench와 DSPStone 벤치마크에서 본 연구에서 제안하는 기법을 통하여 평균 메모리 접근 코드사이즈가 10.3% 감소하였다.

• Journal of the Korean Institute of Telematics and Electronics S
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• v.34S no.1
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• pp.1-8
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• 1997

A wide class of networking application services, such as video teleconferencing, VOD, LAN bridging, and distributed data processing require multipoint communications. The essential component inteh network to achieve this is a multicast packet switch which is capable of packet replication and switching. In this paper, we propose an efficient mukticast addressing scheme using the smallest number of routing bits which is deterministic lower bound. The new scheme performs all point-to-multipoint connection in radix-2 tree ATM switch like banyan network. Also, we provide a simple radix-2 switch block diagram for achieving our algorithm. And we investigate several addressing schemes for implementing multicasting in radix-r tree ATM switch and evaluate several performance factors, such as complexity of the additional header bits, requirement of the internal speedup and complexity of the major hardware.

• Journal of Animal Environmental Science
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• v.2 no.2
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• pp.111-116
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• 1996

An experiment was carried out to study the effect of environmental color on the eating behaviour in broiler chicks. A total of ninety broilers with average 350g of initial body weight were randomly assigned in the $3{\times}3$ randomized complete block design with 3 treatments(yellow, blue, red) and 10 birds per replication of various environmental color at walls, feeders and electric bulbs. The results obtained from these experiments are summarised as follows: 1. Feed Intake and average daily gain were significantly(P<0.05) increased by yellow colored environment. 2. Eating time and eating rate were significantly higher in the red colored than the other, indicating that yellow colored environment would maximize body weight gain and feed conversion for broiler chicks.

• The Korean Journal of Ecology
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• v.6 no.1
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• pp.14-17
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• 1983

For the purpose of rice yield, 3 rice varieties S-235 (Sam-Pung), S-287(Tai-Baik), S-294(Nam-Pung), control experiment College of Agriculture, Seoul National University garden in 1982. Method of experiment are 4 treatment, 4 replication and randomized block design. Unhilled rice were increased S-235 14.8%, S-287 of 16.2%, S-294 of 15.7%. Each varieties were each sigmificant of 1%. And the best increased, Triacon 10 and $CaCl_2$ 15mM. It think that problems were the more study. Among factor of yield, increase is panice no. of hill and the same varieties. Only S-287 of panicle of hill is significant of 5% and also 1000 seed weight is not significant. The factor of increase yield is important of no. of flower. No. of flower increase is concerned Triacon, the mechanism will study.

• Journal of the Korean institute of surface engineering
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• v.37 no.1
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• pp.22-27
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• 2004

Copper electroforming process has been applied to duplicate Koryo Tripitaka (Taejang'kyong), wooden printing block. Thin copper replica printing plates of 1 mm thickness was successfully manufactured from the printing face (54.5${\times}$25.5 cm) of wooden printing plate. Major processes are (1) silicon rubber replication of the master (2) silvering on silicon rubber (3) copper electroforming (4) separation of copper from the silicon mandrel (5) final coloring by brass plating and trimming. This process has various Potential applications in making thin metallic objects such as plaques, statues, bust and hollow metal objects for jewelry.

• Korean Journal of Microbiology
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• v.31 no.1
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• pp.72-78
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• 1993

Since the 'promoter/enhancer region of the major immediate early (IE) ~ene of human cytomegalovirus (HCMV) contains the cyclic AMP (cAMP) response element (CRE) consensus sequence, it was reasonable to hypothesize that cAMP might affect HCMV replication. Cyclic AMP modulating drugs such as 8-bromoadenosine 3',5'-cyclic monophosphate (BrA), and papaverine were used to affect the intracellular levels of cAMP, and the effects of the drugs on HCMV replication were studied. While papaverine effectively inhibited HCMV multiplication and DNA synthesis, BrA exerted little effect on the production of infectious HCMV yields. The synthesis of DNA in HCMV-infected cells appeared to be stimulated by BrA In order to understand the effect of cAMP on the expression of HCMV major IE gene, plasmid (pCMVIE/CAT) containing a reporter gene driven by HCMV IE promoter was transfected into either permissive human embryo lung (HEL) cells or nonpermissive cells. PL,Javerine, which has been reported to block the HCMV-induced increase in cAMP, reduced the expression of pCMVIE/CA T in permissive HEL cells. Treatment of transfected cells with BrA increased the expression of HCMV major IE promoter not only in HEL cells, but also in nonpermissive HeLa and Vero cells. Therefore, it seems that the expression of HCMV major IE gene is regulated by cAMP.

• Toxicological Research
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• v.33 no.4
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• pp.265-272
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• 2017

Aryl hydrocarbons such as 3-nitrobenzanthrone (NBA), 4-aminobiphenyl (ABP), acetylaminofluorene (AAF), benzo(a)pyrene (BaP), and 1-nitropyrene (NP) form bulky DNA adducts when absorbed by mammalian cells. These chemicals are metabolically activated to reactive forms in mammalian cells and preferentially get attached covalently to the $N^2$ or C8 positions of guanine or the $N^6$ position of adenine. The proportion of $N^2$ and C8 guanine adducts in DNA differs among chemicals. Although these adducts block DNA replication, cells have a mechanism allowing to continue replication by bypassing these adducts: translesion DNA synthesis (TLS). TLS is performed by translesion DNA polymerases-Pol ${\eta}$, ${\kappa}$, ${\iota}$, and ${\zeta}$ and Rev1-in an error-free or error-prone manner. Regarding the NBA adducts, namely, 2-(2'-deoxyguanosin-$N^2$-yl)-3-aminobenzanthrone (dG-$N^2$-ABA) and N-(2'-deoxyguanosin-8-yl)-3-aminobenzanthrone (dG-C8-ABA), dG-$N^2$-ABA is produced more often than dG-C8-ABA, whereas dG-C8-ABA blocks DNA replication more strongly than dG-$N^2$-ABA. dG-$N^2$-ABA allows for a less error-prone bypass than dG-C8-ABA does. Pol ${\eta}$ and ${\kappa}$ are stronger contributors to TLS over dG-C8-ABA, and Pol ${\kappa}$ bypasses dG-C8-ABA in an error-prone manner. TLS efficiency and error-proneness are affected by the sequences surrounding the adduct, as demonstrated in our previous study on an ABP adduct, N-(2'-deoxyguanosine-8-yl)-4-aminobiphenyl (dG-C8-ABP). Elucidation of the general mechanisms determining efficiency, error-proneness, and the polymerases involved in TLS over various adducts is the next step in the research on TLS. These TLS studies will clarify the mechanisms underlying aryl hydrocarbon mutagenesis and carcinogenesis in more detail.

• Molecular & Cellular Toxicology
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• v.5 no.2
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• pp.160-164
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• 2009

Notch signaling plays a crucial role in development of the nervous system. Neurodevelopmental hypothesis on etiology of schizophrenia has been implicated. The aim of this study is to determine whether single nucleotide polymorphisms (SNPs) of Notch homolog 4 (Drosophila) (NOTCH4) gene are associated with schizophrenia. This study included 283 schizophrenia patients diagnosed according to DSM-IV and 301 normal control subjects. Control subjects without history of psychiatric disorders were recruited. Four missense SNPs [rs915894 (exon 3, Lys117Gln), rs2071282 (exon 4, Pro204Leu), rs422951 (exon 6, Thr320Ala), and rs17604492 (exon 18, Gly942Arg)] of NOTCH4 gene were genotyped by the direct sequencing method. Multiple logistic regression models (codominant, dominant, and recessive models) were employed to evaluate odds ratio, 95% confidence interval, and p value. For analysis of genetic data, SNPStats, Haploview, HapAnalyzer, SNPAnalyzer, and Helixtree programs were also used. Of 4 SNPs, rs2071282 was weekly associated with schizophrenia in two alternative models (codominant model, P=0.049; dominant, P=0.041). However, these associations were not significant after Bonferroni correction. At 4 SNPs, one linkage disequilibrium (LD) block was made. This block consisted of rs915894 and rs2071282. In haplotype analysis, AC haplotype was weakly associated with schizophrenia (dominant, P=0.04). This association was disappeared after Bonferroni correction. Our result shows possibility that some SNPs of NOTCH4 gene may be weekly associated with development of schizophrenia in Korean population. However, replication result by other population will be needed.