• Nuclear Engineering and Technology
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• v.50 no.8
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• pp.1330-1338
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• 2018

High-density UMo/Zr monolithic nuclear fuel plates have a promising application prospect in high flux research and test reactors. The solid state welding method called co-rolling is used for their fabrication. Hot co-rolling simulations for the composite blanks of UMo/Zr monolithic nuclear fuel plates are performed. The effects of coupon sizes and mechanical property parameters on the contact pressures between the to-be-bonded surfaces are investigated and analyzed. The numerical simulation results indicate that 1) the maximum contact pressures between the fuel coupon and the Zircaloy cover exist near the central line along the plate length direction; as a whole the contact pressures decrease toward the edges in the plate width direction; and lower contact pressures appear at a large zone near the coupon corner, where de-bonding is easy to take place in the in-pile irradiation environments; 2) the maximum contact pressures between the fuel coupon and the Zircaloy parts increase with the initial coupon thickness; after reaching a certain thickness value, the contact pressures hardly change, which was mainly induced by the complex deformation mechanism and special mechanical constitutive relation of fuel coupon; 3) softer fuel coupon will result in lower contact pressures and form interfaces being more out-of-flatness.

• Transactions of Materials Processing
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• v.25 no.1
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• pp.12-20
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• 2016

Press machines and dies are commonly used for 3D curved sheet forming. Using conventional die forming can cause economic problems since various modifications of the die shape are required depending on the product shape. Various types of flexible forming such as multi-point dieless forming (MDF), flexible incremental roll forming have been developed to improve the needed process flexibility. Although MDF can reduce the production cost using reconfigurable dies, it still has significant material loss. Drawbacks such as wrinkling, dimpling, and forming errors can also occur despite continuous investigations to mitigate these defects. A novel sheet forming process for 3D curved surfaces, a flexibly-reconfigurable roll forming (FRRF), has been recently proposed to overcome the economic and technical limitations of current practice. FRRF has no limitation on blank size in the longitudinal direction, and also minimizes or eliminates forming defects such as wrinkling and dimpling. Feasibility studies of FRRF have been conducted using FE simulations for multi-curved shapes and various sheet thicknesses. Therefore, the fabrication of a FRRF apparatus is required for any follow-up studies. In the current study, experiments with reconfigurable rollers were conducted using a simple design pre-FRRF apparatus prior to fabricating the full size FRRF apparatus. There are three candidates for the reconfigurable roller: a bar-type shaft, a flexible shaft, a ground flexible shaft. Among these candidates, the suitable reconfigurable roller for FRRF is determined through various forming tests.

• Membrane Journal
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• v.21 no.4
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• pp.377-388
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• 2011

Flat sheet microfiltration membranes were prepared with polysulfone (PSF), polyethersulfone (PES), and polyphenylsulfone (PPS) by an immersion precipitation phase inversion method. In this method, dimethyl formamide (DMF) and polyvinylpyrrolidone (PVP) were used as a solvent and a wetting polymer additive, respectively. 2-butoxyethanol (BE) was used as a nonsolvent additive catalyst to form pore. The morphology of membranes was investigated by scanning electron microscopy and micropermporometer. The permeability of the membranes was evaluated with the flux of pure water. When the BE was added, the pore size of membranes became larger than blank membranes. The changes in the morphology of membrane due to the BE addition depend on polymer structure. All membranes have similar mean pore size and porosity. The mean pore sizes of PSF, PES, and PPS membranes were 0.282, 0.330 $0.308{\mu}m$, respectively. The porosities of PSF, PES and PPS membranes were 68.5, 66.1, 66.4%, respectively. However, the PPS membrane showed higher pore density on surface and narrower pore size distribution than PSF or PES membrane does. As a result, the pure water flux of PPS membrane ($357L/m^2\;hr$) was higher than that of PSF ($196L/m^2\;hr$) or PES membrane ($214L/m^2\;hr$).

• Transactions of Materials Processing
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• v.15 no.6 s.87
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• pp.445-452
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• 2006

In most of automobile body panel manufacturing, trimming process is generally performed before flanging. To find feasible trimming line is crucial in obtaining accurate edge profile after flanging. Section-based method develops blank along manually chosen section planes and find trimming line by generating loop of end points. This method suffers from inaccurate results of edge profile. On the other hand, simulation-based method can produce more accurate trimming line by iterative strategy. In this study, new fast simulation-based method to find feasible trimming line is proposed. Finite element inverse method is used to analyze the flanging process because final shape after flanging can be explicitly defined and most of strain paths are simple in flanging. In utilizing finite element inverse method, the main obstacle is the initial guess generation for general mesh. Robust initial guess generation method is developed to handle genera] mesh with very different size and undercut. The new method develops final triangular mesh incrementally onto the drawing tool surface. Also in order to remedy mesh distortion during development, energy minimization technique is utilized. Trimming line is extracted from the outer boundary after finite element inverse method simulation. This method has many advantages since trimming line can be obtained in the early design stage. The developed method is verified by shrink/stretch flange forming and successfully applied to the complex industrial applications such as door outer flanging process.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.12
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• pp.6363-6368
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• 2012

Objective: The study aim was to prepare poly-DL-lactide-poly (PELA) microspheres encapsulating recombinant tissue inhibitors of metalloproteinase-1 (TIMP-1) in an adenovirus to investigate its inhibition on the proliferation of hepatocellular carcinoma cells HepG2. Methods: Microspheres were prepared by encapsulating the recombinant TIMP-1 adenovirus into biodegradable PELA. The particle size, viral load, encapsulation efficiency and in-vitro release were measured. Microspheres were used to infect HepG2 cells, then infection efficiency was examined under a fluorescent microscope and ultrastructural changes assessed by TEM. Expression of TIMP-1 mRNA in HepG2 cells was examined by semi-quantitative RT-PCR and proliferation by MTT and cell growth curve assays. Results: We successfully prepared microspheres encapsulating recombinant TIMP-1 adenovirus with a diameter of $1.965{\mu}m$, an encapsulation efficiency of 60.0%, a viral load of $10.5{\times}10^8/mg$ and approximate 60% of virus release within 120 h, the total releasing time of which was longer than 240 h. The microspheres were confirmed to be non-toxic with blank microspheres. Infected HepG2 cells could stably maintain in-vitro expression of TIMP-1, with significantly effects on biological behaviour Conclusion: PELA microspheres encapsulating a recombinant TIMP-1 adenovirus can markedly inhibit the proliferation of HepG2 cells, which provides an experimental basis for polymer/chemistry-based gene therapy of hepatocellular carcinomas.

• Journal of Welding and Joining
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• v.20 no.3
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• pp.122-128
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• 2002

The laser welding in the automotive industries has been used widely for the butt joint of blank sheets rather than the lap joint of automotive body panels. But as a substitute far the spot welding of automotive body panels, the so called three dimensional laser welding will be important far the body panel engineers. Specially the laser welding of body panels with a smooth weld line is applied increasingly, for example, to the side panels. So far, some criteria of the laser weld quality was suggested by in-house regulations or national standards from experiences and/or rule of thumbs. In the manufacturing places, a go or no-go criterion is adopted because of the simplicity or a lack of rational criteria. It is true specially for the selection of the process parameters, which gives the basic causes for the good quality of laser welds. In this study, the effects of joint combination, gap and welding speed on the lap joint $CO_2$ laser welding of two mild steel sheets with different thicknesses are obtained through a $2{\times}3{\times}7$ factorial experiment. The results of the weld quality are statistically analysed using analysis of variance (ANOVA) and compared between two characteristic zones, which are separated by the type of sectional shapes and the level of input energy per volume. The thickness combinations are 0.8mm/1.2mm, 1.2mm/0.8mm of mild steel sheets. The welding speed covers from the deep penetration to the partial penetration. The gap size has three levels of no-gap, 0.16m, and 0.26mm. The bead width, penetration depth and input energy per volume are measured and used as the weld quality criteria.

• Publications of The Korean Astronomical Society
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• v.11 no.1
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• pp.109-123
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• 1996

We have developed a 5GHz continuum receiver system. The receiver is a direct type receiver. In order to reduce the noise due to the fluctuation of the gain in the amplifiers, the system employs the Dicke switching method. We made the 5GHz low-noise amplifier and the bandpass filter. The low-noise amplifier gives ${\sim}35dB$ gain and has ${\sim}210K$ noise temperature. The bandpass filter has a passband between 4.3 and 5.4GHz. We also made switch driver, video amplifiers, phase detector, and integrator. Using a 1.8 meter offset parabolic antenna, we measured the efficiency of the system. Since the antenna does not have a driver to track objects, observations were performed with the antenna fixed. The measured noise temperature of the system is ${\sim}650K$. From the observation of the blank sky, noise level was measured. It was found that the systematic noise(${\sim}0.5K$: peak to peak value) is much larger than the thermal noise. The systematic noise is possibly related to the stability of the DC power supplied to the receiver system. Besides the noise of the system, it was found that the airplanes are the very serious noise sources. We measured the radio flux of the Sun using the developed system. The observed radio flux of the Sun is ${\sim}10^6Jy$, which is close to the known value of the quiet Sun. The test observation of the Sun shows that the angular beam size of the antenna is ${\sim}2.2^{\circ}$.

• Journal of Pharmaceutical Investigation
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• v.27 no.4
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• pp.303-311
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• 1997

Proliposomal patch of clenbuterol, ${\beta}_2-agonist$ bronchodilator, was prepared and its feasibility as a novel transdermal drug delivery system was examined. Proliposomal granules containing clenbuterol was prepared by a standard method using sorbitol and lecithin with (Rx 2) or without cholesterol (Rx 1). The porous structure of sorbitol in the proliposomes was maintained allowing tree flowability of the granules. Following contact with water, the granules were converted probably to liposomes almost completely within several minutes. It indicates that proliposomes may be hydrated, when they are applied on the skin under occlusive condition in vivo, by the sweat to form liposomes. Clenbuterol release from Rx 1 and Rx 2 proliposomes to pH 7.4 isotonic phospate buffer (PBS) across cellulose membrane (mol. wt. cut-off of 12000-14000) was retarded significantly compared with that from the mixture of clenbuterol powder and blank proliposomes. Interestingly, proliposomes prepared with lecithin and cholesterol (i.e., Rx 2 proliposomes) showed much more retarded release of clenbuterol than proliposomes prepared only with lecithin (i.e.. Rx 1 proliposomes), indicating that clenbuterol release from proliposomes can be controlled by the addition of cholesterol to the proliposomes. Proliposomal patches were prepared using PVC film as an occlusive backing sheet, two sides adhesive tape (urethane, 1.45 mm thickness) as a reservoir for proliposome granules and Millipore MF-membrane (0.45 mm pore size) as a drug release-controlling membrane. Rx 1 or Rx 2 proliposomes containing 4.6 mg of clenbuterol were loaded into the reservoir of the patch. Clenbuterol release from the patches to pH 7.4 PBS was determined using USP paddle (50 rpm)-over-disc release method. Clenbuterol release from the proliposomal patches was much more retarded even than from a matrix type clenbuterol patch (Boehringer Ingelheim ltd). Being consistent with clenbuterol release from the proliposomal granules, the release from the patches was highly dependent on the presence of cholesterol in the proliposomes : Patches containing Rx 2 proliposomes showed several fold slower drug release than patches containing Rx 1 proliposomes. When the patch containing Rx 1 proliposomes was applied on to the back of a hair-removed rat, clenbuterol concentration in the rat blood was maintained during 6-72 hrs. Transdermal absorption of clenbuterol from the patch was accelerated when the patch was prehydrated with 50 ml of pH 7.4 PBS before topical application. Above results indicate that sustained transdermal delivery of clenbuterol is feasible using proliposomal patches if the cholesterol content and pore size of the release rate-controlling membrane of patches, for example, are appropriately controlled.

• Analytical Science and Technology
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• v.28 no.5
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• pp.309-316
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• 2015

The analytical method of lead in plasma by ICP-MS was validated after securing environment within class 1,000 classification. We tested specificity and accuracy of within-run and between-run. According to measurement of the amount of suspended particulates in a clean room, 0.3~62 particles were detected in 0.3 µm size while 0.0~28.3 particles were observed in 0.5 µm size. Total suspended particulates met required environment with up to 90.3 particles. The MDL (Method detection limit) of the sample which has been fabricated using fetal bovine serum (FBS) blank was 1.77 ng/L, and LOQ (Limit of quantification) was 5.55 ng/L. The slope, intercept and correlation coefficient of the calibration curve were y=1.09×10⁻³x+4.88×10⁻² and r=0.9999, which showed good correlation. The specificity, within-run and between-run accuracy satisfied the standard at more than 50 ng/L. The average lead concentration in plasma of the general people, current workers and retired workers was 55.4 ng/L, 440 ng/L, and 132 ng/L.

• Proceedings of the Korean Radioactive Waste Society Conference
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• 2005.06a
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• pp.239-247
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• 2005

In this study, an experimental study on the sorption properties of uranium(VI) onto bentonite colloids generated from a domestic calcium bentonite (called as Gyeongju bentonite). Gyeongju bentonite has been considered as a potential candidate buffer material in the Korean disposal concept for high-level radioactive wastes. The size and concentration of the bentonite colloids used in the sorption experiment were measured by a filtration method. The result showed that the concentration of the synthesized bentonite colloid suspension was 5100ppm and the size of the most of bentonite colloids(over $98\%$) was in the range of 200-450nm in diameter. The amount of uranium lost by the sorption onto bottle walls, by precipitation, and by ultrafiltration or colloid formation was analyzed by carrying out some blank tests. The loss of uranium by the ultrafiltration was significant in the lower ionic strength(i.e., in the case of 0.001M $NaClO_4$) due to the cationic sorption effect onto the ultrafilter by a surface charge reversion. The distribution coefficient (or pseudo-colloid formation constant) for the sorption of uranium(VI) onto bentonite colloids was $10^4^{\sim}10^6$ mL/g depending upon pH and the distribution coefficient was highest in the neutral pH around 6.5.