• Title/Summary/Keyword: Bland-Altman Plot

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Statistical Analysis of Agreement by Q-Q plot (Q-Q 플롯에 의한 Agreement의 통계적 분석)

  • Lee, Jae-Young;Rhee, Seong-Won;Lee, Jae-Woo
    • Journal of the Korean Data and Information Science Society
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    • v.9 no.1
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    • pp.11-18
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    • 1998
  • In clinical measurement comparison of a new measurement technique with an established one is often needed to see whether they agree sufficiently for the new to replace the old. Such investigations are often analysed inappropriately, notably by using the correlation coefficient(r). So, the measurement for agreement was determined by Bland & Altman's method recently. In this article, we will analyse the measurement for agreement by using Q-Q plot and by applying Bland and Altman's method through graph. And we will show characteristics for these techniques.

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Prediction of Energy Expenditure by Using a Tri-axial Accelerometer (단일 3축 가속도센서를 사용한 보행 시 대사에너지 예측)

  • Lee, Hee-Young;Kim, Seung-Hyeon;Lee, Dong-Yeop;Park, Sun-Woo;Kim, Young-Ho
    • Korean Journal of Applied Biomechanics
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    • v.21 no.2
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    • pp.253-258
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    • 2011
  • The purpose of this study was to compare metabolic energy expenditure with the computed kinetic energy for different speeds of walking and running over the treadmill and to find the relevance for individual and group equation by performing a statistical analysis, Bland-Altman plot. Seven male subjects participated, and they were required to walk and run on the treadmill with the gas analyzer and triaxial accelerometer. Walking speeds were 3.0, 4.0, 5.0 and 6.0 km/h and running speeds were 7.0, 8.0 and 9.0 km/h respectively. Kinetic energy was calculated by the integration of acceleration data and compared with the metabolic energy measured by a gas analyzer. Correlation coefficients showed relatively good between the measured metabolic energy and the calculated kinetic energy. In addition, a dramatic increase in kinetic energy was also observed at the transition speed of walking and running, and two standard deviations in Bland-Altman plot, derived from the difference between measured and predicted values, were 1.14, 2.53, 2.93, 1.80, 2.80, 0.60 and 2.48 respectively. It was showed that there is no difference for methods of how to predict the kinetic energy expenditure for individual and group even though people had each different physical characteristic.

Assessment of Early Dental Caries by Using Optical Coherence Tomography (Optical Coherence Tomography를 이용한 초기 치아우식 검사)

  • Min, Ji-Hyun
    • Journal of dental hygiene science
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    • v.16 no.4
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    • pp.257-262
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    • 2016
  • The purpose of this study was to assess the correlation between integrated mineral loss (volume % mineral${\times}{\mu}m$, ${\Delta}Z_{TMR}$) determined using transverse microradiography (TMR) and integrated reflectivity ($dB{\times}{\mu}m$, ${\Delta}R_{OCT}$) determined using optical coherence tomography (OCT) for detecting early dental caries with lesion depth more than $200{\mu}m$. Sixty tooth specimens were made from sound bovine teeth. They were immersed in a demineralized solution for 20, 30, and 40 days. The ${\Delta}R_{OCT}$ was obtained from the cross-sectional OCT image. The ${\Delta}Z_{TMR}$ was obtained from the TMR image. The correlation between ${\Delta}R_{OCT}$ and ${\Delta}Z_{TMR}$ was examined using Pearson correlation. The Bland-Altman plot was constructed using the ${\Delta}R_{OCT}$ and ${\Delta}Z_{TMR}$ values. A significant correlation between ${\Delta}R_{OCT}$ and ${\Delta}Z_{TMR}$ was confirmed (r=0.491, p=0.003). Moreover, most of the difference between ${\Delta}R_{OCT}$ and ${\Delta}Z_{TMR}$ was included in the error section of the Bland-Altman plot. Therefore, OCT could be used as a substitute for TMR when analyzing mineral loss in early dental caries.

A Comparative Study on Measurement of Physical Activity between Smartphone App and Self-Reported Questionnaire (스마트폰 앱과 자가보고식 설문지의 신체활동 측정 비교)

  • Suh, Minhee;Seo, Kyoungsan
    • Journal of muscle and joint health
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    • v.29 no.2
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    • pp.91-99
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    • 2022
  • Purpose: The purpose of this study was to examine the level of agreement between smartphone apps and self-reported physical activity questionnaires. Methods: Quantitative methods were used to assess the correlation and agreement between the number of steps counted by a smartphone app and the amount of walking reported in a survey. A total of 29 adults who used smartphones were recruited from a university, and their step counts from their smartphone pedometers and responses to the international physical activity questionnaire (IPAQ) were collected over a 10-week period. Results: An analysis of 170 data pairs with Spearman's rho correlation and a Bland-Altman plot revealed a positive correlation between step counts from the smartphone app and walking activity from the IPAQ. The Bland-Altman plot also demonstrated the agreement to be improved among female participants. Conclusion: In assessing walking activity, smartphone pedometer apps showed good correlation with the IPAQ and improved agreement with the IPAQ among women. Therefore, it is suggested that the participants' gender and activity intensity, as well as the accuracy of measurement tools, should be considered in an evaluation of the delivery of physical activity promotion programs through smartphone apps.

Hematocrit Determination using a Volumetric Absorptive Microsampling Technique in Patients with Pancreatic Cancer

  • Yeolmae Jung;Seunghyun Yoo;Minseo Kang;Hayun Lim;Myeong Hwan Lee;Ji Kon Ryu;Jangik Lee
    • Korean Journal of Clinical Pharmacy
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    • v.33 no.3
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    • pp.195-201
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    • 2023
  • Background: Hematocrit is usually measured from venous blood collected by invasive venipuncture. This study was performed to determine hematocrit accurately and precisely using minimally invasive volumetric absorptive microsampling (VAMS) technique. Such technique is to be applied to determining hematocrit in various clinical settings for the care, including therapeutic drug monitoring, of neonatal or epileptic patients, or patients with high risk of infection or bleeding. Methods: The study was performed using 31 VAMS samples obtained from 21 pancreatic cancer patients. Hematocrit was determined using the values of potassium concentrations obtained from blood in VAMS tips (HctVAMS). HctVAMS was compared with hematocrit measured from blood collected by venipuncture (HctVP). The accuracy and precision of HctVAMS in comparison to HctVP were evaluated using Bland-Altman plot, Deming regression and mountain plot. Results: Bland-Altman plot displayed a random scattering pattern of the differences between HctVAMS and HctVP with the mean bias of -0.010 and the 95% limit of agreement ranging from -0.063 to 0.044. Deming regression for HctVAMS and HctVP line demonstrated very small proportional and constant biases of 1.04 and -0.003, respectively. Mountain plot exhibited a narrow and symmetrical distribution of the differences with their median of -0.011 and central 95% range from -0.049 to 0.033. Conclusion: Hematocrit was accurately and precisely determined using less invasive VAMS technique. Such technique appears to be applicable to determining hematocrit in situations that venipuncture is not favorable or possible.

Validation of acid-base titration equivalence between spectroscopic titrator (SPT) and conventional titrators (분광학적 적정기(SPT)와 기존 적정기의 산-염기 적정 동등성 검증)

  • Shin, Jiwon;Kim, Yeajin;Lee, Hyoseong;Shin, Jisun;Yoo, Hyein;Chae, Won-Seok
    • Analytical Science and Technology
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    • v.34 no.6
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    • pp.267-274
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    • 2021
  • Acid-base titration experiments were carried out using the same sample to obtain a direct comparison of analysis results between a new titrator and conventional Spectrator (SPT) titrators. This allowed the confirmation of an endpoint both by spectroscopic detection and by conventional titrators (automatic burette (ABT) and autotitrator (ATT)). Statistical analysis was performed on the measured values (endpoints) obtained using different titrators, to assess their differences by comparison of straightness, equivalence, ANOVA, F-test, and t-test results. The coefficients of determination, confirmed by straightness, were all >0.999. Thus, the null hypothesis that there was no statistical difference could not be rejected. The Bland-Altman analysis method was used to confirm agreement with the new experimental method. No discrepancy was found in the measured values obtained using different titrators used in this study.

Statistical Test of Agreement between Measurements in Method-comparison Study (검사법의 일치도 평가를 위한 분석기법)

  • Pak, Son-Il;Oh, Tae-Ho
    • Journal of Veterinary Clinics
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    • v.28 no.1
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    • pp.108-112
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    • 2011
  • In clinical settings, researchers often want to assess agreement between two measurements (or tests) of the same continuous variable. For example, when new point-of-care analyzer for testing blood glucose level were introduced clinicians need to compare results from standard or established laboratory method of measurement to those of new or point-of-care analyzer. The question in a method-comparison study would either of two different methods be used to measure the same variable equivalently. In this paper common misuse of statistical methodologies seen in the medical literatures such as correlation coefficient and paired t-test are discussed. The Bland-Altman technique has been widely used for this purpose and provides a graphic in presentation of the findings from a method-comparison study, with a mean value of measurement, this bias and the limits of agreement. For ease of application and interpretation of this technique we discussed the analysis procedure and illustrated with two worked examples. Finally, a number of alternative ways in which data can be analysed and reported in such studies were reviewed.

Statistical methods for accessing agreement between repeated measurements in dental research (치의학 연구에서 반복 계측한 자료의 일치도 평가방법)

  • Kim, Ki-Yeol
    • The Journal of the Korean dental association
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    • v.54 no.11
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    • pp.880-896
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    • 2016
  • The comparison of the repeated measurements is often needed to see whether they agree sufficiently, when a measurement is repeated under identical conditions by different raters. Such investigations are often analyzed inappropriately, by using correlation coefficient. The purpose of this study is to introduce statistical methods for accessing the agreement of the repeated measurements, which include Bland-Altman plot, intra class correlation, Passing-Bablok regression and Cohen's kappa coefficient, and to show how to execute them using examples.

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Determination of midsagittal plane for evaluation of facial asymmetry using three-dimensional computed tomography

  • Kim, Tae-Young;Baik, Jee-Seon;Park, Joo-Young;Chae, Hwa-Sung;Huh, Kyung-Hoe;Choi, Soon-Chul
    • Imaging Science in Dentistry
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    • v.41 no.2
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    • pp.79-84
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    • 2011
  • Purpose : The aim of the present study was to investigate the disagreement of cephalometric analysis depending on the reference determination of midsagittal plane on three-dimensional computed tomography. Materials and Methods : A total of 102 young women with class III dentofacial deformity were evaluated using three-dimensional computed tomography. The cranial and facial midsagittal planes were defined and the amounts of jaw deviation were calculated. The amounts of jaw deviation were compared with paired t-test (2-tailed) and Bland-Altman plot was drawn. Results : The landmark tracing were reproducible ($r{\ge}.978$). The jaws relative to the cranial midsagittal plane were 10-17 times more significantly deviated than to the facial midsagittal plane (P<.001). Bland-Altman plot demonstrated that the differences between the amounts of jaw deviation from two midsagittal planes were not normally distributed versus the average of the amounts of jaw deviation from two midsagittal planes. Conclusion : The cephalometric analyses of facial asymmetry were significantly inconsistent depending on the reference determination of midsagittal plane. The reference for midsagittal plane should be carefully determined in three-dimensional cephalometric analysis of facial asymmetry of patients with class III dentofacial deformity.

The accuracy of linear measurements of maxillary and mandibular edentulous sites in conebeam computed tomography images with different fields of view and voxel sizes under simulated clinical conditions

  • Ganguly, Rumpa;Ramesh, Aruna;Pagni, Sarah
    • Imaging Science in Dentistry
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    • v.46 no.2
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    • pp.93-101
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    • 2016
  • Purpose: The objective of this study was to investigate the effect of varying resolutions of cone-beam computed tomography images on the accuracy of linear measurements of edentulous areas in human cadaver heads. Intact cadaver heads were used to simulate a clinical situation. Materials and Methods: Fiduciary markers were placed in the edentulous areas of 4 intact embalmed cadaver heads. The heads were scanned with two different CBCT units using a large field of view ($13cm{\times}16cm$) and small field of view ($5cm{\times}8cm$) at varying voxel sizes (0.3 mm, 0.2 mm, and 0.16 mm). The ground truth was established with digital caliper measurements. The imaging measurements were then compared with caliper measurements to determine accuracy. Results: The Wilcoxon signed rank test revealed no statistically significant difference between the medians of the physical measurements obtained with calipers and the medians of the CBCT measurements. A comparison of accuracy among the different imaging protocols revealed no significant differences as determined by the Friedman test. The intraclass correlation coefficient was 0.961, indicating excellent reproducibility. Inter-observer variability was determined graphically with a Bland-Altman plot and by calculating the intraclass correlation coefficient. The Bland-Altman plot indicated very good reproducibility for smaller measurements but larger discrepancies with larger measurements. Conclusion: The CBCT-based linear measurements in the edentulous sites using different voxel sizes and FOVs are accurate compared with the direct caliper measurements of these sites. Higher resolution CBCT images with smaller voxel size did not result in greater accuracy of the linear measurements.