• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.24 no.2
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• pp.238-243
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• 2021

Caudal regression syndrome (CRS) is a rare neural tube defect that affects the terminal spinal segment, manifesting as neurological deficits and structural anomalies in the lower body. We report a case of a 31-month-old boy presenting with constipation who had long been considered to have functional constipation but was finally confirmed to have CRS. Small, flat buttocks with bilateral buttock dimples and a short intergluteal cleft were identified on close examination. Plain radiographs of the abdomen, retrospectively reviewed, revealed the absence of the distal sacrum and the coccyx. During the 5-year follow-up period, we could find his long-term clinical course showing bowel and bladder dysfunction without progressive neurologic deficits. We present this case to highlight the fact that a precise physical examination, along with a close evaluation of plain radiographs encompassing the sacrum, is necessary with a strong suspicion of spinal dysraphism when confronting a child with chronic constipation despite the absence of neurologic deficits or gross structural anomalies.

• The Journal of Korean Medicine
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• v.16 no.1 s.29
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• pp.9-20
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• 1995

I would like to state my own opinion on arthralgia syndrome(痺病) through the literatural studies. First of all, arthralgia symdrome(痺病) must be classified into six type basically, which are migratory arthralgia(痺病(行痺)), arthritis of heat type(濕痺), arthritis due to blood stasis(瘀血痺) and deficient rheumatism(虛痺), and then could be considered to try the compound names of arthralgia syndrome. These can come from according to the rise and decline of causes in wind(風), cold(寒), damp(濕), heat(熱), blood stasis(瘀血) and qi-blood(氣血). For example, it would be possible to apply the wind-dampness rheymatism(風濕痺) of damp-heat rheumatism(濕熱痺) in terminology of arthralgia syndrome(痺病). As rheumatoid arthritis(歷節風), rheumatoid arthritis like white tiger bite (白虎歷節風) and gout (痛風) not to mean the gout in western medicine have been announced a kind of arthralgia syndromes(痺病) by many doctors since Ming dynasty(明代) and proved it to be true, it is reasonabie not to try it any longer. And tingling and deficiency of sensation(廢木 不仁) is a symptome showing the decline of muscle power including mainly the abnormal sensation of skin, it would be recommended to be classified into fliaccidity syndrome(?痺). And then the names rheumatism invoiving lendon and ligament(筋痺), rheumatism involving blood vessels(脈痺), rheumatism involving muscle(肌痺), numbness of skin (皮痺) and rheumatism involving bone(骨痺), which have been used as the classification title with the season be received bad-qi(邪氣), must be classlfied to the location appearing aymptomes. Though obstruction of the liver-qi(肝痺), obstruction of the heart-qi(心痺), stagnation of the spleen-qi(脾痺), stagnation of the lung-qi(肺痺), stagnation of the kidney-qi(腎痺) and dysfunction of the bladder(胞痺) that used visceral and bladder name, that stated a kind of arthralgia syndrome(痺病), but it must be classified into a different diseases from arthragia syndrome.

• Korean Journal of Acupuncture
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• v.21 no.3
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• pp.147-158
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• 2004

Objectives : This study was aimed to investigate the methods for acupuncture and moxibustional treatment to insomnia Methods : The insomnia is classified by seven cause at main subject. According to this, arrange the acupuncture and moxibustional treatment for classical books, and explain eight meridian related to insomnia. Results : 1. Insomnia means deficiency of sleeping and it is the word generally used when a short period of sleeping, difficulty for deep sleeping and difficulty for recovery of original vital energy comes out. In oriental medicine, they understand that uneasiness condition occurred by abnormal operation of the internal organs as heart, liver, gallbladder, spleen, stomach, kidney, etc. caused by external affection or internal injury becomes Insomnia. 2. Cause of insomnia can be classified majorly as fire-transformation of liver and gallbladder , inner shaking of phlegm-heat , insufficiency of both the heart and the spleen, disharmony between heat and kidney, the dysfunction of the stomach, timidity of heart and gallbladder, the deficiency of Qi of the lung. They make insomnia with bad influence upon body and spirit. 3. The meridian system such as Heart Meridian of Hand Soeum, Pericardium Meridian of Hand Gworeum, Stomach Meridian of Foot Yangmyeong, Spleen Meridian of Foot Taeeum, Bladder Meridian of Foot Taeyang, Kidney Meridian of Foot Soeum, Gallbladder Meridian of Foot Soyang, Liver Meridian of Foot Gworeum and Lung Meridian of Hand Taeeum are used to treat insomnia. Sinmun acupoint and Naegwan acupoint are often used in particular because the they are good for calmming the spirit, the heart and purging the heart of (pathogenic) fire. 4. Especialy, Back-Su points of Bladder Meridian of Foot Taeyang was used by each causes. The Back-su Points was mainly used for heal the insomnia because the Back-Su points has good competent to control the ability of internal organs by direct effect to it. It is because the vitality flows through around back-Su. Conclusions : It comes to a conclusion as follows with research for relevancy of the main cause of insomnia and meridian system includes meridian point.

• Childhood Kidney Diseases
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• v.19 no.2
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• pp.180-183
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• 2015

We report the case of a 14-year-old girl who visited the emergency room because of suprapubic discomfort and sudden acute urinary retention. She did not have any significant medical and surgical history, and her neurological examinations were all normal. Urinary catheterization led to the passage of 500 mL urine. Abdominal ultrasonography showed a hematocolpos that was compressing the urinary bladder. Gynecologic history taking revealed that the patient has not had menarche yet. Therefore, a cruciate incision was performed and her urination became normal. As the surgical outcome after adequate hymenotomy for imperforate hymen is usually good, the diagnosis of imperforate hymen is important. However, this condition is easily missed in the clinic because the first physician visited by the patient rarely takes a detailed gynecologic history or performs appropriate physical examinations. Although rare, imperforate hymen should be considered as a cause of acute urinary retention in the adolescence period. If an adolescent girl presents with abdominal pain and voiding dysfunction, a detailed gynecologic history and appropriate physical examinations of the genital introitus should be performed.

• Journal of Korean Neurosurgical Society
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• v.47 no.6
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• pp.473-476
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• 2010

Sacral nerve stimulation (SNS) is an effective treatment for bladder and bowel dysfunction, and also has a role in the treatment of chronic pelvic pain. We report two cases of intractable pain associated with cauda equina syndrome (CES) that were treated successfully by SNS. The first patient suffered from intractable pelvic pain with urinary incontinence and fecal incontinence after surgery for a herniated lumbar disc. The second patient underwent surgery for treatment of a burst fracture and developed intractable pelvic area pain, right leg pain, excessive urinary frequency, urinary incontinence, voiding difficulty and constipation one year after surgery. A SNS trial was performed on both patients. Both patients' pain was significantly improved and urinary symptoms were much relieved. Neuromodulation of the sacral nerves is an effective treatment for idiopathic urinary frequency, urgency, and urge incontinence. Sacral neuromodulation has also been used to control various forms of pelvic pain. Although the mechanism of action of neuromodulation remains unexplained, numerous clinical success reports suggest that it is a therapy with efficacy and durability. From the results of our research, we believe that SNS can be a safe and effective option for the treatment of intractable pelvic pain with incomplete CES.

• Journal of Physiology & Pathology in Korean Medicine
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• v.21 no.4
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• pp.815-821
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• 2007

Concept of Cho was used both etiologically and symptomatically at the same time. Hwa was the main cause of diseases derived from Cho, and its damage is on Jin-Eum. Cho is one of the members of Euk-Eum, which belongs to Whae-In, but it is also recognized as pathogen of internal dysfunction, therefore symptoms can be classified into two groups. Whae-cho-zheung and Nae-cho-zheung. Organs related to Cho are lung, stomach, intestine, kidney, liver and gall Bladder. Symptoms of Whae-cho usually combines Pyo-zheung, manifesting on lung and skin, whereas symptoms of Nae-cho combines Rhee-zheung, manifesting on internal organs and tissues. In treating of Cho, Ja-eum-yang-hyul-chung-yeolis the main principle. Chung-Yun-Pe-Weis used in Whae-cho-zheung and Sang-cho-byung, while Yu-Yang-Gan-Shin is used in Nae-cho-zheung and Ha-cho-byung.

• Childhood Kidney Diseases
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• v.4 no.1
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• pp.69-76
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• 2000

Purpose: The Pathogenesis of primary noctllrnal enuresis(PNE) is still controversial. Genetic factor and maturational delay of micturition reflex including arousal disorder, lack of nocturnal Arginine Vasopressin(AVP) release and functional bladder capacity have been suggested. We analyzed the risk factors of PNE. Methods: Fifty five children with PNE (20 enuretics diagnosed at school physical examination of the first grade students at Mok-Dong Elementary School and 35 enuretics (Age 6-7 year) diagnosed at Ewha Womans University Mok Dong Hospital) and 221 control students without PNE at school physical examination were included. Genetic, stress and developmental factors, arousability, water intake, urine volume, maximun voiding volume and daytime voiding dysfunction were compared. Results: 1) There was no significant difference between PNE and control group in sex ratio, birth order, percentage of working mothers, parental and child personality, age to start walking, school record and duration of sleep. 2) Family history in the PNE group was significantly higher than control group ($20.0\%\;vs\;2.7\%$)(P<0.05). 3) The difficulty in arousal in the PNE group was significantly more common than the control group ($70.9\%\;vs\;54.3\%$)(P<0.05). 4) Nocturnal water intake in the PNE group was significantly greater than the control group ($330{\pm}158.2\;mL\;vs\;235{\pm}129.5\;mL$). Nocturnal urine volume in the PNE group was significantly greater than the control group ( $390{\pm}61.5\;mL\;vs\;140{\pm}43.2\;mL$)(P<0.05). Daily water intake and daily urine volume did not significantly differ between the two groups. 5) Maximum urine volume per void in the PNE group was significantly lower than the control group ($107{\pm}35.9\;mL\;vs\;236{\pm}41.3\;mL$). Daytime voiding dysfunction in the PNE group was significantly more common than the control group ($80.0\%\;vs\;57.9\%$). The voiding frequency in the PNE group was significantly greater than the control group ($7.0{\pm}3.6\;vs\;5.4{\pm}1.6$)(P<0.05). Conclusion: In addition to genetic factors and maturational delay of micturition reflex (difficulty in arousal, nocturnal polyuria and decreased functional bladder capacity) nocturnal polydypsia was found to be the important risk factors fur PNE. So nocturnal fluid restriction should be encouraged as the first-line management of PNE.

• Korean Journal of Medicinal Crop Science
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• v.25 no.4
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• pp.231-237
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• 2017

Background: Cisplatin is one of the most extensively used chemotherapeutic agents for the treatment of cancer, including bladder, and ovarian cancers. However, it has been shown to induce nephrotoxicity, despite being an outstanding anti-cancer drug. In this study, we investigated the protective effect of dopaol ${\beta}$-D-glucoside (dopaol) on cisplatin-induced nephrotoxicity. Methods and Results: To confirm the protective effect of dopaol on cisplatin-induced nephrotoxicity, HK-2 cells were treated with $20{\mu}M$ cisplatin and $80{\mu}M$ dopaol. Cisplatin increased apoptosis, caspase-3 activity and mitochondrial dysfunction; however pretreatment with $80{\mu}M$ dopaol successfully attenuated apoptosis, caspase-3 activity and mitochondrial dysfunction. To evaluate the protective effect dopaol on cisplatin-induced nephrotoxicity in vivo, we used an animal model (balb/c mice, 20 mg/kg, i.p. once/day for 3 day). The results were similar to those obtained using HK-2 cells; renal tubular damage and neutrophilia induced by cisplatin reduced following dopaol injection (10 mg/kg, i.p. once/day for 3 day). Conclusions: These results indicate that dopaol treatment reduced cisplatin-induced nephrotoxicity in vitro and in vivo, and can be used to treat cisplatin-induced nephrotoxicity. However, further studies are required to determine the toxicity high dose dopaol and the signal pathways involved in its mechanism of action in animal models.

• Journal of Korean Physical Therapy Science
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• v.3 no.2
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• pp.1011-1019
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• 1996

The incidence of spinal cord injury increase due to traffic accident, industrial accident and leisure sports. Spinal cord injury damages motor and sensory function below the injury level, also affects autonomic functions associated with voiding and defecation. Sexual dysfunction and psychosocial, vocational maladaptations are also some of the unwanted consequences of injury. The purpose of this study is look for means to prevent and to manage complications in spinal cord injury through investigation and analysis. The subjects of this study in spinal cord injured patients were admitted to the department of physical therapy, Kwangju christian Hospital, Nam Kwang Hospital, Chun Nam university Hospital and Cho Sun university Hospital, from April, 1, 1995 to March, 31, 1996. The results are as follows: 1. The subjects comprised 96 cases of spinal cord injury, ranging from 17 to 85(mean-40.8 yrs) and included 72 males and 24 females. Among these patients, 58 were cervical injury, 20 were thoracic injury and 18 were lumbar injury. 2. As for a major causative of spinal cord injury were traffic accident(59.4%), fall down (27.1 %), and motocycle(4.2%).. 3. The bladder control were taken by indwelling cathetar(41.7%), Crede maneuver(37.5%) and self voiding(16.7%). The bowel control were taken by all aid(61.5%), assitance(32.3%) and self defecation(6.2%). 4. Possible of sexual function were 35 cases (47.9%). 5. The device of transfer used wheel chair(69.8%) and bed(16.7%). 6. The patients with higher cord lesion got more serious pain than lower cord lesion. Also the patients with higher cord lesion got a serious spasticity. 7. The incidence of decubitus ulcer among 96 patients were in case 46(47.9%). The largest group of the pressure sore sites were sacral portion(82.0%), less than 1 month of onset occured a large numbers(50%). Incidence of pressure sore by spasticity occured many patients in case of mild or moderate. Incidence of pressure sore by pain occured many patients in case of severe pain.

• Journal of Korean Neurosurgical Society
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• v.29 no.8
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• pp.1037-1042
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• 2000

Objective : The goal of this study was to recognize the clinical feature and associated risk factors in spinal epidural abscess(SEA), and to improve the outcome accordingly. Methods : A retrospective study was performed in 14 patients with SEA who underwent surgical intervention at our hospital between 1990 and 1999. Results : After a mean follow-up period of 10.2 months(range, 1-57 months), 8 patients had no or minimal deficits, 4 patients had severe paresis or plegia and/or bowel/bladder dysfunction, and 2 patients died due to medical complications. Staphylococcus aureus was the predominant pathogen, isolated in 9 patients(64.3%). Cervical and thoracic spinal epidural abscesses showed a tendency to develop rapidly and were associated with severe neurological deficits. Conclusion : Thoracic spinal epidural abscesses were associated with a poorer prognosis than those in other regions. Therefore, it should be treated more aggressively. Good neurological recovery can be obtained despite severe neurologic deficit when treated by early diagnosis and prompt surgical intervention.