• Title/Summary/Keyword: Bivariate Measures

Search Result 27, Processing Time 0.022 seconds

Limited Diagnostic Value of microRNAs for Detecting Colorectal Cancer: A Meta-analysis

  • Zhou, Xuan-Jun;Dong, Zhao-Gang;Yang, Yong-Mei;Du, Lu-Tao;Zhang, Xin;Wang, Chuan-Xin
    • Asian Pacific Journal of Cancer Prevention
    • /
    • v.14 no.8
    • /
    • pp.4699-4704
    • /
    • 2013
  • Background: MicroRNAs have been demonstrated to play important roles in the development and progression of colorectal cancer. Several studies utilizing microRNAs as diagnostic biomarkers for colorectal cancer (CRC) have been reported. The aim of this meta-analysis was to comprehensively and quantitatively summarize the diagnostic value of microRNAs for detecting colorectal cancer. Methods: We searched PubMed, Embase and Cochrane Library for published studies that used microRNAs as biomarkers for the diagnosis of colorectal cancer. Summary estimates for sensitivity, specificity and other measures of accuracy of microRNAs in the diagnosis of colorectal cancer were calculated using the bivariate random effects model. A summary receiver operating characteristic (SROC) curve was also generated to summarize the overall effectiveness of the test. Result: Thirteen studies from twelve published articles met the inclusion criteria and were included. The overall sensitivity, specificity, positive likelihood ratio, negative likelihood ratio and diagnostic odd ratio of microRNAs for the diagnosis of colorectal cancer were 0.81 (95%CI: 0.79-0.84), 0.78 (95%CI: 0.75-0.82), 4.14 (95%CI: 2.90-5.92), 0.24 (95%CI: 0.19-0.30), and 19.2 (95%CI: 11.7-31.5), respectively. The area under the SROC curve was 0.89. Conclusions: The current evidence suggests that the microRNAs test might not be used alone as a screening tool for CRC. Combining microRNAs testing with other conventional tests such as FOBT may improve the diagnostic accuracy for detecting CRC.

Effect of combined application of manipulation and stabilization exercises on pain and spinal curvature in patients with chronic back Pain (도수 교정과 안정화 운동 복합적용이 만성 허리통증 환자의 통증과 척추 만곡도에 미치는 영향)

  • Jang, Jae Sun;Kim, Yong Nam
    • Journal of Korean Physical Therapy Science
    • /
    • v.29 no.2
    • /
    • pp.38-47
    • /
    • 2022
  • Background: The purpose of this study was to investigate the effect of the combined application of manipulation and stabilization exercises on pain and spinal curvature in patients with chronic back pain. Design: Randomized controlled trial Methods: The research subjects included 24 women in their 40s and 50s who have chronic back pain. The sample was evenly divided into an experimental group, which received the combined application of manipulation and stabilization exercises, and a control group, which received stabilization exercises only. The 30-minute intervention was applied five times a week for eight weeks. A bivariate repeated measures analysis of variances was conducted to identify the differences between the two groups before the experiment, after the fourth week, and at the end of the eight-week experiment. The level of statistical significance was set at.05. This analysis examined the within-group changes and the between-group changes using a paired t-test and an independent t-test, respectively. Results: Changes in pain differed significantly depending on the time of the measurement, the interaction between the time of the measurement and each group, and between the two groups (p<.05). Changes in the curvature of the bones of the neck, the bones of the back, and the lumbar vertebrae differed significantly depending on the time of the measurement and the interaction between the time of the measurement and each group (p<.05). Conclusion: The combined application of manipulation and stabilization exercises demonstrated a positive effect on changes in pain and spinal curvature, and the method is expected to be a useful intervention for reducing pain and improving spinal curvature in patients with back pain.

Evaluation on the implementation of the immunization registry program at the Public Health Centers (보건소 예방접종 전산프로그램의 운영 현황 분석)

  • 이건세;이석구;이무식;신의철;김영택;이연경
    • Health Policy and Management
    • /
    • v.13 no.2
    • /
    • pp.67-84
    • /
    • 2003
  • Immunization has been one of the most effective measures preventing from infectious diseases. However, children routine vaccination rate of Korea was 68.2% and it was not higher than expected. Korean government revised the School Health Law for every primary school children to submit the vaccination certificate record from 2005. It is quite important national Infectious disease prevention policy to keep the immunizations rate high and monitor the immunizations rate continuously. To do this, National Institute of Health introduced the National Immunization Registry(NIR) Program at 2000. Objective : The aims of this study was to evaluate the Immunization Registry program which has been implementing since 2000 at the Public Health Centers(PHC). Methods : The mail survey was done from November 2001 to January 2002. 169 (69%) Public Health Centers among 244 PHC were responded. Results : The respondents of PHC sud the Immunization Registry(IR) program had reduced the workload (18.5%). 69.2% said they inputted the immunization data into the IR program after the shots were given. 86.5% said they hadn´t checked or retrieved the children lists who had missed the scheduled immunization. Only 17.2% said the speed of internet for the R program was good. It showed that 20% of respondents hadn´t written down documents, records on immunization any more. Even there were a lot of negative results, the respondents of PHC thought that the IR program was effective. They especially agreed that the IR program could make the job accurate (81.5%), convenient (71.3%), and reduced the chances of making mistakes (71.3%), increase the service quality (78.5%). And they were well adapting the job process of the IR (79.63%). Bivariate analysis showed that the software program was the important determinants of IR success. The only Bit Computer software program has been evaluated to be less satisfactory than the Integrated (Posdata operating system + Bit software) program. Other variables, such as age, duration of present job, and location of PHC (metropolitan, small city, rural area) were not significantly related. Conclusion : It seemed that the success of NIR might depend on the software program. Because Integrated program, which has been developed from 1994, include not only the general operating and management program for PHC but also IR program. It was natural to prefer Integrated program to Bit software program. So we can suggest that it is essential for the NIR to be successful that not only the immunization software program but also hardware equipments and public health information system should be further improved.

Study on the Characteristics of Spatial Relationship between Heat Concentration and Heat-deepening Factors Using MODIS Based Heat Distribution Map (MODIS 기반의 열 분포도를 활용한 열 집중지역과 폭염 심화요인 간의 공간관계 특성 연구)

  • Kim, Boeun;Lee, Mihee;Lee, Dalgeun;Kim, Jinyoung
    • Korean Journal of Remote Sensing
    • /
    • v.36 no.5_4
    • /
    • pp.1153-1166
    • /
    • 2020
  • The purpose of this study was to analyze the spatial correlation between the heat distribution map of the satellite imaging base and the factors that deepen the heat wave, and to explore the heat concentration area and the space where the risk of future heat wave may increase. The global Moran's I of population, land use, and buildings, which are the causes of heat concentration and heat wave deepening, is found to be high and concentrated in specific spaces. According to the analysis results of local Moran's I, heat concentration areas appeared mainly in large cities such as metropolitan and metropolitan areas, and forests were dominant in areas with relatively low temperatures. Areas with high population growth rates were distributed in the surrounding areas of Gyeonggi-do, Daejeon, and Busan, and the use of land and buildings were concentrated in the metropolitan area and large cities. Analysis by Bivarate Local Moran's I has shown that population growth is high in heat-intensive areas, and that artificial and urban building environments and land use take place. The results of this research can lead to the ranking of heat concentration areas and explore areas with environments where heat concentration is concentrated nationwide and deepens it, so ultimately it is considered to contribute to the establishment of preemptive measures to deal with extreme heat.

Exploring Variables Related to Students' Understanding of the Convergence of Basic and Applied Science (기초과학과 응용과학의 융합에 관한 학생들의 이해와 관련된 변인 분석)

  • Ha, Min-Su;Lee, Jun-Ki
    • Journal of The Korean Association For Science Education
    • /
    • v.32 no.2
    • /
    • pp.320-330
    • /
    • 2012
  • Understanding the relation between basic science and applied science is important for students in understanding the importance of learning science, the relationship between scientific knowledge and human life, and for enhancing their science motivation. In this study, we evaluated the statistical validity of this hypothetical model and explored the effect of gender and students' preferred courses (e.g., humanities, science, and art) on four dependent variables. We also evaluated the differences of students' understanding across scientific domains and students' understanding concerning basic and applied scientific knowledge. Three hundred and twenty five 10th grade students participated in this survey research. Statistically, we employed bivariate correlation, partial correlation, path analysis, two-way ANOVA, and repeated measures ANOVA. Our findings illustrated that our hypothetical model was statistically valid. In addition, the significant interaction effects of gender and students' preferred courses on each dependent variable were shown. Students have different levels of understanding of the convergence of basic and applied science, the relation between scientific knowledge and human life, and the importance of learning science across scientific domains (e.g., physics, chemistry, earth science and biology).

Does Social Distance Always Increase Content Performance in Online Distribution Channels? (온라인 유통 채널에서 컨텐츠의 성과는 사회적 거리에 의해 항상 증가하는가? YouTube의 문화별컨텐츠를 중심으로)

  • Son, Jung-Min;Kang, Seong-Ho
    • Journal of Distribution Science
    • /
    • v.13 no.8
    • /
    • pp.97-104
    • /
    • 2015
  • Purpose - This study examines the positive impact of the social distance between producers and users of online content, investigating and analyzing the most popular Web content. In addition, it tries to elicit the matching effect that appears when the individuals'cultural background is consistent with social distance. Research design, data, and methodology - We collected and analyzed actual data about 4,981 videos clips on YouTube, looking at six countries in order to verify the content of this study. Based on the results of the data analysis, the study conducted behavioral measurements on popularity, social distance, culture, and user engagement. The unit of analysis was the content and we collected information about the content producers and the content records. We controlled the views, comments, likes, calendar dates, and ages in the empirical models. The data was collected in 2011, with the records coming from South Korea, Japan, China, U.S., German, and France. A total of 4,980 elements were analyzed in the model. The empirical model estimated is the bivariate negative binomial distribution (NBD) model. Results - It turns out that there is a possibility that the matching effect can be diminished by variables that reflect the psychological involvement of user engagement. This study proposes academic and practical implications based on these research results. This research shows the positive effect of social distance between users and producers on the increased performance of the online content. We find the effect of social distance to be a stronger tendency in collectivism. The collectivists follow their sense of friendship and intimacy in their culture and, the social congruence effect can be found there as well. The effect, however, could erode in a social case where users are motivated by strong intrinsic and psychological factors. In addition, user engagement complicates the process of user decision making regarding the information. Conclusions - This study examines how the differential effects of social distance caused by culture could disappear through user commitment as a complicated user motivation. Some potential implications are as follows. First, a firm in the collectivism culture has to communicate based on the social distance. In fact, most online channels do not have a function that indicates the social distance as measured by favorites or subscribers. This function could help increase the performance of the content in online channels, but this increasing effect can only be found in a collectivist culture. Based on this, the firms have to communicate and announce to users the actual social distance between users and producers. Second, firms should develop a system that discovers the social distance and culture and shows these measures to users and producers, since the congruence effect between social distance and culture is found only for low user engagement. The firms can take the advantage of the congruence effect only for the development of the social distance and culture visualized system.

The Effect of School Library-Assisted Instruction on Self-Directed Learning Ability in Home Economics Education (가정과 교육에서 학교도서관 활용수업이 중학생의 자기주도적 학습능력에 미치는 효과)

  • Lee, Hyo-Soon;Yoo, Tae-Myung
    • Journal of Korean Home Economics Education Association
    • /
    • v.19 no.4
    • /
    • pp.201-218
    • /
    • 2007
  • This study is a quasi-experimental study to find out the effect of school library-assisted instruction on middle school students' self-directed learning ability in Home Economics Education. For this purpose, the following research questions were established. 14 hours of school library-assisted instruction and traditional lecture were carried out to 164 9th grade female students(82 of experimental group, 82 of comparison group) of a girls' middle school in Jinju, Gyeongnam. To verify the instructional effect, a pre-test and a post-test for self-directed learning ability were carried out. SPSS 12.0 was used for statistical analysis. For statistical analysis, reliability analysis, frequency analysis, x2-test, t-test, repeated measures-ANOVA, and bivariate analysis were used. The results of this research were as follows: First, there was a statistically significant difference between experimental group and comparison group in the self-directed learning ability in all the subordinate items. Second, the change of self-directed learning ability by grade within the experimental group showed no interactional effect in all the sub-items except problem solving ability. Problem solving ability showed a meaningful difference in the rate of grade rising in accordance with academic achievement level and a higher synergy effect was shown in the low academic achievement group. Third, the experimental group showed a higher rate of rising in the self-directed learning ability than the comparison group, and the low academic achievement group showed a higher rising rate of grade than the high academic achievement group. Based on the results of this research, we concluded that the school library-assisted instruction was effective in enhancing middle school students' self-directed learning ability especially for the low academic achievement group.

  • PDF