• Title/Summary/Keyword: Bischler-Napieralski reaction

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Synthesis of Xylopinine (크실로피닌의 합성)

  • Hwang, Soon-Ho;Kim, Nam-Jae;Hong, You-Hwa;Kim, In-Jong;Kim, Sin-Kyu
    • YAKHAK HOEJI
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    • v.40 no.2
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    • pp.131-134
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    • 1996
  • 3,4-Dimethoxyphenethyl amine(1) and 3,4-dimethoxybenzaldehyde were converted to compounds(4) through sucessive condensation and reduction reaction. Compound(4) was treated with methylthioacetyl chloride to give compound(5) then m-chloroperbenzoic acid(m-CPBA) treatment of compound(5) produced S-oxide(6). To obtain isoquinoline derivative(7),(8), compound(6) were treated with p-TsOH. Xylopinine(9) and it's derivatives(10) were produced by Bischler-Napieralski reaction.

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