• 제목/요약/키워드: Bioscience

검색결과 8,146건 처리시간 0.043초

Cytotoxicity of Urushiols Isolated from Sap of Korean Lacquer Tree (Rhus vernicifera Stokes)

  • Hong, Dong-Ho;Han, Sang-Bae;Lee, Chang-Woo;Park, Se-Hyung;Jeon, Young-Jin;Kim, Myong-Jo;Kwak, Sang-Soo;Kim, Hwan-Mook
    • Archives of Pharmacal Research
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    • 제22권6호
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    • pp.638-641
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    • 1999

  • Cytotoxicities of four urushiols, congeners isolated from the sap of Korean lacquer tree (Rhus vernicifera Stokes), to 29 human cancer cell lines originated from 9 organs were evaluated. Their values of 50% growth inhibition were below $4{\mu}g/ml$, and showed cell line specific cytotoxicity. The present results is the first report on the cytotoxicity of urushiols suggesting that they would have an anticancer activity to human cancer cells.

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Erythropoietin increases neuronal cell differentiation : association of transcriptional factors AP-l and NF-$\kappa$B activation

  • Lee, Sang-Min;Park, Hye-Ji;Lee, Yoot-Mo;Moon, Dong-Cheul;Kim, Kyong-Soon;Cho, Kyong-Ju;Yoon, Do-Young;Song, Suk-Gil;Hong, Jin-Tae
    • 대한약학회:학술대회논문집
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    • 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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    • pp.169.2-170
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    • 2003

  • Erythropietin (EPO), a hematopoietic factor is also required for normal brain development, and its receptor is localized in brain. Therefore, it is possible that EPO could act as a neurotropic factor inducing differentiation of neurons. The present study, we therefore investigated whether EPO can increase differentiation of undifferentiated cortical neuron isolated from postneonatal (Day 1) rat brains and PC12 cell, undifferentiated dopaminagic cell line. EPO dose (1-100 U/ml) dependently increased cell differentiation and expression of differentiation marker gene (neurofilament and tyrosine hydroxylase) in both cells. (omitted)

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A New Benzofuran from the Stem-bark of Styrax japonica

  • Min, Byung-Sun;Yoon, Jeong-Hyeon;Park, Bo-Young;An, Ren-Bo;Lee, Joong-Ku;Kim, Tae-Jin;Joung, Hyo-Uk;Lee, Hyeong-Kyu
    • 대한약학회:학술대회논문집
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    • 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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    • pp.195.1-195.1
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    • 2003

  • Styrax japonica Sieb. et Zucc. (Styracaceae) is a deciduous tree growing in Korea, Japan, and China. The pericarps of this plant have been used as a folk medicine for treatment of cough. Jegosaponins, deacyl jegosaponins and benzofurans have been reported from the fruits and seeds of this plant, and these compounds have been shown antisweet and cytotoxic activities. As a part of a research aimed at the discovery of biological active compounds from plant sources, we have studied a chemical constituent of the stem-bark of S. japonica. (omitted)

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