• Genomics & Informatics
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• v.17 no.2
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• pp.15.1-15.7
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• 2019

Automatically detecting mentions of pharmaceutical drugs and chemical substances is key for the subsequent extraction of relations of chemicals with other biomedical entities such as genes, proteins, diseases, adverse reactions or symptoms. The identification of drug mentions is also a prior step for complex event types such as drug dosage recognition, duration of medical treatments or drug repurposing. Formally, this task is known as named entity recognition (NER), meaning automatically identifying mentions of predefined entities of interest in running text. In the domain of medical texts, for chemical entity recognition (CER), techniques based on hand-crafted rules and graph-based models can provide adequate performance. In the recent years, the field of natural language processing has mainly pivoted to deep learning and state-of-the-art results for most tasks involving natural language are usually obtained with artificial neural networks. Competitive resources for drug name recognition in English medical texts are already available and heavily used, while for other languages such as Spanish these tools, although clearly needed were missing. In this work, we adapt an existing neural NER system, NeuroNER, to the particular domain of Spanish clinical case texts, and extend the neural network to be able to take into account additional features apart from the plain text. NeuroNER can be considered a competitive baseline system for Spanish drug and CER promoted by the Spanish national plan for the advancement of language technologies (Plan TL).

• Proceedings of the Korea Contents Association Conference
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• 2010.05a
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• pp.425-427
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• 2010

Large-scaled information extraction consists of named-entity recognition, terminology extraction and relation extraction. Since all the elementary technologies have been studied independently so far, test collections for related machine learning models also have been constructed independently. As a result, it is difficult to handle scientific documents to extract both named-entities and technical terms at once. In this study, we integrate named-entities and terminologies with PLOT(Person, Location, Organization, Terminology) in a biomedical domain and construct a test collection of PLOT and relations between PLOTs.

• Journal of Information Management
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• v.40 no.4
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• pp.1-22
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• 2009

Large-scaled information extraction plays an important role in advanced information retrieval as well as question answering and summarization. Information extraction can be defined as a process of converting unstructured documents into formalized, tabular information, which consists of named-entity recognition, terminology extraction, coreference resolution and relation extraction. Since all the elementary technologies have been studied independently so far, it is not trivial to integrate all the necessary processes of information extraction due to the diversity of their input/output formation approaches and operating environments. As a result, it is difficult to handle scientific documents to extract both named-entities and technical terms at once. In this study, we define scientific as a set of 10 types of named entities and technical terminologies in a biomedical domain. in order to automatically extract these entities from scientific documents at once, we develop a framework for scientific core entity extraction which embraces all the pivotal language processors, named-entity recognizer, co-reference resolver and terminology extractor. Each module of the integrated system has been evaluated with various corpus as well as KEEC 2009. The system will be utilized for various information service areas such as information retrieval, question-answering(Q&A), document indexing, dictionary construction, and so on.

• Proceedings of the Korean Society for Bioinformatics Conference
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• 2003.10a
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• pp.95-100
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• 2003

In this paper, we propose solutions to resolve the problem of many spelling variants and the problem of lack of annotated corpus for training, which are two among the main difficulties in named entity recognition in biomedical domain. To resolve the problem of spotting valiants, we propose a use of edit-distance as a feature for SVM. And we propose a use of virtual examples to automatically expand the annotated corpus to resolve the lack-of-corpus problem. Using virtual examples, the annotated corpus can be extended in a fast, efficient and easy way. The experimental results show that the introduction of edit-distance produces some improvements in protein name recognition performance. And the model, which is trained with the corpus expanded by virtual examples, outperforms the model trained with the original corpus. According to the proposed methods, we finally achieve the performance 75.80 in F-measure(71.89% in precision,80.15% in recall) in the experiment of protein name recognition on GENIA corpus (ver.3.0).

• 한국어정보학회:학술대회논문집
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• 2016.10a
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• pp.321-323
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• 2016

최근 연구에서 기계학습 중 지도학습 방법으로 개체명 인식을 하고 있다. 그러나 지도 학습 방법은 데이터를 만드는 비용과 시간이 많이 필요로 한다. 본 연구에서는 주석 된 말뭉치를 사용하여 지도 학습 방법을 사용 한다. 의생명 개체명 인식은 Protein, RNA, DNA, Cell type, Cell line 등을 포함한 텍스트 처리에 중요한 기초 작업입니다. 그리고 의생명 지식 검색에서 가장 기본과 핵심 작업 중 하나이다. 본 연구에서는 순환형 신경망과 워드 임베딩을 자질로 사용한 조건적 임의 필드에 대한 성능을 비교한다. 조건적 임의 필드에 N_Gram만을 자질로 사용한 것을 기준점으로 설정 하였고, 기준점의 결과는 70.09% F1 Score이다. RNN의 jordan type은 60.75% F1 Score, elman type은 58.80% F1 Score의 성능을 보여준다. 조건적 임의 필드에 CCA, GLOVE, WORD2VEC을 사용 한 결과는 각각 72.73% F1 Score, 72.74% F1 Score, 72.82% F1 Score의 성능을 얻을 수 있다.

• Proceedings of the Korean Society for Bioinformatics Conference
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• 2003.10a
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• pp.3-3
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• 2003

With biomedical literature expanding so rapidly, there is an urgent need to discover and organize knowledge extracted from texts. Although factual databases contain crucial information the overwhelming amount of new knowledge remains in textual form (e.g. MEDLINE). In addition, new terms are constantly coined as the relationships linking new genes, drugs, proteins etc. As the size of biomedical literature is expanding, more systems are applying a variety of methods to automate the process of knowledge acquisition and management. In my talk, I focus on the project, GENIA, of our group at the University of Tokyo, the objective of which is to construct an information extraction system of protein - protein interaction from abstracts of MEDLINE. The talk includes (1) Techniques we use fDr named entity recognition (1-a) SOHMM (Self-organized HMM) (1-b) Maximum Entropy Model (1-c) Lexicon-based Recognizer (2) Treatment of term variants and acronym finders (3) Event extraction using a full parser (4) Linguistic resources for text mining (GENIA corpus) (4-a) Semantic Tags (4-b) Structural Annotations (4-c) Co-reference tags (4-d) GENIA ontology I will also talk about possible extension of our work that links the findings of molecular biology with clinical findings, and claim that textual based or conceptual based biology would be a viable alternative to system biology that tends to emphasize the role of simulation models in bioinformatics.

• Annual Conference on Human and Language Technology
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• 2016.10a
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• pp.321-323
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• 2016

최근 연구에서 기계학습 중 지도학습 방법으로 개체명 인식을 하고 있다. 그러나 지도 학습 방법은 데이터를 만드는 비용과 시간이 많이 필요로 한다. 본 연구에서는 주석 된 말뭉치를 사용하여 지도 학습 방법을 사용 한다. 의생명 개체명 인식은 Protein, RNA, DNA, Cell type, Cell line 등을 포함한 텍스트 처리에 중요한 기초 작업입니다. 그리고 의생명 지식 검색에서 가장 기본과 핵심 작업 중 하나이다. 본 연구에서는 순환형 신경망과 워드 임베딩을 자질로 사용한 조건적 임의 필드에 대한 성능을 비교한다. 조건적 임의 필드에 N_Gram만을 자질로 사용한 것을 기준점으로 설정 하였고, 기준점의 결과는 70.09% F1 Score이다. RNN의 jordan type은 60.75% F1 Score, elman type은 58.80% F1 Score의 성능을 보여준다. 조건적 임의 필드에 CCA, GLOVE, WORD2VEC을 사용 한 결과는 각각 72.73% F1 Score, 72.74% F1 Score, 72.82% F1 Score의 성능을 얻을 수 있다.