• 센서학회지
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• 제17권2호
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• pp.87-94
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• 2008

Blood pressure (BP), one of the most important vital signs, is used to identify an emergency state and reflects the blood flow characteristics of the cardiovascular system. The conventional noninvasive method of measuring BP is inconvenient because patients must wear a cuff on their arm and the measurement process takes time. This paper proposes an algorithm for estimating the BP using the pulse transit time (PTT) of the photoplethysmography (PPG) and pressure pulse from finger at the same time as a more convenient way to measure the BP. After recording the electrocardiogram (ECG), measuring the pressure pulse, and performing PPG, we calculated the PTT from the acquired signals. Then, we used a multiple regression analysis to measure the systolic and diastolic BP indirectly. Comparing the BP measured indirectly using the proposed algorithm and the real BP measured with a sphygmomanometer, the systolic pressure had a mean error of ${\pm}3.240$ mmHg and a standard deviation of 2.530 mmHg, while the diastolic pressure had a satisfactory result, i.e., a mean error of ${\pm}1.807$ mmHg and a standard deviation of 1.396 mmHg. These results are more superior than existing method estimating blood pressure using the one PTT and satisfy the ANSI/AAMI regulations for certifying a sphygmomanometer i.e., the measurement error should be within a mean error of ${\pm}5$ mmHg and a standard deviation of 8 mmHg. These results suggest the possibility of applying our method to a portable, long-term BP monitoring system.

• 환경영향평가
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• 제15권4호
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• pp.271-277
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• 2006

In this study, we investigated the applicable plan of GIS on the environmental impact assessment of 60 Hz Powerline. So we assessed distance data based on calculations by use of 2D and 3D Geographical information systems(GIS) and distance data based on measurements on 1: 5000 maps accord with on site distance measurements to use input data for calculating magnetic field. One hundred eight of the on site measured addresses were selected from residences. The data were achieved by measuring the distance between residence and power line on maps with scales of 1: 5000. The digital map was obtained from National Geographic Information Institute with scales of 1: 5000, and we made 2D and 3D map. Correlation analyses were performed for statistical analyses. For the 3D GIS versus on site comparison of different exposure categories, 70 of 108 measurements were assigned to the correct category. Similarly for 2D GIS versus on site comparison, 71 of 108 were correctly categorized. When comparing map measurement with on site measurement, 62 of 108 were correctly categorized. When the correlation analysis was performed, best correlation was found between 3D GIS and on site measurements with r = 0.84947 (p<0.0001). The correlation between map and on site measurement yielded an r of 0.76517 (p<0.0001). Since the GIS measurements and map measurement were made from the center point in the building and the on site measurements had to be made from the closest wall on the building, this might introduce and additional error in urban areas. The difference between 2D and 3D calculations were resulted from the height of buildings.

• 대한의용생체공학회:의공학회지
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• 제31권2호
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• pp.123-128
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• 2010

The thermometers is widely used in diagnostic medical devices, and the safety and accurate performance of these devices are important in the diagnosis and monitoring of personal health. Especially, the accuracy of infra-red thermometer is highly emphasized. Here two typical thermometers are utilized for this purpose: the electronic thermometers measure body temperature by contacting to subject while infra-red thermometers measure by no contacting to subject. Therefore, the evaluating items of each thermometer are different, and the standard for each temperature is highly needed. But, there have been no international standards of each thermometer such as IEC. In this paper, we developed the standards of electronic and infra-red thermometer based on national standards such as KS, ASTM, EN, JIS and FDA guidance. The new standards focused on the safety and suitable performance for health care. This standards were applied to enact and revise the electronic medical device standards. So it can be applied to evaluate the safety and performance on technical file review. We predict that this standard will improve the quality of diagnostic medical devices (thermometers) and increase the international competitive power of domestic product.

• 대한의용생체공학회:의공학회지
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• 제37권5호
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• pp.168-177
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• 2016

In this paper we present an implantable pressure sensor to measure real-time blood pressure by monitoring mechanical movement of artery. Sensor is composed of inductors (L) and capacitors (C) which are formed by microfabrication and direct bonding on two biocompatible substrates (quartz). When electrical potential is applied to the sensor, the inductors and capacitors generates a LC resonance circuit and produce characteristic resonant frequencies. Real-time variation of the resonant frequency is monitored by an external measurement system using inductive coupling. Structural and electrical simulation was performed by Computer Aided Engineering (CAE) programs, ANSYS and HFSS, to optimize geometry of sensor. Ultrafast laser (femto-second) cutting and MEMS process were executed as sensor fabrication methods with consideration of brittleness of the substrate and small radial artery size. After whole fabrication processes, we got sensors of $3mm{\times}15mm{\times}0.5mm$. Resonant frequency of the sensor was around 90 MHz at atmosphere (760 mmHg), and the sensor has good linearity without any hysteresis. Longterm (5 years) stability of the sensor was verified by thermal acceleration testing with Arrhenius model. Moreover, in-vitro cytotoxicity test was done to show biocompatiblity of the sensor and validation of real-time blood pressure measurement was verified with animal test by implant of the sensor. By integration with development of external interrogation system, the proposed sensor system will be a promising method to measure real-time blood pressure.

• 한국항행학회논문지
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• 제13권1호
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• pp.79-86
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• 2009

원격계측기술의 발달에 따라 실내 및 실외의 환경에 대한 날씨, 온도 등을 센서를 통하여 모니터링이 가능할 뿐만 아니라 신체의 생화학적 상태를 모니터링 할 수 있다. 센서로부터 측정된 데이터는 제어실로 무선 공중 데이터 망을 통하여 전송될 수 있다. 본 논문에서는 다양한 형태의 여러 센서 데이터를 측정하여 이를 한 시스템에 원격으로 전송하여 처리를 한다. 측정되는 센서의 데이터는 시설물, 장비 등의 동특성 및 정특성에 따라 제어도 가능하도록 구현하였다. 본 논문에서 구현한 시스템은 유선 및 무선을 통한 데이터 수집으로 여러 분야에 적용할 수 있으며 가정이나 사무실 등의 장소에 구애없이 공중망이 제공되는 어느 곳에서 데이터의 수집 및 제어가 가능한 시스템을 구성하였다.

• Journal of Ecology and Environment
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• 제38권3호
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• pp.307-318
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• 2015

The objectives of this study were to identify multi-level stressors from blood biomarkers to community-level bioindicators and diagnose the stream ecosystem health in polluted streams. Blood chemistry such as total protein ($T_{Pro}$), blood urea nitrogen ($B_{UN}$), total cholesterol ($T_{Cho}$) and $A_{lb}$umin ($A_{lb}$) were analyzed from sentinel fish tissues; the functions of kidney, gill and liver were significantly decreased in the impacted zone ($I_z$), compared to the control zone ($C_z$). Histopathological analysis showed that fish liver tissues were normal in the $C_z$. Fish liver tissues in the $I_z$, however, showed large cell necrosis and degeneration and also had moderate lobular inflammation and inflammatory cell infiltration of lymphocytic histocytes. Species biotic index (SBI) at species level and stream health assessment (SHA) at community level indicated that chemical impacts were evident in the $I_z$ (ecological health; poor - very poor), and this was matched with the blood tissue analysis and histopathological analysis. The impairments of the streams were supported by water chemistry analysis (nitrogen, phosphorus). Tolerance guild analysis and trophic guild analysis of fish were showed significant differences (P < 0.01) between $C_z$ and $I_z$. Overall, multiple parameter analysis from biomarker level (blood tissues) to bioindicator level (community health) showed significantly greater impacts in the $I_z$ than $C_z$. This approach may be effective as a monitoring tool in identifying the multilateral and forthcoming problems related to chemical pollution and habitat degradation of stream ecosystems.

• 한국전자파학회논문지
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• 제19권2호
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• pp.191-199
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• 2008

본 논문에서는 호흡 및 심박수 측정을 위한 2.4 GHz 바이오 레이더 시스템의 성능을 분석하고 이를 통한 설계 및 구현 과정을 제시하였다. 먼저 2.4 GHz 시스템의 성능을 정량적으로 분석하기 위해, 인체 조직의 전자기적 성질을 이용하여 사람 몸에 의한 손실을 구하였고, 거리에 따른 복조기 출력에서의 SNR을 분석하였다. 5 Hz 대역폭일 때, 50 cm에서 90 % 이상의 success ratio를 성능지표로 삼아 바이오 레이더 성능을 MATLAB을 이용하여 시뮬레이션 하였고, 전체 시스템의 링크 버젯을 완성하였다. 분석 결과를 활용하여 4층 PCB 기판 위에 계산된 링크 버젯을 만족하는 직접 변환 방식의 바이오 레이더 수신기를 설계 및 제작하였다. 측정 결과, 0 dBm 출력에서 5 Hz 대역폭일 때, 50 cm의 거리에서 약 80 %의 success ratio가 측정되어 설계 과정을 검증하였다.

• Biomolecules & Therapeutics
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• 제15권4호
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• pp.266-272
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• 2007

A rapid analytical method was developed to quantify very long-chain fatty acids (VLCFAs, C22:0, C24:0, C26:0) in human plasma with good sensitivity and specificity using tert-butyldimethylsilyl (TBDMS) derivatization and stable isotope GC-MS selective ion monitoring (GC-MS/SIM). Two-hundred and fifty ${\mu}L$ of plasma was fortified with deuterated stable isotope internal standards (d3-C22:0, d3-C24:0, d3-C26:0) and standard mixtures of chloroform and methanol, and then extracted with hexane and acetonitrile. To upper layer of liquid-liquid-extraction, N-(t-Butyldimethylsilyl)-N-methyltrifluoroacetamide was added and then heated to $60^{\circ}C$ for 30 min to produce the TBDMS derivatives. Derivatives of VLCFAs were analyzed by GC-MS/SIM. Calibration curves showed a linear relationship for the target compounds in the concentration range of $10^{-4}{\sim}2{\times}10^3\;{\mu}g/mL$ with the correlation coefficient ranging from 0.996 to 0.999. The limit of quantification for the plasma was $10^{-4}{\sim}2{\times}10^{-4}\;{\mu}g/mL$ (S/N=3). When applied to the plasma specimens of patients with peroxisomal disorder, X-linked adrenoleucodystropy (ALD, Mckusick 202370), the method clearly differentiated normal subjects from ALD patients. The C24:0/C22:0 and C26:0/C22:0 ratios were significantly elevated in the plasma of patients with X-linked ALD compared to normal subjects. The new developed method might be useful for a rapid and sensitive diagnosis of X-linked ALD and other peroxisomal disorders.

• Parasites, Hosts and Diseases
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• 제53권1호
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• pp.43-49
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• 2015

The aim of the study was to explore the possible molecular markers of chloroquine resistance in Plasmodium vivax isolates in Thailand. A total of 30 P. vivax isolates were collected from a malaria endemic area along the Thai-Myanmar border in Mae Sot district of Thailand. Dried blood spot samples were collected for analysis of Pvmdr1 and Pvcrt-o polymorphisms. Blood samples ($100{\mu}l$) were collected by finger-prick for in vitro chloroquine susceptibility testing by schizont maturation inhibition assay. Based on the cut-off $IC_{50}$ of 100 nM, 19 (63.3%) isolates were classified as chloroquine resistant P. vivax isolates. Seven non-synonymous mutations and 2 synonymous were identified in Pvmdr1 gene. Y976F and F1076L mutations were detected in 7 (23.3%) and 16 isolates (53.3%), respectively. Analysis of Pvcrt-o gene revealed that all isolates were wild-type. Our results suggest that chloroquine resistance gene is now spreading in this area. Monitoring of chloroquine resistant molecular markers provide a useful tool for future control of P. vivax malaria.

• 한국정보통신학회논문지
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• 제17권3호
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• pp.533-539
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• 2013

최근 의료 및 생체공학 분야의 액추에이터(actuator)와 센서 및 연료전지로 활용할 수 있는 새로운 재료인 IPMC(Ionic Polymer Metal Composite)에 대한 관심이 높아지고 있다. 이러한 IPMC의 특징은 센서(sensor)와 액추에이터(actuator)의 성질을 동시에 가지는 있는 특이한 성질을 가진 복합재료로서 IPMC에 전압을 가하면 움직임이 생기며, IPMC에 움직임이 발생하면 IPMC 내부에 전압이 충전되는 성질이 있어 모션 센서나 힘 센서로도 활용할 수 있다. 본 논문에서는 이러한 IPMC에 대한 몇 가지 특성을 파악하고 IT 기술인 스마트폰의 연계하여 원격지에서 IPMC의 동작을 제어할 수 있도록 시스템을 구성하였다. 또한, 스마트폰을 기반으로 하여 영상정보를 전송하여 모니터링 하도록 하였다. IPMC의 동작제어는 스마트폰의 블루투스를 이용하여 동작명령을 전송하도록 시스템을 구현하였다. 본 논문의 실험 및 구현으로부터 IPMC 물성에 대한 정확한 분석은 부족하지만 향후 IPMC의 활용에 있어서 IT 기술과의 융합을 통하여 센서, 액추에이터, 연료전지 등과 같은 분야에 적극 활용할 수 있음을 확인할 수 있었다.