• 대한의용생체공학회:의공학회지
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• 제35권4호
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• pp.87-94
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• 2014

Recent technological advances have increased interest in personal health monitoring. Electrocardiogram(ECG) monitoring is a basic healthcare activity and can provide decisive information regarding cardiovascular system status. In this study, we developed a capacitive ECG measurement system that can be included within a cloth mattress pad. The device permits ECG data to be obtained during sleep by using capacitive electrodes. However, it is difficult to detect R-wave peaks automatically because signals obtained from the system can include a high level of noise from various sources. Because R-peak detection is important in ECG applications, we developed an algorithm that can reduce noise and improve detection accuracy under noisy conditions. Algorithm reliability was evaluated by determining its sensitivity(Se), positive predictivity(+P), and error rate(Er) by using data from the MIT-BIH Polysomnographic Database and from our capacitive ECG system. The results showed that Se = 99.75%, +P = 99.77%, and Er = 0.47% for MIT-BIH Polysomnographic Database while Se = 96.47%, +P = 99.32%, and Er = 4.34% for our capacitive ECG system. Based on those results, we conclude that our R-peak detection method is capable of providing useful ECG information, even under noisy signal conditions.

• 대한의용생체공학회:의공학회지
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• 제21권3호
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• pp.255-260
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• 2000

본 연구는 중환자실, 응급실, 수술실등 병실내에서 환자를 구속하지 않고. 무선으로 환자의 활력징후 신호등을 관찰할 수 있는 생체신호 무선 전송장치를 설계 제작하는데 목적을 두었다. 본 무선 환자감시장치는 활력징후 신호 수집기, 무선 송수신 장치 및 활력징후 관찰기로 구성된다. 활력징후 신호 수집부는 생체신호를 증폭하기 위한 아날로그신호 증폭기와 디지털데이터 변환을 위한 단일 칩 마이크로 컨트롤러로 구성된다. 전송신호의 품질을 확보하고 신호처리 및 구성이 간단하여 저 비용으로 구성할 수 있는 주파수편이변조(FSK) 방법을 사용하였고 디지털신호는 UHF 대역의 미약 무선주파수에 의하여 송수신되었다. 활력징후 신호 관찰기는 무선 수신기에 의해 디지털 데이터를 복조하고 활력징후 신호를 상시 모니터링하기 위한 액정모니터(LCD) 및 신호를 기록하기 위한 감열기록장치(thermal Printer)로 설계 제작되었다.

• Biomedical Engineering Letters
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• 제8권4호
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• pp.365-371
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• 2018

Uninterrupted monitoring of multiple subjects is required for mass causality events, in hospital environment or for sports by medical technicians or physicians. Movement of subjects under monitoring requires such system to be wireless, sometimes demands multiple transmitters and a receiver as a base station and monitored parameter must not be corrupted by any noise before further diagnosis. A Bluetooth Piconet network is visualized, where each subject carries a Bluetooth transmitter module that acquires vital sign continuously and relays to Bluetooth enabled device where, further signal processing is done. In this paper, a wireless network is realized to capture ECG of two subjects performing different activities like cycling, jogging, staircase climbing at 100 Hz frequency using prototyped Bluetooth module. The paper demonstrates removal of baseline drift using Fast Fourier Transform and Inverse Fast Fourier Transform and removal of high frequency noise using moving average and S-Golay algorithm. Experimental results highlight the efficacy of the proposed work to monitor any vital sign parameters of multiple subjects simultaneously. The importance of removing baseline drift before high frequency noise removal is shown using experimental results. It is possible to use Bluetooth Piconet frame work to capture ECG simultaneously for more than two subjects. For the applications where there will be larger body movement, baseline drift removal is a major concern and hence along with wireless transmission issues, baseline drift removal before high frequency noise removal is necessary for further feature extraction.

• 한국융합학회논문지
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• 제12권1호
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• pp.127-132
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• 2021

의료기관에서 사용되는 수액 모니터링 시스템은 원격으로 환자에게 투입된 수액량과 투여의 종료시점 정보를 제공하기 위해서 개발되었다. 수액 투입량을 측정하기 위해서는 수액 내부에서 외부로 나가는 정량을 무게로 혹은 유량을 측정센서로 측정할 수 있다. 여기에 적용되는 장치의 기준은 정확성, 경계성이다. 또한 소형으로 환자에게 수액 설치시 사용에 용이해야 한다. 의료기관에서는 측정값의 정확도가 높아야 하며, 경제적으로 저가의 장치를 요구하고 있다. 본 연구에서는 저가의 소형 무게 중심 로드셀 센서를 적용하였으며, 측정값의 정확도를 위해 자이로센서와 융합하여 외부 움직임에 의한 아트펙트를 줄이는 알고리즘을 적용하였다. 그 결과 측정의 오차를 줄일 수 있어 수액 모니터링 측정값의 정확도를 향상시키는 효과를 확인하였다.

• 대한의용생체공학회:의공학회지
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• 제42권4호
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• pp.175-185
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• 2021

Purpose: Vital sign are used to help assess the general physical health of a person, give clues to possible diseases, and show progress toward recovery. Researchers are using vital sign data and AI(artificial intelligence) to manage a variety of diseases and predict mortality. In order to analyze vital sign data using AI, it is important to select and extract vital sign data suitable for research purposes. Methods: We developed a method to visualize vital sign and early warning scores by processing retrospective vital sign data collected from EMR(electronic medical records) and patient monitoring devices. The vital sign data used for development were obtained using the open EMR big data MIMIC-III and the wearable patient monitoring device(CareTaker). Data processing and visualization were developed using Python. We used the development results with machine learning to process the prediction of mortality in ICU patients. Results: We calculated NEWS(National Early Warning Score) to understand the patient's condition. Vital sign data with different measurement times and frequencies were sampled at equal time intervals, and missing data were interpolated to reconstruct data. The normal and abnormal states of vital sign were visualized as color-coded graphs. Mortality prediction result with processed data and machine learning was AUC of 0.892. Conclusion: This visualization method will help researchers to easily understand a patient's vital sign status over time and extract the necessary data.

• 한국컴퓨터정보학회논문지
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• 제27권11호
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• pp.157-163
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• 2022

이 논문에서는 블루투스 건강기기 프로파일(HDP) 기반 스마트폰 시스템을 개발하여 고양이에서 많이 발생하는 비뇨기계 질환의 조기 발견에 활용하는 것을 제안하고자 한다. 이에 우리는 블루투스 HDP를 기반으로 소변검사 결과를 해석할 수 있는 고양이 활동, 화장실 사용, 요로 질환 및 건강 상태를 모니터링할 수 있는 장치 및 모바일 애플리케이션 시스템(Mycatner®)을 개발하였고 고양이의 건강 상태 모니터링에 활용 가능함을 평가하였다. 이 시스템의 특징은 첫째, 고양이 배뇨 횟수를 측정하여 요로계 질병이 의심되는 비정상 상태를 조기에 감별할 수 있고, 둘째, 소변 검사지로 미리 검사하여 동물병원과 공유할 수 있어 시간과 비용을 절감할 수 있고, 셋째, 이 기술을 당뇨병 등 다른 다양한 고양이 질환에 응용 가능한 특성을 지니고 있다. 이로써 고양이의 비뇨기 건강 상태를 무선으로 모니터링할 수 있는 장치는 우리의 식견으로는 최초로 개발한 것으로 평가된다.

• 대한의용생체공학회:의공학회지
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• 제44권2호
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• pp.125-138
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• 2023

The development of AI systems for radiation therapy is important to improve the accuracy, effectiveness, and safety of cancer treatment. The current system has the disadvantage of monitoring patients using CCTV, which can cause errors and mistakes in the treatment process, which can lead to misalignment of radiation. Developed the PMRP system, an AI automation system that uses depth cameras to measure patient's fine movements, segment patient's body into parts, align Z values of depth cameras with Z values, and transmit measured feedback to positioning devices in real time, monitoring errors and treatments. The need for such a system began because the CCTV visual monitoring system could not detect fine movements, Z-direction movements, and body part movements, hindering improvement of radiation therapy performance and increasing the risk of side effects in normal tissues. This study could provide the development of a field of radiotherapy that lags in many parts of the world, along with the economic and social importance of developing an independent platform for radiotherapy devices. This study verified its effectiveness and efficiency with data through phantom experiments, and future studies aim to help improve treatment performance by improving the posture correction mechanism and correcting left and right up and down movements in real time.

• 대한의용생체공학회:의공학회지
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• 제44권6호
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• pp.392-403
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• 2023

This study presents a new hybrid fNIRS-EEG system to meet the demand for a lightweight and low-cost sleep pattern monitoring device. For multiple-channel configuration, a six-channel electroencephalogram (EEG) and a functional near-infrared spectroscopy (fNIRS) system with eight photodiodes (PD) and four dual-wavelength LEDs are designed. To enhance the convenience of signal measurement, the device is miniaturized into a patch-like form, enabling simultaneous measurement on the forehead. Due to its fully integrated functionality, the developed system is advantageous for performing sleep stage classification with high-temporal and spatial resolution data. This can be realized by utilizing a two-dimensional (2D) brain activation map based on the concentration changes in oxyhemoglobin and deoxyhemoglobin during sleep stage transitions. For the system verification, the phantom model with known optical properties was tested at first, and then the sleep experiment for a human subject was conducted. The experimental results show that the developed system qualifies as a portable hybrid fNIRS-EEG sleep pattern monitoring device.

• Macromolecular Research
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• 제12권6호
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• pp.564-572
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• 2004

Modem applications could benefit from multifunctional materials having anisotropic optical, electrical, thermal, or mechanical properties, especially when coupled with locally controlled distribution of the directional response. Such materials are difficult to engineer by conventional methods, but the electric field-aided technology presented herein is able to locally tailor electroactive composites. Applying an electric field to a polymer in its liquid state allows the orientation of chain- or fiber-like inclusions or phases from what was originally an isotropic material. Such composites can be formed from liquid solutions, melts, or mixtures of pre-polymers and cross-linking agents. Upon curing, a 'created composite' results; it consists of these 'pseudofibers' embedded in a matrix. One can also create oriented composites from embedded spheres, flakes, or fiber-like shapes in a liquid plastic. Orientation of the externally applied electric field defines the orientation of the field-aided self-assembled composites. The strength and duration of exposure of the electric field control the degree of anisotropy created. Results of electromechanical testing of these modified materials, which are relevant to sensing and actuation applications, are presented. The materials' micro/nanostructures were analyzed using microscopy and X-ray diffraction techniques.

• Biotechnology and Bioprocess Engineering:BBE
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• 제9권2호
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• pp.86-92
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• 2004

In this paper miniaturized disposable micro/nanofluidic components applicable to bio chip, chemical analyzer and biomedical monitoring system, such as blood analysis, micro dosing system and cell experiment, etc are reported. This system includes various microfluidic components including a micropump, micromixer, DNA purification chip and single-cell assay chip. For low voltage and low power operation, a surface tension-driven micropump is presented, as well as a micromixer, which was implemented using MEMS technology, for efficient liquid mixing is also introduced. As bio-reactors, DNA purification and single-cell assay devices, for the extraction of pure DNA from liquid mixture or blood and for cellular engineering or high-throughput screening, respectively, are presented.