• 한국소성가공학회:학술대회논문집
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• 한국소성가공학회 2003년도 The 8th Asian Symposium on Precision Forging ASPF
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• pp.115-122
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• 2003

This paper presents the development of a virtual forging factory framework. The technologies of virtual reality and relational database had been integrated in the developed framework using Microsoft $Windows^{(R)}$ programming as the main technique so as to emulate a physical forging factory. The developed virtual forging factory consists of forging cells and a forging cell is comprised of forging machine, forging die, and forging operations forming a forging production line. The technology of virtual reality had been successfully adopted in the production simulation of manufacturing such as CNC and robotics. However, the application in virtual forging factory seems to have not been studied yet. Potential application of a virtual forging factory can be beneficial to (1) computer aided instruction, (2) shorten the learning curve of a novice, (3) remote diagnosis and monitoring when remote monitoring and control technology and signal inspection is considered, (4) improve adverse forging environment when remote forging technology is applied, and (5) virtual reality application.

• 한국컴퓨터정보학회:학술대회논문집
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• 한국컴퓨터정보학회 2016년도 제53차 동계학술대회논문집 24권1호
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• pp.331-334
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• 2016

본 연구에서는 표준 게이트웨이 기반의 다중 생체계측 장비 및 CMCIS(Central Monitoring and Cardiology Information System) 기반의 통합 시스템을 개발하기 위한 타당성 분석을 위한 국내외 동향을 분석한 연구이다. 개발의 필요성을 타진하기 위하여 기술, 사회, 경제적 중요성과 국내외 관련기술의 현황을 분석하였다. 분석한 결과, 대부분 해외의 다국적 기업에 의존하는 실정이며 심혈관계 질환의 지속적 증가로 효율적인 의료 서비스를 위한 기술개발의 필요성이 높게 평가되었다. 또한 표준 게이트웨이 기술의 확보로 진단용 심전계 표준 게이트웨이를 적용함으로써 다양한 HIS 인터페이스가 가능하며, 편의성이 증대되어 활용성이 높아질 것으로 예상된다.

• Journal of Microbiology and Biotechnology
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• 제24권3호
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• pp.297-312
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• 2014

Food safety is increasingly becoming an important public health issue, as foodborne diseases present a widespread and growing public health problem in both developed and developing countries. The rapid and precise monitoring and detection of foodborne pathogens are some of the most effective ways to control and prevent human foodborne infections. Traditional microbiological detection and identification methods for foodborne pathogens are well known to be time consuming and laborious as they are increasingly being perceived as insufficient to meet the demands of rapid food testing. Recently, various kinds of rapid detection, identification, and monitoring methods have been developed for foodborne pathogens, including nucleic-acid-based methods, immunological methods, and biosensor-based methods, etc. This article reviews the principles, characteristics, and applications of recent rapid detection methods for foodborne pathogens.

• 한국정보전자통신기술학회논문지
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• 제2권3호
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• pp.17-22
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• 2009

본 연구의 목적은 운동역학 및 정형외과 등에서 많이 사용하는 근전기록장치의 범용 신호처리 소프트웨어를 개발하는 것이다. 개발한 신호처리 소프트웨어는 임상, 재활, 인간공학 및 스포츠 등에서 많이 사용하는 근전기록장치에 범용적으로 사용 가능하다. 모니터링, 주파수 분석, 제로 크로싱 및 비교 분석 등의 신호처리가 자동으로 처리 가능한 각각의 모듈을 개발하였다. 그리고 연속적인 모니터링, 분석이 쉬운 출력물, 사용이 쉬운 UI가 가능하도록 개발하였다. 개발된 신호처리 소프트웨어는 임상, 재활, 인간공학 및 스포츠 등의 여러 분야에 사용 가능하도록 개발하였고, 작동 실험 결과에서 볼 수 있듯이 측정된 근전신호는 좋은 특성 결과를 보였다. 본 연구에서 개발된 신호처리 소프트웨어는 신경외과 및 정형외과 등에서 사용하는 근전기록장치의 소프트웨어로 적용 가능할 것으로 판단된다.

• 대한의용생체공학회:의공학회지
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• 제39권6호
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• pp.278-283
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• 2018

Nowdays, many people suffer from the neck pain due to forward head posture(FHP) and text neck(TN). To assess the severity of the FHP and TN the craniovertebral angle(CVA) is used in clinincs. However, it is difficult to monitor the neck posture using the CVA in daily life. We propose a new method using the cervical flexion angle(CFA) obtained from a wearable sensor to monitor neck posture in daily life. 15 participants were requested to pose FHP and TN. The CFA from the wearable sensor was compared with the CVA observed from a 3D motion camera system to analyze their correlation. The determination coefficients between CFA and CVA were 0.80 in TN and 0.57 in FHP, and 0.69 in TN and FHP. From the monitoring the neck posture while using laptop computer for 20 minutes, this wearable sensor can estimate the CVA with the mean squared error of 2.1 degree.

• 대한의용생체공학회:의공학회지
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• 제35권5호
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• pp.125-131
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• 2014

The purpose of this study is to verify the utility of reflected photoplethysmography sensor using two green light emitting diodes that influenced by ambient light. Recently it has been studied that green light emitting diode is suitable for light source of reflected photoplethysmography sensor at low temperature and high temperature. Another study showed that, green light is better for monitoring heart rate during motion than led light. However, it has a bad characteristic about ambient light noise. To verify the utility of reflected photoplethysmography sensor using green light emitting diode, this study measures the photoplethysmography signal that is distorted by ambient light and will propose a solution. This study has two parts of research method. One is measurement system that composed sensor and board. The sensor is made up PE-foam and Non-woven fabric for flexible sensor. The photoplethysmography signal is measured by measurement board that composed high-pass filter, low-pass filter and amplifier. Ambient light source is light bulb and white light emitting diode that has three steps brightness. Photoplethysmography signal is measured with lead II electrocardiography signal at the same time and it is measured at the finger and radial artery for 1 minute, 1000 Hz sampling rate. The lead II electrocardiography signal is a standard signal for heart rate and photoplethysmography signal that measured at the finger is a standard signal for waveform. The test is repeated 3 times using three sensor. The data is processed by MATLAB to verify the utility by comparing the correlation coefficient score and heart rate. The photoplethysmography sensor using two green light emitting diodes is shown better utility than using one green light emitting diode and red light emitting diode at the ambient light. The waveform and heart rate that measured by two green light emitting diodes are more identical than others. The amount of electricity used is less than red light emitting diode and error peak detectability factor is the lowest.

• Laboraroty Animal Research
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• 제34권4호
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• pp.302-310
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• 2018

CD47 (integrin-associated protein), a multi-spanning transmembrane protein expressed in all cells including red blood cells (RBCs) and leukocytes, interacts with signal regulatory protein ${\alpha}$ ($SIRP{\alpha}$) on macrophages and thereby inhibits phagocytosis of RBCs. Recently, we generated a novel C57BL/6J CD47 knockout ($CD47^{-/-}$ hereafter) mouse line by employing a CRISPR/Cas9 system at Center for Mouse Models of Human Disease, and here report their hematological phenotypes. On monitoring their birth and development, $CD47^{-/-}$ mice were born viable with a natural male-to-female sex ratio and normally developed from birth through puberty to adulthood without noticeable changes in growth, food/water intake compared to their age and sex-matched wild-type littermates up to 26 weeks. Hematological analysis revealed a mild but significant reduction of RBC counts and hemoglobin in 16 week-old male $CD47^{-/-}$ mice which were aggravated at the age of 26 weeks with increased reticulocyte counts and mean corpuscular volume (MCV), suggesting hemolytic anemia. Interestingly, anemia in female $CD47^{-/-}$ mice became evident at 26 weeks, but splenomegaly was identified in both genders of $CD47^{-/-}$ mice from the age of 16 weeks, consistent with development of hemolytic anemia. Additionally, helper and cytotoxic T cell populations were considerably reduced in the spleen, but not in thymus, of $CD47^{-/-}$ mice, suggesting a crucial role of CD47 in proliferation of T cells. Collectively, these findings indicate that our $CD47^{-/-}$ mice have progressive hemolytic anemia and splenic depletion of mature T cell populations and therefore may be useful as an in vivo model to study the function of CD47.

• 분석과학
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• 제18권2호
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• pp.163-167
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• 2005

본 연구에서는 ESI/MS/MS를 이용하여 혈장에서 카르니틴을 신속하게 정량하는 분석방법을 개발하였다. 분석방법은 free carnitine (FC)는 유도체화 없이 혈액여지를 80% 메탄올로 추출하여 분석하였고, Total carnitine (TC)은 가수분해 한 후 추출하여 multiple reaction monitoring (MRM) scan mode로 분석하였다. Acyl carnitine (AC)는 TC에서 FC를 뺀 값을 사용하였다. 카르니틴의 분석에서 상관계수 ($r^2$)는 0.9995, 회수율은 97%, 재현성은 변동계수가 10% 이하, 검출한계는 $0.0016{\mu}mol/L$ 였다. 이 방법은 기존의 액체 크로마토그래피 보다 전처리가 간다하고 짧은 분석시간과 좋은 감도와 재현성을 보여 주었다. 정상인은 AC가 낮고 FC는 높은 패턴을 보였고, 유전성대사질환 환자는 FC는 낮고 AC가 높은 패턴으로 나타나 카르니틴의 3분획 분석은 유전성대사질환 환자의 확진 및 모니터링에 유용함을 보여주었다.

• Parasites, Hosts and Diseases
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• 제56권2호
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• pp.205-210
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• 2018

Waterborne parasitic protozoa, particularly Giardia lamblia and Cryptosporidium spp., are common causes of diarrhea and gastroenteritis worldwide. The most frequently identified source of infestation is water, and exposure involves either drinking water or recreation in swimming pools or natural bodies of water. In practice, studies on Cryptosporidium oocysts and Giardia cysts in surface water are challenging owing to the low concentrations of these microorganisms because of dilution. In this study, a 3-year monitoring of Cryptosporidium parvum, Giardia lamblia, and Naegleria fowleri was conducted from August 2014 to June 2016 at 5 surface water sites including 2 lakes, 1 river, and 2 water intake plants. A total of 50 water samples of 40 L were examined. Cryptosporidium oocysts were detected in 22% of samples and Giardia cysts in 32%. Water at the 5 sampling sites was all contaminated with Cryptosporidium oocysts (0-36/L), Giardia cysts (0-39/L), or both. The geometric mean concentrations of Cryptosporidium and Giardia were 1.14 oocysts/L and 4.62 cysts/L, respectively. Thus, effective monitoring plans must take into account the spatial and temporal parameters of contamination because they affect the prevalence and distribution of these protozoan cysts in local water resources.

• Journal of Animal Science and Technology
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• 제57권3호
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• pp.7.1-7.7
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• 2015

To meet the increasing demands of specific pathogen free (SPF) minipigs in biomedical researches, 8 pregnant Chinese Wuzhishan minipigs (WZSP) sows with clear background were chosen to obtain SPF WZSP by hysterectomy. At $111{\pm}days2$ of the pregnancy, piglets were aseptically taken out from the sows and artificially suckled for 40 to 45 days in the positive isolators. Then, the piglets defined as F0 were transferred to barrier environment and fed with standard feeds. The original SPF colony was formed for breeding by selected piglets from F0 group of 6-8 months old. Biological characteristics of SPF WZSP were collected and further compared to those of conventional (CV) WZSP, including growth performance, reproductive performance, hematology and blood biochemistry, and major pathogens detection. As a result, 61 F0 piglets were obtained from 8 candidate sows, and 55 out of them survived. After strictly selection, 35 F0 piglets were used to form the original SPF colony, which produced 14 litters of SPF piglets defined as F1. Piglet survival rates, growth performance, and reproductive performance of SPF WZSP were similar to CV WZSP. Some hematology and blood biochemistry parameters showed significant differences between SPF and CV WZSP. Eighteen kinds of pathogens were identified to be free in F0 and F1 SPF colony by repeated pathogen detections. In conclusion, we established a satisfied SPF WZSP colony maintaining original characteristics, free of controlled diseases, and being proved to be a suitable laboratory animal.