• Journal of Biomedical Engineering Research
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• v.27 no.6
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• pp.370-375
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• 2006

The purpose of this work is to predict the systolic blood pressure (BP) during exercise from pulse transit time (PTT) for warning of possible danger. PTT was calculated as the time between R-peak of ECG and the peak of differential photoplethysmograph (PPG). For the PTT-BP model, we used regress equations from previous studies and 3 kinds of new models combining linear and nonlinear regress equation. The model parameters were estimated with the data measured under low to middle intensity exercise, and then was tested with the data measured under high intensity exercise. Predicted BP values after high intensity exercise were compared with those measured by cuff-type sphygmomanometer. The results showed that the error between measured and predicted values were acceptable for the monitoring BP. We tested PTT-BP models 1 month after the identification without further calibration. Models could predict the BP and the errors between measured and predicted BP were about 5mmHg. The suggested system is expected to be helpful in recognizing any danger during exercise.

• Biomedical Science Letters
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• v.29 no.4
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• pp.344-354
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• 2023

This study emphasizes the importance of early diagnosis and response to COVID-19, leading to the development of a rapid diagnostic kit using quantum dots. The research focuses on finely tuning bioconjugation with quantum dots to enhance the accuracy and sensitivity of COVID-19 diagnosis. We have developed a COVID-19 rapid diagnostic kit that exhibits a sensitivity more than 50 times higher than existing COVID-19 diagnostic kits. Quantum dots enable the accurate detection of COVID-19 viral antigens even at low concentrations, providing a rapid response in the early stages of infection. The COVID-19 quantum dot diagnostic kit offers quick analysis time, utilizing the quantum properties of particles to swiftly measure COVID-19 infection for immediate response and isolation measures. Additionally, this diagnostic kit allows for multiple analyses with ease, as multiple quantum dots can detect various antigens and antibodies simultaneously in a single experiment. This efficiency enhances testing, reduces sample requirements, and lowers experimental costs. The application of this diagnostic technology is anticipated in the future for early diagnosis and monitoring of other infectious diseases.

• Journal of Biomedical Engineering Research
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• v.16 no.3
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• pp.317-324
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• 1995

A need exists for the accurate identification of time series models having time varying parameters, as is important in the case of real time identification of nonstationary EMG signal. Thls paper describes real time identification and muscle fatigue monitoring method of nonstationary EMG signal. The method is composed of the efficient identifier which estimates the autoregressive parameters of nonstationary EMG signal model, and its real time implementation by using T805 parallel processing computer. The method is verified through experiment with real EMG signals which are obtained from surface electrode. As a result, the proposed method provides a new approach for real time Implementation of muscle fatigue monitoring and the execution time is 0.894ms/sample for 1024Hz EMG signal.

• Journal of Institute of Control, Robotics and Systems
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• v.10 no.11
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• pp.1089-1094
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• 2004

Diseases in the gastro-intestinal track are on an increasing trend. In order to diagnose a patient, the various signals of the digestive organ, such as temperature, pH, and pressure, can offer the helpful information. Among the above mentioned signals, we choose the pressure variation as a monitoring signal. The variation of a pressure signal of the gastro-intestinal track can offer the information of a digestive trouble or some clues of the diseases. In this paper, a pressure monitoring system for the digestive organs of a living pig is presented. This system concept is to transmit the measured biomedical signals from a transmitter in a living pig to wireless receiver that is positioned out of body. The integrated solution includes the following parts: (1) the swallow type pressure capsule, (2) the receiving set consisting of a receiver, decoder box, and PC. The merit of the proposed system if that the monitoring system can supply the precise and repeatable pressure in the gastro-intestinal track. In addition, the design of low power consumption enables it to keep sending reliable signals while the pressure capsule is working in the digestive organ. The subject of the study for the pressure monitoring system is in-vivo experiments for a living pig. We achieved the pressure tracings in digestive organs and verified the validity of system after several in-vivo tests using pressure monitoring system. As a result, we found each organ has its own characterized pressure fluctuation.

• Journal of Sensor Science and Technology
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• v.21 no.3
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• pp.223-228
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• 2012

In this study, a fiber-optic pH sensor based on a pH sol-gel film is fabricated. The sol-gel film is made by co-polymerizing tetramethoxysilane, trimethoxymethylsilane, ethanol and distilled water. As a pH indicator, a neutral red is immobilized in a thin porous film formed by the sol-gel process. The pH change in a sensing probe gives rise to a change in the color of the pH sol-gel film, and the absorbance of reflected light through the pH sol-gel film is also changed. By using a spectrometer, therefore, the spectra of reflected lights in the sensing probe with different pH values are measured. Also, the relationships between the pH values and the absorbance are analyzed on the basis of the color variations of the pH sol-gel films. In repeated experiments, the fiber-optic pH sensor shows that it has reversibility, a high reproducibility and a wide absorbance change in a pH range from pH 5 to 9. Also, we confirmed that the fabricated pH sol-gel film exhibits a fast response time, little or no pH indicator leaching and a dynamic range of 2.04 dB from pH 5 to 9. Based on the results of this study, a fiber-optic pH sensor can be developed for the pH monitoring in the harsh environments.

• Journal of Biomedical Engineering Research
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• v.37 no.1
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• pp.53-60
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• 2016

Monitoring of dermal collagen is important to assess various scar conditions, and many diagnostic methods have been applied to quantify collagen contents in scar tissue. In this study, Monte Carlo simulation was used to evaluate diffuse reflectance distributions in scar condition by a near-infrared laser source. The results showed that the effective distance of the light source and the detector was 2 mm to monitor the various scar conditions using diffuse reflectance spectroscopy. This study may suggest to the optimal design for a near infrared diffuse reflectance spectroscopy during the scar treatment.

• Journal of the Optical Society of Korea
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• v.14 no.2
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• pp.77-89
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• 2010

Digital holography (DH) is a potentially disruptive new technology for many areas of imaging science, especially in microscopy and metrology. DH offers a number of significant advantages such as the ability to acquire holograms rapidly, availability of complete amplitude and phase information of the optical field, and versatility of the interferometric and image processing techniques. This article provides a review of the digital holography, with an emphasis on its applications in biomedical microscopy. The quantitative phase microscopy by DH is described including some of the special techniques such as optical phase unwrapping and holography of total internal reflection. Tomographic imaging by digital interference holography (DIH) and related methods is described, as well as its applications in ophthalmic imaging and in biometry. Holographic manipulation and monitoring of cells and cellular components is another exciting new area of research. We discuss some of the current issues, trends, and potentials.

• Proceedings of the KIEE Conference
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• 2008.10b
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• pp.476-477
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• 2008

본 연구에서는 가속도 센서를 이용하여 보행패턴을 검출하고 가속도 센서의 출력 값을 무선으로 PC에 실시간으로 전달할 수 있는 휴대용 모듈을 개발하였다. PC에서는 휴대장치로부터 전송되는 데이터를 수집하여 운동패턴을 화면에 실시간으로 출력할 수 있게 하였다. 휴대 장치의 전력 소모를 최대한 줄이기 위해 무선 전송 부분은 zigbee 통신을 사용하였다. 착용자의 걸음걸이 패턴을 분석하기 위해 2축 가속도 센서를 사용하였으며 기본적인 보행수는 임계치를 사용하는 moving average 알고리즘을 이용하여 마이크로 콘트롤러에서 처리하였다.

• Journal of Biomedical Engineering Research
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• v.13 no.4
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• pp.269-274
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• 1992

In this paper, we describe the design methodology and specifications of the developed module-based bedside monitors for patient monitoring. The bedside monitor consists of a main unit and module cases with various parameter modules. The main unit includes a 12.1" TFT color LCD, a main CPU board, and peripherals such as a module controller, Ethernet LAN card, video card, rotate/push button controller, etc. The main unit can connect at maximum three module cases each of which can accommodate up to 7 parameter modules. They include the modules for electrocardiograph, respiration, invasive blood pressure, noninvasive blood pressure, temperature, and SpO2 with Plethysmograph.raph.

• Proceedings of the Korea Information Processing Society Conference
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• 2015.04a
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• pp.1051-1053
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• 2015

다양한 종류의 생체 신호들을 모니터링하는 연구들이 활발히 진행되면서 이제는 병원이나 전문기관뿐만 아니라 일상 생활 속 에서 사람들이 스마트폰을 이용하여 특별한 제약 없이 편리하게 측정 가능하다. 이러한 스마트폰의 특성을 살리고 그 중 카메라 PPG (Photo-plethysmography) 모듈을 통해 얻은 생체 신호 정보를 분석하여 사용자에게 분석된 정보를 보여줄 수 있다. 또한 얻은 생체 신호로 심박수를 구하고 얻어진 심박수 정보를 활용하여 이를 사용자에게 Hologram으로 보여주는 것을 목표로 한다.