• 대한의용생체공학회:의공학회지
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• 제29권1호
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• pp.40-45
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• 2008

Therapeutic ultrasound which is developed for rehabilitation therapy have already been used for healing joint contracture, synechia, acute and chronic inflammatory diseases. Medical devices for pain-relief and healing using therapeutic ultrasound are actively being developed. This study measured the change of PTT with the transmitted ultrasound through the human body to find out the increase of compliance of blood vessels. Measurement method of PTT in this study is employed as useful ways to acquire physiological information of patients in the clinical case in order to measure the change of mechanical characteristics of blood vessels. This study confirmed the PTT change of rehabilitation patients through the thermal effects of ultrasound by using PTT and also found that it is possible to increase PTT by adjusting the warm water and ultrasound. The increase of PTT means the decrease of the pulse wave velocity from the cardiovascular system to the peripheral arteries. The physiological effects occurred using the warm water and ultrasound.

• 대한의용생체공학회:의공학회지
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• 제40권6호
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• pp.223-229
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• 2019

The number of knee-related disease patients and knee joint surgeries is steadily increasing every year, and for knee rehabilitation training for these knee joint patients, it is necessary to strengthen the muscle of vastus medialis and quadriceps femoris. However, because of the cost and time-consuming difficulties of receiving regular hospital treatment in the course of knee rehabilitation, we developed knee exoskeleton using rapid prototype for knee rehabilitation with feedback from the electromyogram (EMG) and inertia motion unit (IMU) sensor. The modules was built on the basis of EMG and an IMU sensor applied complementary filter, measuring muscle activity in the vastus medialis and the range of joint operation of the knee, and then performing the game based on this measurement. The IMU sensor performed up to 97.2% accuracy in experiments with ten subjects. The functional game contents consisted of an exergaming platform based on EMG and IMU for the real-time monitoring and performance assessment of personalized isometric and isotonic exercises. This study combined EMG and IMU-based functional game with knee rehabilitation training to enable voluntary rehabilitation training by providing immediate feedback to patients through biometric information, thereby enhancing muscle strength efficiency of rehabilitation.

• 대한의용생체공학회:의공학회지
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• 제27권5호
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• pp.250-259
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• 2006

The information of eye movement is used in various fields such as psychology, ophthalmology, physiology, rehabilitation medicine, web design, HMI(human-machine interface), and so on. Various devices to detect the eye movement have been developed but they are too expensive. The general methods of eye movement tracking are EOG(electro-oculograph), Purkinje image tracker, scleral search coil technique, and video-oculograph(VOG). The purpose of this study is to embody the algorithm which tracks the location of the gazing point at a pupil. Two kinds of location data were compared to track the gazing point. One is the reference points(infrared LEDs) which is effected from the globe. Another is the center point of the pupil which is gained with a CCD camera. The reference point was captured with the CCD camera and infrared lights which were not recognized by human eyes. Both of images which were thrown and were not thrown an infrared light on the globe were captured and saved. The reflected reference points were detected with the brightness difference between the two saved images. In conclusion, the circumcenter theory of a triangle was used to look for the center of the pupil. The location of the gazing point was relatively indicated with the each center of the pupil and the reference point.

• Asian-Australasian Journal of Animal Sciences
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• 제31권12호
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• pp.1974-1979
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• 2018

Objective: This study compared fatty acid compositions and antioxidant activities of high-preference cuts (loin, tenderloin, and rib) and low-preference cuts (brisket, topside, and shank) of Hanwoo (Bos taurus coreanae) cows to obtain potentially useful information for promoting the consumption of various low-preference cuts. Methods: Individual 500 g samples of fresh beef were collected from each of the six cuts from 10 Hanwoo cows (quality grade 1) and immediately freeze-dried. The dried samples were evaluated for fatty acid composition, free radical scavenging activities (hydroxyl, alkyl, and 2, 2'-diphenyl-1-picrylhydrazyl [DPPH] radical), and antioxidative enzyme activities (glutathione peroxidase [GPx], glutathione-S-transferase [GST], and superoxide dismutase [SOD]). Results: The percentages of total polyunsaturated fatty acids were significantly higher in low-preference cuts than in high-preference cuts (p<0.05). Hydroxyl, alkyl, and DPPH radical scavenging activities were significantly higher in low-preference cuts than in high-preference cuts (p<0.05). In addition, the activities of antioxidant enzymes, such as GPx, GST, and SOD, were significantly higher in low-preference cuts compared with high-preference cuts (p<0.05). Conclusion: These results may influence consumers to include more low-preference cuts in their selections based on the nutritional facts, which could help to balance the beef market in South Korea.

• 미생물학회지
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• 제55권3호
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• pp.280-282
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• 2019

본 논문에서는 농흉 환자의 흉막액에서분리된 Bifidobacterium dentium ATCC 15424균주의 유전체 염기서열을 분석하여 보고한다. 이 균주의 유전체는 구강에서 분리된 다른 B. dentium 균주에 존재하지 않는 type III 및 IV secretion system proteins, N-acetylmuramoyl-L-alanine amidase 그리고 PRTRC system protein E를 암호화하는 유전자 등 247개의 ATCC 15424균주 특이적인 유전자들을 포함한다. 이 유전체의 서열 정보는 B. dentium의 자연적 변이와 세균 종 내의 유전체 다양성을 이해하는 데 유용할 것이다.

• International Journal of Industrial Entomology and Biomaterials
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• 제45권2호
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• pp.56-69
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• 2022

Silk is a unique natural biopolymer with outstanding biocompatibility, high mechanical strength, and superior optical transparency. Due to its excellent properties, silk has been widely reported as an ideal biomaterial for several biomedical applications. Recently, fluorescent silk protein, a variant of native silk, has been reported as a biophotonic material with the potential for bioimaging and biosensing. Despite the realization of fluorescent silk, the traditional degumming process of fluorescence silk is crude and often results in fluorescence loss. The loss of fluorescent properties is attributed to the sensitivity of silk fibroin to temperature and solvent concentration during degumming. However, there is no comprehensive information on the influence of these processing parameters on fluorescence evolution and decay during fluorescent silk processing. Therefore, we conducted a spectroscopic study on fluorescence decay as a function of temperature, concentration, and duration for fluorescent silk cocoon degumming. Sodium carbonate solution was tested for degumming the fluorescent silk cocoons with different concentrations and temperatures; also, sodium carbonate solution is combined with Alcalase enzyme and triton x-100 to find optimal degumming conditions. Additionally, we conducted a molecular dynamics study to investigate the fundamental effect of temperature on the stability of the fluorescent protein. We observed degumming temperature as the prime source of fluorescent intensity reduction. From the MD study, fluorescence degradation originated from the thermal agitation of fluorescent protein Cα atoms and fluctuations of amino acid residues located in the chromophore region. Overall, degumming fluorescent silk with sodium carbonate and Alcalase enzyme solution at 25 ℃ preserved fluorescence.

• Mycobiology
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• 제50권5호
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• pp.374-381
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• 2022

In the mating of filamentous basidiomycetes, dikaryotic mycelia are generated through the reciprocal movement of nuclei to a monokaryotic cytoplasm where a nucleus of compatible mating type resides, resulting in the establishment of two different dikaryotic strains having the same nuclei but different mitochondria. To better understand the role of mitochondria in mushrooms, we created four sets of dikaryotic strains of Lentinula edodes, including B2×E13 (B2 side) and B2×E13 (E13 side), B5×E13 (B5 side) and B5×E13 (E13 side), E8×H3 (E8 side) and E8×H3 (H3 side), and K3×H3 (K3 side) and K3×H3 (H3 side). The karyotypes and mitochondrial types of the dikaryotic strains were successfully identified by the A mating type markers and the mitochondrial variable length tandem repeat markers, respectively. Comparative analyses of the dikaryotic strains on the mycelial growth, substrate browning, fruiting characteristics, and mitochondrial gene expression revealed that certain mitochondria are more effective in the mycelial growth and the production of fruiting body, possibly through the activated energy metabolism. Our findings indicate that mitochondria affect the physiology of dikaryotic strains having the same nuclear information and therefore a selection strategy aimed at mitochondrial function is needed in the development of new mushroom strain.

• 대한의용생체공학회:의공학회지
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• 제43권4호
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• pp.259-270
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• 2022

Artificial intelligence (AI) has been studied in various fields of medical imaging. Currently, top-notch deep learning (DL) techniques have led to high diagnostic accuracy and fast computation. However, they are rarely used in real clinical practices because of a lack of reliability concerning their results. Most DL models can achieve high performance by extracting features from large volumes of data. However, increasing model complexity and nonlinearity turn such models into black boxes that are seldom accessible, interpretable, and transparent. As a result, scientific interest in the field of explainable artificial intelligence (XAI) is gradually emerging. This study aims to review diverse XAI approaches currently exploited in medical imaging. We identify the concepts of the methods, introduce studies applying them to imaging modalities such as computational tomography (CT), magnetic resonance imaging (MRI), and endoscopy, and lastly discuss limitations and challenges faced by XAI for future studies.

• 대한의용생체공학회:의공학회지
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• 제28권2호
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• pp.287-293
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• 2007

The researchers have studied for a long time about the depth of anesthesia but they don't make criteria for the depth of anesthesia. Anesthetists can't make a prediction about patient's reaction. Therefore, patients have potential risk such as poisonous side effect, late-awake, early-awake and strain reaction. In this study, the distributed characteristics on the bispectrum and bicoherence, the type of nonlinear signal processing, as a result of the coupling of EEG were presented according to depth of anesthesia. These results were consistent with a trend of delta ratio that the index of evaluation for the depth of anesthesia. The higher-order spectrum (HOS), the bispectrum and bicoherence, gives the useful information about depth of anaesthesia than other indexes.

• 한국HCI학회:학술대회논문집
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• 한국HCI학회 2008년도 학술대회 1부
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• pp.499-503
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• 2008

In this paper, a novel human activity recognition method is proposed which utilizes independent components of activity shape information from image sequences and Hidden Markov Model (HMM) for recognition. Activities are represented by feature vectors from Independent Component Analysis (ICA) on video images, and based on these features; recognition is achieved by trained HMMs of activities. Our recognition performance has been compared to the conventional method where Principle Component Analysis (PCA) is typically used to derive activity shape features. Our results show that superior recognition is achieved with our proposed method especially for activities (e.g., skipping) that cannot be easily recognized by the conventional method.