• Biomolecules & Therapeutics
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• 제28권6호
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• pp.527-536
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• 2020

Liver fibrosis constitutes a significant health problem worldwide due to its rapidly increasing prevalence and the absence of specific and effective treatments. Growing evidence suggests that apoptosis-signal regulating kinase 1 (ASK1) is activated in oxidative stress, which causes hepatic inflammation and apoptosis, leading to liver fibrogenesis through a mitogen-activated protein kinase (MAPK) downstream signals. In this study, we investigated whether selonsertib, a selective inhibitor of ASK1, shows therapeutic efficacy for liver fibrosis, and elucidated its mechanism of action in vivo and in vitro. As a result, selonsertib strongly suppressed the growth and proliferation of hepatic stellate cells (HSCs) and induced apoptosis by increasing Annexin V and TUNEL-positive cells. We also observed that selonsertib inhibited the ASK1/MAPK pathway, including p38 and c-Jun N-terminal kinase (JNK) in HSCs. Interestingly, dimethylnitrosamine (DMN)-induced liver fibrosis was significantly alleviated by selonsertib treatment in rats. Furthermore, selonsertib reduced collagen deposition and the expression of extracellular components such as α-smooth muscle actin (α-SMA), fibronectin, and collagen type I in vitro and in vivo. Taken together, selonsertib suppressed fibrotic response such as HSC proliferation and extracellular matrix components by blocking the ASK1/MAPK pathway. Therefore, we suggest that selonsertib may be an effective therapeutic drug for ameliorating liver fibrosis.

• 한국광학회지
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• 제21권1호
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• pp.16-20
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• 2010

본 연구에서는 고 에너지 광자선을 조사 할 때, 선량보강 영영에서의 피부 선량률을 측정을 위해 유기 섬광체와 플라스틱 광섬유를 사용한 광섬유 방사선량계를 제작하였다. 광섬유 방사선량계의 센서부에서 발생된 섬광빛은 30 m 길이의 광섬유를 통해 전달되어 광증배관과 전류계로 측정된다. 광섬유 방사선량계로 측정한 선량보강 영역에서의 피부 선량률은 이온 전리함 및 GAFCHROMIC EBT 필름의 측정 결과와 비교 및 분석 하였다.

• 한국운동역학회지
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• 제26권3호
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• pp.303-308
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• 2016

Objective: This study evaluated the vertical and horizontal forces in the frontal plane acting on a pedal due to the vertical alignment of the lower limbs. Method: Seven male subjects (age: $25.3{\pm} 0.8years$, height: $175.4{\pm}4.7cm$, weight: $74.7{\pm}14.2kg$, foot size: $262.9{\pm}7.6mm$) participated in two 2-minute cycle pedaling tests, with the same load and cadence (60 revolutions per minute) across all subjects. The subject's saddle height was determined by the height when the knee was at $25^{\circ}$ flexion when the pedal crank was at the 6 o'clock position (knee angle method). The horizontal force acting on the pedal, vertical force acting on the pedal in the frontal plane, ratio of the two forces, and knee range of motion in the frontal plane were calculated for four pedaling phases (phase 1: $330{\sim}30^{\circ}$, phase 2: $30{\sim}150^{\circ}$, phase 3: $150{\sim}210^{\circ}$, phase 4: $210{\sim}330^{\circ}$) and the complete pedaling cycle. Results: The range of motion of the knee in the frontal plane was decreased, and the ratio of vertical force to horizontal force and overall pedal force in the complete cycle were increased after vertical alignment. Conclusion: The ratio of vertical force to horizontal force in the frontal plane may be used as an injury prevention index of the lower limb.

• 대한의용생체공학회:의공학회지
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• 제28권2호
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• pp.229-234
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• 2007

Diffuse optical tomography (DOT) is a relatively new medical imaging modality which uses near infrared light to image large-sized tissues noninvasively. We constructed a frequency-domain DOT system to measure the optical properties of optical phantoms and human tissues. The FD-DOT uses the intensity-modulated infrared light source that illuminates the biological tissues. The phase shift and modulation changes at each detector site are separately processed to measure the optical properties. The absorption and scattering coefficients are separately estimated using inverse algorithms.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2008년도 학술대회 논문집 정보 및 제어부문
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• pp.472-473
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• 2008

심실조기수축(PVC: Premature Ventricular Contraction)은 성인에게서 가장 흔하게 발생되는 심장 부정맥 증상 중의 하나이다. 심실조기수축 부정맥이 자주 발현되는 사람의 경우 관상 동맥질환, 고혈압 등의 심혈관계 질환이 진행되고 있을 가능성이 많고, 심실빈맥이나 심실세동으로 전이되는 경우 심정지 등을 유발하여 사망에 이르기 때문에 지속적으로 관찰이 필요한 증상이다. 따라서 본 연구에서는 R-R 간격 정보를 이용하여 심실조기수축 부정맥 증상을 실시간으로 검출할 수 있는 신호처리 알고리즘을 구현하고자 하였다.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2006년도 제37회 하계학술대회 논문집 D
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• pp.2157-2158
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• 2006

Heart Rate Variability (HRV) system is useful for evaluating the balance in homeostasis of autonomic nervous system. In this study, we implement HRV monitoring system by performing real time FFT spectrum analysis on R-R intervals data acquired from Electrocardiogram (ECG) acquisition and transmitting the data by RF communication module.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1995년도 춘계학술대회
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• pp.259-261
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• 1995

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1993년도 춘계학술대회
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• pp.54-56
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• 1993

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1996년도 추계학술대회
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• pp.107-110
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• 1996

We proposed a new system for the postural balance rehabilitation training. For the purpose, we used the virtual hiking system using virtual reality technology. We evaluated the system by measuring the parameters such as path deviation, path deviation velocity, cycling time, and head movement. From our results, we verified the usefulness of virtual reality technology in rehabilitation. Our results showed that this system was effective postural balance rehabilitation training device and might be useful as the clinical equipment.

• 대한의용생체공학회:의공학회지
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• 제43권4호
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• pp.251-258
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• 2022

Silk fibroin microparticles were fabricated using a phase separation technique between silk fibroin solution and polyvinyl alcohol. We found that the concentration of polyvinyl alcohol determines the size of microparticles. The mean diameter of the silk fibroin microparticles varied from 3.48 ㎛ to 4.05 ㎛. The silk fibroin microparticle size increased as a function of the concentration of PVA in aqueous silk solution. The resulting silk fibroin microparticles have narrow size distribution (i.e. monodisperse) and smooth/spherical surface. Also, we studied the effects of mouse serum, sodium phosphate buffer (PBS), and pH on the stability of the silk fibroin microparticles. Overall, we demonstrated the simple method to fabricate and to control the silk fibroin microparticles that makes our silk microparticles to be usable for a potential drug delivery carrier.